Published in Nature on May 01, 1980
Molecular cloning and complete primary sequence of human erythrocyte porphobilinogen deaminase. Nucleic Acids Res (1986) 2.56
Regional gene assignment of human porphobilinogen deaminase and esterase A4 to chromosome 11q23 leads to 11qter. Proc Natl Acad Sci U S A (1981) 2.50
Characterization of the porphobilinogen deaminase deficiency in acute intermittent porphyria. Immunologic evidence for heterogeneity of the genetic defect. J Clin Invest (1981) 1.22
Modification of hydroxymethylbilane synthase (porphobilinogen deaminase) by pyridoxal 5'-phosphate. Demonstration of an essential lysine residue. Biochem J (1984) 1.20
Purification, N-terminal amino acid sequence and properties of hydroxymethylbilane synthase (porphobilinogen deaminase) from Escherichia coli. Biochem J (1986) 1.19
Acute intermittent porphyria: characterization of a novel mutation in the structural gene for porphobilinogen deaminase. Demonstration of noncatalytic enzyme intermediates stabilized by bound substrate. J Clin Invest (1985) 1.11
Human uroporphyrinogen III synthase: molecular cloning, nucleotide sequence, and expression of a full-length cDNA. Proc Natl Acad Sci U S A (1988) 1.09
Evidence that the pyrromethane cofactor of hydroxymethylbilane synthase (porphobilinogen deaminase) is bound through the sulphur atom of a cysteine residue. Biochem J (1988) 1.08
Conversion of 5-aminolaevulinate into haem by liver homogenates. Comparison of rat and chick embryo. Biochem J (1981) 1.06
Purification and properties of uroporphyrinogen III synthase (co-synthetase) from Euglena gracilis. Biochem J (1985) 1.06
Evidence that the pyrromethane cofactor of hydroxymethylbilane synthase (porphobilinogen deaminase) is bound to the protein through the sulphur atom of cysteine-242. Biochem J (1988) 0.92
Evidence that pyridoxal phosphate modification of lysine residues (Lys-55 and Lys-59) causes inactivation of hydroxymethylbilane synthase (porphobilinogen deaminase). Biochem J (1989) 0.92
Studies on the mechanism of hydroxymethylbilane synthase concerning the role of arginine residues in substrate binding. Biochem J (1991) 0.91
Rat hepatic uroporphyrinogen III co-synthase. Purification and evidence for a bound folate coenzyme participating in the biosynthesis of uroporphyrinogen III. Biochem J (1984) 0.88
Uroporphyrinogen III synthase knock-in mice have the human congenital erythropoietic porphyria phenotype, including the characteristic light-induced cutaneous lesions. Am J Hum Genet (2006) 0.85
Structure and mechanistic implications of a uroporphyrinogen III synthase-product complex. Biochemistry (2008) 0.85
HemQ: An iron-coproporphyrin oxidative decarboxylase for protoheme synthesis in Firmicutes and Actinobacteria. Arch Biochem Biophys (2015) 0.83
Genetic heterogeneity in acute intermittent porphyria: characterisation and frequency of porphobilinogen deaminase mutations in Finland. Br Med J (Clin Res Ed) (1985) 0.79
Heme-biosynthetic porphobilinogen deaminase protects Aspergillus nidulans from nitrosative stress. Appl Environ Microbiol (2011) 0.79
Analysis and separation of natural and synthetic mixtures of uroporphyrins by high-pressure liquid chromatography. Biochem J (1982) 0.79
A tale of two reductases: extending the bacteriochlorophyll biosynthetic pathway in E. coli. PLoS One (2014) 0.75
Transition-metal complexes of expanded porphyrins. Acc Chem Res (2007) 0.75
Forkhead containing transcription factor Albino controls tetrapyrrole-based body pigmentation in planarian. Cell Discov (2016) 0.75
In vitro and in vivo evaluation of A-56268 (TE-031), a new macrolide. Antimicrob Agents Chemother (1986) 4.51
ABT-538 is a potent inhibitor of human immunodeficiency virus protease and has high oral bioavailability in humans. Proc Natl Acad Sci U S A (1995) 3.18
Tired, weak, or in need of rest: fatigue among general practice attenders. BMJ (1990) 2.70
Biosynthesis of vitamin B12: identity of fragment extruded during ring contraction to the corrin macrocycle. Proc Natl Acad Sci U S A (1981) 2.60
