Published in N Engl J Med on June 03, 1982
Comparison of Western blot (immunoblot) and glycoprotein G-specific immunodot enzyme assay for detecting antibodies to herpes simplex virus types 1 and 2 in human sera. J Clin Microbiol (1988) 8.09
Diagnosis of herpes simplex virus by direct immunofluorescence and viral isolation from samples of external genital lesions in a high-prevalence population. J Clin Microbiol (1987) 1.64
Rapid diagnosis of herpes simplex virus infections by enzyme-linked immunosorbent assay. J Clin Microbiol (1984) 1.57
Successful treatment of herpes labialis with topical acyclovir. Br Med J (Clin Res Ed) (1983) 1.45
Recent advances in management of genital herpes. Can Fam Physician (2000) 1.44
Penetration of guinea pig skin by acyclovir in different vehicles and correlation with the efficacy of topical therapy of experimental cutaneous herpes simplex virus infection. Antimicrob Agents Chemother (1984) 1.37
Topical acyclovir in the treatment of initial genital herpes. Br J Vener Dis (1983) 1.26
6-Deoxyacyclovir: a xanthine oxidase-activated prodrug of acyclovir. Proc Natl Acad Sci U S A (1984) 1.25
Genital herpes: hype or hope? Br Med J (Clin Res Ed) (1983) 1.25
Early, patient-initiated treatment of herpes labialis with topical 10% acyclovir. Antimicrob Agents Chemother (1984) 1.12
Acyclovir. Br Med J (Clin Res Ed) (1982) 1.10
Failure of topical acyclovir in ointment to penetrate human skin. Antimicrob Agents Chemother (1986) 1.09
Humanized antibodies for antiviral therapy. Proc Natl Acad Sci U S A (1991) 1.07
Effect of acyclovir treatment of primary genital herpes on the antibody response to herpes simplex virus. J Clin Invest (1984) 1.07
Acyclovir prophylaxis of recurrent genital herpes: randomised placebo controlled crossover study. Genitourin Med (1985) 1.02
Genital herpes: an increasing problem? Genitourin Med (1985) 0.99
Regulation by recombinant interleukin-2 of protective immunity against recurrent herpes simplex virus type 2 genital infection in guinea pigs. J Virol (1987) 0.97
Antiviral therapy: current concepts and practices. Clin Microbiol Rev (1992) 0.96
Factors influencing quantitative isolation of varicella-zoster virus. J Clin Microbiol (1984) 0.94
The role of oral acyclovir in the management of genital herpes simplex. CMAJ (1987) 0.93
Acyclovir in first attacks of genital herpes and prevention of recurrences. Genitourin Med (1986) 0.91
Safety and pharmacokinetics of aciclovir in women following release from a silicone elastomer vaginal ring. J Antimicrob Chemother (2012) 0.91
Cutaneous adverse reactions to acyclovir: case reports. Genitourin Med (1985) 0.90
Efficacies of topical formulations of foscarnet and acyclovir and of 5-percent acyclovir ointment (Zovirax) in a murine model of cutaneous herpes simplex virus type 1 infection. Antimicrob Agents Chemother (2000) 0.84
Sodium lauryl sulfate increases the efficacy of a topical formulation of foscarnet against herpes simplex virus type 1 cutaneous lesions in mice. Antimicrob Agents Chemother (2000) 0.82
Xylotubercidin against herpes simplex virus type 2 in mice. Antimicrob Agents Chemother (1986) 0.81
Comparison of the vaginal microbial communities in women with recurrent genital HSV receiving acyclovir intravaginal rings. Antiviral Res (2013) 0.81
Chitosan and Kappa-Carrageenan Vaginal Acyclovir Formulations for Prevention of Genital Herpes. In Vitro and Ex Vivo Evaluation. Mar Drugs (2015) 0.78
Chemotherapy for herpes simplex virus infections. West J Med (1985) 0.78
Alteration of lymphocyte transformation response to herpes simplex virus infection by acyclovir therapy. Antimicrob Agents Chemother (1984) 0.76
Comparison of effects of adjuvants on efficacy of virion envelope herpes simplex virus vaccine against labial infection of BALB/c mice. Infect Immun (1983) 0.75
