Published in Antimicrob Agents Chemother on July 01, 1981
In vitro activity of temocillin (BRL 17421), a novel beta-lactamase-stable penicillin. Antimicrob Agents Chemother (1982) 2.06
Antibacterial activity and beta-lactamase stability of temocillin. Antimicrob Agents Chemother (1982) 1.87
ESBLs: A Clear and Present Danger? Crit Care Res Pract (2011) 1.77
Comparative in vitro study of temocillin (BRL 17421), a new penicillin. Antimicrob Agents Chemother (1982) 1.73
In vitro activity of temocillin (BRL 17421), a novel beta-lactam antibiotic. Antimicrob Agents Chemother (1982) 1.61
In vitro antibacterial properties of BRL 36650, a novel 6 alpha-substituted penicillin. Antimicrob Agents Chemother (1984) 1.50
Use of temocillin in typhoid fever, hepatobiliary disease and other infections. Drugs (1985) 1.47
In vitro activity of BRL 17421 against Haemophilus influenzae, Neisseria gonorrhoeae, and Branhamella catarrhalis. Antimicrob Agents Chemother (1982) 1.34
Multiply resistant mutants of Enterobacter cloacae selected by beta-lactam antibiotics. Antimicrob Agents Chemother (1986) 1.34
In vitro antimicrobial susceptibilities of penicillinase-producing and non-penicillinase-producing strains of Neisseria gonorrhoeae isolated in Durban, South Africa. Antimicrob Agents Chemother (1984) 1.29
Multidrug-resistant and extensively drug-resistant Gram-negative pathogens: current and emerging therapeutic approaches. Expert Opin Pharmacother (2014) 1.19
Temocillin efficacy in experimental Klebsiella pneumoniae meningitis after infusion into rabbit plasma to simulate antibiotic concentrations in human serum. Antimicrob Agents Chemother (1988) 1.02
Comparative in vitro activities of temocillin and cefazolin against Klebsiella pneumoniae. Antimicrob Agents Chemother (1982) 0.99
A new strategy to fight antimicrobial resistance: the revival of old antibiotics. Front Microbiol (2014) 0.94
Performance of a diffusional clearance model for beta-lactam antimicrobial agents as influenced by extravascular protein binding and interstitial fluid kinetics. Antimicrob Agents Chemother (1985) 0.93
Effect of temocillin in combination with other beta-lactam antibiotics. Antimicrob Agents Chemother (1984) 0.92
Affinity of temocillin for Escherichia coli K-12 penicillin-binding proteins. Antimicrob Agents Chemother (1984) 0.91
Renal clearance of temocillin in volunteers. Drugs (1985) 0.89
In vitro activity of temocillin, a new beta-lactamase-stable penicillin active against enterobacteria. Antimicrob Agents Chemother (1982) 0.88
Activity of temocillin against KPC-producing Klebsiella pneumoniae and Escherichia coli. Antimicrob Agents Chemother (2009) 0.87
A survey of temocillin sensitivity of strains resistant to newer beta-lactam antibiotics. Drugs (1985) 0.82
Pharmacokinetics of temocillin in volunteers. Drugs (1985) 0.81
Antimicrobial activity and beta-lactamase stability of foramidocillin. Antimicrob Agents Chemother (1986) 0.80
Binding to and antibacterial effect of aztreonam, temocillin, gentamicin and tobramycin on human faeces. J Hyg (Lond) (1985) 0.79
Influence of temocillin on human bowel flora. Drugs (1985) 0.79
Studies with temocillin in a hamster model of antibiotic-associated colitis. Antimicrob Agents Chemother (1985) 0.78
Clinical efficacy, tolerance and pharmacokinetics of temocillin in patients with respiratory tract infections. Drugs (1985) 0.77
In vitro activity of temocillin against clinical isolates. Drugs (1985) 0.75
In vitro activity of BRL 36650, a new penicillin. Antimicrob Agents Chemother (1986) 0.75
Effect of temocillin and moxalactam on platelet responsiveness and bleeding time in normal volunteers. Antimicrob Agents Chemother (1985) 0.75
Quantification of temocillin biliary excretion and gallbladder bile concentration in healthy subjects. Drugs (1985) 0.75
Biliary concentrations of temocillin. Drugs (1985) 0.75
A study of the penetration of temocillin in the cerebrospinal fluid. Drugs (1985) 0.75
Antibacterial activity of temocillin in combination with other beta-lactam antibiotics. Drugs (1985) 0.75
