PubRank

A Bretscher

Author PubWeight™ 152.75‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Polarization of cell growth in yeast. J Cell Sci 2000 7.23
2 Villin is a major protein of the microvillus cytoskeleton which binds both G and F actin in a calcium-dependent manner. Cell 1980 4.83
3 Identification of EBP50: A PDZ-containing phosphoprotein that associates with members of the ezrin-radixin-moesin family. J Cell Biol 1997 4.32
4 Localization of actin and microfilament-associated proteins in the microvilli and terminal web of the intestinal brush border by immunofluorescence microscopy. J Cell Biol 1978 3.98
5 A kinase-regulated PDZ-domain interaction controls endocytic sorting of the beta2-adrenergic receptor. Nature 1999 3.95
6 Structure of the ERM protein moesin reveals the FERM domain fold masked by an extended actin binding tail domain. Cell 2000 3.94
7 Fimbrin, a new microfilament-associated protein present in microvilli and other cell surface structures. J Cell Biol 1980 3.93
8 Tropomyosin-containing actin cables direct the Myo2p-dependent polarized delivery of secretory vesicles in budding yeast. J Cell Biol 1998 3.89
9 Construction of a GAL1-regulated yeast cDNA expression library and its application to the identification of genes whose overexpression causes lethality in yeast. Genetics 1992 3.86
10 Polarization of cell growth in yeast. I. Establishment and maintenance of polarity states. J Cell Sci 2000 3.73
11 Disruption of the single tropomyosin gene in yeast results in the disappearance of actin cables from the cytoskeleton. Cell 1989 3.62
12 Ezrin self-association involves binding of an N-terminal domain to a normally masked C-terminal domain that includes the F-actin binding site. Mol Biol Cell 1995 3.36
13 Villin: the major microfilament-associated protein of the intestinal microvillus. Proc Natl Acad Sci U S A 1979 3.27
14 The FERM domain: a unique module involved in the linkage of cytoplasmic proteins to the membrane. Trends Biochem Sci 1998 3.24
15 Myosin V orientates the mitotic spindle in yeast. Nature 2000 3.20
16 cDNA cloning and sequencing of the protein-tyrosine kinase substrate, ezrin, reveals homology to band 4.1. EMBO J 1989 3.10
17 Purification of microvilli and an analysis of the protein components of the microfilament core bundle. Exp Cell Res 1978 3.09
18 Purification of an 80,000-dalton protein that is a component of the isolated microvillus cytoskeleton, and its localization in nonmuscle cells. J Cell Biol 1983 3.03
19 Ezrin is concentrated in the apical microvilli of a wide variety of epithelial cells whereas moesin is found primarily in endothelial cells. J Cell Sci 1993 3.02
20 Parallel secretory pathways to the cell surface in yeast. J Cell Biol 1995 2.92
21 The COOH-terminal domain of Myo2p, a yeast myosin V, has a direct role in secretory vesicle targeting. J Cell Biol 1999 2.84
22 An apical PDZ protein anchors the cystic fibrosis transmembrane conductance regulator to the cytoskeleton. J Biol Chem 1998 2.80
23 Characterization of TPM1 disrupted yeast cells indicates an involvement of tropomyosin in directed vesicular transport. J Cell Biol 1992 2.76
24 The protein-tyrosine kinase substrate, p81, is homologous to a chicken microvillar core protein. J Cell Biol 1986 2.63
25 Fimbrin is a cytoskeletal protein that crosslinks F-actin in vitro. Proc Natl Acad Sci U S A 1981 2.56
26 Smooth muscle caldesmon. Rapid purification and F-actin cross-linking properties. J Biol Chem 1984 2.14
27 Ezrin oligomers are major cytoskeletal components of placental microvilli: a proposal for their involvement in cortical morphogenesis. J Cell Biol 1995 2.08
28 Calcium control of the intestinal microvillus cytoskeleton: its implications for the regulation of microfilament organizations. Proc Natl Acad Sci U S A 1980 1.92
