Published in Agents Actions on June 01, 1984
From delocalized lipophilic cations to hypoxia: blocking tumor cell mitochondrial function leads to therapeutic gain with glycolytic inhibitors. Mol Nutr Food Res (2009) 0.99
Small mitochondria-targeting molecules as anti-cancer agents. Mol Aspects Med (2009) 0.91
Computational approaches to analyse and predict small molecule transport and distribution at cellular and subcellular levels. Biopharm Drug Dispos (2013) 0.77
Mitochondria-Targeted Triphenylphosphonium-Based Compounds: Syntheses, Mechanisms of Action, and Therapeutic and Diagnostic Applications. Chem Rev (2017) 0.76
The respiratory chain and oxidative phosphorylation. Adv Enzymol Relat Subj Biochem (1956) 20.40
Localization of mitochondria in living cells with rhodamine 123. Proc Natl Acad Sci U S A (1980) 7.31
Monitoring of relative mitochondrial membrane potential in living cells by fluorescence microscopy. J Cell Biol (1981) 3.97
Rhodamine 6G. A potent inhibitor of mitochondrial oxidative phosphorylation. J Biol Chem (1974) 1.87
Elimination of mitochondrial elements and improved viability in hybrid cells. Somatic Cell Genet (1981) 1.78
Unusual retention of rhodamine 123 by mitochondria in muscle and carcinoma cells. Proc Natl Acad Sci U S A (1982) 1.72
Probing mitochondria in living cells with rhodamine 123. Cold Spring Harb Symp Quant Biol (1982) 1.46
Electrophysiology of cells and organelles: studies with optical potentiometric indicators. Int Rev Cytol Suppl (1981) 1.22
Selective toxicity of rhodamine 123 in carcinoma cells in vitro. Cancer Res (1983) 1.19
In vitro studies on single beating rat heart cells. II. Intercellular communication. Exp Cell Res (1963) 1.15
Age-related loss of DNA repair synthesis in isolated rat myocardial cells. Exp Cell Res (1975) 1.07
Status of mitochondria in living human fibroblasts during growth and senescence in vitro: use of the laser dye rhodamine 123. J Cell Biol (1981) 1.02
Proliferation of mitochondria during the cell cycle of the human cell line (HL-60). J Cell Biol (1981) 1.01
Monitoring the effect of anti-cancer drugs on L1210 cells by a mitochondrial probe, rhodamine-123. Int J Cancer (1982) 0.99
Decreased uptake and retention of rhodamine 123 by mitochondria in feline sarcoma virus-transformed mink cells. Cell (1982) 0.97
Structural and functional effects of adriamycin on cardiac cells in vitro. Cancer Res (1980) 0.94
Effects of adriamycin on rat heart cells in culture: increased accumulation and nucleoli fragmentation in cardiac muscle v. non-muscle cells. J Mol Cell Cardiol (1981) 0.79
Localization of mitochondria in living cells with rhodamine 123. Proc Natl Acad Sci U S A (1980) 7.31
HSP70 stimulates cytokine production through a CD14-dependant pathway, demonstrating its dual role as a chaperone and cytokine. Nat Med (2000) 6.20
Intracellular heterogeneity in mitochondrial membrane potentials revealed by a J-aggregate-forming lipophilic cation JC-1. Proc Natl Acad Sci U S A (1991) 5.78
Efflux-mediated multidrug resistance in Bacillus subtilis: similarities and dissimilarities with the mammalian system. Proc Natl Acad Sci U S A (1991) 5.45
Differentiation and reversal of malignant changes in colon cancer through PPARgamma. Nat Med (1998) 5.16
The intranuclear location of a herpes simplex virus DNA-binding protein is determined by the status of viral DNA replication. Cell (1984) 4.90
Microtubules and the endoplasmic reticulum are highly interdependent structures. J Cell Biol (1986) 4.59
Dynamic behavior of endoplasmic reticulum in living cells. Cell (1988) 4.59
J-aggregate formation of a carbocyanine as a quantitative fluorescent indicator of membrane potential. Biochemistry (1991) 4.11
Presence of an SH2 domain in the actin-binding protein tensin. Science (1991) 4.03
Monitoring of relative mitochondrial membrane potential in living cells by fluorescence microscopy. J Cell Biol (1981) 3.97
Mitogenic activity of blood components. I. Thrombin and prothrombin. Proc Natl Acad Sci U S A (1975) 3.20
Mitochondrial membrane potential monitored by JC-1 dye. Methods Enzymol (1995) 2.90
Correlation between tumor induction and the large external transformation sensitive protein on the cell surface. Proc Natl Acad Sci U S A (1976) 2.76
Localization of endoplasmic reticulum in living and glutaraldehyde-fixed cells with fluorescent dyes. Cell (1984) 2.73
Studies on intercellular LETS glycoprotein matrices. Cell (1978) 2.44
Mitochondrial and plasma membrane potentials cause unusual accumulation and retention of rhodamine 123 by human breast adenocarcinoma-derived MCF-7 cells. J Biol Chem (1985) 2.18