Studies with temocillin in the hamster model of antibiotic-associated colitis. Drugs (1985) 0.75
Comparative in vitro activity of temocillin. Drugs (1985) 0.75
Lung tissue penetration of temocillin. Drugs (1985) 0.75
Temocillin pharmacokinetics in normal and impaired renal function. Drugs (1985) 0.75
Temocillin in the treatment of gram-negative septicaemia. Drugs (1985) 0.75
Temocillin. In vitro antibacterial activity. Drugs (1985) 0.75
Bacteriostatic and bactericidal activity of penicillins at constant and variable concentrations. Drugs (1985) 0.75
Temocillin treatment of serious infections due to gram-negative bacilli in an intensive care unit. Drugs (1985) 0.75
In vitro combination-effect of temocillin with ticarcillin and aminoglycosides on gram-negative and gram-positive bacteria. Drugs (1985) 0.75
Clinical evaluation of temocillin in urinary tract infections. Drugs (1985) 0.75
The place of temocillin in the treatment of hospital infections. Drugs (1985) 0.75
Influence of temocillin on colonisation resistance and consequences for therapy. Drugs (1985) 0.75
Temocillin. Summary of safety studies. Drugs (1985) 0.75
Temocillin sensitivity of Enterobacteriaceae species resistant to cefotaxime. Drugs (1985) 0.75
Effect of renal function and dialysis on temocillin pharmacokinetics. Drugs (1985) 0.75
Treatment of severe infections with temocillin. Clinical and bacteriological evaluation. Drugs (1985) 0.75
Human pharmacokinetics and antimicrobial activities of the temocillin epimers. Drugs (1985) 0.75
Temocillin treatment of gynaecological infections with special reference to blood and tissue concentrations. Drugs (1985) 0.75
Antibacterial activity of temocillin. Drugs (1985) 0.75
Temocillin. In vitro activity compared with other antibiotics. Drugs (1985) 0.75
The activity of temocillin against Enterobacteriaceae, Pseudomonas and Haemophilus influenzae. Drugs (1985) 0.75
Temocillin in the treatment of chest infections. Drugs (1985) 0.75
The treatment of complicated and uncomplicated urinary tract infections with temocillin. Drugs (1985) 0.75
Temocillin in the treatment of serious gram-negative infections. Drugs (1985) 0.75
The beta-lactamases of gram-negative bacteria and their possible physiological role. Adv Microb Physiol (1973) 25.78
The beta-lactamases of gram-negative bacteria and their role in resistance to beta-lactam antibiotics. J Antimicrob Chemother (1976) 18.58
Comparative activity and beta-lactamase stability of cefoperazone, a piperazine cephalosporin. Antimicrob Agents Chemother (1979) 7.65
Plasmid-mediated beta-lactamases of Gram-negative bacteria: properties and distribution. J Antimicrob Chemother (1979) 7.39
In vitro activity of LY127935. Antimicrob Agents Chemother (1979) 7.01
GR 20263, a new broad-spectrum cephalosporin with anti-pseudomonal activity. Antimicrob Agents Chemother (1980) 6.77
In vitro antibacterial activity and susceptibility of the cephalosporin Ro 13-9904 to beta-lactamases. Antimicrob Agents Chemother (1980) 3.68
Description and classification of the newer cephalosporins and their relationships with the established compounds. J Antimicrob Chemother (1979) 3.47
Influence of protein binding of antibiotics on serum pharmacokinetics and extravascular penetration: clinically useful concepts. Rev Infect Dis (1980) 2.91
Advances in penicillin research. Adv Drug Res (1973) 1.69
Effects of teacher attention on study behavior. J Appl Behav Anal (1968) 22.34
Comparative genomics of Listeria species. Science (2001) 12.94
Clavulanic acid: a beta-lactamase-inhiting beta-lactam from Streptomyces clavuligerus. Antimicrob Agents Chemother (1977) 11.58
Active human immunodeficiency virus protease is required for viral infectivity. Proc Natl Acad Sci U S A (1988) 10.77
B.M.A. deputizing service in Sheffield, 1970. Br Med J (1973) 9.83
Signals and transduction mechanisms for activation of plant defenses against microbial attack. Cell (1989) 9.42
