Published in J Protozool on February 01, 1981
Cure of Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense infections in mice with an irreversible inhibitor of S-adenosylmethionine decarboxylase. Antimicrob Agents Chemother (1990) 1.74
Characterization of Trypanosoma brucei brucei S-adenosyl-L-methionine decarboxylase and its inhibition by Berenil, pentamidine and methylglyoxal bis(guanylhydrazone). Biochem J (1986) 1.13
Arginine decarboxylase inhibitors reduce the capacity of Trypanosoma cruzi to infect and multiply in mammalian host cells. Proc Natl Acad Sci U S A (1987) 1.11
Novel S-adenosylmethionine decarboxylase inhibitors for the treatment of human African trypanosomiasis. Antimicrob Agents Chemother (2009) 1.03
Efficacy of combinations of difluoromethylornithine and bleomycin in a mouse model of central nervous system African trypanosomiasis. Proc Natl Acad Sci U S A (1983) 0.84
Fluorescence analysis of the interaction of isometamidium with Trypanosoma congolense. Biochem J (1993) 0.82
S-adenosyl-L-methionine decarboxylase of Acanthamoeba castellanii (Neff): purification and properties. Biochem J (1993) 0.76
Polyamine metabolism: a potential therapeutic target in trypanosomes. Science (1980) 2.41
In vivo effects of difluoromethylornithine on trypanothione and polyamine levels in bloodstream forms of Trypanosoma brucei. Mol Biochem Parasitol (1987) 1.97
Cure of Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense infections in mice with an irreversible inhibitor of S-adenosylmethionine decarboxylase. Antimicrob Agents Chemother (1990) 1.74
In vivo effects of alpha-DL-difluoromethylornithine on the metabolism and morphology of Trypanosoma brucei brucei. Mol Biochem Parasitol (1983) 1.69
Expression of cardiac cytokines and inducible form of nitric oxide synthase (NOS2) in Trypanosoma cruzi-infected mice. J Mol Cell Cardiol (1999) 1.49
Methionine recycling pathways and antimalarial drug design. Antimicrob Agents Chemother (1995) 1.40
Catalytic irreversible inhibition of Trypanosoma brucei brucei ornithine decarboxylase by substrate and product analogs and their effects on murine trypanosomiasis. Biochem Pharmacol (1985) 1.32
Effect of DL-alpha-difluoromethylornithine on methionine cycle intermediates in Trypanosoma brucei brucei. Mol Biochem Parasitol (1988) 1.19
Inducible resistance to oxidant stress in the protozoan Leishmania chagasi. J Biol Chem (2000) 1.15
Effects of the ornithine decarboxylase inhibitors DL-alpha-difluoromethylornithine and alpha-monofluoromethyldehydroornithine methyl ester alone and in combination with suramin against Trypanosoma brucei brucei central nervous system models. Am J Trop Med Hyg (1987) 1.10
New drug combination for experimental late-stage African trypanosomiasis: DL-alpha-difluoromethylornithine (DFMO) with suramin. Am J Trop Med Hyg (1984) 1.06
Novel alkylpolyamine analogues that possess both antitrypanosomal and antimicrosporidial activity. Bioorg Med Chem Lett (2001) 0.99
Substrate specificities of 5'-deoxy-5'-methylthioadenosine phosphorylase from Trypanosoma brucei brucei and mammalian cells. Mol Biochem Parasitol (1988) 0.98
In vitro trypanocidal activities of new S-adenosylmethionine decarboxylase inhibitors. Antimicrob Agents Chemother (1996) 0.98
Effects of intermediates of methionine metabolism and nucleoside analogs on S-adenosylmethionine transport by Trypanosoma brucei brucei and a drug-resistant Trypanosoma brucei rhodesiense. Biochem Pharmacol (1998) 0.96
Uptake of alpha-difluoromethylornithine by Trypanosoma brucei brucei. Biochem Pharmacol (1986) 0.96
Differential sensitivity of Trypanosoma brucei rhodesiense isolates to in vitro lysis by arsenicals. Exp Parasitol (1991) 0.96
Antagonism by polyamines of the curative effects of alpha-difluoromethylornithine in Trypanosoma brucei brucei infections. Biochem Pharmacol (1981) 0.95
Polyamines with N-(3-phenylpropyl) substituents are effective competitive inhibitors of trypanothione reductase and trypanocidal agents. Bioorg Med Chem Lett (2001) 0.93
Further studies on difluoromethylornithine in African trypanosomes. Med Biol (1981) 0.92
Protein methylases in Trypanosoma brucei brucei: activities and response to DL-alpha-difluoromethylornithine. J Gen Microbiol (1991) 0.92
