Intracellular heterogeneity in mitochondrial membrane potentials revealed by a J-aggregate-forming lipophilic cation JC-1.

PubWeight™: 5.78‹?› | Rank: Top 1%

🔗 View Article (PMC 51514)

Published in Proc Natl Acad Sci U S A on May 01, 1991

Authors

S T Smiley1, M Reers, C Mottola-Hartshorn, M Lin, A Chen, T W Smith, G D Steele, L B Chen

Author Affiliations

1: Dana-Farber Cancer Institute, Boston, MA.

Articles citing this

(truncated to the top 100)

Mitochondrial fusion in human cells is efficient, requires the inner membrane potential, and is mediated by mitofusins. Mol Biol Cell (2002) 4.48

Redox state is a central modulator of the balance between self-renewal and differentiation in a dividing glial precursor cell. Proc Natl Acad Sci U S A (2000) 2.99

Large-scale chemical dissection of mitochondrial function. Nat Biotechnol (2008) 2.91

Inhibition of mitochondrial translation as a therapeutic strategy for human acute myeloid leukemia. Cancer Cell (2011) 2.68

Imaging in five dimensions: time-dependent membrane potentials in individual mitochondria. Biophys J (1993) 2.66

Mitochondrial proliferation and paradoxical membrane depolarization during terminal differentiation and apoptosis in a human colon carcinoma cell line. J Cell Biol (1997) 2.44

Subcellular metabolic transients and mitochondrial redox waves in heart cells. Proc Natl Acad Sci U S A (1998) 2.42

TRPM7 regulates quiescent/proliferative metabolic transitions in lymphocytes. Cell Cycle (2010) 2.29

No effects of intermittent 50 Hz EMF on cytoplasmic free calcium and on the mitochondrial membrane potential in human diploid fibroblasts. Radiat Environ Biophys (2004) 2.13

Alterations in mitochondrial structure and function are early events of dexamethasone-induced thymocyte apoptosis. J Cell Biol (1995) 2.12

Mitochondrial hyperpolarization and ATP depletion in patients with systemic lupus erythematosus. Arthritis Rheum (2002) 2.08

Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release. Physiol Rev (2014) 1.96

Elevation of mitochondrial transmembrane potential and reactive oxygen intermediate levels are early events and occur independently from activation of caspases in Fas signaling. J Immunol (1999) 1.88

Integrins engage mitochondrial function for signal transduction by a mechanism dependent on Rho GTPases. J Cell Biol (2002) 1.88

Mitochondrial membrane potential in single living adult rat cardiac myocytes exposed to anoxia or metabolic inhibition. J Physiol (1995) 1.76

Regulation of transgenes in three-dimensional cultures of primary mouse mammary cells demonstrates oncogene dependence and identifies cells that survive deinduction. Genes Dev (2009) 1.76

Complementation of mutant and wild-type human mitochondrial DNAs coexisting since the mutation event and lack of complementation of DNAs introduced separately into a cell within distinct organelles. Mol Cell Biol (1994) 1.75

Cyclin D1 determines mitochondrial function in vivo. Mol Cell Biol (2006) 1.75

CP-31398 restores mutant p53 tumor suppressor function and inhibits UVB-induced skin carcinogenesis in mice. J Clin Invest (2007) 1.71

Intrinsic apoptotic and thioredoxin pathways in human prostate cancer cell response to histone deacetylase inhibitor. Proc Natl Acad Sci U S A (2006) 1.67

Contribution of the mitochondrial compartment to the optical properties of the rat liver: a theoretical and practical approach. Biophys J (1994) 1.57

Mitochondria are selective targets for the protective effects of heat shock against oxidative injury. Proc Natl Acad Sci U S A (1996) 1.56

Mitochondrial superoxide radicals mediate programmed cell death in Trypanosoma cruzi: cytoprotective action of mitochondrial iron superoxide dismutase overexpression. Biochem J (2007) 1.55

Methionine sulfoxide reductase A protects neuronal cells against brief hypoxia/reoxygenation. Proc Natl Acad Sci U S A (2004) 1.54

