Published in Kidney Int on May 01, 1981
WNK kinases regulate thiazide-sensitive Na-Cl cotransport. J Clin Invest (2003) 3.67
Molecular pathogenesis of inherited hypertension with hyperkalemia: the Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4. Proc Natl Acad Sci U S A (2003) 3.48
Disease-causing mutant WNK4 increases paracellular chloride permeability and phosphorylates claudins. Proc Natl Acad Sci U S A (2004) 2.10
Antagonistic regulation of ROMK by long and kidney-specific WNK1 isoforms. Proc Natl Acad Sci U S A (2006) 1.93
The WNKs: atypical protein kinases with pleiotropic actions. Physiol Rev (2011) 1.88
WNK1, a kinase mutated in inherited hypertension with hyperkalemia, localizes to diverse Cl- -transporting epithelia. Proc Natl Acad Sci U S A (2003) 1.82
WNK1 activates SGK1 to regulate the epithelial sodium channel. Proc Natl Acad Sci U S A (2005) 1.76
Paracellular Cl- permeability is regulated by WNK4 kinase: insight into normal physiology and hypertension. Proc Natl Acad Sci U S A (2004) 1.68
Comparison of insulin action on glucose versus potassium uptake in humans. Clin J Am Soc Nephrol (2011) 1.57
Hyperkalemia. West J Med (1984) 1.42
SPAK isoforms and OSR1 regulate sodium-chloride co-transporters in a nephron-specific manner. J Biol Chem (2012) 1.21
WNK kinases and renal sodium transport in health and disease: an integrated view. Hypertension (2008) 1.19
Regulation of ROMK channel and K+ homeostasis by kidney-specific WNK1 kinase. J Biol Chem (2009) 1.17
Acute insulin stimulation induces phosphorylation of the Na-Cl cotransporter in cultured distal mpkDCT cells and mouse kidney. PLoS One (2011) 1.13
Role of with-no-lysine [K] kinases in the pathogenesis of Gordon's syndrome. Pediatr Nephrol (2006) 1.11
WNK1-related Familial Hyperkalemic Hypertension results from an increased expression of L-WNK1 specifically in the distal nephron. Proc Natl Acad Sci U S A (2013) 1.03
Overexpression of pendrin in intercalated cells produces chloride-sensitive hypertension. J Am Soc Nephrol (2013) 0.99
Phosphatidylinositol 3-kinase/Akt signaling pathway activates the WNK-OSR1/SPAK-NCC phosphorylation cascade in hyperinsulinemic db/db mice. Hypertension (2012) 0.99
Negative regulators of sodium transport in the kidney: key factors in understanding salt-sensitive hypertension? J Clin Invest (2003) 0.97
A new locus on chromosome 12p13.3 for pseudohypoaldosteronism type II, an autosomal dominant form of hypertension. Am J Hum Genet (2000) 0.97
Characterization of the kinase activity of a WNK4 protein complex. Am J Physiol Renal Physiol (2009) 0.95
KLHL3 regulates paracellular chloride transport in the kidney by ubiquitination of claudin-8. Proc Natl Acad Sci U S A (2015) 0.95
Distal potassium handling based on flow modulation of maxi-K channel activity. Curr Opin Nephrol Hypertens (2009) 0.93
A minor role of WNK3 in regulating phosphorylation of renal NKCC2 and NCC co-transporters in vivo. Biol Open (2011) 0.88
WNK4 kinase stimulates caveola-mediated endocytosis of TRPV5 amplifying the dynamic range of regulation of the channel by protein kinase C. J Biol Chem (2010) 0.86
SPAK deficiency corrects pseudohypoaldosteronism II caused by WNK4 mutation. PLoS One (2013) 0.80
The molecular basis of blood pressure variation. Pediatr Nephrol (2012) 0.78
New roles for chloride in renal physiology and pathophysiology. Trans Am Clin Climatol Assoc (1991) 0.75
Pseudohypoaldosteronism: case report and discussion of the syndrome. Yale J Biol Med (1992) 0.75
Liddle's syndrome: heritable human hypertension caused by mutations in the beta subunit of the epithelial sodium channel. Cell (1994) 5.29
Permeability characteristics of the human small intestine. J Clin Invest (1965) 4.62
The mechanisms of sodium absorption in the human small intestine. J Clin Invest (1968) 4.58