29 The secretion-stimulated 80K phosphoprotein of parietal cells is ezrin, and has properties of a membrane cytoskeletal linker in the induced apical microvilli. EMBO J 1991 1.91
30 Preliminary biochemical characterization of the stereocilia and cuticular plate of hair cells of the chick cochlea. J Cell Biol 1989 1.74
31 Tropomyosin is essential in yeast, yet the TPM1 and TPM2 products perform distinct functions. J Cell Biol 1995 1.73
32 Moesin, like ezrin, colocalizes with actin in the cortical cytoskeleton in cultured cells, but its expression is more variable. J Cell Sci 1993 1.73
33 The carboxyl-terminal region of EBP50 binds to a site in the amino-terminal domain of ezrin that is masked in the dormant molecule. J Biol Chem 1998 1.70
34 Heterotypic and homotypic associations between ezrin and moesin, two putative membrane-cytoskeletal linking proteins. Proc Natl Acad Sci U S A 1993 1.70
35 Identification and localization of immunoreactive forms of caldesmon in smooth and nonmuscle cells: a comparison with the distributions of tropomyosin and alpha-actinin. J Cell Biol 1985 1.62
36 Immunohistochemical localization of several cytoskeletal proteins in inner ear sensory and supporting cells. Hear Res 1982 1.52
37 C-terminal threonine phosphorylation activates ERM proteins to link the cell's cortical lipid bilayer to the cytoskeleton. Biochem Biophys Res Commun 1998 1.50
38 Reassociation of microvillar core proteins: making a microvillar core in vitro. J Cell Biol 1989 1.40
39 Hierarchy of merlin and ezrin N- and C-terminal domain interactions in homo- and heterotypic associations and their relationship to binding of scaffolding proteins EBP50 and E3KARP. J Biol Chem 2000 1.36
40 Mapping of the microvillar 110K-calmodulin complex: calmodulin-associated or -free fragments of the 110-kD polypeptide bind F-actin and retain ATPase activity. J Cell Biol 1988 1.35
41 Calcium-regulated cooperative binding of the microvillar 110K-calmodulin complex to F-actin: formation of decorated filaments. J Cell Biol 1987 1.33
42 Identification of a novel member of the chloride intracellular channel gene family (CLIC5) that associates with the actin cytoskeleton of placental microvilli. Mol Biol Cell 2000 1.31
43 The rho-GAP encoded by BEM2 regulates cytoskeletal structure in budding yeast. Mol Biol Cell 1995 1.29
44 Nodes of Ranvier form in association with ezrin-radixin-moesin (ERM)-positive Schwann cell processes. Proc Natl Acad Sci U S A 2001 1.29
45 Identification of EPI64, a TBC/rabGAP domain-containing microvillar protein that binds to the first PDZ domain of EBP50 and E3KARP. J Cell Biol 2001 1.26
46 Purification of tropomyosin from Saccharomyces cerevisiae and identification of related proteins in Schizosaccharomyces and Physarum. Proc Natl Acad Sci U S A 1989 1.25
47 Moesin, the major ERM protein of lymphocytes and platelets, differs from ezrin in its insensitivity to calpain. FEBS Lett 1999 1.24
48 Identification of ezrin as an 81-kDa tyrosine-phosphorylated protein in T cells. J Immunol 1992 1.21
49 Ras regulates the polarity of the yeast actin cytoskeleton through the stress response pathway. Mol Biol Cell 2001 1.20
50 Villin associates with specific microfilamentous structures as seen by immunofluorescence microscopy on tissue sections and cells microinjected with villin. Exp Cell Res 1981 1.17
51 Smooth muscle caldesmon is an extended flexible monomeric protein in solution that can readily undergo reversible intra- and intermolecular sulfhydryl cross-linking. A mechanism for caldesmon's F-actin bundling activity. J Biol Chem 1987 1.14
52 Microinjection of villin into cultured cells induces rapid and long-lasting changes in cell morphology but does not inhibit cytokinesis, cell motility, or membrane ruffling. J Cell Biol 1990 1.11