Pharmacokinetic enhancement of inhibitors of the human immunodeficiency virus protease by coadministration with ritonavir. Antimicrob Agents Chemother (1997) 2.57
ABT-378, a highly potent inhibitor of the human immunodeficiency virus protease. Antimicrob Agents Chemother (1998) 2.23
Gait and balance impairment in early multiple sclerosis in the absence of clinical disability. Mult Scler (2006) 1.95
Biosynthesis of porphyrins and related macrocycles. Part 10. Vitamin B12: biochemical derivation of cobyrinic acid from uroporphyrinogen III. Studies with corresponding ring c methyl heptacarboxylic prophyrinogen, and proof of seven intact methyl transfers. J Chem Soc Perkin 1 (1977) 1.69
A novel mechanism of enzymic ester hydrolysis. Inversion of configuration and carbon-oxygen bond cleavage by secondary alkylsulphohydrolases from detergent-degrading micro-organisms. Biochem J (1977) 1.59
Occurrence of Cryptosporidium oocysts in fecal samples submitted for routine microbiological examination. J Clin Microbiol (1985) 1.57
Minimizing errors of omission: behavioural reenforcement of heparin to avert venous emboli: the BEHAVE study. Crit Care Med (2006) 1.52
Physicians declining patient enrollment in a critical care trial: a case study in thromboprophylaxis. Intensive Care Med (2013) 1.46
Biosynthesis of vitamin B12: structure of precorrin-6x octamethyl ester. Proc Natl Acad Sci U S A (1990) 1.46
Purification, properties and cellular localization of the stereospecific CS2 secondary alkylsulphohydrolase of Comamonas terrigena. Biochem J (1977) 1.43
Oral acyclovir for chickenpox. Cutis (1991) 1.40
Fertility desires and fertility: hers, his, and theirs. Demography (1990) 1.40
Carcinoma of the colon associated with systemic sclerosis. N Y State J Med (1990) 1.39
Preparation and characterization of substrates suitable for the study of stereospecific secondary alkylsulphohydrolases of detergent-degrading micro-organisms. Biochem J (1977) 1.38
Identification of primary HIV-1C infection in Botswana. AIDS Care (2008) 1.29
Determination of ritonavir, a new HIV protease inhibitor, in biological samples using reversed-phase high-performance liquid chromatography. J Chromatogr B Biomed Sci Appl (1997) 1.24
Alkaloid biosynthesis. XII. The biosynthesis of narcotine. J Chem Soc Perkin 1 (1968) 1.23
Amyotrophic lateral sclerosis severity scale. Neuroepidemiology (1989) 1.21
Modification of hydroxymethylbilane synthase (porphobilinogen deaminase) by pyridoxal 5'-phosphate. Demonstration of an essential lysine residue. Biochem J (1984) 1.20
Purification, N-terminal amino acid sequence and properties of hydroxymethylbilane synthase (porphobilinogen deaminase) from Escherichia coli. Biochem J (1986) 1.19
Immunological features of idiopathic Addison's disease: characterization of the adrenocortical antigens. Clin Exp Immunol (1968) 1.19
Purification of porphobilinogen deaminase from Euglena gracilis and studies of its kinetics. Biochem J (1981) 1.15
Venous thromboembolic disease: an observational study in medical-surgical intensive care unit patients. J Crit Care (2000) 1.14
Studies of enzyme-mediated reactions. Part 13. Stereochemical course of the formation of histamine by decarboxylation of (2S)-histidine with enzymes from Clostridium welchii and Lactobacillus 30a. J Chem Soc Perkin 1 (1980) 1.14
Vitamin K deficiency and D-dimer levels in the intensive care unit: a prospective cohort study. Blood Coagul Fibrinolysis (2002) 1.11
A novel, picomolar inhibitor of human immunodeficiency virus type 1 protease. J Med Chem (1996) 1.09
Susceptibility testing of macrolide antibiotics against Haemophilus influenzae and correlation of in vitro results with in vivo efficacy in a mouse septicemia model. Antimicrob Agents Chemother (1987) 1.08
Evidence that the pyrromethane cofactor of hydroxymethylbilane synthase (porphobilinogen deaminase) is bound through the sulphur atom of a cysteine residue. Biochem J (1988) 1.08
