Published in Lab Anim on July 01, 1984
Genealogies of mouse inbred strains. Nat Genet (2000) 8.06
P450 genes: structure, evolution, and regulation. Annu Rev Biochem (1987) 6.72
P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature. Pharmacogenetics (1996) 6.12
Immune system impairment and hepatic fibrosis in mice lacking the dioxin-binding Ah receptor. Science (1995) 6.03
Mammalian genes coordinately regulated by growth arrest signals and DNA-damaging agents. Mol Cell Biol (1989) 5.25
Substrate-inducible microsomal aryl hydroxylase in mammalian cell culture. I. Assay and properties of induced enzyme. J Biol Chem (1968) 3.74
Characterization of the common genetic defect in humans deficient in debrisoquine metabolism. Nature (1988) 3.69
The P450 gene superfamily: recommended nomenclature. DNA (1987) 2.95
Evolution of the P450 gene superfamily: animal-plant 'warfare', molecular drive and human genetic differences in drug oxidation. Trends Genet (1990) 2.63
The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence. Pharmacogenetics (1997) 2.55
An athymic nude mutation in the rat. Nature (1978) 2.54
Human dioxin-inducible cytochrome P1-450: complementary DNA and amino acid sequence. Science (1985) 2.11
Use of enzyme-labeled antibody for electron microscope localization of lymphocytic choriomeningitis virus antigens in infected cell cultures. J Natl Cancer Inst (1969) 2.01
Nomenclature for human CYP2D6 alleles. Pharmacogenetics (1996) 1.91
Comparison of the flanking regions and introns of the mouse 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible cytochrome P1-450 and P3-450 genes. J Biol Chem (1985) 1.79
Variations among sublines of inbred AKR mice. Nat New Biol (1973) 1.78
Reduced adhesion formation following laparoscopic versus open colorectal surgery. Br J Surg (2008) 1.77
Human debrisoquine 4-hydroxylase (P450IID1): cDNA and deduced amino acid sequence and assignment of the CYP2D locus to chromosome 22. Genomics (1988) 1.75
The murine Ah locus. Comparison of the complete cytochrome P1-450 and P3-450 cDNA nucleotide and amino acid sequences. J Biol Chem (1984) 1.75
Eukaryotic aldehyde dehydrogenase (ALDH) genes: human polymorphisms, and recommended nomenclature based on divergent evolution and chromosomal mapping. Pharmacogenetics (1999) 1.74
Metabolism of polycyclic aromatic hydrocarbons: etiologic role in carcinogenesis. Pharmacol Rev (1982) 1.70
Response to selection for body weight and egg weight in chickens. Genetics (1967) 1.69
Polymorphisms in drug-metabolizing enzymes: what is their clinical relevance and why do they exist? Am J Hum Genet (1997) 1.67
New mutant and congenic mouse stocks expressing the murine leukemia virus-associated thymocyte surface antigen GIX. J Exp Med (1975) 1.59
Autoregulation plus upstream positive and negative control regions associated with transcriptional activation of the mouse P1(450) gene. Nucleic Acids Res (1985) 1.55
The chemical defensome: environmental sensing and response genes in the Strongylocentrotus purpuratus genome. Dev Biol (2006) 1.54
Regulatory gene product of the Ah locus. Characterization of receptor mutants among mouse hepatoma clones. J Biol Chem (1982) 1.52
Knockout of the mouse glutamate cysteine ligase catalytic subunit (Gclc) gene: embryonic lethal when homozygous, and proposed model for moderate glutathione deficiency when heterozygous. Biochem Biophys Res Commun (2000) 1.51
The in vivo and in vitro induction of aryl hydrocarbon hydroxylase in mammalian cells of different species, tissues, strains, and developmental and hormonal states. Arch Biochem Biophys (1969) 1.50
Recommendations for locus-specific databases and their curation. Hum Mutat (2008) 1.49
Regulation of mouse CYP1A1 gene expression by dioxin: requirement of two cis-acting elements during induction. Mol Cell Biol (1989) 1.49
Regional linkage analysis of the dioxin-inducible P-450 gene family on mouse chromosome 9. Biochem Biophys Res Commun (1985) 1.47
Complete cDNA and protein sequence of a pregnenolone 16 alpha-carbonitrile-induced cytochrome P-450. A representative of a new gene family. J Biol Chem (1985) 1.46
Substrate-inducible microsomal aryl hydroxylase in mammalian cell culture. II. Cellular responses during enzyme induction. J Biol Chem (1968) 1.45
Microdetermination of proteoglycans and glycosaminoglycans in the presence of guanidine hydrochloride. Anal Biochem (1987) 1.43