53 Thin filament regulatory proteins of smooth- and non-muscle cells. Nature 1986 1.09
54 Yeast actin is relatively well behaved. Eur J Biochem 1992 1.08
55 ATPase activity of the microvillar 110 kDa polypeptide-calmodulin complex is activated in Mg2+ and inhibited in K+-EDTA by F-actin. FEBS Lett 1987 1.08
56 Tropomyosin from bovine brain contains two polypeptide chains of slightly different molecular weights. FEBS Lett 1978 1.07
57 Microvillus 110K-calmodulin: effects of nucleotides on isolated cytoskeletons and the interaction of the purified complex with F-actin. J Cell Biol 1985 1.04
58 The calmodulin and F-actin binding sites of smooth muscle caldesmon lie in the carboxyl-terminal domain whereas the molecular weight heterogeneity lies in the middle of the molecule. J Biol Chem 1989 1.03
59 Identification and molecular characterization of the calmodulin-binding subunit gene (CMP1) of protein phosphatase 2B from Saccharomyces cerevisiae. An alpha-factor inducible gene. Eur J Biochem 1992 1.01
60 Purification of the intestinal microvillus cytoskeletal proteins villin, fimbrin, and ezrin. Methods Enzymol 1986 1.01
61 Characterization and ultrastructural role of the major components of the intestinal microvillus cytoskeleton. Cold Spring Harb Symp Quant Biol 1982 1.00
62 Induced morphological changes in isolated microvilli: regulation of membrane topology in vitro by submembranous microfilaments. Eur J Cell Biol 1983 1.00
63 Molecular architecture of the microvillus cytoskeleton. Ciba Found Symp 1983 0.99
64 alpha-Actinins from chicken skeletal muscle and smooth muscle show considerable chemical and immunological differences. Eur J Biochem 1979 0.98
65 Plasma membranes from intestinal microvilli and erythrocytes contain cytochromes b5 and P-420. Biochim Biophys Acta 1980 0.90
66 F-actin aggregates in transformed cells contain alpha-actinin and fimbrin but apparently lack tropomyosin. Eur J Cell Biol 1986 0.88
67 Microfilament organization in the cytoskeleton of the intestinal brush border. Cell Muscle Motil 1983 0.88
68 Fodrin is part of a filamentous cortical sheath of the detergent resistant cytoskeleton of cultured cells before and after cytochalasin treatment. Eur J Cell Biol 1986 0.86
69 Identification of two distinct structural motifs that, when added to the C-terminal tail of the rat LH receptor, redirect the internalized hormone-receptor complex from a degradation to a recycling pathway. Mol Endocrinol 2001 0.84
70 Hibernation induces expression of moesin in intestinal epithelial cells. Cryobiology 1998 0.84
71 Mutations synthetically lethal with tpm1delta lie in genes involved in morphogenesis. Genetics 1997 0.83
72 Purification of caldesmon. Methods Enzymol 1986 0.83
73 Brush border myosin-I microinjected into cultured cells is targeted to actin-containing surface structures. J Cell Sci 1994 0.80
74 Landmark mapping: a general method for localizing cysteine residues within a protein. Proc Natl Acad Sci U S A 1989 0.80
75 Dynamic association of moesin with the membrane skeleton of thrombin- activated platelets. Blood 1999 0.80
76 Mapping of the microvillar 110K-calmodulin complex (brush border myosin I). Identification of fragments containing the catalytic and F-actin-binding sites and demonstration of a calcium ion dependent conformational change. Biochemistry 1990 0.78
77 Immunoblot detection of antigens in immunoprecipitates. Biotechniques 2001 0.78
78 The cytoskeletal linker protein moesin: decreased levels in Wiskott-Aldrich syndrome platelets and identification of a cleavage pathway in normal platelets. Br J Haematol 1999 0.77
79 Preparation of immobilized monomeric actin and its use in the isolation of protease-free and ribonuclease-free pancreatic deoxyribonuclease I. Eur J Biochem 1989 0.76