Published in J Biol Chem on September 25, 1988
Potency of Michael reaction acceptors as inducers of enzymes that protect against carcinogenesis depends on their reactivity with sulfhydryl groups. Proc Natl Acad Sci U S A (2001) 3.17
Introducing the "TCDD-inducible AhR-Nrf2 gene battery". Toxicol Sci (2009) 1.50
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The antioxidant transcription factor Nrf2 negatively regulates autophagy and growth arrest induced by the anticancer redox agent mitoquinone. J Biol Chem (2010) 1.33
Presence of a heterozygous substitution and its relationship to DT-diaphorase activity. Br J Cancer (1995) 1.28
NAD(P)H:quinone oxidoreductase1 (DT diaphorase) specifically prevents the formation of benzo[a]pyrene quinone-DNA adducts generated by cytochrome P4501A1 and P450 reductase. Proc Natl Acad Sci U S A (1994) 1.26
NQO1 polymorphisms and de novo childhood leukemia: a HuGE review and meta-analysis. Am J Epidemiol (2008) 1.25
The quinone reductase gene: a unique estrogen receptor-regulated gene that is activated by antiestrogens. Proc Natl Acad Sci U S A (1997) 1.20
Enzymology of bioreductive drug activation. Br J Cancer Suppl (1996) 0.94
Modulation of gene expression in subjects at risk for colorectal cancer by the chemopreventive dithiolethione oltipraz. J Clin Invest (1996) 0.92
The Role of Human Aldo-Keto Reductases in the Metabolic Activation and Detoxication of Polycyclic Aromatic Hydrocarbons: Interconversion of PAH Catechols and PAH o-Quinones. Front Pharmacol (2012) 0.90
Hydroquinones cause specific mutations and lead to cellular transformation and in vivo tumorigenesis. Br J Cancer (1998) 0.90
NAD(P)H:quinone oxidoreductase 1 reduces the mutagenicity of DNA caused by NADPH:P450 reductase-activated metabolites of benzo(a)pyrene quinones. Br J Cancer (1998) 0.89
Mouse liver NAD(P)H:quinone acceptor oxidoreductase: protein sequence analysis by tandem mass spectrometry, cDNA cloning, expression in Escherichia coli, and enzyme activity analysis. Protein Sci (1994) 0.87
Expression of rat liver NAD(P)H:quinone-acceptor oxidoreductase in Escherichia coli and mutagenesis in vitro at Arg-177. Biochem J (1992) 0.87
Marked increases in hepatic NAD(P)H:oxidoreductase gene transcription and mRNA levels correlated with a mouse chromosome 7 deletion. Proc Natl Acad Sci U S A (1989) 0.85
Association of NQO1 rs1800566 polymorphism and the risk of colorectal cancer: a meta-analysis. Int J Colorectal Dis (2012) 0.84
NAD(P)H:quinone oxidoreductase 1 Arg139Trp and Pro187Ser polymorphisms imbalance estrogen metabolism towards DNA adduct formation in human mammary epithelial cells. J Steroid Biochem Mol Biol (2009) 0.83
Persistent induction of hepatic and pulmonary phase II enzymes by 3-methylcholanthrene in rats. Toxicol Sci (2008) 0.83
A unique cytosolic activity related but distinct from NQO1 catalyses metabolic activation of mitomycin C. Br J Cancer (2000) 0.81
DT-diaphorase activity in NSCLC and SCLC cell lines: a role for fos/jun regulation. Br J Cancer (1999) 0.80
Implications of NQO1 in cancer therapy. BMB Rep (2015) 0.79
Subunit functional studies of NAD(P)H:quinone oxidoreductase with a heterodimer approach. Proc Natl Acad Sci U S A (1995) 0.79
Depleting Tumor-NQO1 Potentiates Anoikis and Inhibits Growth of NSCLC. Mol Cancer Res (2015) 0.76
Short-term Exposure to 50-Hz Electromagnetic Field and Alterations in NQO1 and NQO2 Expression in MCF-7 Cells. Open Access Maced J Med Sci (2016) 0.75
CstF-64 and 3'-UTR cis-element determine Star-PAP specificity for target mRNA selection by excluding PAPα. Nucleic Acids Res (2015) 0.75
Isolation and regional localization of a large collection (2,000) of single-copy DNA fragments on human chromosome 3 for mapping and cloning tumor suppressor genes. Hum Genet (1991) 12.52
Polyadenylic acid sequences: role in conversion of nuclear RNA into messenger RNA. Science (1971) 10.54
Mechanisms for the incorporation of proteins in membranes and organelles. J Cell Biol (1982) 9.67
Cloning the chromosomal breakpoint of t(14;18) human lymphomas: clustering around JH on chromosome 14 and near a transcriptional unit on 18. Cell (1985) 7.29
Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease. Science (1987) 6.89
Interleukin-2 receptor gamma chain mutation results in X-linked severe combined immunodeficiency in humans. Cell (1993) 6.83
P450 genes: structure, evolution, and regulation. Annu Rev Biochem (1987) 6.72
P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature. Pharmacogenetics (1996) 6.12
Immune system impairment and hepatic fibrosis in mice lacking the dioxin-binding Ah receptor. Science (1995) 6.03
Mammalian genes coordinately regulated by growth arrest signals and DNA-damaging agents. Mol Cell Biol (1989) 5.25
L-myc, a new myc-related gene amplified and expressed in human small cell lung cancer. Nature (1985) 4.66
Construction of mutant and chimeric genes using the polymerase chain reaction. Nucleic Acids Res (1989) 4.19
Processed genes: a dispersed human immunoglobulin gene bearing evidence of RNA-type processing. Nature (1982) 4.14
Hydrolysis of GTP on rab11 is required for the direct delivery of transferrin from the pericentriolar recycling compartment to the cell surface but not from sorting endosomes. Proc Natl Acad Sci U S A (1998) 4.03
Actin microfilaments play a critical role in endocytosis at the apical but not the basolateral surface of polarized epithelial cells. J Cell Biol (1993) 4.00
Evidence that all messenger RNA molecules (except histone messenger RNA) contain Poly (A) sequences and that the Poly(A) has a nuclear function. J Mol Biol (1972) 3.93
Substrate-inducible microsomal aryl hydroxylase in mammalian cell culture. I. Assay and properties of induced enzyme. J Biol Chem (1968) 3.74
Characterization of the common genetic defect in humans deficient in debrisoquine metabolism. Nature (1988) 3.69
Biogenesis and characterization of histone messenger RNA in HeLa cells. J Mol Biol (1972) 3.14
The P450 superfamily: updated listing of all genes and recommended nomenclature for the chromosomal loci. DNA (1989) 3.03
Human thyroid peroxidase: complete cDNA and protein sequence, chromosome mapping, and identification of two alternately spliced mRNAs. Proc Natl Acad Sci U S A (1987) 3.00
The P450 gene superfamily: recommended nomenclature. DNA (1987) 2.95
Transfer of genetic information by purified metaphase chromosomes. Proc Natl Acad Sci U S A (1973) 2.88
Evolution of the P450 gene superfamily: animal-plant 'warfare', molecular drive and human genetic differences in drug oxidation. Trends Genet (1990) 2.63
Further evidence on the nuclear origin and transfer to the cytoplasm of polyadenylic acid sequences in mammalian cell RNA. J Mol Biol (1973) 2.61
The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence. Pharmacogenetics (1997) 2.55
Cloning and characterization of a vasopressin V2 receptor and possible link to nephrogenic diabetes insipidus. Nature (1992) 2.37
Chromosomal location of human kappa and lambda immunoglobulin light chain constant region genes. J Exp Med (1982) 2.30
Synthesis and maturation of ribosomal RNA in Escherichia coli. J Mol Biol (1969) 2.24
Report of the committee on the genetic constitution of chromosome 11. Cytogenet Cell Genet (1989) 2.21
The gene for human p53 cellular tumor antigen is located on chromosome 17 short arm (17p13). Proc Natl Acad Sci U S A (1986) 2.18
Developmental defects in Gorlin syndrome related to a putative tumor suppressor gene on chromosome 9. Cell (1992) 2.15
Genes for cytochrome P-450 and their regulation. CRC Crit Rev Biochem (1986) 2.12
Human dioxin-inducible cytochrome P1-450: complementary DNA and amino acid sequence. Science (1985) 2.11
Cloning of the cDNA encoding an RNA regulatory protein--the human iron-responsive element-binding protein. Proc Natl Acad Sci U S A (1990) 2.03
cDNA cloning, chromosomal mapping, and functional characterization of the human peroxisome proliferator activated receptor. Biochemistry (1993) 2.03
Human nonmuscle myosin heavy chains are encoded by two genes located on different chromosomes. Circ Res (1991) 1.98
Secretion of endogenous and exogenous proteins from polarized MDCK cell monolayers. Proc Natl Acad Sci U S A (1986) 1.95
Nomenclature for human CYP2D6 alleles. Pharmacogenetics (1996) 1.91
Organization, structure, and polymorphisms of the human profilaggrin gene. Biochemistry (1990) 1.89
