Published in J Biol Chem on August 10, 1984
A neo-substrate that amplifies catalytic activity of parkinson's-disease-related kinase PINK1. Cell (2013) 1.84
Femtosecond dynamics coupled to chemical barrier crossing in a Born-Oppenheimer enzyme. Proc Natl Acad Sci U S A (2011) 1.46
Covalent modification of the beta-1,4-N-acetylmuramoylhydrolase of Streptococcus faecium with 5-mercaptouridine monophosphate. Proc Natl Acad Sci U S A (1988) 1.20
Transition State Structure for the Hydrolysis of NAD Catalyzed by Diphtheria Toxin. J Am Chem Soc (1997) 1.20
Transition-state analysis of S. pneumoniae 5'-methylthioadenosine nucleosidase. J Am Chem Soc (2007) 1.15
Transition states of Plasmodium falciparum and human orotate phosphoribosyltransferases. J Am Chem Soc (2009) 1.11
Transition-state variation in human, bovine, and Plasmodium falciparum adenosine deaminases. J Am Chem Soc (2007) 0.98
An oxocarbenium-ion intermediate of a ribozyme reaction indicated by kinetic isotope effects. Proc Natl Acad Sci U S A (2003) 0.94
Site-specific labeling of nucleotides for making RNA for high resolution NMR studies using an E. coli strain disabled in the oxidative pentose phosphate pathway. J Biomol NMR (2010) 0.90
Transition state analysis of thymidine hydrolysis by human thymidine phosphorylase. J Am Chem Soc (2010) 0.89
Ground-state destabilization in orotate phosphoribosyltransferases by binding isotope effects. Biochemistry (2011) 0.88
Mechanisms for enzymatic cleavage of the N-glycosidic bond in DNA. Org Biomol Chem (2014) 0.88
Transition states of native and drug-resistant HIV-1 protease are the same. Proc Natl Acad Sci U S A (2012) 0.84
Leaving group activation and pyrophosphate ionic state at the catalytic site of Plasmodium falciparum orotate phosphoribosyltransferase. J Am Chem Soc (2010) 0.83
Pyrophosphate interactions at the transition states of Plasmodium falciparum and human orotate phosphoribosyltransferases. J Am Chem Soc (2010) 0.83
Arsenate and phosphate as nucleophiles at the transition states of human purine nucleoside phosphorylase. Biochemistry (2011) 0.83
Determination of relative rate constants for in vitro RNA processing reactions by internal competition. Anal Biochem (2014) 0.82
Transition state analysis of the arsenolytic depyrimidination of thymidine by human thymidine phosphorylase. Biochemistry (2011) 0.82
The rate of spontaneous cleavage of the glycosidic bond of adenosine. Bioorg Chem (2010) 0.81
Transition-state analysis of Trypanosoma cruzi uridine phosphorylase-catalyzed arsenolysis of uridine. J Am Chem Soc (2011) 0.81
Uridine phosphorylase from Trypanosoma cruzi: kinetic and chemical mechanisms. Biochemistry (2011) 0.79
Heavy atom labeled nucleotides for measurement of kinetic isotope effects. Biochim Biophys Acta (2015) 0.78
Transition state for the NSD2-catalyzed methylation of histone H3 lysine 36. Proc Natl Acad Sci U S A (2016) 0.78
Expression, purification and analysis of the activity of enzymes from the pentose phosphate pathway. Protein Expr Purif (2010) 0.77
Determination of hepatitis delta virus ribozyme N(-1) nucleobase and functional group specificity using internal competition kinetics. Anal Biochem (2015) 0.77
Evidence that Oxidative Dephosphorylation by the Non-heme Fe(II), α-Ketoglutarate:UMP Oxygenase Occurs by Stereospecific Hydroxylation. FEBS Lett (2017) 0.75
Continuous Fluorescence Assays for Reactions Involving Adenine. Anal Chem (2016) 0.75
Transition States. J Biol Chem (2009) 0.75
Chemistry of gene silencing: the mechanism of NAD+-dependent deacetylation reactions. Biochemistry (2001) 2.54
Thresholds for treatment in cataract surgery. J Public Health Med (1994) 2.12
One-third-the-sites transition-state inhibitors for purine nucleoside phosphorylase. Biochemistry (1998) 1.99
The extracapsular spread of tumors in cervical node metastasis. Arch Otolaryngol (1981) 1.92
Transition state structure of purine nucleoside phosphorylase and principles of atomic motion in enzymatic catalysis. Biochemistry (2001) 1.86
