Published in N Engl J Med on July 10, 1980
Effect of High Levels of Oxygen and Smoking on the Lungs in Human Volunteers | NCT00001464
Oxygen free radicals in ischemic acute renal failure in the rat. J Clin Invest (1984) 2.88
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Effect of oxygen on the lungs after blast injury and burns. J Clin Pathol (1981) 1.46
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Maturational differences in lung NF-kappaB activation and their role in tolerance to hyperoxia. J Clin Invest (2004) 1.35
Genetic basis of murine responses to hyperoxia-induced lung injury. Immunogenetics (2006) 1.13
Association of p53 and WAF1 expression with apoptosis in diffuse alveolar damage. Am J Pathol (1996) 1.11
Febrile-range hyperthermia augments pulmonary neutrophil recruitment and amplifies pulmonary oxygen toxicity. Am J Pathol (2003) 1.10
The potential role of BAX and BCL-2 expression in diffuse alveolar damage. Am J Pathol (1997) 1.07
Lung cell oxidant injury. Enhancement of polymorphonuclear leukocyte-mediated cytotoxicity in lung cells exposed to sustained in vitro hyperoxia. J Clin Invest (1982) 1.06
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Hyperoxia potentiates Ureaplasma urealyticum pneumonia in newborn mice. Infect Immun (1990) 0.97
Alveolar macrophage procoagulant activity is increased in acute hyperoxic lung injury. Am J Pathol (1988) 0.90
Sheep lung cytochrome P4501A1 (CYP1A1): cDNA cloning and transcriptional regulation by oxygen tension. J Clin Invest (1995) 0.89
Sequelae of the adult respiratory distress syndrome. Thorax (1994) 0.88
Smoking is a factor in causing acute chest syndrome in sickle cell anemia. J Natl Med Assoc (1992) 0.86
Excessive mechanical stress increases HMGB1 expression in human lung microvascular endothelial cells via STAT3. Microvasc Res (2013) 0.85
Immunohistochemical quantitation of collagen types I, II, IV and V in the ventilated and non-ventilated rabbit middle ear with otitis media with effusion. Eur Arch Otorhinolaryngol (1994) 0.84
Inhibition of the phospholipase A2 activity of peroxiredoxin 6 prevents lung damage with exposure to hyperoxia. Redox Biol (2015) 0.84
Decreased neutrophil apoptosis in tracheal fluids of preterm infants at risk of chronic lung disease. Arch Dis Child Fetal Neonatal Ed (2003) 0.82
Attenuation of oxidant-induced lung injury by 21-aminosteroids (lazaroids): correlation with the mRNA expression for E-selectin, P-selectin, ICAM-1, and VCAM-1. Environ Health Perspect (1994) 0.79
Oxidative/Nitrosative stress and the pathobiology of chronic obstructive pulmonary disease. J Clin Diagn Res (2013) 0.79
Effects of long-term low-dose oxygen supplementation on the epithelial function, collagen metabolism and interstitial fibrogenesis in the guinea pig lung. Respir Res (2008) 0.78
Supplemental postoperative oxygen in the prevention of surgical wound infection after lower limb vascular surgery: a randomized controlled trial. World J Surg (2011) 0.77
Histologic evaluation of normobaric oxygen therapy safety in an animal model. Jundishapur J Nat Pharm Prod (2012) 0.76
Occult mineral oil pneumonitis in anorexia nervosa. West J Med (1988) 0.75
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Use of Saliva Biomarkers to Monitor Efficacy of Vitamin C in Exercise-Induced Oxidative Stress. Antioxidants (Basel) (2017) 0.75
Application of normobaric hyperoxygenation to an ischemic flap and a composite skin graft. Plast Reconstr Surg Glob Open (2014) 0.75
Intravenous high mobility group box 1 upregulates the expression of HIF‑1α in the myocardium via a protein kinase B-dependent pathway in rats following acute myocardial ischemia. Mol Med Rep (2015) 0.75
A brief review of the adult respiratory distress syndrome. J Natl Med Assoc (1982) 0.75
