Published in Science on February 17, 1978
The actions of tubocurarine at the frog neuromuscular junction. J Physiol (1979) 3.69
Nickel and calcium ions modify the characteristics of the acetylcholine receptor-channel complex at the frog neuromuscular junction. J Physiol (1980) 1.22
The effect of (+)-tubocurarine on neuromuscular transmission during repetitive stimulation in the rat, mouse, and frog. J Physiol (1981) 1.19
Triphenylmethylphosphonium is an ion channel ligand of the nicotinic acetylcholine receptor. Proc Natl Acad Sci U S A (1982) 0.99
[3H]Phencyclidine: a probe for the ionic channel of the nicotinic receptor. Proc Natl Acad Sci U S A (1980) 0.94
Tetraethylammonium: voltage-dependent action on endplate conductance and inhibition of ligand binding to postsynaptic proteins. Proc Natl Acad Sci U S A (1979) 0.89
Current-dependent block of endplate channels by guanidine derivatives. J Gen Physiol (1984) 0.75
C. elegans CED-12 acts in the conserved crkII/DOCK180/Rac pathway to control cell migration and cell corpse engulfment. Dev Cell (2001) 3.39
Fast and slow mammalian muscles after denervation. Exp Neurol (1970) 2.83
International Union of Pharmacology. XX. Current status of the nomenclature for nicotinic acetylcholine receptors and their subunits. Pharmacol Rev (1999) 2.76
The brain metabolite kynurenic acid inhibits alpha7 nicotinic receptor activity and increases non-alpha7 nicotinic receptor expression: physiopathological implications. J Neurosci (2001) 2.61
Environmental risk factors and Parkinson's disease: a case-control study in Taiwan. Neurology (1997) 2.61
A comparative study of membrane properties of innervated and chronically denervated fast and slow skeletal muscles of the rat. Acta Physiol Scand (1968) 2.42
Choline is a selective agonist of alpha7 nicotinic acetylcholine receptors in the rat brain neurons. Eur J Neurosci (1997) 2.18
Diversity of nicotinic acetylcholine receptors in rat hippocampal neurons. I. Pharmacological and functional evidence for distinct structural subtypes. J Pharmacol Exp Ther (1993) 2.13
Batrachotoxin: chemistry and pharmacology. Science (1971) 2.09
Common mechanism of toxicity: a case study of organophosphorus pesticides. Toxicol Sci (1998) 2.08
Human bronchial epithelial and endothelial cells express alpha7 nicotinic acetylcholine receptors. Mol Pharmacol (2001) 1.89
Acetylcholine receptor and ion conductance modulator sites at the murine neuromuscular junction: evidence from specific toxin reactions. Proc Natl Acad Sci U S A (1973) 1.82
Choline and selective antagonists identify two subtypes of nicotinic acetylcholine receptors that modulate GABA release from CA1 interneurons in rat hippocampal slices. J Neurosci (1999) 1.80
Clinical experiences of infectious scleral ulceration: a complication of pterygium operation. Br J Ophthalmol (1997) 1.68
Neuronal nicotinic acetylcholine receptor activation modulates gamma-aminobutyric acid release from CA1 neurons of rat hippocampal slices. J Pharmacol Exp Ther (1997) 1.67
Nicotinic acetylcholine receptor alpha7 and alpha4beta2 subtypes differentially control GABAergic input to CA1 neurons in rat hippocampus. J Neurophysiol (2001) 1.57
Human and rodent bronchial epithelial cells express functional nicotinic acetylcholine receptors. Mol Pharmacol (1998) 1.56
Perhydrohistrionicotoxin: a potential ligand for the ion conductance modulator of the acetylcholine receptor. Proc Natl Acad Sci U S A (1977) 1.55
alpha-bungarotoxin- and methyllycaconitine-sensitive nicotinic receptors mediate fast synaptic transmission in interneurons of rat hippocampal slices. Brain Res (1998) 1.55
Reaction of tetraethylammonium with the open and closed conformations of the acetylcholine receptor ionic channel complex. J Gen Physiol (1979) 1.54