Detection of phosphotyrosine-containing 34,000-dalton protein in the framework of cells transformed with Rous sarcoma virus. Proc Natl Acad Sci U S A (1981) 2.09
The adenomatous polyposis coli-binding protein EB1 is associated with cytoplasmic and spindle microtubules. Proc Natl Acad Sci U S A (1998) 2.05
The N-terminal region of GAP regulates cytoskeletal structure and cell adhesion. EMBO J (1993) 1.91
Surface ruffles as markers for studies of cell transformation by Rous sarcoma virus. Proc Natl Acad Sci U S A (1975) 1.86
Role of small t antigen in the acute transforming activity of SV40. Cell (1982) 1.76
Alteration in cell surface LETS protein during myogenesis. Cell (1977) 1.72
Unusual retention of rhodamine 123 by mitochondria in muscle and carcinoma cells. Proc Natl Acad Sci U S A (1982) 1.72
Increased mRNA expression of a laminin-binding protein in human colon carcinoma: complete sequence of a full-length cDNA encoding the protein. Proc Natl Acad Sci U S A (1988) 1.62
Construction of the endoplasmic reticulum. J Cell Biol (1989) 1.60
In vitro traits of adenovirus-transformed cell lines and their relevance to tumorigenicity in nude mice. Cell (1977) 1.60
Construction, expression and recognition of an H-2 molecule lacking its carboxyl terminus. Nature (1984) 1.57
beta-catenin expression pattern in stage I and II ovarian carcinomas : relationship with beta-catenin gene mutations, clinicopathological features, and clinical outcome. Am J Pathol (1999) 1.55
The interaction of mammalian reoviruses with the cytoskeleton of monkey kidney CV-1 cells. Virology (1982) 1.55
Transmembrane-4 superfamily proteins CD81 (TAPA-1), CD82, CD63, and CD53 specifically associated with integrin alpha 4 beta 1 (CD49d/CD29). J Immunol (1996) 1.54
Hypersensitization of tumor cells to glycolytic inhibitors. Biochemistry (2001) 1.52
Effects of protease treatment on growth, morphology, adhesion, and cell surface proteins of secondary chick embryo fibroblasts. Cell (1976) 1.52
Probing mitochondria in living cells with rhodamine 123. Cold Spring Harb Symp Quant Biol (1982) 1.46
Extra-anatomic venous graft for portal vein thrombosis in liver transplantation. Transpl Int (1997) 1.45
An upper limit on the stochastic gravitational-wave background of cosmological origin. Nature (2009) 1.42
Detection of individual fluorescently labeled reovirions in living cells. Proc Natl Acad Sci U S A (1990) 1.41
Inhibition of energy metabolism alters the processing of amyloid precursor protein and induces a potentially amyloidogenic derivative. J Biol Chem (1994) 1.40
Serum level of the periostin, a homologue of an insect cell adhesion molecule, as a prognostic marker in nonsmall cell lung carcinomas. Cancer (2001) 1.40
Interactions of tensin with actin and identification of its three distinct actin-binding domains. J Cell Biol (1994) 1.40
Inactivation of DNA-dependent protein kinase by protein kinase Cdelta: implications for apoptosis. Mol Cell Biol (1998) 1.40
Expression of the focal adhesion protein paxillin in lung cancer and its relation to cell motility. Oncogene (1999) 1.39
[Considerations on the treatment of incipient diabetic nephropathy (lst of 2 parts)]. An Med Interna (1996) 1.39
Mitogenicity of thrombin and surface alterations on mouse splenocytes. Exp Cell Res (1976) 1.38
Expression of cyclooxygenase 2 (COX-2) in human glioma and in vitro inhibition by a specific COX-2 inhibitor, NS-398. Cancer Res (2000) 1.35
Mutational evidence for control of cell adhesion through integrin diffusion/clustering, independent of ligand binding. J Exp Med (1997) 1.35
Absence of intermediate filaments in a human adrenal cortex carcinoma-derived cell line. Exp Cell Res (1986) 1.35
Specific disruption of vimentin filament organization in monkey kidney CV-1 cells by diphtheria toxin, exotoxin A, and cycloheximide. Proc Natl Acad Sci U S A (1980) 1.33
Plasminogen-independent fibrinolysis by proteases produced by transformed chick embryo fibroblasts. Proc Natl Acad Sci U S A (1975) 1.32
Detection of the large external transformation-sensitive protein on some epithelial cells. Exp Cell Res (1977) 1.31
Multiple molecular chaperones complex with misfolded large oligomeric glycoproteins in the endoplasmic reticulum. J Biol Chem (1997) 1.31
Effect of microtubules and intermediate filaments on mitochondrial distribution. J Cell Sci (1983) 1.26
Analysis of MHC class II presentation of particulate antigens of B lymphocytes. J Immunol (1996) 1.24
BCR/ABL induces multiple abnormalities of cytoskeletal function. J Clin Invest (1997) 1.23