Nitric oxide-dependent mitochondrial biogenesis generates Ca2+ signaling profile of lupus T cells. J Immunol (2004) 1.54

An integrated imaging approach to the study of oxidative stress generation by mitochondrial dysfunction in living cells. Environ Health Perspect (2010) 1.52

Mitochondrial membrane potential in axons increases with local nerve growth factor or semaphorin signaling. J Neurosci (2008) 1.51

Suppression of the JNK pathway by induction of a metabolic stress response prevents vascular injury and dysfunction. Circulation (2008) 1.50

Vhlh gene deletion induces Hif-1-mediated cell death in thymocytes. Mol Cell Biol (2004) 1.48

Uncoupling protein 2 impacts endothelial phenotype via p53-mediated control of mitochondrial dynamics. Circ Res (2013) 1.48

Label-free Raman observation of cytochrome c dynamics during apoptosis. Proc Natl Acad Sci U S A (2011) 1.43

Inhibition of inflammatory arthritis using fullerene nanomaterials. PLoS One (2015) 1.42

Overexpression of Bcl-2 by activated human hepatic stellate cells: resistance to apoptosis as a mechanism of progressive hepatic fibrogenesis in humans. Gut (2006) 1.42

Altered mitochondrial membrane potential, mass, and morphology in the mononuclear cells of humans with type 2 diabetes. Transl Res (2010) 1.40

T cell activation-induced mitochondrial hyperpolarization is mediated by Ca2+- and redox-dependent production of nitric oxide. J Immunol (2003) 1.39

Persistent mitochondrial hyperpolarization, increased reactive oxygen intermediate production, and cytoplasmic alkalinization characterize altered IL-10 signaling in patients with systemic lupus erythematosus. J Immunol (2002) 1.39

Increased μ-Calpain Activity in Blasts of Common B-Precursor Childhood Acute Lymphoblastic Leukemia Correlates with Their Lower Susceptibility to Apoptosis. PLoS One (2015) 1.39

Hypoxia inducible factor 1 alpha regulates T cell receptor signal transduction. Proc Natl Acad Sci U S A (2005) 1.38

Optical and pharmacological tools to investigate the role of mitochondria during oxidative stress and neurodegeneration. Prog Neurobiol (2006) 1.34

IL-6 protects against hyperoxia-induced mitochondrial damage via Bcl-2-induced Bak interactions with mitofusins. Am J Respir Cell Mol Biol (2009) 1.33

Glucose-stimulated insulin secretion correlates with changes in mitochondrial and cytosolic Ca2+ in aequorin-expressing INS-1 cells. J Clin Invest (1996) 1.29

Mitochondrial contribution to the anoxic Ca2+ signal in maize suspension-cultured cells Plant Physiol (1998) 1.28

Genetically encoded fluorescent thermosensors visualize subcellular thermoregulation in living cells. Nat Methods (2013) 1.25

Acrolein, a toxicant in cigarette smoke, causes oxidative damage and mitochondrial dysfunction in RPE cells: protection by (R)-alpha-lipoic acid. Invest Ophthalmol Vis Sci (2007) 1.24

A programmed cell death pathway in the malaria parasite Plasmodium falciparum has general features of mammalian apoptosis but is mediated by clan CA cysteine proteases. Cell Death Dis (2010) 1.23

Signal transduction pathways involved in oxidative stress-induced intestinal epithelial cell apoptosis. Pediatr Res (2005) 1.23

Physiological cytosolic Ca2+ transients evoke concurrent mitochondrial depolarizations. Proc Natl Acad Sci U S A (1994) 1.22

Cyclosporine A attenuates mitochondrial permeability transition and improves mitochondrial respiratory function in cardiomyocytes isolated from dogs with heart failure. J Mol Cell Cardiol (2006) 1.21

Ian4 is required for mitochondrial integrity and T cell survival. Proc Natl Acad Sci U S A (2003) 1.19

Cerium dioxide nanoparticles induce apoptosis and autophagy in human peripheral blood monocytes. ACS Nano (2012) 1.19