Fine-structure mapping and functional analysis of temperature-sensitive mutants in the gene encoding the herpes simplex virus type 1 immediate early protein VP175. J Virol (1980) 9.30
Activation tagging in Arabidopsis. Plant Physiol (2000) 7.09
Cloning of the gene and cDNA for mammalian beta-adrenergic receptor and homology with rhodopsin. Nature (1986) 7.06
"Practis". (General) Practice Recording and Computer Terminal Information System. J R Coll Gen Pract (1969) 6.99
New semi-synthetic penicillin active against Pseudomonas pyocyanea. Nature (1967) 6.96
Nitric oxide functions as a signal in plant disease resistance. Nature (1998) 6.94
Naturally-occurring beta-lactamase inhibitors with antibacterial activity. J Antibiot (Tokyo) (1976) 6.48
Activation tagging identifies a conserved MYB regulator of phenylpropanoid biosynthesis. Plant Cell (2000) 6.12
Amoxycillin: a new semi-synthetic penicillin. Br Med J (1972) 5.57
Cloning of bovine GAP and its interaction with oncogenic ras p21. Nature (1988) 5.56
Reactive oxygen intermediates mediate a systemic signal network in the establishment of plant immunity. Cell (1998) 5.46
The binding of antibiotics to serum proteins. Br J Pharmacol Chemother (1965) 5.04
cDNA for the human beta 2-adrenergic receptor: a protein with multiple membrane-spanning domains and encoded by a gene whose chromosomal location is shared with that of the receptor for platelet-derived growth factor. Proc Natl Acad Sci U S A (1987) 4.61
Ubiquitous cell-surface glycoprotein on tumor cells is proliferation-associated receptor for transferrin. Proc Natl Acad Sci U S A (1981) 4.50
Use it or lose it: engaged lifestyle as a buffer of cognitive decline in aging? Psychol Aging (1999) 4.45
Rapid transient induction of phenylalanine ammonia-lyase mRNA in elicitor-treated bean cells. Proc Natl Acad Sci U S A (1985) 4.30
Controlled trial of oxprenolol and practolol in hypertension. Br Med J (1970) 4.23
A randomized trial of group outpatient visits for chronically ill older HMO members: the Cooperative Health Care Clinic. J Am Geriatr Soc (1997) 4.09
Salicylic acid potentiates an agonist-dependent gain control that amplifies pathogen signals in the activation of defense mechanisms. Plant Cell (1997) 4.08
Carbenicillin: a new semisynthetic penicillin active against Pseudomonas pyocyanea. Br Med J (1967) 3.94
Phytoalexins: enzymology and molecular biology. Adv Enzymol Relat Areas Mol Biol (1983) 3.89
Activation, structure, and organization of genes involved in microbial defense in plants. Adv Genet (1990) 3.78
Stress Responses in Alfalfa (Medicago sativa L.): X. Molecular Cloning and Expression of S-Adenosyl-l-Methionine:Caffeic Acid 3-O-Methyltransferase, a Key Enzyme of Lignin Biosynthesis. Plant Physiol (1991) 3.76
Elicitor rapidly induces chalcone synthase mRNA in Phaseolus vulgaris cells at the onset of the phytoalexin defense response. Proc Natl Acad Sci U S A (1984) 3.63
Abnormal plant development and down-regulation of phenylpropanoid biosynthesis in transgenic tobacco containing a heterologous phenylalanine ammonia-lyase gene. Proc Natl Acad Sci U S A (1990) 3.60
Inhibition of the -lactamases of Escherichia coli and Klebsiella aerogenes by semi-synthetic penicillins. Biochem J (1972) 3.57
Zebrafish genetic map with 2000 microsatellite markers. Genomics (1999) 3.56
A plant homolog of the neutrophil NADPH oxidase gp91phox subunit gene encodes a plasma membrane protein with Ca2+ binding motifs. Plant Cell (1998) 3.55
Identification of two serine residues involved in agonist activation of the beta-adrenergic receptor. J Biol Chem (1989) 3.51
Functional organization of the simian virus 40 origin of DNA replication. Mol Cell Biol (1986) 3.40
Adenocarcinoma of colon differentiating as dome epithelium of gut-associated lymphoid tissue. Histopathology (2000) 3.36
Structure and function of G protein-coupled receptors. Annu Rev Biochem (1994) 3.36
R-factor mediated beta-lactamase in Pseudomonas aeruginosa. Nature (1970) 3.32
Antibacterial activity of mupirocin (pseudomonic acid), a new antibiotic for topical use. Antimicrob Agents Chemother (1985) 3.19