Reactive oxygen species in cell signaling. Am J Physiol Lung Cell Mol Physiol (2000) 6.49
Activation of the JAK-STAT pathway by reactive oxygen species. Am J Physiol (1998) 2.37
Regulation of cellular glutathione. Am J Physiol (1989) 2.26
Activation of an H2O2-generating NADH oxidase in human lung fibroblasts by transforming growth factor beta 1. J Biol Chem (1995) 2.13
Regulation of STAT3 by direct binding to the Rac1 GTPase. Science (2000) 1.77
Interaction of oxygen and oxy-radicals with carotenoids. J Natl Cancer Inst (1982) 1.49
Mechanical properties of rat cardiac muscle during experimental hypertrophy. Circ Res (1971) 1.48
Involvement of cell surface heparin sulfate in the binding of lipoprotein lipase to cultured bovine endothelial cells. J Clin Invest (1981) 1.38
Increased angiotensin-converting enzyme in peripheral blood monocytes from patients with sarcoidosis. J Clin Invest (1985) 1.38
Elevated serum angiotensin I converting enzyme in sarcoidosis. Am Rev Respir Dis (1976) 1.36
Dual effect of serotonin on growth of bovine pulmonary artery smooth muscle cells in culture. Circ Res (1991) 1.34
Serotonin stimulates mitogen-activated protein kinase activity through the formation of superoxide anion. Am J Physiol (1999) 1.22
Experimental cardiac hypertrophy. N Engl J Med (1970) 1.21
Regulation of endothelial cell xanthine dehydrogenase xanthine oxidase gene expression by oxygen tension. Am J Physiol (1994) 1.10
Serotonin produces both hyperplasia and hypertrophy of bovine pulmonary artery smooth muscle cells in culture. Am J Physiol (1994) 1.10
Transforming growth factor-beta 1-induced activation of the ERK pathway/activator protein-1 in human lung fibroblasts requires the autocrine induction of basic fibroblast growth factor. J Biol Chem (2000) 1.10
Endothelin 1: mitogenic activity on pulmonary artery smooth muscle cells and release from hypoxic endothelial cells. Proc Soc Exp Biol Med (1992) 1.08
Superoxide as an intermediate signal for serotonin-induced mitogenesis. Free Radic Biol Med (1998) 1.07
Coexistence of mucinous cystadenoma of the ovary and ovarian sarcoidosis. Am J Obstet Gynecol (1990) 1.05
Serotonin uptake by bovine pulmonary artery endothelial cells in culture. II. Stimulation by hypoxia. Am J Physiol (1986) 1.04
Pneumocystis carinii and cytomegalovirus pneumonia in a previously healthy adult. Am Rev Respir Dis (1982) 1.03
Ras-dependent and -independent regulation of reactive oxygen species by mitogenic growth factors and TGF-beta1. FASEB J (2000) 1.02
Glycolytic activity and enhancement of serotonin uptake by endothelial cells exposed to hypoxia/anoxia. Circ Res (1987) 1.02
Effects of hypoxia and hyperoxia on proteoglycan production by bovine pulmonary artery endothelial cells. J Cell Physiol (1986) 1.00
H(2)O(2) signals 5-HT-induced ERK MAP kinase activation and mitogenesis of smooth muscle cells. Am J Physiol Lung Cell Mol Physiol (2001) 1.00
Oxidative protein cross-linking reactions involving L-tyrosine in transforming growth factor-beta1-stimulated fibroblasts. J Biol Chem (2001) 1.00
Membrane-bound angiotensin-converting enzyme from rat lung. J Biol Chem (1974) 0.99
Tyrosine phosphorylation regulates H2O2 production in lung fibroblasts stimulated by transforming growth factor beta1. J Biol Chem (1998) 0.99
Angiotensin-converting enzyme from human tissues. Physicochemical, catalytic, and immunological properties. J Biol Chem (1985) 0.98
Endothelial cell damage after gamma-irradiation in vitro: impaired uptake of alpha-aminoisobutyric acid. Am Rev Respir Dis (1982) 0.97
Regulation of PDGF production and ERK activation by estrogen is associated with TSC2 gene expression. Am J Physiol Cell Physiol (2003) 0.95
Angiotensin I converting enzyme from human plasma. Biochemistry (1977) 0.95
Dexfenfluramine as a mitogen signal via the formation of superoxide anion. FASEB J (2001) 0.95
