Published in Proc Natl Acad Sci U S A on March 19, 2004
The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinases. Biochem J (2005) 3.52
Intestinal barrier function: molecular regulation and disease pathogenesis. J Allergy Clin Immunol (2009) 2.63
Angiotensin II signaling increases activity of the renal Na-Cl cotransporter through a WNK4-SPAK-dependent pathway. Proc Natl Acad Sci U S A (2009) 2.30
Biology of claudins. Am J Physiol Renal Physiol (2008) 2.17
Claudins and the modulation of tight junction permeability. Physiol Rev (2013) 2.05
WNK3 kinase is a positive regulator of NKCC2 and NCC, renal cation-Cl- cotransporters required for normal blood pressure homeostasis. Proc Natl Acad Sci U S A (2005) 1.96
Mechanisms of WNK1 and WNK4 interaction in the regulation of thiazide-sensitive NaCl cotransport. J Clin Invest (2005) 1.96
Antagonistic regulation of ROMK by long and kidney-specific WNK1 isoforms. Proc Natl Acad Sci U S A (2006) 1.93
The WNKs: atypical protein kinases with pleiotropic actions. Physiol Rev (2011) 1.88
WNK1 activates SGK1 to regulate the epithelial sodium channel. Proc Natl Acad Sci U S A (2005) 1.76
The claudins. Genome Biol (2009) 1.76
Activation of the renal Na+:Cl- cotransporter by angiotensin II is a WNK4-dependent process. Proc Natl Acad Sci U S A (2012) 1.73
Paracellular Cl- permeability is regulated by WNK4 kinase: insight into normal physiology and hypertension. Proc Natl Acad Sci U S A (2004) 1.68
Intersectin links WNK kinases to endocytosis of ROMK1. J Clin Invest (2007) 1.67
An SGK1 site in WNK4 regulates Na+ channel and K+ channel activity and has implications for aldosterone signaling and K+ homeostasis. Proc Natl Acad Sci U S A (2007) 1.65
The thiazide-sensitive Na+-Cl- cotransporter: molecular biology, functional properties, and regulation by WNKs. Am J Physiol Renal Physiol (2009) 1.58
Kelch-like 3 and Cullin 3 regulate electrolyte homeostasis via ubiquitination and degradation of WNK4. Proc Natl Acad Sci U S A (2013) 1.56
WNK4 regulates activity of the epithelial Na+ channel in vitro and in vivo. Proc Natl Acad Sci U S A (2007) 1.46
The kidney-specific WNK1 isoform is induced by aldosterone and stimulates epithelial sodium channel-mediated Na+ transport. Proc Natl Acad Sci U S A (2004) 1.43
Claudin family of proteins and cancer: an overview. J Oncol (2010) 1.42
Dysregulation of claudin-7 leads to loss of E-cadherin expression and the increased invasion of esophageal squamous cell carcinoma cells. Am J Pathol (2007) 1.41
Claudin-4 forms paracellular chloride channel in the kidney and requires claudin-8 for tight junction localization. Proc Natl Acad Sci U S A (2010) 1.36
The salt-wasting phenotype of EAST syndrome, a disease with multifaceted symptoms linked to the KCNJ10 K+ channel. Pflugers Arch (2011) 1.23
WNK kinases and renal sodium transport in health and disease: an integrated view. Hypertension (2008) 1.19
Potassium ion movement in the inner ear: insights from genetic disease and mouse models. Physiology (Bethesda) (2009) 1.18
Regulation of ROMK channel and K+ homeostasis by kidney-specific WNK1 kinase. J Biol Chem (2009) 1.17
Immunolocalization of WNK4 in mouse kidney. Histochem Cell Biol (2011) 1.17
Regulation of transport in the connecting tubule and cortical collecting duct. Compr Physiol (2012) 1.16
Phosphorylation of claudin-4 by PKCepsilon regulates tight junction barrier function in ovarian cancer cells. Exp Cell Res (2007) 1.12
Role of with-no-lysine [K] kinases in the pathogenesis of Gordon's syndrome. Pediatr Nephrol (2006) 1.11
Claudins and the kidney. Annu Rev Physiol (2012) 1.11
WNK3, a kinase related to genes mutated in hereditary hypertension with hyperkalaemia, regulates the K+ channel ROMK1 (Kir1.1). J Physiol (2005) 1.07
Emerging roles of claudins in human cancer. Int J Mol Sci (2013) 1.05
Cardiovascular expression of the mouse WNK1 gene during development and adulthood revealed by a BAC reporter assay. Am J Pathol (2006) 1.03