Purine nucleoside phosphorylase. Catalytic mechanism and transition-state analysis of the arsenolysis reaction. Biochemistry (1993) 1.82
Climate change and the integrity of science. Science (2010) 1.80
Mechanism of 3-mercaptopicolinic acid inhibition of hepatic phosphoenolpyruvate carboxykinase (GTP). J Biol Chem (1976) 1.74
Subtemporal-preauricular infratemporal fossa approach to large lateral and posterior cranial base neoplasms. J Neurosurg (1987) 1.69
The 2.0 A structure of human hypoxanthine-guanine phosphoribosyltransferase in complex with a transition-state analog inhibitor. Nat Struct Biol (1999) 1.57
Anterior skull base surgery for benign and malignant disease. Laryngoscope (1979) 1.55
What do international comparisons of health care expenditures really show? Community Med (1989) 1.51
The reaction mechanism for CD38. A single intermediate is responsible for cyclization, hydrolysis, and base-exchange chemistries. Biochemistry (1998) 1.43
Operative exposure and management of the petrous and upper cervical internal carotid artery. Neurosurgery (1986) 1.40
The role of adenosine monophosphate nucleosidase in the regulation of adenine nucleotide levels in Azotobacter vinelandii during aerobic-anaerobic transitions. Arch Biochem Biophys (1978) 1.40
Pattern of ophthalmological accidents and emergencies presenting to hospitals. J Epidemiol Community Health (1993) 1.32
Chordoma and chondrosarcoma of the cranial base: an 8-year experience. Neurosurgery (1989) 1.28
Antimicrobial prophylaxis for contaminated head and neck surgery. Laryngoscope (1984) 1.27
Transition-state analogs as inhibitors of human and malarial hypoxanthine-guanine phosphoribosyltransferases. Nat Struct Biol (1999) 1.25
Regulation of adenosine monophosphate levels as a function of adenosine triphosphate and inorganic phosphate. A proposed metabolic role for adenosine monophosphate nucleosidase from Azotobacter vinelandii. J Biol Chem (1973) 1.25
A new method to predict safe resection of the internal carotid artery. Laryngoscope (1990) 1.24
Covalent modification of the beta-1,4-N-acetylmuramoylhydrolase of Streptococcus faecium with 5-mercaptouridine monophosphate. Proc Natl Acad Sci U S A (1988) 1.20
Cervical lymph node metastases. Incidence and implications of extracapsular carcinoma. Arch Otolaryngol (1985) 1.18
Evaluation of orbital cellulitis and results of treatment. Laryngoscope (1982) 1.17
Immucillin H, a powerful transition-state analog inhibitor of purine nucleoside phosphorylase, selectively inhibits human T lymphocytes. Proc Natl Acad Sci U S A (2001) 1.17
Reconstruction of the cranial base following tumour resection. Br J Plast Surg (1987) 1.16
Evaluation of a Hong Kong Chinese version of a self-administered questionnaire for assessing symptom severity and functional status of carpal tunnel syndrome: cross-cultural adaptation and reliability. Hong Kong Med J (2007) 1.14
Pertussis toxin: transition state analysis for ADP-ribosylation of G-protein peptide alphai3C20. Biochemistry (1997) 1.14
Management of inverted papilloma of the nose and paranasal sinuses. Laryngoscope (1981) 1.14
Nucleoside hydrolase from Leishmania major. Cloning, expression, catalytic properties, transition state inhibitors, and the 2.5-å crystal structure. J Biol Chem (1999) 1.10
Kinetic isotope effect characterization of the transition state for oxidized nicotinamide adenine dinucleotide hydrolysis by pertussis toxin. Biochemistry (1997) 1.10
Transition-state analysis of nucleoside hydrolase from Crithidia fasciculata. Biochemistry (1991) 1.08
Hydrolysis of soluble, linear, un-cross-linked peptidoglycans by endogenous bacterial N-acetylmuramoylhydrolases. J Bacteriol (1984) 1.07
Extracapsular spread of carcinoma in cervical lymph nodes. Impact upon survival in patients with carcinoma of the supraglottic larynx. Cancer (1985) 1.05