alpha-Bungarotoxin-sensitive hippocampal nicotinic receptor channel has a high calcium permeability. Biophys J (1995) 1.53
Purification and molecular properties of the acetylcholine receptor from Torpedo electroplax. Arch Biochem Biophys (1973) 1.51
Effect of histrionicotoxin on the ionic conductance modulator of the cholinergic receptor: a quantitative analysis of the end-plate current. J Pharmacol Exp Ther (1974) 1.51
Blockade of nicotinic currents in hippocampal neurons defines methyllycaconitine as a potent and specific receptor antagonist. Mol Pharmacol (1992) 1.50
Levels of batrachotoxin and lack of sensitivity to its action in poison-dart frogs (Phyllobates). Science (1980) 1.46
Kinetic analysis of end plate currents altered by atropine and scopolamine. Mol Pharmacol (1978) 1.45
Human vascular endothelial cells express functional nicotinic acetylcholine receptors. J Pharmacol Exp Ther (1998) 1.45
Nicotinic receptor activation in human cerebral cortical interneurons: a mechanism for inhibition and disinhibition of neuronal networks. J Neurosci (2000) 1.45
Elevated levels of anticardiolipin antibodies and epilepsy in lupus patients. Lupus (1996) 1.44
A study of the reinnervation of fast and slow mammalian muscles. J Gen Physiol (1973) 1.44
A study of the irreversible cholinesterase inhibitor, diisopropylfluorophosphate, on time course of end-plate currents in frog sartorius muscle. J Pharmacol Exp Ther (1974) 1.43
Effects of batrachotoxin on membrane potential and conductance of squid giant axons. J Gen Physiol (1971) 1.41
Effects of vinblastine and colchicine on neural regulation of the fast and slow skeletal muscles of the rat. Exp Neurol (1972) 1.40
Choline and acetylcholine have similar kinetic properties of activation and desensitization on the alpha7 nicotinic receptors in rat hippocampal neurons. Brain Res (2000) 1.37
A nicotinic acetylcholine receptor regulating cell adhesion and motility is expressed in human keratinocytes. J Invest Dermatol (1995) 1.35
Early membrane depolarization of the fast mammalian muscle after denervation. Pflugers Arch (1971) 1.28
Activation, inactivation, and desensitization of acetylcholine receptor channel complex detected by binding of perhydrohistrionicotoxin. Proc Natl Acad Sci U S A (1980) 1.28
Studies on the nature of the cholinergic receptor. Eur J Pharmacol (1968) 1.27
An electrophysiological and morphological study of the neuromuscular junction in patients with myasthenia gravis. Exp Neurol (1976) 1.26
Binding of perhydro-histrionicotoxin to the postsynaptic membrane of skeletal muscle in relation to its blockage of acetylcholine-induced depolarization. Mol Pharmacol (1977) 1.24
The pharmacology of batrachotoxin. II. Effect on electrical properties of the mammalian nerve and skeletal muscle membranes. J Pharmacol Exp Ther (1971) 1.23
A possible involvement of cyclic AMP in the expression of desensitization of the nicotinic acetylcholine receptor. A study with forskolin and its analogs. FEBS Lett (1986) 1.23
Emergency medical technicians' disaster training by tabletop exercise. Am J Emerg Med (2001) 1.20
A muscarone-binding material in electroplax and its relation to the acetylcholine receptor. II. Dialysis assay. Proc Natl Acad Sci U S A (1970) 1.19
The density of acetylcholine receptors and their sensitivity in the postsynaptic membrane of muscle endplates. Proc Natl Acad Sci U S A (1974) 1.19
Differential effects of perhydrohistrionicotoxin on neurally and iontophoretically evoked endplate currents. Proc Natl Acad Sci U S A (1978) 1.17
Diisopropylfluorophosphate: suppression of ionic conductance of the cholinergic receptor. Science (1973) 1.17
Effects of histrionicotoxin on the chemosensitive and electrical properties of skeletal muscle. Exp Neurol (1975) 1.15