Upregulated expression of fibroblast growth factor (FGF) receptors by transforming growth factor-beta1 (TGF-beta1) mediates enhanced mitogenic responses to FGFs in cultured human lung fibroblasts. Biochem Biophys Res Commun (1998) 0.95
TGF-beta 1 produces a "prooxidant" effect on bovine pulmonary artery endothelial cells in culture. Am J Physiol (1991) 0.92
Prostaglandins and the lung. Am Rev Respir Dis (1973) 0.91
Serotonin uptake by bovine pulmonary artery endothelial cells in culture. I. Characterization. Am J Physiol (1986) 0.91
Calcium transport in isolated sarcoplasmic reticulum during muscle maturation. Nature (1968) 0.91
Angiotensin I-converting enzyme localization on cultured fibroblasts by immunofluorescence. In Vitro (1982) 0.90
Labeling of RNA in the perfused heart: the problem of bacterial contamination. Biochim Biophys Acta (1969) 0.89
Elevation of glutathione levels in bovine pulmonary artery endothelial cells by N-acetylcysteine. Am J Respir Cell Mol Biol (1992) 0.89
Increase in endothelial cell glutathione and precursor amino acid uptake by diethyl maleate and hyperoxia. Am J Physiol (1989) 0.89
Immunochemical comparison of angiotensin 1 converting enzymes from different rat organs. Int J Biochem (1979) 0.89
Myocardial glutathione depletion impairs recovery after short periods of ischemia. Circulation (1989) 0.88
Chloride efflux in cyclic AMP-induced configurational change of bovine pulmonary artery endothelial cells. Circ Res (1990) 0.87
The effect of lathyrogen beta-amino proprionitrile (BAPN) on the mechanical properties of experimentally hypertrophied rat cardiac muscle. Circ Res (1978) 0.87
Familial elevation of serum angiotensin converting enzyme. Q J Med (1985) 0.87
Enhanced rate of H2O2 release from bovine pulmonary artery endothelial cells induced by TGF-beta 1. Am J Physiol (1993) 0.86
Serotonin uptake and configurational change of bovine pulmonary artery smooth muscle cells in culture. J Cell Physiol (1989) 0.86
Ribonucleic acid synthesis in experimental cardiac hypertrophy in rats. I. Characterization and kinetics of labeling. Circ Res (1968) 0.86
Association of Tyr phosphorylation of GTPase-activating protein with mitogenic action of serotonin. Am J Physiol (1997) 0.86
Drug therapy reviews: treatment of sarcoidosis. Am J Hosp Pharm (1979) 0.85
Regulation of serotonin-induced DNA synthesis of bovine pulmonary artery smooth muscle cells. Am J Physiol (1994) 0.85
The effect of oxygen tension on the in vitro production and release of angiotensin-converting enzyme by bovine pulmonary artery endothelial cells. Am Rev Respir Dis (1984) 0.85
Stimulation of bovine pulmonary artery endothelial cell ACE by dexamethasone: involvement of steroid receptors. Am J Physiol (1992) 0.85
Influence of exogenously generated oxidant species on myocardial function. Am J Physiol (1986) 0.85
Development of competitive enzyme immunoassays for human serum angiotensin-1-converting enzyme: a comparison of four assay configurations. Anal Biochem (1982) 0.84
Bleomycin upregulates gene expression of angiotensin-converting enzyme via mitogen-activated protein kinase and early growth response 1 transcription factor. Am J Respir Cell Mol Biol (2001) 0.84
Angiotensin-converting enzyme in bronchoalveolar lining fluid. Lancet (1979) 0.84
Transient depletion of lung glutathione by diethylmaleate enhances oxygen toxicity. J Appl Physiol (1985) (1985) 0.84
Acutely administered melatonin reduces oxidative damage in lung and brain induced by hyperbaric oxygen. J Appl Physiol (1985) (1997) 0.84
Potentiation of oxygen toxicity in rats by dietary protein or amino acid deficiency. J Appl Physiol Respir Environ Exerc Physiol (1983) 0.83
Ribonucleic acid synthesis in experimental cardiac hypertrophy in rats. II. Aspects of regulation. Circ Res (1968) 0.83
