Published in Biochemistry on June 23, 1981
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A specificity-enhancing factor for the ClpXP degradation machine. Science (2000) 3.31
Combinatorial cassette mutagenesis as a probe of the informational content of protein sequences. Science (1988) 3.13
DNA recognition by beta-sheets in the Arc repressor-operator crystal structure. Nature (1994) 3.07
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The N-terminal arms of lambda repressor wrap around the operator DNA. Nature (1982) 2.90
Alternative packing arrangements in the hydrophobic core of lambda repressor. Nature (1989) 2.89
The role of internal packing interactions in determining the structure and stability of a protein. J Mol Biol (1991) 2.83
Regulatory functions of the lambda repressor reside in the amino-terminal domain. Nature (1979) 2.77
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Overlapping recognition determinants within the ssrA degradation tag allow modulation of proteolysis. Proc Natl Acad Sci U S A (2001) 2.59
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The complete amino acid sequence of ubiquitin, an adenylate cyclase stimulating polypeptide probably universal in living cells. Biochemistry (1975) 2.51
Mouse prepro-epidermal growth factor synthesis by the kidney and other tissues. Nature (1985) 2.49
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Equilibrium dissociation and unfolding of the Arc repressor dimer. Biochemistry (1989) 2.27
Changing the DNA-binding specificity of a repressor. Cell (1983) 2.24
Generation of enhancer trap lines in Arabidopsis and characterization of expression patterns in the inflorescence. Plant J (1999) 2.24
Molecular determinants of complex formation between Clp/Hsp100 ATPases and the ClpP peptidase. Nat Struct Biol (2001) 2.18
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Lambda repressor mutations that increase the affinity and specificity of operator binding. Cell (1985) 2.12
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Cleavage of the lambda and P22 repressors by recA protein. J Biol Chem (1982) 1.97
Amino-acid sequence of substance P. Nat New Biol (1971) 1.96
Effects of protein stability and structure on substrate processing by the ClpXP unfolding and degradation machine. EMBO J (2001) 1.95
Carboxy-terminal determinants of intracellular protein degradation. Genes Dev (1990) 1.95
Identifying determinants of folding and activity for a protein of unknown structure. Proc Natl Acad Sci U S A (1989) 1.93
Induction of a heat shock-like response by unfolded protein in Escherichia coli: dependence on protein level not protein degradation. Genes Dev (1989) 1.92
Isolation and chemical properties of porcine parathyroid hormone. Biochemistry (1971) 1.92
Two structurally distinct classes of kappa-chains in human immunoglobulins. Nature (1967) 1.90
Optimizing the stability of single-chain proteins by linker length and composition mutagenesis. Proc Natl Acad Sci U S A (1998) 1.87
Diverse effects of mutations in the signal sequence on the secretion of beta-lactamase in Salmonella typhimurium. Cell (1982) 1.86
Structural and energetic consequences of disruptive mutations in a protein core. Biochemistry (1992) 1.85
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Single amino acid substitutions uncouple the DNA binding and strand scission activities of Fok I endonuclease. Proc Natl Acad Sci U S A (1993) 1.77
Bacteriophage lambda cro mutations: effects on activity and intracellular degradation. Proc Natl Acad Sci U S A (1986) 1.77
The amino acid sequence of bovine parathyroid hormone I. Hoppe Seylers Z Physiol Chem (1970) 1.75
Identification of endogenous SsrA-tagged proteins reveals tagging at positions corresponding to stop codons. J Biol Chem (2001) 1.72
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Protein stability effects of a complete set of alanine substitutions in Arc repressor. Nat Struct Biol (1994) 1.71
Reverse hydrophobic effects relieved by amino-acid substitutions at a protein surface. Nature (1990) 1.70