Synthesis and insertion of cytochrome P-450 into endoplasmic reticulum membranes. Proc Natl Acad Sci U S A (1980) 1.88
Comparison of the flanking regions and introns of the mouse 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible cytochrome P1-450 and P3-450 genes. J Biol Chem (1985) 1.79
Human debrisoquine 4-hydroxylase (P450IID1): cDNA and deduced amino acid sequence and assignment of the CYP2D locus to chromosome 22. Genomics (1988) 1.75
The murine Ah locus. Comparison of the complete cytochrome P1-450 and P3-450 cDNA nucleotide and amino acid sequences. J Biol Chem (1984) 1.75
Eukaryotic aldehyde dehydrogenase (ALDH) genes: human polymorphisms, and recommended nomenclature based on divergent evolution and chromosomal mapping. Pharmacogenetics (1999) 1.74
Chromosomal mapping of the simian sarcoma virus onc gene analogue in human cells. Proc Natl Acad Sci U S A (1982) 1.72
Metabolism of polycyclic aromatic hydrocarbons: etiologic role in carcinogenesis. Pharmacol Rev (1982) 1.70
Tight linkage between the syndrome of generalized thyroid hormone resistance and the human c-erbA beta gene. Mol Endocrinol (1988) 1.69
Induction by ionizing radiation of the gadd45 gene in cultured human cells: lack of mediation by protein kinase C. Mol Cell Biol (1991) 1.69
Human ethanol-inducible P450IIE1: complete gene sequence, promoter characterization, chromosome mapping, and cDNA-directed expression. Biochemistry (1988) 1.69
Cotransfer of thymidine kinase and galactokinase genes by chromosome-mediated gene transfer. Proc Natl Acad Sci U S A (1978) 1.67
Polymorphisms in drug-metabolizing enzymes: what is their clinical relevance and why do they exist? Am J Hum Genet (1997) 1.67
Sorting and endocytosis of viral glycoproteins in transfected polarized epithelial cells. J Cell Biol (1986) 1.66
cDNA sequence, protein structure, and chromosomal location of the human gene for poly(ADP-ribose) polymerase. Proc Natl Acad Sci U S A (1987) 1.66
Isolation of the human peroxisome proliferator activated receptor gamma cDNA: expression in hematopoietic cells and chromosomal mapping. Gene Expr (1995) 1.63
cDNA cloning, mRNA distribution and heterogeneity, chromosomal location, and RFLP analysis of human osteopontin (OPN). Genomics (1990) 1.60
Human interleukin 2 receptor beta-chain gene: chromosomal localization and identification of 5' regulatory sequences. Proc Natl Acad Sci U S A (1990) 1.59
Analysis of the mammalian gadd45 gene and its response to DNA damage. J Biol Chem (1993) 1.58
Direct association of messenger RNA with microsomal membranes in human diploid fibroblasts. J Cell Biol (1975) 1.57
Isolation, characterization and chromosomal localization of the human GADD153 gene. Gene (1992) 1.55
Autoregulation plus upstream positive and negative control regions associated with transcriptional activation of the mouse P1(450) gene. Nucleic Acids Res (1985) 1.55
Signals for the incorporation and orientation of cytochrome P450 in the endoplasmic reticulum membrane. J Cell Biol (1988) 1.55
The chemical defensome: environmental sensing and response genes in the Strongylocentrotus purpuratus genome. Dev Biol (2006) 1.54
Chromosomal protein HMG-14. Identification, characterization, and chromosome localization of a functional gene from the large human multigene family. J Biol Chem (1989) 1.53
Regulatory gene product of the Ah locus. Characterization of receptor mutants among mouse hepatoma clones. J Biol Chem (1982) 1.52
Knockout of the mouse glutamate cysteine ligase catalytic subunit (Gclc) gene: embryonic lethal when homozygous, and proposed model for moderate glutathione deficiency when heterozygous. Biochem Biophys Res Commun (2000) 1.51
Somatic allelic deletion of nm23 in human cancer. Cancer Res (1991) 1.50
The in vivo and in vitro induction of aryl hydrocarbon hydroxylase in mammalian cells of different species, tissues, strains, and developmental and hormonal states. Arch Biochem Biophys (1969) 1.50
Recommendations for locus-specific databases and their curation. Hum Mutat (2008) 1.49
Evolution and organization of the fibrinogen locus on chromosome 4: gene duplication accompanied by transposition and inversion. Proc Natl Acad Sci U S A (1985) 1.49