IFN-gamma acts directly on activated CD4+ T cells during mycobacterial infection to promote apoptosis by inducing components of the intracellular apoptosis machinery and by inducing extracellular proapoptotic signals. J Immunol (2007) 1.18

Antibody production and in vitro behavior of CD27-defined B-cell subsets: persistent hepatitis C virus infection changes the rules. J Virol (2006) 1.18

Histamine induces oscillations of mitochondrial free Ca2+ concentration in single cultured rat brain astrocytes. J Physiol (1996) 1.17

Rac2-MRC-cIII-generated ROS cause genomic instability in chronic myeloid leukemia stem cells and primitive progenitors. Blood (2012) 1.16

Combination treatment with TRA-8 anti death receptor 5 antibody and CPT-11 induces tumor regression in an orthotopic model of pancreatic cancer. Clin Cancer Res (2007) 1.14

Anaerobic and aerobic pathways for salvage of proximal tubules from hypoxia-induced mitochondrial injury. Am J Physiol Renal Physiol (2000) 1.14

Enhancing lysosome biogenesis attenuates BNIP3-induced cardiomyocyte death. Autophagy (2012) 1.13

Ciprofloxacin induces apoptosis and inhibits proliferation of human colorectal carcinoma cells. Br J Cancer (2002) 1.12

Phospho-sulindac (OXT-922) inhibits the growth of human colon cancer cell lines: a redox/polyamine-dependent effect. Carcinogenesis (2010) 1.12

GSK-3beta promotes cell survival by modulating Bif-1-dependent autophagy and cell death. J Cell Sci (2010) 1.12

Analysis of mitochondrial dynamics and functions using imaging approaches. Curr Protoc Cell Biol (2010) 1.12

Regulation of density of functional presynaptic terminals by local energy supply. Mol Brain (2015) 1.11

Cell death induced by ozone and various non-thermal plasmas: therapeutic perspectives and limitations. Sci Rep (2014) 1.10

Mitochondrial structure, function and dynamics are temporally controlled by c-Myc. PLoS One (2012) 1.09

Arrested oocyst maturation in Plasmodium parasites lacking type II NADH:ubiquinone dehydrogenase. J Biol Chem (2011) 1.09

Pantethine rescues a Drosophila model for pantothenate kinase-associated neurodegeneration. Proc Natl Acad Sci U S A (2010) 1.09

The function of mitochondria in presynaptic development at the neuromuscular junction. Mol Biol Cell (2007) 1.08

Bax-like protein Drob-1 protects neurons from expanded polyglutamine-induced toxicity in Drosophila. EMBO J (2005) 1.08

Formulations of biodegradable Nanogel carriers with 5'-triphosphates of nucleoside analogs that display a reduced cytotoxicity and enhanced drug activity. J Control Release (2007) 1.07

Semliki forest virus-induced endoplasmic reticulum stress accelerates apoptotic death of mammalian cells. J Virol (2010) 1.07

Emerging understanding of Bcl-2 biology: Implications for neoplastic progression and treatment. Biochim Biophys Acta (2015) 1.05

Down-regulation of the Notch pathway mediated by a gamma-secretase inhibitor induces anti-tumour effects in mouse models of T-cell leukaemia. Br J Pharmacol (2009) 1.04

Abnormal calcium homeostasis and mitochondrial polarization in a human encephalomyopathy. Proc Natl Acad Sci U S A (1995) 1.04

Role of mitochondria in calcium regulation of spontaneously contracting cardiac muscle cells. Biophys J (1998) 1.03

Drug-induced permeabilization of parasite's digestive vacuole is a key trigger of programmed cell death in Plasmodium falciparum. Cell Death Dis (2011) 1.02

Intracellular pH governs the subcellular distribution of hexokinase in a glioma cell line. Biochem J (1996) 1.02

Diosgenin, a plant steroid, induces apoptosis in human rheumatoid arthritis synoviocytes with cyclooxygenase-2 overexpression. Arthritis Res Ther (2004) 1.01