P22 Arc repressor: folding kinetics of a single-domain, dimeric protein. Biochemistry (1994) 1.70
Simultaneous and functional binding of SmpB and EF-Tu-TP to the alanyl acceptor arm of tmRNA. J Mol Biol (2001) 1.68
Automated Edman degradation: the protein sequenator. Methods Enzymol (1973) 1.68
Regulation of high affinity nickel uptake in bacteria. Ni2+-Dependent interaction of NikR with wild-type and mutant operator sites. J Biol Chem (2000) 1.66
Bovine parathyroid hormone: minimum chain length of synthetic peptide required for biological activity. Endocrinology (1973) 1.65
Mutations defining the operator-binding sites of bacteriophage lambda repressor. Cold Spring Harb Symp Quant Biol (1983) 1.64
The DegP and DegQ periplasmic endoproteases of Escherichia coli: specificity for cleavage sites and substrate conformation. J Bacteriol (1996) 1.62
Primary structure of the phage P22 repressor and its gene c2. Biochemistry (1981) 1.61
Folded proteins occur frequently in libraries of random amino acid sequences. Proc Natl Acad Sci U S A (1994) 1.59
Sequence determinants of C-terminal substrate recognition by the Tsp protease. J Biol Chem (1996) 1.59
Bacteriophage P22 Mnt repressor. DNA binding and effects on transcription in vitro. J Mol Biol (1987) 1.59
Structure of two human ovarian inhibins. Biochem Biophys Res Commun (1986) 1.57
Barriers to protein folding: formation of buried polar interactions is a slow step in acquisition of structure. Proc Natl Acad Sci U S A (1996) 1.57
Protein factors associated with the SsrA.SmpB tagging and ribosome rescue complex. Proc Natl Acad Sci U S A (2001) 1.57
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The bacteriophage P22 arc and mnt repressors. Overproduction, purification, and properties. J Biol Chem (1985) 1.51
Structural analysis of human proparathyroid hormone by a new microsequencing approach. Nature (1974) 1.50
Synthesis of a biologically active N-terminal tetratriacontapeptide of parathyroid hormone. Proc Natl Acad Sci U S A (1971) 1.50
The crystal structure of a mutant protein with altered but improved hydrophobic core packing. Proc Natl Acad Sci U S A (1994) 1.48
Lon and Clp family proteases and chaperones share homologous substrate-recognition domains. Proc Natl Acad Sci U S A (1999) 1.48
Probing the roles of residues at the e and g positions of the GCN4 leucine zipper by combinatorial mutagenesis. Protein Sci (1993) 1.46
Characterization of degQ and degS, Escherichia coli genes encoding homologs of the DegP protease. J Bacteriol (1996) 1.46
NikR is a ribbon-helix-helix DNA-binding protein. Protein Sci (1999) 1.45
P22 Arc repressor: enhanced expression of unstable mutants by addition of polar C-terminal sequences. Protein Sci (1993) 1.45
Deletion of the prc (tsp) gene provides evidence for additional tail-specific proteolytic activity in Escherichia coli K-12. Mol Gen Genet (1994) 1.43
Lambda repressor inactivation: properties of purified ind- proteins in the autodigestion and RecA-mediated cleavage reactions. J Mol Biol (1986) 1.43
Differential DNA-binding specificity of the engrailed homeodomain: the role of residue 50. Biochemistry (1994) 1.42
Evolution of a protein fold in vitro. Science (1999) 1.42
Identification of C-terminal extensions that protect proteins from intracellular proteolysis. J Biol Chem (1989) 1.42
Radioimmunoassay for substance P. Nat New Biol (1973) 1.41
Phage P22 tail protein: gene and amino acid sequence. Biochemistry (1982) 1.40
Isolation and analysis of arc repressor mutants: evidence for an unusual mechanism of DNA binding. Proteins (1986) 1.39
P22 Arc repressor: transition state properties inferred from mutational effects on the rates of protein unfolding and refolding. Biochemistry (1995) 1.38
Stabilization of lambda repressor against thermal denaturation by site-directed Gly----Ala changes in alpha-helix 3. Proteins (1986) 1.37
An engineered intersubunit disulfide enhances the stability and DNA binding of the N-terminal domain of lambda repressor. Biochemistry (1986) 1.37
The amino-acid sequence of the amino-terminal 37 residues of human parathyroid hormone. Proc Natl Acad Sci U S A (1974) 1.37