Effect of hyperoxia on glutathione levels and glutamic acid uptake in endothelial cells. J Appl Physiol (1985) (1987) 0.83
Reduction of glutathione is associated with growth restriction and enlargement of bovine pulmonary artery endothelial cells produced by transforming growth factor-beta 1. Am J Respir Cell Mol Biol (1992) 0.82
Transglutaminase 2-mediated serotonylation in pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol (2013) 0.82
Angiotensin-1-converting enzyme (ACE) activity in human serum following plasma exchange. Proc Soc Exp Biol Med (1983) 0.82
Oxygen toxicity of the lung: an update. Br J Anaesth (1982) 0.82
Enhancement by disulfiram (Antabuse) of toxic effects of 95 to 97% O2 on the rat lung. J Pharmacol Exp Ther (1979) 0.82
Phospholipase D signaling in serotonin-induced mitogenesis of pulmonary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol (2008) 0.81
Involvement of glutathione enzymes in O2 tolerance development by diethyldithiocarbamate. Biochem Pharmacol (1980) 0.81
Angiotensin-1-converting enzyme activity in the spontaneously hypertensive rat. Proc Soc Exp Biol Med (1980) 0.81
Elevation of bovine endothelial cell angiotensin converting enzyme by cationophores and inhibition by ouabain. Biochim Biophys Acta (1990) 0.81
Calcium transport by skeletal muscle sarcoplasmic reticulum in the hypothyroid rat. J Clin Invest (1969) 0.81
Serotonin produces a configurational change of cultured smooth muscle cells that is associated with elevation of intracellular cAMP. J Cell Physiol (1992) 0.81
Elevation of angiotensin converting enzyme by 3-isobutyl-1-methylxanthine in cultured endothelial cells: a possible role for calmodulin. J Cell Physiol (1988) 0.80
Mechanism of basal and transforming growth factor beta 1 stimulated H2O2 release by endothelial cells. Trans Assoc Am Physicians (1993) 0.80
Stimulation of bovine endothelial cell angiotensin-I-converting enzyme activity by cyclic AMP-related agents. J Cell Physiol (1986) 0.80
Conversion of angiotensin 1 to angiotensin 2 in the isolated perfused dog lung. J Appl Physiol (1973) 0.80
Lung angiotensin converting enzyme activity in rats with differing susceptibilities to chronic hypoxia. Thorax (1988) 0.80
Prostaglandins E1 and E2 stimulate the proliferation of pulmonary artery smooth muscle cells. Prostaglandins (1992) 0.80
Hormonal influence on endothelial cell angiotensin-converting enzyme activity. Am J Physiol (1984) 0.79
Regulation of Cu,Zn-superoxide dismutase in bovine pulmonary artery endothelial cells. J Cell Physiol (1992) 0.79
Angiotensin-1-converting enzyme activity of murine macrophages isolated from granulomas elicited by eggs of Schistosoma mansoni. Infect Immun (1983) 0.79
Cu,Zn superoxide dismutase in vascular cells: changes during cell cycling and exposure to hyperoxia. Am J Physiol (1993) 0.79
Modulation of transforming growth factor-beta 1 antiproliferative effects on endothelial cells by cysteine, cystine, and N-acetylcysteine. J Clin Invest (1992) 0.79
Effect of bleomycin on collagenolytic activity of the rat alveolar macrophage. Am Rev Respir Dis (1980) 0.79
Pyrimidine nucleotide synthesis in the normal and hypertrophying rat heart. Relative importance of the de novo and "salvage" pathways. Circ Res (1970) 0.79
Protein deficiency potentiates oxygen toxicity. Exp Lung Res (1988) 0.79
Elevation of angiotensin converting enzyme in bovine endothelial cells quantitated by an ELISA. Life Sci (1990) 0.79
Plasma antioxidants in subjects before hematopoietic stem cell transplantation. Bone Marrow Transplant (2006) 0.78
Endothelial cell inhibition of hypoxia-induced stimulation of serotonin uptake by vascular smooth muscle cells. Am Rev Respir Dis (1989) 0.78
A noninducible cystine transport system in rat alveolar type II cells. Am J Physiol (1995) 0.78