Published in Br J Pharmacol on September 01, 1982
The role of glutathione and glutathione S-transferases in the metabolism of chemical carcinogens and other electrophilic agents. Adv Cancer Res (1979) 4.54
Oral nitroglycerin as a prophylactic antianginal drug: clinical, physiologic, and statistical evidence of efficacy based on a three-phase experimental design. Am Heart J (1975) 1.90
Organic nitrates: relationship between biotransformation and rational angina pectoris therapy. J Pharmacol Exp Ther (1972) 1.67
Metabolism of drugs in old rats. II. Metabolism in vivo and effect of drugs in old rats. Jpn J Pharmacol (1968) 1.23
Blood levels after sublingual nitroglycerin. Circulation (1979) 1.22
Tolerance to the vascular effects of glyceryl trinitrate. J Pharmacol Exp Ther (1970) 1.13
Sex differences in drug metabolism by rat liver microsomes. Mol Pharmacol (1967) 1.12
Effect of development on the activity of microsomal drug-metabolizing enzymes in rat liver. Biochem J (1971) 1.11
Glutathione S-transferase in the formation of cyanide from organic thiocyantes and as an organic nitrate reductase. Biochem Biophys Res Commun (1975) 1.10
Organic nitrate metabolism. Annu Rev Pharmacol Toxicol (1976) 1.09
The metabolism of glyceryl trinitrate by liver and blood from different species. Biochem Pharmacol (1973) 0.97
Nitroglycerin--the first one hundred years: new facts about an old drug. J Pharm Pharmacol (1979) 0.95
Clearance and metabolism of organic nitrates. J Pharmacol Exp Ther (1972) 0.89
Pharmacokinetics of nitroglycerin in rats. J Pharm Sci (1978) 0.84
Influence of aging and induction of rat liver and kidney microsomal mixed function oxidase systems. Toxicol Appl Pharmacol (1980) 0.82
The respiration of human liver tissue. Biochem Pharmacol (1967) 0.80
Species differences in microsomal monooxygenase activity and their relationship to biological half-lives. Drug Metab Rev (1978) 0.79
Decline in hepatic microsomal monooxygenase components in middle-aged Fischer 344 rats. Exp Gerontol (1981) 0.78
Drug metabolism in the ferret: effects of age, sex and strain. Gen Pharmacol (1977) 0.78
Effect of sex and castration on hepatic and intestinal activity of drug-metabolizing enzymes. Pharmacology (1974) 0.78
The absorption and biotransformation of glyceryl trinitrate-1,3-14C by rats. Biochem Pharmacol (1968) 0.78
Prophylactic therapy of angina pectoris with organic nitrates: relationship of drug efficacy and clinical experimental design. J Clin Pharmacol (1973) 0.77
Micro determination of glyceryl trinitrate in biological fluids; effect of deuteration of glyceryl trinitrate on its pharmacokinetic properties. J Pharm Pharmacol (1981) 0.77
Method for analysis of cellular DNA content of paraffin-embedded pathological material using flow cytometry. J Histochem Cytochem (1983) 9.40
A rapid single step staining technique for DNA analysis by flow microfluorimetry. J Histochem Cytochem (1980) 2.76
A fluorimetric study of the hydroxylation of biphenyl in vitro by liver preparations of various species. Biochem J (1965) 2.47
Clinical and biological significance of aneuploidy in human tumours. J Clin Pathol (1984) 2.39
Carbenoxolone in the treatment of duodenal ulcer. Practitioner (1967) 1.95
Application of DNA flow cytometry to paraffin-embedded archival material for the study of aneuploidy and its clinical significance. Cytometry (1985) 1.78
A spectrofluorimetric study of the 7-hydroxylation of coumarin by liver microsomes. Biochem J (1965) 1.76
Kinetic and structural characteristics of the inhibition of enoyl (acyl carrier protein) reductase by triclosan. Biochemistry (1999) 1.70
Cell proliferation kinetics of MCF-7 human mammary carcinoma cells in culture and effects of tamoxifen on exponentially growing and plateau-phase cells. Cancer Res (1983) 1.65
Influence of cellular DNA content on survival in advanced ovarian cancer. Cancer Res (1984) 1.58
An evaluation of DNA fluorochromes, staining techniques, and analysis for flow cytometry. I. Unperturbed cell populations. J Histochem Cytochem (1980) 1.53
Tamoxifen induces accumulation of MCF 7 human mammary carcinoma cells in the G0/G1 phase of the cell cycle. Eur J Cancer Clin Oncol (1983) 1.49
The pharmacokinetics of amlodipine in healthy volunteers after single intravenous and oral doses and after 14 repeated oral doses given once daily. Br J Clin Pharmacol (1986) 1.45