Products of the Parkinson's disease-related glyoxalase DJ-1, D-lactate and glycolate, support mitochondrial membrane potential and neuronal survival. Biol Open (2014) 1.00

Repetitive transient depolarizations of the inner mitochondrial membrane induced by proton pumping. Biophys J (2005) 1.00

VPS41, a protein involved in lysosomal trafficking, is protective in Caenorhabditis elegans and mammalian cellular models of Parkinson's disease. Neurobiol Dis (2009) 1.00

The AF4-mimetic peptide, PFWT, induces necrotic cell death in MV4-11 leukemia cells. Leuk Res (2007) 1.00

Cystathionine γ-lyase deficiency protects mice from galactosamine/lipopolysaccharide-induced acute liver failure. Antioxid Redox Signal (2013) 1.00

[Pt(O,O'-acac)(gamma-acac)(DMS)], a new Pt compound exerting fast cytotoxicity in MCF-7 breast cancer cells via the mitochondrial apoptotic pathway. Br J Pharmacol (2007) 1.00

Regulation of HSP27 on NF-kappaB pathway activation may be involved in metastatic hepatocellular carcinoma cells apoptosis. BMC Cancer (2009) 1.00

On the evolutionary conservation of the cell death pathway: mitochondrial release of an apoptosis-inducing factor during Dictyostelium discoideum cell death. Mol Biol Cell (2001) 0.99

Binding, degradation and apoptotic activity of stearoylethanolamide in rat C6 glioma cells. Biochem J (2002) 0.99

Strain-dependent induction of epithelial cell oncosis by Campylobacter jejuni is correlated with invasion ability and is independent of cytolethal distending toxin. Microbiology (2007) 0.99

Targeting wild-type and mutant p53 with small molecule CP-31398 blocks the growth of rhabdomyosarcoma by inducing reactive oxygen species-dependent apoptosis. Cancer Res (2010) 0.98

A cell-based high-throughput screen to identify synergistic TRAIL sensitizers. Cancer Immunol Immunother (2008) 0.98

Activation of c-Jun N-terminal kinase is essential for mitochondrial membrane potential change and apoptosis induced by doxycycline in melanoma cells. Br J Pharmacol (2010) 0.98

Critical role for Gimap5 in the survival of mouse hematopoietic stem and progenitor cells. J Exp Med (2011) 0.98

Antitumor activity of the combination of an HSP90 inhibitor and a PI3K/mTOR dual inhibitor against cholangiocarcinoma. Oncotarget (2014) 0.95

Mitochondrial nutrients improve immune dysfunction in the type 2 diabetic Goto-Kakizaki rats. J Cell Mol Med (2008) 0.95

Secreted frizzled-related protein 4: an angiogenesis inhibitor. Am J Pathol (2010) 0.94

Low infra red laser light irradiation on cultured neural cells: effects on mitochondria and cell viability after oxidative stress. BMC Complement Altern Med (2009) 0.94

Hydroxytyrosol protects retinal pigment epithelial cells from acrolein-induced oxidative stress and mitochondrial dysfunction. J Neurochem (2007) 0.94

The oxysterol 27-hydroxycholesterol increases β-amyloid and oxidative stress in retinal pigment epithelial cells. BMC Ophthalmol (2010) 0.94

Flow cytometric readout based on Mitotracker Red CMXRos staining of live asexual blood stage malarial parasites reliably assesses antibody dependent cellular inhibition. Malar J (2012) 0.94

Oscillatory growth in lily pollen tubes does not require aerobic energy metabolism. Plant Physiol (2009) 0.94

DJ-1 knock-down impairs astrocyte mitochondrial function. Neuroscience (2011) 0.94

Articles by these authors

Identification of two related pentapeptides from the brain with potent opiate agonist activity. Nature (1975) 10.33

Changes in forest biomass carbon storage in China between 1949 and 1998. Science (2001) 7.39

Localization of mitochondria in living cells with rhodamine 123. Proc Natl Acad Sci U S A (1980) 7.31