Human dioxin-inducible cytosolic NAD(P)H:menadione oxidoreductase. cDNA sequence and localization of gene to chromosome 16. J Biol Chem (1988) 1.42
The Ah locus: genetic regulation of the metabolism of carcinogens, drugs, and other environmental chemicals by cytochrome P-450-mediated monooxygenases. CRC Crit Rev Biochem (1979) 1.41
Structural gene products of the Ah locus. Transcriptional regulation of cytochrome P1-450 and P3-450 mRNA levels by 3-methylcholanthrene. Mol Pharmacol (1984) 1.37
Studies on the immunobiology of rnu/rnu "nude" rats with congenital aplasia of the thymus. Eur J Immunol (1980) 1.36
Mutations affecting the regulation of transcription of the cytochrome P1-450 gene in the mouse Hepa-1 cell line. J Biol Chem (1985) 1.36
Regulatory gene product of the Ah locus. Characterization of the cytosolic inducer-receptor complex and evidence for its nuclear translocation. J Biol Chem (1979) 1.36
Cyp1a2(-/-) null mutant mice develop normally but show deficient drug metabolism. Proc Natl Acad Sci U S A (1996) 1.35
The UDP glucuronosyltransferase gene superfamily: suggested nomenclature based on evolutionary divergence. DNA Cell Biol (1991) 1.35
Aryl hydrocarbon hydroxylase induction by polycyclic hydrocarbons: simple autosomal dominant trait in the mouse. Nat New Biol (1972) 1.35
Genetic regulation of aryl hydrocarbon hydroxylase induction. II. Simple Mendelian expression in mouse tissues in vivo. J Biol Chem (1972) 1.34
Genetic control of interindividual variations in the inducibility of aryl hydrocarbon hydroxylase in cultured human lymphocytes. Cancer Res (1976) 1.34
Human P1-450 gene sequence and correlation of mRNA with genetic differences in benzo[a]pyrene metabolism. Nucleic Acids Res (1985) 1.33
Isolation and sequence of cDNA encoding a cytochrome P-450 from an insecticide-resistant strain of the house fly, Musca domestica. Proc Natl Acad Sci U S A (1989) 1.29
Genetic regulation of aryl hydrocarbon hydroxylase induction in the mouse. Fed Proc (1972) 1.28
The Ah locus and the metabolism of chemical carcinogens and other foreign compounds. Adv Cancer Res (1977) 1.27
Dioxin-dependent activation of murine Cyp1a-1 gene transcription requires protein kinase C-dependent phosphorylation. Mol Cell Biol (1992) 1.27
Human CYP1A1 gene: cosegregation of the enzyme inducibility phenotype and an RFLP. Am J Hum Genet (1991) 1.25
Tetrahymanol biosynthesis. Studies in vitro on squalene cyclization. J Biol Chem (1970) 1.25
Human CYP1A2: sequence, gene structure, comparison with the mouse and rat orthologous gene, and differences in liver 1A2 mRNA expression. Mol Endocrinol (1989) 1.24
Clinical pharmacology. Possible clinical importance of genetic differences in drug metabolism. Br Med J (Clin Res Ed) (1981) 1.24
Targeted knockout of Cyp1a1 gene does not alter hepatic constitutive expression of other genes in the mouse [Ah] battery. Biochem Biophys Res Commun (2000) 1.24
Temperature-dependent cytosol-to-nucleus translocation of the Ah receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin in continuous cell culture lines. J Biol Chem (1980) 1.23
The human dioxin-inducible NAD(P)H: quinone oxidoreductase cDNA-encoded protein expressed in COS-1 cells is identical to diaphorase 4. Eur J Biochem (1991) 1.23
The Ah locus: correlation of intranuclear appearance of inducer-receptor complex with induction of cytochrome P1-450 mRNA. Cell (1982) 1.21
Quantitative approaches for assessing dose-response relationships in genetic toxicology studies. Environ Mol Mutagen (2012) 1.19
Gleason scoring varies among pathologists and this affects clinical risk in patients with prostate cancer. Clin Oncol (R Coll Radiol) (2005) 1.19
The murine Ah locus: in utero toxicity and teratogenesis associated with genetic differences in benzo[a]pyrene metabolism. Teratology (1979) 1.18
Tissue-specific expression of the mouse dioxin-inducible P(1)450 and P(3)450 genes: differential transcriptional activation and mRNA stability in liver and extrahepatic tissues. Mol Cell Biol (1986) 1.17
Structural gene products of the Ah locus. Genetic and immunochemical evidence for two forms of mouse liver cytochrome P-450 induced by 3-methylcholanthrene. J Biol Chem (1979) 1.17
Sulfobetaine derivatives of bile acids: nondenaturing surfactants for membrane biochemistry. Anal Biochem (1983) 1.15