A cluster of Legionnaires' disease caused by Legionella longbeachae linked to potting compost in Scotland, 2008-2009. Euro Surveill (2010) 1.07
Purification and properties of uroporphyrinogen III synthase (co-synthetase) from Euglena gracilis. Biochem J (1985) 1.06
The sequence of hemC, hemD and two additional E. coli genes. Nucleic Acids Res (1988) 1.03
Autophagy is altered in skeletal and cardiac muscle of spontaneously hypertensive rats. Acta Physiol (Oxf) (2013) 1.03
Radiation exposure to children during cardiac catheterization. Br J Radiol (1997) 1.02
Biosynthesis of porphyrins and related macrocycles. Part VI. Nature of the rearrangement process leading to the natural type III porphyrins. J Chem Soc Perkin 1 (1976) 1.01
Discovery of ritonavir, a potent inhibitor of HIV protease with high oral bioavailability and clinical efficacy. J Med Chem (1998) 0.97
CANCER RESEARCH AND THE SCIENTIFIC METHOD. Science (1931) 0.97
Progressive resistance training did not improve walking but can improve muscle performance, quality of life and fatigue in adults with multiple sclerosis: a randomized controlled trial. Mult Scler (2011) 0.96
A fluorescence polarization assay for inhibitors of Hsp90. Anal Biochem (2006) 0.96
Evidence that the pyrromethane cofactor of hydroxymethylbilane synthase (porphobilinogen deaminase) is bound to the protein through the sulphur atom of cysteine-242. Biochem J (1988) 0.92
Evidence that pyridoxal phosphate modification of lysine residues (Lys-55 and Lys-59) causes inactivation of hydroxymethylbilane synthase (porphobilinogen deaminase). Biochem J (1989) 0.92
The action of natural and synthetic isomers of quisqualic acid at a well-defined glutamatergic synapse. Brain Res (1986) 0.92
The esophageal motility disorder of polymyositis. A prospective study. Arch Intern Med (1983) 0.92
Studies on the mechanism of hydroxymethylbilane synthase concerning the role of arginine residues in substrate binding. Biochem J (1991) 0.91
If you build it, will they come? Using a mobile safety centre to disseminate safety information and products to low-income urban families. Inj Prev (2009) 0.91
Synthesis and antitumour activities of quinolone antineoplastic agents. Drugs Exp Clin Res (1992) 0.90
The discovery of nature's biosynthetic pathways. Experientia (1978) 0.89
Biosynthesis of terpenoid alkaloids. Biochem Soc Symp (1970) 0.89
Lung volume reduction for emphysema and the Canadian Lung Volume Reduction Surgery (CLVR) Project. Can Respir J (1999) 0.89
A randomized, controlled trial comparing thoracoscopy and limited thoracotomy for lung biopsy in interstitial lung disease. Ann Thorac Surg (2000) 0.88
Determination of the structure of seleno-methionine-labelled hydroxymethylbilane synthase in its active form by multi-wavelength anomalous dispersion. Acta Crystallogr D Biol Crystallogr (1999) 0.86
Persistence of pneumococcal antibodies after immunization in patients with systemic lupus erythematosus. J Rheumatol (1984) 0.86
Rheumatoid arthritis in a patient with sickle cell disease. J Rheumatol (1990) 0.84
Retrograde intramedullary nails with distal screws locked to the nail have higher fatigue strength than locking plates in the treatment of supracondylar femoral fractures: A cadaver-based laboratory investigation. Bone Joint J (2014) 0.83
Rhabdomyolysis after exercise. Postgrad Med (1993) 0.83
Studies of enzyme-mediated reactions. I. Syntheses of deuterium- or tritium-labelled (3S)-and (3R)-phenylalanines: stereochemical course of the elimination catalysed by L-phenylalanine ammonia-lyase. J Chem Soc Perkin 1 (1972) 0.82
Biosynthesis of porphyrins and related macrocycles. Part 9. Biosynthesis of the corrin macrocycle of vitamin B12 including the sterochemistry of C-methylation in ring. J Chem Soc Perkin 1 (1977) 0.82
Biosynthesis of porphyrins and related macrocycles. Part VIII. Enzymic decarboxylation of uroporphyrinogen-II: Structure of an intermediate, phyriaporphyrinogen-III, and synthesis of the corresponding porphyrin and of two isomeric porphyrins. J Chem Soc Perkin 1 (1976) 0.81