Phosphorylation of claudin-2 on serine 208 promotes membrane retention and reduces trafficking to lysosomes. J Cell Sci (2012) 1.02
Regulation of Potassium Homeostasis. Clin J Am Soc Nephrol (2014) 1.01
Dragon enhances BMP signaling and increases transepithelial resistance in kidney epithelial cells. J Am Soc Nephrol (2010) 0.98
Downregulation of NCC and NKCC2 cotransporters by kidney-specific WNK1 revealed by gene disruption and transgenic mouse models. Hum Mol Genet (2010) 0.98
Acute regulation of tight junction ion selectivity in human airway epithelia. Proc Natl Acad Sci U S A (2009) 0.97
Potassium excretion during antinatriuresis: perspective from a distal nephron model. Am J Physiol Renal Physiol (2011) 0.96
Characterization of the kinase activity of a WNK4 protein complex. Am J Physiol Renal Physiol (2009) 0.95
WNK3 positively regulates epithelial calcium channels TRPV5 and TRPV6 via a kinase-dependent pathway. Am J Physiol Renal Physiol (2008) 0.95
KLHL3 regulates paracellular chloride transport in the kidney by ubiquitination of claudin-8. Proc Natl Acad Sci U S A (2015) 0.95
Caenorhabditis elegans WNK-STE20 pathway regulates tube formation by modulating ClC channel activity. EMBO Rep (2007) 0.94
The kidney tight junction (Review). Int J Mol Med (2014) 0.92
Cloning and characterization of a new intestinal inflammation-associated colonic epithelial Ste20-related protein kinase isoform. Biochim Biophys Acta (2007) 0.91
WNK kinases, renal ion transport and hypertension. Am J Nephrol (2008) 0.91
Expression transformation of claudin-1 in the process of gastric adenocarcinoma invasion. World J Gastroenterol (2008) 0.90
Claudins and the kidney. J Am Soc Nephrol (2014) 0.87
Tight junctions: from simple barriers to multifunctional molecular gates. Nat Rev Mol Cell Biol (2016) 0.87
Regulation of with-no-lysine kinase signaling by Kelch-like proteins. Biol Cell (2014) 0.86
Regulation of two renal chloride transporters, AE1 and pendrin, by electrolytes and aldosterone. PLoS One (2013) 0.84
Regulation of paracellular transport in the distal nephron. Curr Opin Nephrol Hypertens (2012) 0.80
Claudin-1 required for HCV virus entry has high potential for phosphorylation and O-glycosylation. Virol J (2011) 0.79
Aldosterone signaling regulates the over-expression of claudin-4 and -8 at the distal nephron from type 1 diabetic rats. PLoS One (2017) 0.77
Claudins in barrier and transport function-the kidney. Pflugers Arch (2016) 0.76
Recent progress in histochemistry and cell biology. Histochem Cell Biol (2012) 0.76
Hypertension: the missing WNKs. Am J Physiol Renal Physiol (2016) 0.76
Ca(2+) is a Regulator of the WNK/OSR1/NKCC Pathway in a Human Salivary Gland Cell Line. Korean J Physiol Pharmacol (2015) 0.75
Paracellular transport in the collecting duct. Curr Opin Nephrol Hypertens (2016) 0.75
Claudin expression in the rat endolymphatic duct and sac - first insights into regulation of the paracellular barrier by vasopressin. Sci Rep (2017) 0.75
The role of renal transporters and novel regulatory interactions in the TAL that control blood pressure. Physiol Genomics (2017) 0.75
Human hypertension caused by mutations in WNK kinases. Science (2001) 8.71
Paracellin-1, a renal tight junction protein required for paracellular Mg2+ resorption. Science (1999) 6.04
Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins. J Cell Biol (1999) 5.06
WNK4 regulates the balance between renal NaCl reabsorption and K+ secretion. Nat Genet (2003) 4.08
WNK1, a novel mammalian serine/threonine protein kinase lacking the catalytic lysine in subdomain II. J Biol Chem (2000) 3.97
WNK kinases regulate thiazide-sensitive Na-Cl cotransport. J Clin Invest (2003) 3.67
Conversion of zonulae occludentes from tight to leaky strand type by introducing claudin-2 into Madin-Darby canine kidney I cells. J Cell Biol (2001) 3.66