"Buffalo hump" in men with HIV-1 infection. Lancet (1998) 3.93
Measurement of intracellular pH of skeletal muscle with pH-sensitive glass microelectrodes. J Clin Invest (1967) 3.62
Residential culturable fungi, (1-3, 1-6)-β-d-glucan, and ergosterol concentrations in dust are not associated with asthma, rhinitis, or eczema diagnoses in children. Indoor Air (2013) 3.27
Hyperlipidemia and insulin resistance are induced by protease inhibitors independent of changes in body composition in patients with HIV infection. J Acquir Immune Defic Syndr (2000) 3.11
Mechanism of glomerulotubular balance. I. Effect of aortic constriction and elevated ureteropelvic pressure on glomerular filtration rate, fractional reabsorption, transit time, and tubular size in the proximal tubule of the rat. J Clin Invest (1966) 2.96
Countercurrent multiplication system without active transport in inner medulla. Kidney Int (1972) 2.95
A high ratio of dietary animal to vegetable protein increases the rate of bone loss and the risk of fracture in postmenopausal women. Study of Osteoporotic Fractures Research Group. Am J Clin Nutr (2001) 2.76
Disruption of the acyl-CoA:cholesterol acyltransferase gene in mice: evidence suggesting multiple cholesterol esterification enzymes in mammals. Proc Natl Acad Sci U S A (1996) 2.70
Water and solute movement in the small intestine of patients with sprue. J Clin Invest (1967) 2.60
Mechanism of bicarbonate absorption and its relationship to sodium transport in the human jejunum. J Clin Invest (1970) 2.43
Diuretics, serum and intracellular electrolyte levels, and ventricular arrhythmias in hypertensive men. JAMA (1992) 2.42
Growth hormone replacement in healthy older men improves body composition but not functional ability. Ann Intern Med (1996) 2.36
Mechanism of glomerulotubular balance. II. Regulation of proximal tubular reabsorption by tubular volume, as studied by stopped-flow microperfusion. J Clin Invest (1966) 2.19
Estimation of net endogenous noncarbonic acid production in humans from diet potassium and protein contents. Am J Clin Nutr (1998) 2.00
Effects of surgery on plasma volume and salt and water excretion in rats. Am J Physiol (1977) 1.96
Metabolic effects of indinavir in healthy HIV-seronegative men. AIDS (2001) 1.90
Expression of AT2 receptors in the developing rat fetus. J Clin Invest (1991) 1.89
The effects of recombinant human growth hormone on body composition and glucose metabolism in HIV-infected patients with fat accumulation. J Clin Endocrinol Metab (2001) 1.86
Normotensive salt sensitivity: effects of race and dietary potassium. Hypertension (1999) 1.74
The mechanism of suppression of proximal tubular reabsorption by saline infusions. J Clin Invest (1967) 1.69
Role of the Na+/H+ antiporter in rat proximal tubule bicarbonate absorption. J Clin Invest (1987) 1.59
Symposium on acid-base homeostasis. The generation and maintenance of metabolic alkalosis. Kidney Int (1972) 1.57
Anabolic effects of nandrolone decanoate in patients receiving dialysis: a randomized controlled trial. JAMA (1999) 1.56
Factors governing the transepithelial potential difference across the proximal tubule of the rat kidney. J Clin Invest (1974) 1.55
Localization of diuretic action from the pattern of water and electrolyte excretion. Ann N Y Acad Sci (1966) 1.51
Functional characteristics of the diluting segment of the dog nephron and the effect of extracellular volume expansion on its reabsorptive capacity. J Clin Invest (1967) 1.50
Patterns of nephron perfusion in acute and chronic hydronephrosis. J Clin Invest (1966) 1.49
Normal diet NaCl variation can affect the renal set-point for plasma pH-(HCO3-) maintenance. J Am Soc Nephrol (1990) 1.47
Relation of renal gluconeogenesis to ammonia production in the dog and rat. Am J Physiol (1967) 1.46
Orthostatic hypertension due to vascular adrenergic hypersensitivity. Hypertension (1996) 1.46