Regulation of mouse CYP1A1 gene expression by dioxin: requirement of two cis-acting elements during induction. Mol Cell Biol (1989) 1.49
Localization of the normal allele of T24 human bladder carcinoma oncogene to chromosome 11. Nature (1982) 1.48
Human gene expression in rodent cells after uptake of isolated metaphase chromosomes. Proc Natl Acad Sci U S A (1975) 1.47
Regional linkage analysis of the dioxin-inducible P-450 gene family on mouse chromosome 9. Biochem Biophys Res Commun (1985) 1.47
Complete cDNA and protein sequence of a pregnenolone 16 alpha-carbonitrile-induced cytochrome P-450. A representative of a new gene family. J Biol Chem (1985) 1.46
Substrate-inducible microsomal aryl hydroxylase in mammalian cell culture. II. Cellular responses during enzyme induction. J Biol Chem (1968) 1.45
Localization of human variable and constant region immunoglobulin heavy chain genes on subtelomeric band q32 of chromosome 14. Nucleic Acids Res (1982) 1.45
Transport of influenza HA from the trans-Golgi network to the apical surface of MDCK cells permeabilized in their basolateral plasma membranes: energy dependence and involvement of GTP-binding proteins. J Cell Biol (1990) 1.45
A sorting signal for the basolateral delivery of the vesicular stomatitis virus (VSV) G protein lies in its luminal domain: analysis of the targeting of VSV G-influenza hemagglutinin chimeras. Proc Natl Acad Sci U S A (1989) 1.43
Biosynthesis and intracellular sorting of growth hormone-viral envelope glycoprotein hybrids. J Cell Biol (1985) 1.42
The Ah locus: genetic regulation of the metabolism of carcinogens, drugs, and other environmental chemicals by cytochrome P-450-mediated monooxygenases. CRC Crit Rev Biochem (1979) 1.41
Regional chromosomal localization of N-ras, K-ras-1, K-ras-2 and myb oncogenes in human cells. Nucleic Acids Res (1983) 1.41
Extensive size polymorphism of the human keratin 10 chain resides in the C-terminal V2 subdomain due to variable numbers and sizes of glycine loops. Proc Natl Acad Sci U S A (1992) 1.39
Cotransfer of linked eukaryotic genes and efficient transfer of hypoxanthine phosphoribosyltransferase by DNA-mediated gene transfer. Proc Natl Acad Sci U S A (1980) 1.38
Structural gene products of the Ah locus. Transcriptional regulation of cytochrome P1-450 and P3-450 mRNA levels by 3-methylcholanthrene. Mol Pharmacol (1984) 1.37
Stable expression of rat cytochrome P-450IIB1 cDNA in Chinese hamster cells (V79) and metabolic activation of aflatoxin B1. Proc Natl Acad Sci U S A (1988) 1.37
Mutations affecting the regulation of transcription of the cytochrome P1-450 gene in the mouse Hepa-1 cell line. J Biol Chem (1985) 1.36
Regulatory gene product of the Ah locus. Characterization of the cytosolic inducer-receptor complex and evidence for its nuclear translocation. J Biol Chem (1979) 1.36
Human NAD(P)H:quinone oxidoreductase (NQO1) gene structure and induction by dioxin. Biochemistry (1991) 1.35
Cyp1a2(-/-) null mutant mice develop normally but show deficient drug metabolism. Proc Natl Acad Sci U S A (1996) 1.35
RNA metabolism in T4-infected Escherichia coli. J Mol Biol (1970) 1.35
Aryl hydrocarbon hydroxylase induction by polycyclic hydrocarbons: simple autosomal dominant trait in the mouse. Nat New Biol (1972) 1.35
The UDP glucuronosyltransferase gene superfamily: suggested nomenclature based on evolutionary divergence. DNA Cell Biol (1991) 1.35
Genetic regulation of aryl hydrocarbon hydroxylase induction. II. Simple Mendelian expression in mouse tissues in vivo. J Biol Chem (1972) 1.34
Genetic control of interindividual variations in the inducibility of aryl hydrocarbon hydroxylase in cultured human lymphocytes. Cancer Res (1976) 1.34
Human P1-450 gene sequence and correlation of mRNA with genetic differences in benzo[a]pyrene metabolism. Nucleic Acids Res (1985) 1.33
In its active form, the GTP-binding protein rab8 interacts with a stress-activated protein kinase. Proc Natl Acad Sci U S A (1996) 1.33
A cytochrome P-450 multigene family. Characterization of a gene activated by phenobarbital administration. J Biol Chem (1983) 1.31