Claudins create charge-selective channels in the paracellular pathway between epithelial cells. Am J Physiol Cell Physiol (2002) 3.59
Molecular pathogenesis of inherited hypertension with hyperkalemia: the Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4. Proc Natl Acad Sci U S A (2003) 3.48
Claudin-2 expression induces cation-selective channels in tight junctions of epithelial cells. J Cell Sci (2002) 3.47
Claudin extracellular domains determine paracellular charge selectivity and resistance but not tight junction fibril architecture. Am J Physiol Cell Physiol (2003) 3.38
Regulated expression of claudin-4 decreases paracellular conductance through a selective decrease in sodium permeability. J Clin Invest (2001) 3.28
Regulation of WNK1 by an autoinhibitory domain and autophosphorylation. J Biol Chem (2002) 2.16
Claudin-8 expression in Madin-Darby canine kidney cells augments the paracellular barrier to cation permeation. J Biol Chem (2003) 2.01
Mineralocorticoid-resistant renal hyperkalemia without salt wasting (type II pseudohypoaldosteronism): role of increased renal chloride reabsorption. Kidney Int (1981) 1.83
Localization of the thiazide sensitive Na-Cl cotransporter, rTSC1 in the rat kidney. Kidney Int (1996) 1.54
Localization of the ROMK protein on apical membranes of rat kidney nephron segments. Am J Physiol (1997) 1.50
Chloride transport by the cortical and outer medullary collecting duct. Am J Physiol (1987) 1.30
Interleukin-2 receptor beta subunit-dependent and -independent regulation of intestinal epithelial tight junctions. J Biol Chem (2001) 1.19
Familial hyperpotassemia and hypertension accompanied by normal plasma aldosterone levels: possible hereditary cell membrane defect. Arch Intern Med (1978) 1.03
WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1. J Biol Chem (2005) 3.26
Molecular pathogenesis of pseudohypoaldosteronism type II: generation and analysis of a Wnk4(D561A/+) knockin mouse model. Cell Metab (2007) 2.88
SPAK-knockout mice manifest Gitelman syndrome and impaired vasoconstriction. J Am Soc Nephrol (2010) 2.73
Implications of the aquaporin-4 structure on array formation and cell adhesion. J Mol Biol (2005) 2.50
The KIF3 motor transports N-cadherin and organizes the developing neuroepithelium. Nat Cell Biol (2005) 2.13
Expression and phosphorylation of the Na+-Cl- cotransporter NCC in vivo is regulated by dietary salt, potassium, and SGK1. Am J Physiol Renal Physiol (2009) 2.03
Dietary salt regulates the phosphorylation of OSR1/SPAK kinases and the sodium chloride cotransporter through aldosterone. Kidney Int (2008) 1.92
Cisplatin-induced macroautophagy occurs prior to apoptosis in proximal tubules in vivo. Clin Exp Nephrol (2009) 1.74
ClC-3 chloride channels facilitate endosomal acidification and chloride accumulation. J Biol Chem (2004) 1.61
Progressive adipocyte hypertrophy in aquaporin-7-deficient mice: adipocyte glycerol permeability as a novel regulator of fat accumulation. J Biol Chem (2005) 1.60
Development of enzyme-linked immunosorbent assays for urinary thiazide-sensitive Na-Cl cotransporter measurement. Am J Physiol Renal Physiol (2013) 1.59
Targeted disruption of the Wnk4 gene decreases phosphorylation of Na-Cl cotransporter, increases Na excretion and lowers blood pressure. Hum Mol Genet (2009) 1.56
Assessment and significance of abdominal aortic calcification in chronic kidney disease. Nephrol Dial Transplant (2010) 1.54
Defective water and glycerol transport in the proximal tubules of AQP7 knockout mice. Am J Physiol Renal Physiol (2005) 1.53
Impaired KLHL3-mediated ubiquitination of WNK4 causes human hypertension. Cell Rep (2013) 1.52
Generation and analyses of R8L barttin knockin mouse. Am J Physiol Renal Physiol (2011) 1.52
Enhanced angiotensin receptor-associated protein in renal tubule suppresses angiotensin-dependent hypertension. Hypertension (2013) 1.52
Neuromyelitis optica and anti-aquaporin-4 antibodies measured by an enzyme-linked immunosorbent assay. J Neuroimmunol (2008) 1.51