Excessive ethanol drinking following a history of dependence: animal model of allostasis. Neuropsychopharmacology (2000) 3.15
Modern obstetrics and the general practitioner. Br Med J (1975) 3.15
Conserved aspartic acid residues 79 and 113 of the beta-adrenergic receptor have different roles in receptor function. J Biol Chem (1988) 3.10
Open reading frame expression vectors: a general method for antigen production in Escherichia coli using protein fusions to beta-galactosidase. Proc Natl Acad Sci U S A (1983) 3.09
Metabolism of penicillins to penicilloic acids and 6-aminopenicillanic acid in man and its significance in assessing penicillin absorption. Antimicrob Agents Chemother (1973) 3.07
Dissection of malonyl-coenzyme A decarboxylation from polyketide formation in the reaction mechanism of a plant polyketide synthase. Biochemistry (2000) 3.05
The acquired (non-Wilsonian) type of chronic hepatocerebral degeneration. Medicine (Baltimore) (1965) 3.01
Randomised controlled trial of exercise for low back pain: clinical outcomes, costs, and preferences. BMJ (1999) 2.94
Anaesthetic services to dental patients: England and Wales, 1976. Br Dent J (1978) 2.93
Identification of residues required for ligand binding to the beta-adrenergic receptor. Proc Natl Acad Sci U S A (1987) 2.81
Occurrence of hemophilia in the United States. The Hemophilia Surveillance System Project Investigators. Am J Hematol (1998) 2.78
Function of the oxidative burst in hypersensitive disease resistance. Proc Natl Acad Sci U S A (1995) 2.78
Structure of chalcone synthase and the molecular basis of plant polyketide biosynthesis. Nat Struct Biol (1999) 2.76
The genetic complexity of nitrogen fixation. The ninth Fleming lecture. J Gen Microbiol (1984) 2.73
Ligand binding to the beta-adrenergic receptor involves its rhodopsin-like core. Nature (1987) 2.73
Population screening for congenital hypothyroidism. Br Med J (1980) 2.71
Interstitial cystitis--a time for revision of name and diagnostic criteria in the new millennium? BJU Int (2001) 2.69
Differential induction of chalcone synthase mRNA activity at the onset of phytoalexin accumulation in compatible and incompatible plant-pathogen interactions. Proc Natl Acad Sci U S A (1984) 2.66
Developmental and environmental regulation of a phenylalanine ammonia-lyase-beta-glucuronidase gene fusion in transgenic tobacco plants. Proc Natl Acad Sci U S A (1989) 2.62
Delirium in older medical inpatients and subsequent cognitive and functional status: a prospective study. CMAJ (2001) 2.56
L-Phenylalanine ammonia-lyase from Phaseolus vulgaris. Characterisation and differential induction of multiple forms from elicitor-treated cell suspension cultures. Eur J Biochem (1985) 2.56
Stimulation of de novo synthesis of L-phenylalanine ammonia-lyase in relation to phytoalexin accumulation in Colletotrichum lindemuthianum elicitor-treated cell suspension cultures of french bean (Phaseolus vulgaris). Biochim Biophys Acta (1979) 2.54
Provision of first contact care out of hours in four urban areas in England. Br Med J (Clin Res Ed) (1985) 2.51
Intra-amygdala muscimol decreases operant ethanol self-administration in dependent rats. Alcohol Clin Exp Res (1996) 2.51
Modulation of guanine nucleotides bound to Ras in NIH3T3 cells by oncogenes, growth factors, and the GTPase activating protein (GAP). J Biol Chem (1990) 2.49
Quantitative relationship between phenylalanine ammonia-lyase levels and phenylpropanoid accumulation in transgenic tobacco identifies a rate-determining step in natural product synthesis. Proc Natl Acad Sci U S A (1994) 2.48
Elicitor induction of mRNA activity. Rapid effects of elicitor on phenylalanine ammonia-lyase and chalcone synthase mRNA activities in bean cells. Eur J Biochem (1983) 2.46
Structures of two natural product methyltransferases reveal the basis for substrate specificity in plant O-methyltransferases. Nat Struct Biol (2001) 2.43
Effect of protein binding on antibiotic activity in vivo. J Antimicrob Chemother (1983) 2.42