Long term oral acyclovir in disseminated mucocutaneous herpes simplex: a case report. Br J Vener Dis (1984) 0.75
Genital herpetic infection: a family practice perspective. Can Fam Physician (1982) 0.75
Topical therapy for genital herpes. Can Med Assoc J (1982) 0.75
Comparison of intramuscular recombinant alpha interferon (rIFN-2A) with topical acyclovir for the treatment of first-episode herpes genitalis and prevention of recurrences. Antimicrob Agents Chemother (1989) 0.75
Synergistic activity of combinations of recombinant human alpha interferon and acyclovir, administered concomitantly and in sequence, against a lethal herpes simplex virus type 1 infection in mice. Antimicrob Agents Chemother (1985) 0.75
Obstetrics and gynecology-important advances in clinical medicine: genital herpes and vaginal delivery. West J Med (1983) 0.75
Acyclovir for intravenous use. Committee on Infectious Diseases and Immunization, Canadian Paediatric Society. Can Med Assoc J (1984) 0.75
Contemporary antiviral drug regimens for the prevention and treatment of orolabial and anogenital herpes simplex virus infection in the normal host: Four approved indications and 13 off-label uses. Can J Infect Dis (2003) 0.75
Genital herpes. Can Fam Physician (1987) 0.75
Nonspecific vaginitis. Diagnostic criteria and microbial and epidemiologic associations. Am J Med (1983) 16.63
Acyclovir and transmission of HIV-1 from persons infected with HIV-1 and HSV-2. N Engl J Med (2010) 12.08
Prevention of pelvic inflammatory disease by screening for cervical chlamydial infection. N Engl J Med (1996) 11.91
Etiology of nongonococcal urethritis. N Engl J Med (1975) 9.61
Diagnosis of coliform infection in acutely dysuric women. N Engl J Med (1982) 8.75
Characterization of plasmid deoxyribonucleic acid from Neisseria gonorrhoeae. Infect Immun (1974) 8.30
Comparison of Western blot (immunoblot) and glycoprotein G-specific immunodot enzyme assay for detecting antibodies to herpes simplex virus types 1 and 2 in human sera. J Clin Microbiol (1988) 8.09
Disseminated gonococcal infections caused by Neisseria gonorrhoeae with unique nutritional requirements. J Infect Dis (1975) 7.92
Genital herpes simplex virus infections: clinical manifestations, course, and complications. Ann Intern Med (1983) 7.89
The serological classification of Neisseria gonorrhoeae. I. Isolation of the outer membrane complex responsible for serotypic specificity. J Exp Med (1976) 7.85
Herpes simplex virus type 2 in the United States, 1976 to 1994. N Engl J Med (1997) 7.59
Nonspecific vaginitis: role of Haemophilus vaginalis and treatment with metronidazole. N Engl J Med (1978) 7.07
Causes of the acute urethral syndrome in women. N Engl J Med (1980) 6.91
Anaerobic bacteria in nonspecific vaginitis. N Engl J Med (1980) 6.74
National case-control study of Kaposi's sarcoma and Pneumocystis carinii pneumonia in homosexual men: Part 1. Epidemiologic results. Ann Intern Med (1983) 6.67
Mucosal shedding of human herpesvirus 8 in men. N Engl J Med (2000) 6.59
Campylobacter cinaedi (sp. nov.) and Campylobacter fennelliae (sp. nov.): two new Campylobacter species associated with enteric disease in homosexual men. J Infect Dis (1985) 6.32
Culture-independent diagnosis of Chlamydia trachomatis using monoclonal antibodies. N Engl J Med (1984) 6.08
Clinical and epidemiologic features of primary HIV infection. Ann Intern Med (1996) 6.04
A cohort study of the risk of cervical intraepithelial neoplasia grade 2 or 3 in relation to papillomavirus infection. N Engl J Med (1992) 5.96
Ampicillin-resistant Haemophilus influenzae type B infection. JAMA (1974) 5.90
Plasma viremia in human immunodeficiency virus infection. N Engl J Med (1989) 5.73
Cytotoxic-T-cell responses, viral load, and disease progression in early human immunodeficiency virus type 1 infection. N Engl J Med (1997) 5.72