Subcellular localization of the enzymes of the arginine dihydrolase pathway in Trichomonas vaginalis and Tritrichomonas foetus. J Eukaryot Microbiol (1995) 0.92
A unique transporter of S-adenosylmethionine in African trypanosomes. FASEB J (1997) 0.92
S-(5'-deoxy-5'-adenosyl)-1-aminoxy-4-(methylsulfonio)-2-cyclopentene (AdoMao): an irreversible inhibitor of S-adenosylmethionine decarboxylase with potent in vitro antitrypanosomal activity. J Med Chem (1995) 0.92
Dense Crithidia growth and heme sparing: relation to Fe, Cu, Mo chelation. J Protozool (1978) 0.90
Biopterin content of human and rat fluids and tissues determined protozoologically. Am J Clin Nutr (1974) 0.90
S-adenosylmethionine synthetase in bloodstream Trypanosoma brucei. Biochim Biophys Acta (1993) 0.88
Inhibition by several standard antiprotozoal drugs of growth and O2 uptake of cells and particulate preparations of a Leptomonas. J Protozool (1974) 0.88
Parasite polyamine metabolism: targets for chemotherapy. Biochem Soc Trans (1994) 0.88
Inhibition of polyamine biosynthesis by alpha-difluoromethylornithine in African trypanosomes and Pneumocystis carinii as a basis of chemotherapy: biochemical and clinical aspects. Am J Trop Med Hyg (1986) 0.87
Synthesis and antitrypanosomal activities of a series of 7-deaza-5'-noraristeromycin derivatives with variations in the cyclopentyl ring substituents. Antimicrob Agents Chemother (1997) 0.86
Trichomonas vaginalis: characterization of ornithine decarboxylase. Biochem J (1993) 0.86
Drug-resistant Leptomonas: cross-resistance in trypanocide-resistant clones. Antimicrob Agents Chemother (1975) 0.86
Effects of some antitumor agents on growth and glycolytic enzymes of the flagellate Crithidia. J Bacteriol (1969) 0.85
Antitrypanosomal activity of purine nucleosides can be enhanced by their conversion to O-acetylated derivatives. Antimicrob Agents Chemother (1996) 0.85
Polyamines in trypanosomatids. J Bacteriol (1977) 0.84
Efficacy of combinations of difluoromethylornithine and bleomycin in a mouse model of central nervous system African trypanosomiasis. Proc Natl Acad Sci U S A (1983) 0.84
(+)-7-Deaza-5'-noraristeromycin as an anti-trypanosomal agent. J Med Chem (1997) 0.84
Bleomycin-induced life prolongation of mice infected with Trypanosoma brucei brucei EATRO 110. Trans R Soc Trop Med Hyg (1981) 0.84
Polyamine derivatives as inhibitors of trypanothione reductase and assessment of their trypanocidal activities. Bioorg Med Chem (1997) 0.83
O2-polarographic studies on soluble and mitochondrial enzymes of Crithidia fasciculata; glycerophosphage enzymes. J Protozool (1968) 0.83
Antitumor phthalanilides active in acute and chronic Trypanosoma brucei brucei murine infections. Am J Trop Med Hyg (1984) 0.82
Effect of DL-alpha-difluoromethylornithine on polyamine synthesis and interconversion in Trichomonas vaginalis grown in a semi-defined medium. Mol Biochem Parasitol (1988) 0.82
Synthesis and content of polyamines in bloodstream Trypanosma brucei. J Protozool (1979) 0.82
Ornithine decarboxylase in Trypanosoma brucei brucei: evidence for selective toxicity of difluoromethylornithine. J Protozool (1982) 0.81
Inhibition of Trichomonas vaginalis ornithine decarboxylase by amino acid analogs. Biochem Pharmacol (1992) 0.81
Synthesis and anti-trypanosomal activity of various 8-aza-7-deaza-5'noraristeromycin derivatives. J Med Chem (1997) 0.81
Putrescine activated S-adenosylmethionine decarboxylase from Trypanosoma brucei brucei. Mol Cell Biochem (1992) 0.80
Rapid methylation of cell proteins and lipids in Trypanosoma brucei. J Eukaryot Microbiol (1997) 0.80
In situ kinetic characterization of methylthioadenosine transport by the adenosine transporter (P2) of the African Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense. Biochem Pharmacol (2001) 0.80
Irreversible inhibition of S-adenosylmethionine decarboxylase of Trypanosoma brucei brucei by S-adenosylmethionine analogues. Biochem Pharmacol (1992) 0.79
Inhibitors of histamine metabolism in vitro and in vivo. Correlations with antitrypanosomal activity. Biochem Pharmacol (1984) 0.79
Paradoxical activation of Leptomonas NAD-linked alpha-glycerophosphate dehydrogenase by ethidium and antrycide. Biochem Biophys Res Commun (1977) 0.79
Effects of carboxylmethylation and polyamine synthesis inhibitors on methylation of Trypanosoma brucei cellular proteins and lipids. J Eukaryot Microbiol (1997) 0.79