Diet, evolution and aging--the pathophysiologic effects of the post-agricultural inversion of the potassium-to-sodium and base-to-chloride ratios in the human diet. Eur J Nutr (2001) 1.43
A mark-release-recapture experiment with Culex pipiens fatigans in the village of Okpo, Burma. Ann Trop Med Parasitol (1968) 1.41
Resting transmembrane potential difference of skeletal muscle in normal subjects and severely ill patients. J Clin Invest (1971) 1.38
Sodium, bicarbonate, and chloride absorption by the proximal tubule. Am J Physiol (1983) 1.37
Measurement of intracellular pH with glass microelectrodes. Fed Proc (1967) 1.37
Effects of angiotensin II on insulin receptor binding and mRNA levels in normal and diabetic rats. Diabetologia (1997) 1.37
Effect of age on blood acid-base composition in adult humans: role of age-related renal functional decline. Am J Physiol (1996) 1.36
Control of proximal bicarbonate reabsorption in normal and acidotic rats. J Clin Invest (1979) 1.36
Metabolic and physiologic improvements from consuming a paleolithic, hunter-gatherer type diet. Eur J Clin Nutr (2009) 1.35
Flow dependence of transtubular potential difference in isolated perfused segments of rabbit proximal convoluted tubule. J Clin Invest (1971) 1.35
Effect of luminal bicarbonate concentration on proximal acidification in the rat. Am J Physiol (1982) 1.34
Demonstration of a hormonal inhibitor of proximal tubular reabsorption during expansion of extracellular volume with isotonic saline. J Clin Invest (1968) 1.33
Relation of distal tubular NaCl delivery and glomerular hydrostatic pressure. Kidney Int (1972) 1.32
Increased Vmax for Na+/H+ antiporter activity in proximal tubule brush border vesicles from rabbits with metabolic acidosis. Am J Physiol (1984) 1.32
Mechanism of NaCl and water reabsorption in the proximal convoluted tubule of rat kidney. J Clin Invest (1976) 1.29
Basolateral membrane Na/base cotransport is dependent on CO2/HCO3 in the proximal convoluted tubule. J Gen Physiol (1987) 1.25
The duration of egg, larval and pupal stages of Culex pipiens fatigans in Rangoon, Burma. Bull World Health Organ (1967) 1.24
Potassium bicarbonate reduces urinary nitrogen excretion in postmenopausal women. J Clin Endocrinol Metab (1997) 1.23
Measurement of single-nephron glomerular filtration rate by micropuncture: analysis of error. Am J Physiol (1971) 1.22
Renal potassium wasting in renal tubular acidosis (RTA): its occurrence in types 1 and 2 RTA despite sustained correction of systemic acidosis. J Clin Invest (1971) 1.21
Increased prostaglandin production by glomeruli isolated from rats with streptozotocin-induced diabetes mellitus. J Clin Invest (1985) 1.21
Effect of hemorrhagic shock on transmembrane potential. Surgery (1969) 1.20
Regulation of cell pH by ambient bicarbonate, carbon dioxide tension, and pH in the rabbit proximal convoluted tubule. J Clin Invest (1988) 1.20
Pathophysiology of epidemic St. Louis encephalitis. I. Inappropriate secretion of antidiuretic hormone. II. Pituitary-adrenal function. 3. Cerebral blood flow and metabolism. Ann Intern Med (1969) 1.18
Effects of extracellular fluid volume and plasma bicarbonate concentration on proximal acidification in the rat. J Clin Invest (1983) 1.18
Tissue-specific regulation of type 1 angiotensin II receptor mRNA levels in the rat. Hypertension (1996) 1.18
Energy expenditure in human immunodeficiency virus infection. N Engl J Med (1997) 1.17
Characterization of angiotensin II receptor subtypes in rat heart. Circ Res (1992) 1.17
Evaluation of Wuchereria bancrofti infection in Culex pipiens fatigans in Rangoon, Burma. Bull World Health Organ (1967) 1.17
Measurement of aortic blood flow by Doppler echocardiography: day to day variability in normal subjects and applicability in clinical research. J Am Coll Cardiol (1991) 1.16