Inosine-uridine nucleoside hydrolase from Crithidia fasciculata. Genetic characterization, crystallization, and identification of histidine 241 as a catalytic site residue. Biochemistry (1996) 1.05
The mechanism of soluble peptidoglycan hydrolysis by an autolytic muramidase. A processive exodisaccharidase. J Biol Chem (1984) 1.05
Nucleoside hydrolase from Crithidia fasciculata. Metabolic role, purification, specificity, and kinetic mechanism. J Biol Chem (1991) 1.05
Ricin A-chain: kinetics, mechanism, and RNA stem-loop inhibitors. Biochemistry (1998) 1.05
Free rectus abdominis muscle flap reconstruction of the middle and posterior cranial base. Plast Reconstr Surg (1986) 1.05
Pre-steady-state transition-state analysis of the hydrolytic reaction catalyzed by purine nucleoside phosphorylase. Biochemistry (1995) 1.04
Cervical lymph node metastasis after local excision of early squamous cell carcinoma of the oral cavity. Am J Surg (1986) 1.03
The 2.0 A structure of malarial purine phosphoribosyltransferase in complex with a transition-state analogue inhibitor. Biochemistry (1999) 1.02
Nasal polyps in children. Laryngoscope (1980) 1.02
Structures of purine nucleoside phosphorylase from Mycobacterium tuberculosis in complexes with immucillin-H and its pieces. Biochemistry (2001) 1.02
Structural analysis of adenine phosphoribosyltransferase from Saccharomyces cerevisiae. Biochemistry (2001) 1.01
Determination of free and bound manganese(II) in hepatocytes from fed and fasted rats. J Biol Chem (1982) 1.01
Purine nucleoside phosphorylase. Inosine hydrolysis, tight binding of the hypoxanthine intermediate, and third-the-sites reactivity. Biochemistry (1992) 1.00
Purification and partial characterization of a Nocardia brasiliensis extracellular protease. J Bacteriol (1984) 1.00
Conformational equilibrium isotope effects in glucose by (13)C NMR spectroscopy and computational studies. J Am Chem Soc (2001) 0.98
Molecular cloning and expression of a purine-specific N-ribohydrolase from Trypanosoma brucei brucei. Sequence, expression, and molecular analysis. J Biol Chem (1998) 0.98
Transition-state structures for N-glycoside hydrolysis of AMP by acid and by AMP nucleosidase in the presence and absence of allosteric activator. Biochemistry (1987) 0.97
Action of magnesium ion on diphosphopyridine nucleotide-linked isocitrate dehydrogenase from bovine heart. Characterization of the forms of the substrate and the modifier of the reaction. J Biol Chem (1974) 0.96
Transition-state analysis of AMP deaminase. Biochemistry (1993) 0.96
Characterization of AMD, the AMP deaminase gene in yeast. Production of amd strain, cloning, nucleotide sequence, and properties of the protein. Biochemistry (1989) 0.95
Trypanosomal nucleoside hydrolase. A novel mechanism from the structure with a transition-state inhibitor. Biochemistry (1998) 0.94
Structure and regulation of the AMP nucleosidase gene (amn) from Escherichia coli. Biochemistry (1989) 0.94
Addition of lithiated 9-deazapurine derivatives to a carbohydrate cyclic imine: convergent synthesis of the aza-C-nucleoside immucillins. J Org Chem (2001) 0.94
Sinusitis and its complications in the pediatric patient. Pediatr Clin North Am (1981) 0.93
Mn2+-sensitive and -insensitive forms of phosphoenolpyruvate carboxykinase (GTP). J Biol Chem (1981) 0.93
Effect of 9-beta-D-arabinofuranosyladenine on polymer synthesis in a polyauxotrophic strain of Escherichia coli. J Bacteriol (1966) 0.93
Kinetic studies and active site-binding properties of glutathione S-transferase using spin-labeled glutathione, a product analogue. J Biol Chem (1984) 0.93
The rate constant describing slow-onset inhibition of yeast AMP deaminase by coformycin analogues is independent of inhibitor structure. Biochemistry (1990) 0.92
Comparison of initial velocity and binding data for allosteric adenosine monophosphate nucleosidase. J Biol Chem (1976) 0.92
Mn2(+)-binding properties of a recombinant protein-tyrosine kinase derived from the human insulin receptor. Proc Natl Acad Sci U S A (1990) 0.92