HSP70 stimulates cytokine production through a CD14-dependant pathway, demonstrating its dual role as a chaperone and cytokine. Nat Med (2000) 6.20

Determination of therapeutic and toxic serum digoxin concentrations by radioimmunoassay. N Engl J Med (1969) 6.15

Efflux-mediated multidrug resistance in Bacillus subtilis: similarities and dissimilarities with the mammalian system. Proc Natl Acad Sci U S A (1991) 5.45

Differentiation and reversal of malignant changes in colon cancer through PPARgamma. Nat Med (1998) 5.16

Internists' and surgeons' attitudes toward guns and firearm injury prevention. Ann Intern Med (1998) 5.15

Support for new policies to regulate firearms. Results of two national surveys. N Engl J Med (1998) 5.06

Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1. Nature (1998) 4.97

The intranuclear location of a herpes simplex virus DNA-binding protein is determined by the status of viral DNA replication. Cell (1984) 4.90

Plasma digoxin concentrations in patients with atrial fibrillation. Br Med J (1970) 4.82

Microtubules and the endoplasmic reticulum are highly interdependent structures. J Cell Biol (1986) 4.59

Dynamic behavior of endoplasmic reticulum in living cells. Cell (1988) 4.59

J-aggregate formation of a carbocyanine as a quantitative fluorescent indicator of membrane potential. Biochemistry (1991) 4.11

A structural basis for drug-induced long QT syndrome. Proc Natl Acad Sci U S A (2000) 4.06

Presence of an SH2 domain in the actin-binding protein tensin. Science (1991) 4.03

Monitoring of relative mitochondrial membrane potential in living cells by fluorescence microscopy. J Cell Biol (1981) 3.97

Graded reduction of Pafah1b1 (Lis1) activity results in neuronal migration defects and early embryonic lethality. Nat Genet (1998) 3.89

Fusion between a novel Krüppel-like zinc finger gene and the retinoic acid receptor-alpha locus due to a variant t(11;17) translocation associated with acute promyelocytic leukaemia. EMBO J (1993) 3.58

Recruitment of a ROC1-CUL1 ubiquitin ligase by Skp1 and HOS to catalyze the ubiquitination of I kappa B alpha. Mol Cell (1999) 3.58

The selectins: vascular adhesion molecules. FASEB J (1995) 3.45

A meta-analytic review of research on hostility and physical health. Psychol Bull (1996) 3.27

Digitalis intoxication. A prospective clinical study with serum level correlations. N Engl J Med (1971) 3.27

Mitogenic activity of blood components. I. Thrombin and prothrombin. Proc Natl Acad Sci U S A (1975) 3.20

Cripto is required for correct orientation of the anterior-posterior axis in the mouse embryo. Nature (1998) 3.16

E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle. Proc Natl Acad Sci U S A (1995) 2.99

An open label study of the effects of rituximab in neuromyelitis optica. Neurology (2005) 2.99

Mitochondrial membrane potential monitored by JC-1 dye. Methods Enzymol (1995) 2.90

Endothelial nitric oxide synthase targeting to caveolae. Specific interactions with caveolin isoforms in cardiac myocytes and endothelial cells. J Biol Chem (1996) 2.82

Correlation between tumor induction and the large external transformation sensitive protein on the cell surface. Proc Natl Acad Sci U S A (1976) 2.76

Disruption of Ini1 leads to peri-implantation lethality and tumorigenesis in mice. Mol Cell Biol (2001) 2.76

Tay-sachs disease. Detection of heterozygotes and homozygotes by serum hexosaminidase assay. N Engl J Med (1970) 2.75

Localization of endoplasmic reticulum in living and glutaraldehyde-fixed cells with fluorescent dyes. Cell (1984) 2.73

Efficacy and safety of different doses and retreatment of rituximab: a randomised, placebo-controlled trial in patients who are biological naive with active rheumatoid arthritis and an inadequate response to methotrexate (Study Evaluating Rituximab's Efficacy in MTX iNadequate rEsponders (SERENE)). Ann Rheum Dis (2010) 2.68