Nicotine at concentrations found in cigarette smokers activates and desensitizes nicotinic acetylcholine receptors in CA1 interneurons of rat hippocampus. Neuropharmacology (2000) 1.14
An electrophysiological study of the effects of D-tubocurarine, atropine, and alpha-bungarotoxin on the cholinergic receptor in innervated and chronically denervated mammalian skeletal muscles. Exp Neurol (1974) 1.14
An analysis of the action of atropine and scopolamine on the end-plate current of frog sartorius muscle. J Pharmacol Exp Ther (1976) 1.12
Tryptophan and cystein residues of the acetylcholine receptors of Torpedo species. Relationship to binding of cholinergic ligands. Biochemistry (1975) 1.12
Interaction between calcium and ligand-binding sites of the purified acetylcholine receptor studied by use of a fluorescent lanthanide. Biochem Biophys Res Commun (1976) 1.12
Influence of phospholipase C on some electrical properties of the skeletal muscle membrane. J Physiol (1967) 1.11
Structure and synthesis of a potent glutamate receptor antagonist in wasp venom. Proc Natl Acad Sci U S A (1988) 1.11
Allosteric modulation of nicotinic acetylcholine receptors as a treatment strategy for Alzheimer's disease. Eur J Pharmacol (2000) 1.11
Voltage- and time-dependent action of histrionicotoxin on the endplate current of the frog muscle. J Gen Physiol (1978) 1.11
Phencyclidine interactions with the ionic channel of the acetylcholine receptor and electrogenic membrane. Proc Natl Acad Sci U S A (1980) 1.11
Characterization of batrachotoxin-induced depolarization of the squid giant axons. J Pharmacol Exp Ther (1973) 1.11
Allosteric sensitization of nicotinic receptors by galantamine, a new treatment strategy for Alzheimer's disease. Biol Psychiatry (2001) 1.10
Agonist responses of neuronal nicotinic acetylcholine receptors are potentiated by a novel class of allosterically acting ligands. Mol Pharmacol (1996) 1.10
A survey of emergency medicine in 36 countries. CJEM (2001) 1.09
Sites of action of phencyclidine. II. Interaction with the ionic channel of the nicotinic receptor. Mol Pharmacol (1980) 1.09
Effects of nano-SiO(2) and different ash particle sizes on sludge ash-cement mortar. J Environ Manage (2007) 1.08
Morphological and electrophysiological study of distal motor nerve fiber degeneration and sprouting after irreversible cholinesterase inhibition. Synapse (1991) 1.08
Mechanism of action of amantadine on neuromuscular transmission. Mol Pharmacol (1978) 1.08
Selective blockade of NMDA-activated channel currents may be implicated in learning deficits caused by lead. FEBS Lett (1990) 1.07
Receptors for gamma-aminobutyric acid and voltage-dependent chloride channels as targets for drugs and toxicants. FASEB J (1987) 1.07
Binding of muscarone by extracts of housefly brain: relationship to receptors for acetylcholine. J Neurochem (1970) 1.07
Using MTT viability assay to test the cytotoxicity of antibiotics and steroid to cultured porcine corneal endothelial cells. J Ocul Pharmacol Ther (1996) 1.06
Chlorpyrifos, parathion, and their oxons bind to and desensitize a nicotinic acetylcholine receptor: relevance to their toxicities. Toxicol Appl Pharmacol (1997) 1.06
The behavioral effects of phencyclidines may be due to their blockade of potassium channels. Proc Natl Acad Sci U S A (1981) 1.06
Isolation of acetylcholine receptors. Annu Rev Pharmacol (1972) 1.05
Effects of normal and myasthenic serum factors on innervated and chronically denervated mammalian muscles. Ann N Y Acad Sci (1976) 1.04
Acetylcholine binding to Torpedo electroplax: relationship to acetylcholine receptors. Science (1971) 1.03
Strychnine: a potent competitive antagonist of alpha-bungarotoxin-sensitive nicotinic acetylcholine receptors in rat hippocampal neurons. J Pharmacol Exp Ther (1998) 1.03
Effects of batrachotoxin on nerve membrane potential and conductances. Nat New Biol (1971) 1.03