Amelioration of metabolic acidosis with fludrocortisone therapy in hyporeninemic hypoaldosteronism. N Engl J Med (1977) 1.15
Synthesis and structure-activity relationships of a novel series of non-peptide angiotensin II receptor binding inhibitors specific for the AT2 subtype. J Med Chem (1991) 1.15
Angiotensin II in arterial and renal venous plasma and renal lymph in the dog. J Clin Invest (1971) 1.15
Acetazolamide in studying sodium reabsorption in diluting segment. Am J Physiol (1970) 1.14
Measurement of intrarenal blood flow. I. Analysis of microsphere method. Am J Physiol (1971) 1.14
Effective glomerular filtration pressure and single nephron filtration rate during hydropenia, elevated ureteral pressure, and acute volume expansion with isotonic saline. J Clin Invest (1971) 1.14
Systemic lupus erythematosus with adrenal insufficiency. Am J Med (1973) 1.14
The role of intraluminal sodium in glucose absorption in vivo. J Clin Invest (1972) 1.14
Effect of diet on plasma acid-base composition in normal humans. Kidney Int (1983) 1.14
Pseudohyperkalemia caused by fist clenching during phlebotomy. N Engl J Med (1990) 1.13
The neuroendocrine protein 7B2 is required for peptide hormone processing in vivo and provides a novel mechanism for pituitary Cushing's disease. Cell (1999) 1.12
Adrenal mineralocorticoids causing hypertension. Am J Med (1972) 1.12
The biting cycle of Culex pipiens fatigans on man in Rangoon, Burma, and the microfilarial periodicity. Bull World Health Organ (1967) 1.11
Proton secretion by the kidney. Annu Rev Physiol (1979) 1.10
Selective renal-vein renin sampling in hypertensive patients with segmental renal lesions. N Engl J Med (1974) 1.10
Proximal reabsorption during metabolic acidosis in the rat. Am J Physiol (1982) 1.10
Incidence of radiographically evident bone disease, nephrocalcinosis, and nephrolithiasis in various types of renal tubular acidosis. N Engl J Med (1982) 1.09
Prevalence, pathogenesis, and functional significance of aldosterone deficiency in hyperkalemic patients with chronic renal insufficiency. Kidney Int (1980) 1.09
Safe use of hepatic allografts from donors older than 70 years. Transplantation (1996) 1.09
Studies on glomerulotubular balance during aortic constriction, ureteral obstruction and venous occlusion in hydropenic and saline-loaded rats. Nephron (1969) 1.09
Flow dependence of proximal tubular bicarbonate absorption. Am J Physiol (1983) 1.08
Measurement of intrarenal blood flow. II. Effect of saline diuresis in the dog. Am J Physiol (1971) 1.08
Positive geotaxis in gravid Culex pipiens fatigans. Bull World Health Organ (1966) 1.07
Role of Na+-H+ antiport in rat proximal tubule NaCl absorption. Am J Physiol (1988) 1.07
Serial assessment of glomerular filtration rate in lupus nephropathy. Kidney Int (1988) 1.07
Effect of hyperoncotic albumin expansion upon glomerular ultrafiltration in the rat. Kidney Int (1974) 1.06
Influence of volume expansion on single-nephron filtration rate and plasma flow in the rat. Am J Physiol (1973) 1.06
Effect of saline infusions on intrarenal distribution of glomerular filtrate and proximal reabsorption in the dog. J Clin Invest (1971) 1.06
Effect of chronic mineralocorticoid administration on calcium excretion in the rat. Am J Physiol (1968) 1.05
Cross-sectional and longitudinal evaluation of body composition in men with HIV infection. J Acquir Immune Defic Syndr Hum Retrovirol (1997) 1.05
Nitrocinnamoyl and chlorocinnamoyl derivatives of dihydrocodeinone: in vivo and in vitro characterization of mu-selective agonist and antagonist activity. J Pharmacol Exp Ther (1999) 1.04
Autoradiographic characterization of angiotensin II receptor subtypes in rat intestine. Am J Physiol (1993) 1.04
Renal-vein renin in various forms of renal hypertension. Lancet (1972) 1.04