Digoxin intoxication: the relationship of clinical presentation to serum digoxin concentration. J Clin Invest (1970) 2.66

The distribution of methionine-enkephalin and leucine-enkephalin in the brain and peripheral tissues. Br J Pharmacol (1977) 2.59

Methylation of CpG in a small region of the hMLH1 promoter invariably correlates with the absence of gene expression. Cancer Res (1999) 2.54

Conjugation of Nedd8 to CUL1 enhances the ability of the ROC1-CUL1 complex to promote ubiquitin polymerization. J Biol Chem (2000) 2.53

Mutations in the human alpha-tectorin gene cause autosomal dominant non-syndromic hearing impairment. Nat Genet (1998) 2.52

Reversal of advanced digoxin intoxication with Fab fragments of digoxin-specific antibodies. N Engl J Med (1976) 2.49

Role of the integrin alpha v beta 6 in cell attachment to fibronectin. Heterologous expression of intact and secreted forms of the receptor. J Biol Chem (1994) 2.46

Studies on intercellular LETS glycoprotein matrices. Cell (1978) 2.44

Characterization of antibodies of high affinity and specificity for the digitalis glycoside digoxin. Biochemistry (1970) 2.39

Suspected low-grade glioma: is deferring treatment safe? Ann Neurol (1992) 2.37

Targeted disruption of mouse Pds provides insight about the inner-ear defects encountered in Pendred syndrome. Hum Mol Genet (2001) 2.34

Targeted mutation of plasma phospholipid transfer protein gene markedly reduces high-density lipoprotein levels. J Clin Invest (1999) 2.32

Control of cardiac muscle cell function by an endogenous nitric oxide signaling system. Proc Natl Acad Sci U S A (1993) 2.32

Altered lymphocyte responses and cytokine production in mice deficient in the X-linked lymphoproliferative disease gene SH2D1A/DSHP/SAP. Proc Natl Acad Sci U S A (2001) 2.29

A peripheral blood diagnostic test for acute rejection in renal transplantation. Am J Transplant (2012) 2.25

Mitochondrial and plasma membrane potentials cause unusual accumulation and retention of rhodamine 123 by human breast adenocarcinoma-derived MCF-7 cells. J Biol Chem (1985) 2.18

Plasma sphingomyelin level as a risk factor for coronary artery disease. Arterioscler Thromb Vasc Biol (2000) 2.16

Smoking cessation in China: findings from the 1996 national prevalence survey. Tob Control (2001) 2.10

Technical and biological factors in disease-free survival after hepatic resection for colorectal cancer metastases. Arch Surg (1992) 2.10

Surgical margin in hepatic resection for colorectal metastasis: a critical and improvable determinant of outcome. Ann Surg (1998) 2.10

Detection of phosphotyrosine-containing 34,000-dalton protein in the framework of cells transformed with Rous sarcoma virus. Proc Natl Acad Sci U S A (1981) 2.09

Non-invasive prenatal testing for trisomies 21, 18 and 13: clinical experience from 146,958 pregnancies. Ultrasound Obstet Gynecol (2015) 2.07

HOS, a human homolog of Slimb, forms an SCF complex with Skp1 and Cullin1 and targets the phosphorylation-dependent degradation of IkappaB and beta-catenin. Oncogene (1999) 2.05

The adenomatous polyposis coli-binding protein EB1 is associated with cytoplasmic and spindle microtubules. Proc Natl Acad Sci U S A (1998) 2.05

The RING domains of the promyelocytic leukemia protein PML and the arenaviral protein Z repress translation by directly inhibiting translation initiation factor eIF4E. J Mol Biol (2001) 2.05

Medullomyoblastoma. A histologic, immunohistochemical, and ultrastructural study. Cancer (1984) 2.03

Nitric oxide and cardiac function. Circ Res (1996) 2.01

Kainate receptor-mediated heterosynaptic facilitation in the amygdala. Nat Neurosci (2001) 1.96

Digoxin therapy and mortality after myocardial infarction. Experience in the MILIS Study. N Engl J Med (1986) 1.96