Asymptomatic gonorrhea in men. Diagnosis, natural course, prevalence and significance. N Engl J Med (1974) 5.68
Disseminated gonococcal infection. Ann Intern Med (1971) 5.66
Serological classification of Neisseria gonorrhoeae with monoclonal antibodies. Infect Immun (1982) 5.54
Gonococci causing disseminated gonococcal infection are resistant to the bactericidal action of normal human sera. J Clin Invest (1976) 5.54
Early establishment of a pool of latently infected, resting CD4(+) T cells during primary HIV-1 infection. Proc Natl Acad Sci U S A (1998) 5.48
Biological and virologic characteristics of primary HIV infection. Ann Intern Med (1998) 5.45
Safety of and immunological response to a recombinant vaccinia virus vaccine expressing HIV envelope glycoprotein. Lancet (1991) 5.42
Serological classification of Neisseria gonorrhoeae with use of monoclonal antibodies to gonococcal outer membrane protein I. J Infect Dis (1984) 5.40
Clinical spectrum of pharyngeal gonococcal infection. N Engl J Med (1973) 5.34
A case-control study of chorioamnionic infection and histologic chorioamnionitis in prematurity. N Engl J Med (1988) 5.32
Chronic fatigue in adolescents. Pediatrics (1991) 5.24
Association of antigenic type of Herpesvirus hominis with site of viral recovery. J Immunol (1967) 5.07
Polymicrobial etiology of acute pelvic inflammatory disease. N Engl J Med (1975) 4.99
Quantitative determination of antibody to gonococcal pili. Changes in antibody levels with gonococcal infection. J Clin Invest (1973) 4.90
Genital ulceration as a risk factor for human immunodeficiency virus infection. AIDS (1988) 4.85
Effect of interleukin-2 on the pool of latently infected, resting CD4+ T cells in HIV-1-infected patients receiving highly active anti-retroviral therapy. Nat Med (1999) 4.81
Mucopurulent cervicitis--the ignored counterpart in women of urethritis in men. N Engl J Med (1984) 4.74
AIDS virus infection in Nairobi prostitutes. Spread of the epidemic to East Africa. N Engl J Med (1986) 4.68
Independent associations of bacterial vaginosis and Chlamydia trachomatis infection with adverse pregnancy outcome. JAMA (1986) 4.62
Effect of condoms on reducing the transmission of herpes simplex virus type 2 from men to women. JAMA (2001) 4.54
Treatment of human immunodeficiency virus infection with saquinavir, zidovudine, and zalcitabine. AIDS Clinical Trials Group. N Engl J Med (1996) 4.43
Diagnosis of bacterial vaginosis by direct gram stain of vaginal fluid. J Clin Microbiol (1983) 4.42
Reactivation of genital herpes simplex virus type 2 infection in asymptomatic seropositive persons. N Engl J Med (2000) 4.39
Vidarabine versus acyclovir therapy in herpes simplex encephalitis. N Engl J Med (1986) 4.37
Selective differential human blood bilayer media for isolation of Gardnerella (Haemophilus) vaginalis. J Clin Microbiol (1982) 4.28
Characterization of Campylobacter-like organisms isolated from homosexual men. J Infect Dis (1984) 4.23
Relationships of vaginal Lactobacillus species, cervical Chlamydia trachomatis, and bacterial vaginosis to preterm birth. Obstet Gynecol (1988) 4.23
Comparison of viral isolation, direct immunofluorescence, and indirect immunoperoxidase techniques for detection of genital herpes simplex virus infection. J Clin Microbiol (1981) 4.10
Prevalence of hydrogen peroxide-producing Lactobacillus species in normal women and women with bacterial vaginosis. J Clin Microbiol (1989) 4.03
Virologic characteristics of subclinical and symptomatic genital herpes infections. N Engl J Med (1995) 4.03
Infection with herpes-simplex viruses 1 and 2. 3. N Engl J Med (1973) 3.89
Prior herpes simplex virus type 2 infection as a risk factor for HIV infection. JAMA (1988) 3.89
Risk factors for the sexual transmission of genital herpes. Ann Intern Med (1992) 3.89