Biosynthesis of porphyrins and corrins. Philos Trans R Soc Lond B Biol Sci (1976) 0.81
Studies of enzyme-mediated reactions. Part VII. Stereospecific syntheses of tritium-labelled (2R)- and (2S)-dopamines: stereochemical course of hydroxylation of dopamine by dopamine beta-hydroxylase (E.C. 1.14.17.1). J Chem Soc Perkin 1 (1976) 0.79
1-phenethylisoquinoline alkaloids. IV. Isolation, structural elucidation, and synthesis of c-homoaporphines. J Chem Soc Perkin 1 (1974) 0.79
Origins of etioporphyrins in sediments: evidence from stable carbon isotopes. Geochim Cosmochim Acta (1989) 0.79
Response of uterine glucose-6-phosphate dehydrogenase isoenzymes to estrogen. Endocrinology (1972) 0.79
Ideas and experiments in biosynthesis. Ciba Found Symp (1978) 0.79
Alkaloid biosynthesis. XVII. The structure and chemistry of androcymbine. J Chem Soc Perkin 1 (1972) 0.79
Expression, purification and characterisation of the product from the Bacillus subtilis hemD gene, uroporphyrinogen III synthase. Eur J Biochem (1995) 0.79
Towards consensus in the long-term management of relapse prevention in schizophrenia. Hum Psychopharmacol (2005) 0.78
Seborrheic dermatitis in acquired immunodeficiency syndrome. Cutis (1991) 0.78
Alkaloid biosynthesis. XVI. Colchicine: origin of the tropolone ring and studies with the C 6 -C 3 -C 6 -C 1 system. J Chem Soc Perkin 1 (1972) 0.78
Biosynthesis of porphyrins and related macrocycles. Part V. Structural integrity of the type III porphyrinogen macrocycle in an active biological system; studies on the aromatisation of protoporphyrinogen-IX. J Chem Soc Perkin 1 (1976) 0.78
Homosexuals who are twins. A study of 46 probands. Br J Psychiatry (1992) 0.78
Biosynthesis. XIX. Concerning the biosynthesis of (-)-camphor and (-)-borneol in Salvia officinalis. J Chem Soc Perkin 1 (1972) 0.77
Alkaloid biosynthesis. 18. Biosynthesis of colchicine from the 1-phenethylisoquinoline system. J Chem Soc Perkin 1 (1972) 0.77
Catalytic activities of bovine hemoglobin. Ann N Y Acad Sci (1987) 0.77
Does plugging unused combination screw holes improve the fatigue life of fixation with locking plates in comminuted supracondylar fractures of the femur? J Bone Joint Surg Br (2012) 0.77
Chronic recurrent multifocal osteomyelitis in adult women. N Y State J Med (1992) 0.77
Studies of enzyme-mediated reactions. Part VI. Stereochemical course of the dehydrogenation of stereospecifically labelled benzylamines by the amine oxidase from pea seedlings (E.C. 1.4.3.6.). J Chem Soc Perkin 1 (1976) 0.76
Studies of enzyme-mediated reactions. II. Stereochemistry of the elimination of ammonia from L-tyrosine catalysed by the enzyme from maize. J Chem Soc Perkin 1 (1972) 0.76
Novel azacyclic ureas that are potent inhibitors of HIV-1 protease. Biochem Biophys Res Commun (1996) 0.76
1-phenethylisoquinoline alkaloids. II. The structures of alkaloids from Colchicum cornigerum (Sweinf.) Tackh. et Drar. J Chem Soc Perkin 1 (1971) 0.76
N-Benzoyl-L-phenylalaninol from Catharanthus pusillus (Murr.) G. Don = Vinca pusilla Murr. Tetrahedron Lett (1965) 0.76
Differential activation on fMRI of monozygotic twins discordant for AD. Neurology (2003) 0.76
Stereochemistry of oxidation of benzylamine by the amine oxidase from beef plasma. FEBS Lett (1979) 0.76
Biosynthesis of vitamin B12: the multi-enzyme synthesis of precorrin-4 and factor IV. Chem Biol (1997) 0.75
Late onset hypersensitivity to sulfasalazine in a patient with ankylosing spondylitis: comment on the article by Paul et al. Arthritis Care Res (2000) 0.75
Biosynthesis of vitamin B12: the preparative multi-enzyme synthesis of precorrin-3A and 20-methylsirohydrochlorin (a 2,7,20-trimethylisobacteriochlorin). Biochem J (1996) 0.75
The Atomic Processes of Disease. Can Med Assoc J (1926) 0.75
Origin of petroporphyrins. 2. Evidence from stable carbon isotopes. Energy Fuels (1990) 0.75