Genetic expression of aryl hydrocarbon hydroxylase activity in the mouse. J Cell Physiol (1975) 1.15
Electrofocusing of integral membrane proteins in mixtures of zwitterionic and nonionic detergents. Anal Biochem (1979) 1.15
Derivation of point of departure (PoD) estimates in genetic toxicology studies and their potential applications in risk assessment. Environ Mol Mutagen (2014) 1.15
Genetic mechanisms controlling the induction of polysubstrate monooxygenase (P-450) activities. Annu Rev Pharmacol Toxicol (1981) 1.13
Purification and characterization of heterologously expressed mouse CYP2A5 and CYP2G1: role in metabolic activation of acetaminophen and 2,6-dichlorobenzonitrile in mouse olfactory mucosal microsomes. J Pharmacol Exp Ther (1998) 1.13
Importance of the route of administration for genetic differences in benzo[a]pyrene-induced in utero toxicity and teratogenicity. Teratology (1984) 1.12
Genetic differences in microsomal electron transport: the Ah locus. Methods Enzymol (1978) 1.12
Stereochemistry of tritium at C-1 and C-7 in cholesterol derived from (3R,2R)-2T-mevalonic acid. Tetrahedron Lett (1968) 1.11
Genetic differences in the extent of aryl hydrocarbon hydroxylase induction in mouse fetal cell cultures. J Biol Chem (1970) 1.10
Isolation and characterization of a cloned DNA sequence associated with the murine Ah locus and a 3-methylcholanthrene-induced form of cytochrome P-450. Proc Natl Acad Sci U S A (1981) 1.10
Multiple forms of cytochrome P-450 and the importance of molecular biology and evolution. Biochem Pharmacol (1982) 1.09
Mouse cytochrome P3-450: complete cDNA and amino acid sequence. Nucleic Acids Res (1984) 1.08
P450 gene nomenclature based on evolution. Methods Enzymol (1991) 1.08
Assignment of the human 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible cytochrome P1-450 gene to chromosome 15. Nucleic Acids Res (1985) 1.08
Drug metabolism. Growth signal pathways. Nature (1990) 1.07
Butylated hydroxytoluene exposure is necessary to induce lung tumors in BALB mice treated with 3-methylcholanthrene. Cancer Res (1997) 1.07
Benzo[a]pyrene-induced toxicity: paradoxical protection in Cyp1a1(-/-) knockout mice having increased hepatic BaP-DNA adduct levels. Biochem Biophys Res Commun (2001) 1.06
Nephrotoxicity of Penicillium aurantiogriseum, a possible factor in the aetiology of Balkan endemic nephropathy. Mycopathologia (1988) 1.06
Isolation and characterization of full-length mouse cDNA and genomic clones of 3-methylcholanthrene-inducible cytochrome P1-450 and P3-450. Gene (1984) 1.05
Multiple forms of inducible drug-metabolizing enzymes: a reasonable mechanism by which any organism can cope with adversity. Mol Cell Biochem (1979) 1.05
The Ah locus, a multigene family necessary for survival in a chemically adverse environment: comparison with the immune system. Adv Genet (1982) 1.05
Human CYP1A1 (cytochrome P(1)450) gene: lack of association between the Msp I restriction fragment length polymorphism and incidence of lung cancer in a Norwegian population. Pharmacogenetics (1991) 1.05
Thunderstorm-related asthma--the epidemic of 24/25 June 1994. Clin Exp Allergy (1997) 1.04
Failure of nude (athymic) rats to become resistant to reinfection with the intestinal coccidian parasite Eimeria nieschulzi or the nematode Nippostrongylus brasiliensis. Parasite Immunol (1979) 1.04
Susceptibility to immunosuppression by ultraviolet B radiation in the mouse. Immunogenetics (1994) 1.04
Additional evidence that the K-ras protooncogene is a candidate for the major mouse pulmonary adenoma susceptibility (Pas-1) gene. Exp Lung Res (1998) 1.03
Comparison of beta-naphthoflavone and 3-methylcholanthrene as inducers of hepatic cytochrome(s) P-448 and aryl hydrocarbon (benzo[a]pyrene) hydroxylase activity. Mol Pharmacol (1977) 1.03
Effect of 2,3,7,8-tetrachlorodibenzo-1,4-dioxin on drug metabolism in the rat. Biochem Pharmacol (1972) 1.02
Dioxin causes a sustained oxidative stress response in the mouse. Biochem Biophys Res Commun (1998) 1.02
Genetic differences in susceptibility to chemically induced myelotoxicity and leukemia. Environ Health Perspect (1981) 1.01
A sensitive radiometric assay of aminopyrine N-demethylation. J Pharmacol Exp Ther (1973) 1.01
Wheel activity in 26 strains of mouse. Lab Anim (1977) 1.00