T-cell mediated rejection of gene-modified HIV-specific cytotoxic T lymphocytes in HIV-infected patients. Nat Med (1996) 3.88
Recurrence rates in genital herpes after symptomatic first-episode infection. Ann Intern Med (1994) 3.83
The association between genital ulcer disease and acquisition of HIV infection in homosexual men. JAMA (1988) 3.73
The acquisition of herpes simplex virus during pregnancy. N Engl J Med (1997) 3.73
Antibody to herpes simplex virus type 2 as serological marker of sexual lifestyle in populations. BMJ (1994) 3.71
Invasion of the central nervous system by Treponema pallidum: implications for diagnosis and treatment. Ann Intern Med (1988) 3.71
An African HIV-1 sequence from 1959 and implications for the origin of the epidemic. Nature (1998) 3.69
Preterm labor associated with subclinical amniotic fluid infection and with bacterial vaginosis. Obstet Gynecol (1986) 3.67
Diagnosis and clinical manifestations of bacterial vaginosis. Am J Obstet Gynecol (1988) 3.66
Tetracycline-resistant Mycoplasma hominis strains contain streptococcal tetM sequences. Antimicrob Agents Chemother (1985) 3.66
The natural history of herpes simplex virus infection of mother and newborn. Pediatrics (1980) 3.65
Isolation of viruses, bacteria and other organisms from venereal disease clinic patients: methodology and problems associated with multiple isolations. Health Lab Sci (1973) 3.62
Underdiagnosis of genital herpes by current clinical and viral-isolation procedures. N Engl J Med (1992) 3.56
Comparative study of diagnostic procedures for congenital cytomegalovirus infection. Pediatrics (1980) 3.53
Frequent genital herpes simplex virus 2 shedding in immunocompetent women. Effect of acyclovir treatment. J Clin Invest (1997) 3.52
Membranoproliferative glomerulonephritis associated with hepatitis C virus infection. N Engl J Med (1993) 3.51
Low antibiotic resistance of gonococci causing disseminated infection. N Engl J Med (1973) 3.48
Development of a high-throughput quantitative assay for detecting herpes simplex virus DNA in clinical samples. J Clin Microbiol (1999) 3.48
An estimate of the risk of men acquiring gonorrhea by sexual contact with infected females. Am J Epidemiol (1970) 3.46
Evaluation of cefazolin, a new cephalosporin antibiotic. Antimicrob Agents Chemother (1973) 3.44
Recurrences after oral and genital herpes simplex virus infection. Influence of site of infection and viral type. N Engl J Med (1987) 3.42
Studies of venereal disease. 3. Double-blind comparison of tetracycline hydrochloride and placebo in treatment of nongonococcal urethritis. JAMA (1967) 3.40
Modeling plasma virus concentration during primary HIV infection. J Theor Biol (2000) 3.40
The Chlamydia epidemic. JAMA (1981) 3.35
Suppression of subclinical shedding of herpes simplex virus type 2 with acyclovir. Ann Intern Med (1996) 3.35
Sexual transmission of hepatitis A in homosexual men: incidence and mechanism. N Engl J Med (1980) 3.33
Epidemiology of genital human papillomavirus infection. Epidemiol Rev (1988) 3.32
Risk of recurrence after first episodes of genital herpes. Relation to HSV type and antibody response. N Engl J Med (1981) 3.32
Antigenic and biologic differences in herpesvirus hominis. Prog Med Virol (1968) 3.31
Infections with herpes simplex viruses (1). N Engl J Med (1986) 3.26
National surveillance of antimicrobial resistance in Neisseria gonorrhoeae. The Gonococcal Isolate Surveillance Project. JAMA (1990) 3.25
Hydrogen peroxide-producing lactobacilli and acquisition of vaginal infections. J Infect Dis (1996) 3.23
Emergence of ganciclovir-resistant cytomegalovirus disease among recipients of solid-organ transplants. Lancet (2000) 3.22
Correlation of host immune response with quantitative recovery of Chlamydia trachomatis from the human endocervix. Infect Immun (1983) 3.22