Gene structure of human cardiac hormone precursor, pronatriodilatin. Nature (1985) 2.41
Serologic response to treatment of infectious syphilis. Ann Intern Med (1991) 2.38
Increased disease susceptibility of transgenic tobacco plants with suppressed levels of preformed phenylpropanoid products. Proc Natl Acad Sci U S A (1994) 2.35
High-level mupirocin resistance in Staphylococcus aureus: evidence for two distinct isoleucyl-tRNA synthetases. Antimicrob Agents Chemother (1993) 2.32
Glutathione and fungal elicitor regulation of a plant defense gene promoter in electroporated protoplasts. Proc Natl Acad Sci U S A (1988) 2.31
Hydroxylamine mutagenesis of HSV DNA and DNA fragments: introduction of mutations into selected regions of the viral genome. Virology (1979) 2.30
Physical mapping of herpes simplex virus type 1 ts mutants by marker rescue: correlation of the physical and genetic maps. Virology (1980) 2.30
Childhood lead poisoning. A controlled trial of the effect of dust-control measures on blood lead levels. N Engl J Med (1983) 2.30
Antigenic variation during infection with Neisseria gonorrhoeae: detection of antibodies to surface proteins in sera of patients with gonorrhea. J Infect Dis (1984) 2.28
Co-ordinated synthesis of phytoalexin biosynthetic enzymes in biologically-stressed cells of bean (Phaseolus vulgaris L.). EMBO J (1985) 2.28
c-myc null cells misregulate cad and gadd45 but not other proposed c-Myc targets. Genes Dev (1998) 2.27
Structural basis of beta-adrenergic receptor function. FASEB J (1989) 2.27
Stapled haemorrhoidopexy compared to Milligan-Morgan and Ferguson haemorrhoidectomy: a systematic review. Int J Colorectal Dis (2008) 2.25
Downregulation of caffeic acid 3-O-methyltransferase and caffeoyl CoA 3-O-methyltransferase in transgenic alfalfa. impacts on lignin structure and implications for the biosynthesis of G and S lignin. Plant Cell (2001) 2.23
Plasminogen activator inhibitor-1 gene-deficient mice. I. Generation by homologous recombination and characterization. J Clin Invest (1993) 2.20
Delineation of the intronless nature of the genes for the human and hamster beta 2-adrenergic receptor and their putative promoter regions. J Biol Chem (1987) 2.20
Identification and isolation of a membrane protein necessary for leukotriene production. Nature (1990) 2.20
Differential regulation of phenylalanine ammonia-lyase genes during plant development and by environmental cues. J Biol Chem (1989) 2.17
Emergency admission to hospital from a deputizing service. A controlled study of duration of stay and outcome. Br J Prev Soc Med (1973) 2.14
A C-terminal domain of GAP is sufficient to stimulate ras p21 GTPase activity. EMBO J (1989) 2.14
Age-related cognitive deficits mediated by changes in the striatal dopamine system. Am J Psychiatry (2000) 2.12
Antiherpesvirus activity of 9-(4-hydroxy-3-hydroxy-methylbut-1-yl)guanine (BRL 39123) in cell culture. Antimicrob Agents Chemother (1987) 2.11
Combination of H-box [CCTACC(N)7CT] and G-box (CACGTG) cis elements is necessary for feed-forward stimulation of a chalcone synthase promoter by the phenylpropanoid-pathway intermediate p-coumaric acid. Proc Natl Acad Sci U S A (1992) 2.11
Fibrinolytic activity and coronary-artery disease. Lancet (1968) 2.10
Stress Responses in Alfalfa (Medicago sativa L.): I. Induction of Phenylpropanoid Biosynthesis and Hydrolytic Enzymes in Elicitor-Treated Cell Suspension Cultures. Plant Physiol (1990) 2.10
A simple oral test of growth-hormone secretion in children. Lancet (1968) 2.07
The impact of general-practitioner deputising services on accident and emergency departments in the Sheffield hospital region. J R Coll Gen Pract (1973) 2.06
Purification of simian virus 40 large T antigen by immunoaffinity chromatography. J Virol (1985) 2.01
Decreased brain reward produced by ethanol withdrawal. Proc Natl Acad Sci U S A (1995) 2.00
Pulsed magnetic field therapy for tibial non-union. Interim results of a double-blind trial. Lancet (1984) 2.00