Electronic nature of the transition state for nucleoside hydrolase. A blueprint for inhibitor design. Biochemistry (1993) 0.92
AMP deaminase from yeast. Role in AMP degradation, large scale purification, and properties of the native and proteolyzed enzyme. J Biol Chem (1989) 0.92
Adenylate degradation in Escherichia coli. The role of AMP nucleosidase and properties of the purified enzyme. J Biol Chem (1980) 0.92
AMP nucleosidase: kinetic mechanism and thermodynamics. Biochemistry (1986) 0.92
A transition-state analogue reduces protein dynamics in hypoxanthine-guanine phosphoribosyltransferase. Biochemistry (2001) 0.91
A kinetic isotope effect study and transition state analysis of the S-adenosylmethionine synthetase reaction. J Biol Chem (1987) 0.90
Immucillin-H binding to purine nucleoside phosphorylase reduces dynamic solvent exchange. Protein Sci (2000) 0.90
5'-Deoxyadenosine contacts the substrate radical intermediate in the active site of ethanolamine ammonia-lyase: 2H and 13C electron nuclear double resonance studies. Biochemistry (2001) 0.90
Transition-state structure for the ADP-ribosylation of recombinant Gialpha1 subunits by pertussis toxin. Biochemistry (1998) 0.90
Mammalian and avian liver phosphoenolpyruvate carboxykinase. Alternate substrates and inhibition by analogues of oxaloacetate. J Biol Chem (1990) 0.90
Molecular characterisation of mitochondrial and cytosolic trypanothione-dependent tryparedoxin peroxidases in Trypanosoma brucei. Mol Biochem Parasitol (2001) 0.90
Subcellular location of phosphoenolpyruvate carboxykinase in hepatocytes from fed and starved rats. J Nutr (1986) 0.89
Transition-state analysis of a Vmax mutant of AMP nucleosidase by the application of heavy-atom kinetic isotope effects. Biochemistry (1991) 0.89
Thumb polydactyly: clinical outcome after reconstruction. J Orthop Surg (Hong Kong) (2006) 0.89
Correlation between magnetic resonance imaging and radiographic measurement of cervical spine in cervical myelopathic patients. J Orthop Surg (Hong Kong) (2004) 0.89
Crystal structures of Giardia lamblia guanine phosphoribosyltransferase at 1.75 A(,). Biochemistry (2000) 0.88
Purine nucleoside phosphorylase from Mycobacterium tuberculosis. Analysis of inhibition by a transition-state analogue and dissection by parts. Biochemistry (2001) 0.88
Catalytic mechanism of yeast adenosine 5'-monophosphate deaminase. Zinc content, substrate specificity, pH studies, and solvent isotope effects. Biochemistry (1993) 0.88
Analysis of age-related changes in electric responses from the inner ear of rats. Ann Otol Rhinol Laryngol (1972) 0.88
Spontaneous epimerization of (S)-deoxycoformycin and interaction of (R)-deoxycoformycin, (S)-deoxycoformycin, and 8-ketodeoxycoformycin with adenosine deaminase. Biochemistry (1985) 0.87
Three-dimensional structure of the inosine-uridine nucleoside N-ribohydrolase from Crithidia fasciculata. Biochemistry (1996) 0.87
Patient charges and the use of dental services: some evidence. Br Dent J (1988) 0.86
Acute management of laser-ignited intratracheal explosion. Laryngoscope (1981) 0.86
Cisplatin vestibular ototoxicity: preliminary report. Laryngoscope (1982) 0.86
Cisplatin therapy for adenoid cystic carcinoma. Arch Otolaryngol (1981) 0.85
The manganese(II) economy of rat hepatocytes. Fed Proc (1986) 0.85
Binding modes for substrate and a proposed transition-state analogue of protozoan nucleoside hydrolase. Biochemistry (1995) 0.85
Structure and function of a novel purine specific nucleoside hydrolase from Trypanosoma vivax. J Mol Biol (2001) 0.85
Histologic and electrophysiological changes of the paraspinal muscle after spinal fusion: an experimental study. Spine (Phila Pa 1976) (2008) 0.84
Catalytic and regulatory site composition of yeast AMP deaminase by comparative binding and rate studies. Resolution of the cooperative mechanism. J Biol Chem (1990) 0.84