High polymorphism at the human melanocortin 1 receptor locus. Genetics (1999) 1.94

The N-terminal region of GAP regulates cytoskeletal structure and cell adhesion. EMBO J (1993) 1.91

Inhibition of joint damage and improved clinical outcomes with rituximab plus methotrexate in early active rheumatoid arthritis: the IMAGE trial. Ann Rheum Dis (2010) 1.90

Surface ruffles as markers for studies of cell transformation by Rous sarcoma virus. Proc Natl Acad Sci U S A (1975) 1.86

Energy landscape of streptavidin-biotin complexes measured by atomic force microscopy. Biochemistry (2000) 1.81

Outcome and utilization differences for older persons with stroke in HMO and fee-for-service systems. J Am Geriatr Soc (2000) 1.81

Nitric oxide-dependent parasympathetic signaling is due to activation of constitutive endothelial (type III) nitric oxide synthase in cardiac myocytes. J Biol Chem (1995) 1.80

Prevention of kidney ischemia/reperfusion-induced functional injury and JNK, p38, and MAPK kinase activation by remote ischemic pretreatment. J Biol Chem (2001) 1.77

The integrin alpha 6 beta 4 is a laminin receptor. J Cell Biol (1992) 1.77

Transferrin receptor in normal and neoplastic brain tissue: implications for brain-tumor immunotherapy. J Neurosurg (1990) 1.76

Role of small t antigen in the acute transforming activity of SV40. Cell (1982) 1.76

Carrier frequency for glycogen storage disease type II in New York and estimates of affected individuals born with the disease. Am J Med Genet (1998) 1.75

Vascular bed-specific expression of an endothelial cell gene is programmed by the tissue microenvironment. J Cell Biol (1997) 1.74

The use of the GlideScope for tracheal intubation in patients with ankylosing spondylitis. Br J Anaesth (2006) 1.74

Creatine in Huntington disease is safe, tolerable, bioavailable in brain and reduces serum 8OH2'dG. Neurology (2006) 1.73

Evaluation of common breast problems: guidance for primary care providers. CA Cancer J Clin (1998) 1.72

Alteration in cell surface LETS protein during myogenesis. Cell (1977) 1.72

Unusual retention of rhodamine 123 by mitochondria in muscle and carcinoma cells. Proc Natl Acad Sci U S A (1982) 1.72

Effects of larval mosquitoes (Aedes triseriatus) and stemflow on microbial community dynamics in container habitats. Appl Environ Microbiol (1999) 1.70

Kringle 5 of plasminogen is a novel inhibitor of endothelial cell growth. J Biol Chem (1997) 1.68

The SCF(HOS/beta-TRCP)-ROC1 E3 ubiquitin ligase utilizes two distinct domains within CUL1 for substrate targeting and ubiquitin ligation. Mol Cell Biol (2000) 1.67

National survey of the pattern of care for carcinoma of the lung. J Thorac Cardiovasc Surg (1990) 1.63

Digitalis (third of four parts). N Engl J Med (1973) 1.63

Increased mRNA expression of a laminin-binding protein in human colon carcinoma: complete sequence of a full-length cDNA encoding the protein. Proc Natl Acad Sci U S A (1988) 1.62

A dual micro-CT system for small animal imaging. Proc SPIE Int Soc Opt Eng (2008) 1.62

The incidence and significance of anti-"Mia" in Taiwan. Transfusion (1994) 1.62

The S4-S5 linker couples voltage sensing and activation of pacemaker channels. Proc Natl Acad Sci U S A (2001) 1.60

Alloimmunization among patients with transfusion-dependent thalassemia in Taiwan. Transfus Med (2006) 1.60

Midazolam vs ondansetron for preventing postoperative nausea and vomiting: a randomised controlled trial. Anaesthesia (2007) 1.60

In vitro traits of adenovirus-transformed cell lines and their relevance to tumorigenicity in nude mice. Cell (1977) 1.60

Construction of the endoplasmic reticulum. J Cell Biol (1989) 1.60