Novel combination chemotherapy of experimental trypanosomiasis by using bleomycin and DL-alpha-difluoromethylornithine; reversal by polyamines. Biochem Pharmacol (1982) 0.79
Curative effects of the antipiroplasms amicarbalide and imidocarb on Trypanosoma brucei infection in mice. J Protozool (1979) 0.78
The importance of the 4'-hydroxyl hydrogen for the anti-trypanosomal and antiviral properties of (+)-5'-noraristeromycin and two 7-deaza analogues. Bioorg Med Chem (1998) 0.78
Prevention by polyamines of the curative effect of amicarbalide and imidocarb for Trypanosoma brucei infections in mice. Biochem Pharmacol (1981) 0.78
Unsubstituted agarose as an affinity matrix for isolation of NAD-dependent alpha-glycerophosphate dehydrogenase from the trypanosomatid Crithidia fasciculata. Biochem Biophys Res Commun (1974) 0.78
Properties of a purified NAD-linked alpha-glycerophosphate dehydrogenase from Leptomonas sp.; activation by polyamines. Biochem Biophys Res Commun (1976) 0.78
Crithidia luciliae: effect of purine starvation on S-adenosyl-L-methionine uptake and protein methylation. Exp Parasitol (1995) 0.77
In vivo and in vitro activity by diverse chelators against Trypanosoma brucei brucei. J Protozool (1982) 0.77
Protozoa as tools for nutrition research. Nutr Rev (1980) 0.77
Kinetics of S-adenosylmethionine cellular transport and protein methylation in Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense. Arch Biochem Biophys (1999) 0.76
Kinetics of methionine transport and metabolism by Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense. Arch Biochem Biophys (2000) 0.76
Use of difluoromethylornithine (DFMO, eflornithine) for late-stage African trypanosomiasis. Trans R Soc Trop Med Hyg (1987) 0.76
Polyamines stimulate DNA-directed DNA synthesis catalyzed by mammalian type C retroviral DNA polymerases. J Biol Chem (1981) 0.76
Polyamines antagonize both the antileukemic activity and the reverse transcriptase stimulatory activity of 4,4'-diacetyldiphenylurea bis(guanylhydrazone) (DDUG). Biochem Biophys Res Commun (1987) 0.76
Biochemical properties of trypanosomatid lactate dehydrogenases. J Bacteriol (1970) 0.75
Crithidia fasciculata: acriflavine-induced changes in soluble enzyme levels. Exp Parasitol (1972) 0.75
Rapid in vitro prescreen for chelators as potential trypanocides based on growth of Crithidia fasciculata. J Protozool (1981) 0.75
Chromatographic resolution of two DNA polymerase activities from bloodstream forms of Trypanosoma brucei: differential responses to exogenous polyamine addition. Biochem Biophys Res Commun (1980) 0.75
Bleomycin for the cure of Trypanosoma brucei brucei infections in mice: lack of pulmonary toxicity. Pharmacol Res Commun (1986) 0.75
Oxaloacetate production via carboxylations in Crithidia fasciculata preparations. J Protozool (1970) 0.75
Inhibition of ornithine or arginine decarboxylase as an experimental approach to African or American trypanosomiasis. Adv Exp Med Biol (1988) 0.75
Why a reference collection of living protozoa? J Protozool (1980) 0.75
Minimal defined media for vegetative growth of the acrasian Polysphondylium pallidum WS-320. J Protozool (1966) 0.75
Synthesis, structure, and antiparasitic activity of sulfamoyl derivatives of ribavirin. J Med Chem (1990) 0.75
Effects of exogenous polyamine and trypanocides on the DNA polymerase activities from Trypanosoma brucei brucei, mouse thymus and murine leukemia virus. Mol Biochem Parasitol (1982) 0.75
Trypanocidal analogs of myristate and myristoyllysophosphatidylcholine. Mol Biochem Parasitol (1996) 0.75
Polyamines stimulate natural RNA-directed DNA synthesis by Rauscher murine leukemia virus DNA polymerase. Biochem Biophys Res Commun (1981) 0.75
Polyamine inhibitors in antimicrobial chemotherapy. J Antimicrob Chemother (1988) 0.75
Methods for the study of the treatment of protozoan diseases by inhibitors of ornithine decarboxylase. Methods Enzymol (1983) 0.75
Effect of putrescine on the respiration of Trypanosoma brucei brucei. Mol Biochem Parasitol (1986) 0.75
Induction of ornithine decarboxylase in Leptomonas seymouri. Mol Biochem Parasitol (1984) 0.75
Stimulation of Rauscher leukemia virus DNA polymerase DNA-directed DNA synthesis by cationic trypanocides and polyamines. Cancer Res (1985) 0.75