Disruption of aquaporin-11 produces polycystic kidneys following vacuolization of the proximal tubule. Mol Cell Biol (2005) 1.48
Impaired urea accumulation in the inner medulla of mice lacking the urea transporter UT-A2. Mol Cell Biol (2005) 1.47
Microvesicle-mediated RNA molecule delivery system using monocytes/macrophages. Mol Ther (2010) 1.43
Effects of diuretics on sodium-dependent glucose cotransporter 2 inhibitor-induced changes in blood pressure in obese rats suffering from the metabolic syndrome. J Hypertens (2016) 1.41
Antiproteinuric effect of niceritrol, a nicotinic acid derivative, in chronic renal disease with hyperlipidemia: a randomized trial. Am J Med (2003) 1.41
Identification of a novel aquaporin, AQP12, expressed in pancreatic acinar cells. Biochem Biophys Res Commun (2005) 1.37
Expression and function of the developmental gene Wnt-4 during experimental acute renal failure in rats. J Am Soc Nephrol (2003) 1.28
Impaired phosphorylation of Na(+)-K(+)-2Cl(-) cotransporter by oxidative stress-responsive kinase-1 deficiency manifests hypotension and Bartter-like syndrome. Proc Natl Acad Sci U S A (2011) 1.25
CLC-3 deficiency leads to phenotypes similar to human neuronal ceroid lipofuscinosis. Genes Cells (2002) 1.20
COX-2 and prostaglandin EP3/EP4 signaling regulate the tumor stromal proangiogenic microenvironment via CXCL12-CXCR4 chemokine systems. Am J Pathol (2010) 1.20
Diagnostic usefulness of bone mineral density and biochemical markers of bone turnover in predicting fracture in CKD stage 5D patients--a single-center cohort study. Nephrol Dial Transplant (2011) 1.19
Effect of angiotensin II on the WNK-OSR1/SPAK-NCC phosphorylation cascade in cultured mpkDCT cells and in vivo mouse kidney. Biochem Biophys Res Commun (2010) 1.19
Aquaporins in kidney pathophysiology. Nat Rev Nephrol (2010) 1.18
Aquaporin-2 trafficking is regulated by PDZ-domain containing protein SPA-1. FEBS Lett (2004) 1.18
Water channel activities of Mimosa pudica plasma membrane intrinsic proteins are regulated by direct interaction and phosphorylation. FEBS Lett (2005) 1.17
Immunolocalization of WNK4 in mouse kidney. Histochem Cell Biol (2011) 1.17
SPAK differentially mediates vasopressin effects on sodium cotransporters. J Am Soc Nephrol (2013) 1.16
Reciprocal interaction with G-actin and tropomyosin is essential for aquaporin-2 trafficking. J Cell Biol (2008) 1.15
Aquaporin-11 containing a divergent NPA motif has normal water channel activity. Biochim Biophys Acta (2006) 1.15
Gene transfer of Smad7 using electroporation of adenovirus prevents renal fibrosis in post-obstructed kidney. Kidney Int (2002) 1.15
Identification of a multiprotein "motor" complex binding to water channel aquaporin-2. Biochem Biophys Res Commun (2005) 1.14
Wnt4-transformed mouse embryonic stem cells differentiate into renal tubular cells. Biochem Biophys Res Commun (2005) 1.14
Regulation of aquaporin-2 trafficking and its binding protein complex. Biochim Biophys Acta (2006) 1.13
Acute insulin stimulation induces phosphorylation of the Na-Cl cotransporter in cultured distal mpkDCT cells and mouse kidney. PLoS One (2011) 1.13
Function of chloride channels in the kidney. Annu Rev Physiol (2005) 1.12
Trafficking mechanism of water channel aquaporin-2. Biol Cell (2005) 1.10
Cloning and identification of a new member of water channel (AQP10) as an aquaglyceroporin. Biochim Biophys Acta (2002) 1.09
Activation of the bumetanide-sensitive Na+,K+,2Cl- cotransporter (NKCC2) is facilitated by Tamm-Horsfall protein in a chloride-sensitive manner. J Biol Chem (2011) 1.09
Pathogenesis and treatment of autosomal-dominant nephrogenic diabetes insipidus caused by an aquaporin 2 mutation. Proc Natl Acad Sci U S A (2006) 1.09
Intracellular localization of ClC chloride channels and their ability to form hetero-oligomers. J Cell Physiol (2006) 1.07