The entropic penalty of ordered water accounts for weaker binding of the antibiotic novobiocin to a resistant mutant of DNA gyrase: a thermodynamic and crystallographic study. Biochemistry (1997) 1.41
The effects of some terpenoids and other dietary anutrients on hepatic drug-metabolizing enzymes. Biochem J (1969) 1.37
A prospective toxicity evaluation (COMPACT) on 40 chemicals currently being tested by the National Toxicology Program. Mutagenesis (1990) 1.37
Biochemical characterization and deletion analysis of recombinant human protein phosphatase 2C alpha. Biochem J (1996) 1.27
Interactions of imidazole antifungal agents with purified cytochrome P-450 proteins. Biochem Pharmacol (1987) 1.22
The absorption and excretion of carbenoxolone in man. J Pharm Pharmacol (1970) 1.22
Quantitative and qualitative aspects of the plasma protein binding of carbenoxolone, an ulcer-healing drug. Ann N Y Acad Sci (1973) 1.21
The toxicity of benzene and its metabolism and molecular pathology in human risk assessment. Br J Ind Med (1991) 1.16
A retrospective evaluation of COMPACT predictions of the outcome of NTP rodent carcinogenicity testing. Environ Health Perspect (1995) 1.15
Altered cell cycle progression and aberrant mitosis in adenovirus-infected rodent cells. J Cell Physiol (1982) 1.15
Influence of cellular DNA content on disease-free survival of Stage II breast cancer patients. Cancer Res (1984) 1.11
Flow cytometric analysis of cellular DNA content as an adjunct to the diagnosis of ovarian tumours of borderline malignancy. Pathology (1984) 1.11
Effect of development on the activity of microsomal drug-metabolizing enzymes in rat liver. Biochem J (1971) 1.11
The stimulation of hydroxylation by carcinogenic and non-carcinogenic compounds. Biochem Pharmacol (1966) 1.09
The influence of age on the DNA ploidy levels of breast tumours. Eur J Cancer Clin Oncol (1983) 1.09
Effects of tamoxifen on cell cycle progression of synchronous MCF-7 human mammary carcinoma cells. Cancer Res (1983) 1.08
Changes in sensitivity to radiation and ICRF 159 during the life of monolayer cultures of EMT6 tumour line. Br J Cancer (1977) 1.06
Activation mechanisms to chemical toxicity. Arch Toxicol (1987) 1.05
COMPACT and molecular structure in toxicity assessment: a prospective evaluation of 30 chemicals currently being tested for rodent carcinogenicity by the NCI/NTP. Environ Health Perspect (1996) 1.02
Pharmacology of mucus. Br Med Bull (1978) 1.01
Methotrexate cytotoxicity in cultured human leukemic cells studied by flow cytometry. Cancer Res (1981) 1.00
The metabolism of [2-14C] indole in the rat. Biochem J (1966) 1.00
Purine modulation of methotrexate cytotoxicity in mammalian cell lines. Cancer Res (1982) 0.99
CT findings in osteoradionecrosis of the mandible. Skeletal Radiol (1996) 0.98
Mechanisms of chemical toxicity--a unifying hypothesis. Regul Toxicol Pharmacol (1982) 0.97
The mechanism of action of phenformin in starved rats. Biochem Pharmacol (1983) 0.95
Single-dose pharmacokinetics of perhexiline administered orally to humans. J Chromatogr (1984) 0.95
Adenovirus-induced alterations of the cell growth cycle: effects of mutations in early regions E2A and E2B. J Virol (1982) 0.95
Tumour ploidy, response and survival in patients receiving endocrine therapy for advanced breast cancer. Br J Cancer (1985) 0.95
Interaction of a series of nitriles with the alcohol-inducible isoform of P450: computer analysis of structure-activity relationships. Xenobiotica (1994) 0.93
In vitro enhancement of hepatic microsomal biphenyl 2-hydroxylation by carcinogens. Nature (1974) 0.92
The single dose pharmacokinetics of bisoprolol (10 mg) in renal insufficiency: the clinical significance of balanced clearance. Eur Heart J (1987) 0.92
Cellular DNA content--a stable feature in epithelial ovarian cancer. Br J Cancer (1984) 0.92
Effects of preincubation invitro with 3, 4-benzopyrene and phenobarbital on the drug-metabolism systems present in the microsomal and soluble fractions of the avocado pear (Persea americana). Biochem Soc Trans (1975) 0.91
Induction of cytochrome P450III and P450IV family proteins in streptozotocin-induced diabetes. Biochem J (1990) 0.91
Induction of cytochrome P4501 as an indicator of potential chemical carcinogenesis. Drug Metab Rev (1993) 0.91
Molecular heterogeneity of gamma delta T-cell antigen receptors expressed by CD4- CD8- T-cell clones from normal donors: both disulfide- and non-disulfide-linked receptors are delta TCS1+. Proc Natl Acad Sci U S A (1989) 0.91