Increased tyrosine phosphorylation of focal adhesion proteins in myeloid cell lines expressing p210BCR/ABL. Oncogene (1995) 1.23
Expression of Periostin, homologous with an insect cell adhesion molecule, as a prognostic marker in non-small cell lung cancers. Jpn J Cancer Res (2001) 1.23
MKT-077, a novel rhodacyanine dye in clinical trials, exhibits anticarcinoma activity in preclinical studies based on selective mitochondrial accumulation. Cancer Res (1996) 1.21
Control of a cell surface major glycoprotein by epidermal growth factor. Science (1977) 1.21
Progressive kidney degeneration in mice lacking tensin. J Cell Biol (1997) 1.20
Selective killing of carcinoma cells "in vitro" by lipophilic-cationic compounds: a cellular basis. Biomed Pharmacother (1985) 1.19
Selective toxicity of rhodamine 123 in carcinoma cells in vitro. Cancer Res (1983) 1.19
Prothymosin-alpha mRNA expression correlates with that of c-myc in human colon cancer. Oncogene (1993) 1.19
HRad17 colocalizes with NHP2L1 in the nucleolus and redistributes after UV irradiation. J Biol Chem (1999) 1.18
Characterization of a phosphotyrosyl protein phosphatase activity associated with a phosphoseryl protein phosphatase of Mr = 95,000 from bovine heart. J Biol Chem (1983) 1.18
Anticarcinoma activity in vivo of rhodamine 123, a mitochondrial-specific dye. Science (1983) 1.17
4-Thiouridine photosensitized RNA-protein crosslinking in mammalian cells. Biochem Biophys Res Commun (1986) 1.16
Expression of keratin and vimentin intermediate filaments in rabbit bladder epithelial cells at different stages of benzo[a]pyrene-induced neoplastic progression. J Cell Biol (1981) 1.16
Serum level of the periostin, a homologue of an insect cell adhesion molecule, in thymoma patients. Cancer Lett (2001) 1.16
Two differentially expressed genes in normal human prostate tissue and in carcinoma. Cancer Res (1996) 1.14
Increased expression of human ribosomal phosphoprotein P0 messenger RNA in hepatocellular carcinoma and colon carcinoma. Cancer Res (1992) 1.13
A phosphotyrosyl-protein phosphatase activity associated with acid phosphatase from human prostate gland. Eur J Biochem (1984) 1.13
Epidermodysplasia verruciformis. I. Electron microscope autoradiography and tissue culture studies. Arch Dermatol Forsch (1972) 1.12
Upper limits on a stochastic background of gravitational waves. Phys Rev Lett (2005) 1.11
Focal adhesion as a signal transduction organelle. Cancer Metastasis Rev (1994) 1.09
Thrombin potentiates the mitogenic response of cultured fibroblasts to serum and other growth promoting agents. J Cell Physiol (1977) 1.09
Rhodamine-123 selectively reduces clonal growth of carcinoma cells in vitro. Science (1982) 1.09
Increased expression of the epidermal growth factor receptor on human colon carcinoma cells. Arch Surg (1986) 1.08
Phosphorylation of serines 635 and 645 of human Rad17 is cell cycle regulated and is required for G(1)/S checkpoint activation in response to DNA damage. Proc Natl Acad Sci U S A (2001) 1.08
Age-related loss of DNA repair synthesis in isolated rat myocardial cells. Exp Cell Res (1975) 1.07
p130CAS forms a signaling complex with the adapter protein CRKL in hematopoietic cells transformed by the BCR/ABL oncogene. J Biol Chem (1996) 1.07
Waldenström macroglobulinaemia: presenting features and outcome in a series with 217 cases. Br J Haematol (2001) 1.07
CRKL links p210BCR/ABL with paxillin in chronic myelogenous leukemia cells. J Biol Chem (1995) 1.06
Laser microbeams for partial cell irradiation. Int Rev Cytol (1972) 1.06
Molecular characterization of human tensin. Biochem J (2000) 1.04
Increased rhodamine 123 uptake by carcinoma cells. Cancer Res (1985) 1.04
Several endoplasmic reticulum stress proteins, including ERp72, interact with thyroglobulin during its maturation. J Biol Chem (1994) 1.04
Electron microscopic studies of the endoplasmic reticulum in whole-mount cultured cells fixed with potassium permanganate. J Struct Biol (1991) 1.03
Binding and internalization of thrombin by normal and transformed chick cells. Proc Natl Acad Sci U S A (1977) 1.02
The significance of carbonic anhydrase expression in human colorectal cancer. Gastroenterology (1993) 1.02
The BCR/ABL oncogene alters the chemotactic response to stromal-derived factor-1alpha. Blood (1999) 1.02
Clioquinol-zinc chelate: a candidate causative agent of subacute myelo-optic neuropathy. Mol Med (1998) 1.01
Expression of matrix metalloproteinases and the tissue inhibitors of metalloproteinases and their local invasiveness and metastasis in Chinese human pancreatic cancer. J Surg Oncol (2000) 1.00