Organic nitrate reductase: reassessment of its subcellular localization and tissue distribution and its relationship to the glutathione transferases. Int J Biochem (1989) 0.91
The induction of hepatic microsomal enzymes by safrole. Biochem J (1970) 0.91
The 1990 Pharmaceutical Manufacturers Association of Canada keynote lecture. The role of the cytochromes P450 in the detoxication and activation of drugs and other chemicals. Can J Physiol Pharmacol (1991) 0.91
Hepatic microsomal drug metabolism in the pregnant rat. Xenobiotica (1982) 0.90
Molecular dimensions of the substrate binding site of cytochrome P-448. Biochem Pharmacol (1986) 0.90
Defective expression of cytochrome P450 proteins in the liver of the genetically obese Zucker rat. Eur J Pharmacol (1995) 0.90
Mechanism of induction of hepatic microsomal drug metabolizing enzymes by a series of barbiturates. J Pharm Pharmacol (1975) 0.90
The fate of ( 14 C)carbenoxolone in patients with gastric ulcer. Clin Sci (1972) 0.90
Ploidy as a prognostic factor in ovarian cancer. Int J Gynecol Pathol (1983) 0.90
Cytochromes P450 and species differences in xenobiotic metabolism and activation of carcinogen. Environ Health Perspect (1998) 0.90
The cytochrome P450 I gene family of microsomal hemoproteins and their role in the metabolic activation of chemicals. Drug Metab Rev (1990) 0.90
A study of the possible metabolism of trichlorofluoromethane. Biochem J (1972) 0.89
Cloning and expression of cystolic phospholipase A2 (cPLA2) and a naturally occurring variant. Phosphorylation of Ser505 of recombinant cPLA2 by p42 mitogen-activated protein kinase results in an increase in specific activity. Eur J Biochem (1996) 0.89
Selective induction of rat hepatic CYP1 and CYP4 proteins and of peroxisomal proliferation by green tea. Carcinogenesis (1994) 0.89
Effects of pregnancy on the metabolism of drugs in the rat and rabbit. Biochem Pharmacol (1973) 0.89
Induction of hepatic CYP1A2 by the oral administration of caffeine to rats: lack of association with the Ah locus. Biochim Biophys Acta (1995) 0.88
Spectral and kinetic studies of the interaction of imidazole anti-fungal agents with microsomal cytochromes P-450. Xenobiotica (1987) 0.88
Measurement of cellular DNA content as an adjunct to diagnostic cytology in malignant effusions. Eur J Cancer Clin Oncol (1984) 0.88
Computer modelling in predicting carcinogenicity. Eur J Cancer Prev (1993) 0.87
A comparison of the metabolism of HEOD (dieldrin) in the CF1 mouse with that in the CFE rat. Food Cosmet Toxicol (1972) 0.87
Effect of protein/energy nutrition on rat plasma corticosteroids and liver microsomal hydroxylase activity. Nutr Metab (1975) 0.87
G1-phase arrest of cultured human leukemic T-cells induced by deoxyadenosine. Cancer Res (1981) 0.87
Proceedings: Interaction of carbenoxolone sodium with other drigs bound to plasma proteins. Br J Pharmacol (1975) 0.86
Ovarian tumour xenografts in the study of the biology of human epithelial ovarian cancer. Br J Cancer (1985) 0.86
The cytochromes P-448--a unique family of enzymes involved in chemical toxicity and carcinogenesis. Biochem Pharmacol (1987) 0.86
The absorption of carbenoxolone administered orally as a positioned-release capsule. Gut (1970) 0.85
The effects of benzopyrene and safrole on biphenyl 2-hydroxylase and other drug-metabolizing enzymes. Biochem J (1976) 0.85
Cell cycle regulation by environmental pH. J Cell Physiol (1984) 0.85
Histamine release from rat mast cells induced by the metabolic activation of drugs of abuse into free radicals. Inflamm Res (1998) 0.85
Metabolism of toxic substances. Br Med Bull (1969) 0.85
Polyadenylic acid polymerase activity in normal and leukemic human leukocytes. Cancer Res (1984) 0.85
Further studies on the pharmacokinetics of perhexiline maleate in humans. Xenobiotica (1986) 0.84
Identification and quantitation of tumour cells in cell suspensions: a comparison of cytology and flow cytometry. Br J Cancer (1981) 0.84
Aromatization of shikimic acid in the rat and the role of gastrointestinal micro-organisms. Biochem Soc Trans (1976) 0.84
Metabolic oxidation of the ethynyl group in 4-ethynylbiphenyl. Biochem J (1979) 0.84
Eric Boyland--a pioneer in cancer biochemistry. Xenobiotica (1987) 0.84
The effects of chronic drug administration on hepatic enzyme induction and folate metabolism. Br J Clin Pharmacol (1978) 0.84
An examination of DNA strand breakage in the comet assay and antioxidant capacity in diabetic patients. Mutat Res (1998) 0.84