| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
The metabolism of menadione (2-methyl-1,4-naphthoquinone) by isolated hepatocytes. A study of the implications of oxidative stress in intact cells.
|
J Biol Chem
|
1982
|
2.81
|
|
2
|
Menadione-induced cytotoxicity is associated with protein thiol oxidation and alteration in intracellular Ca2+ homeostasis.
|
Arch Biochem Biophys
|
1984
|
1.53
|
|
3
|
Bleb formation in hepatocytes during drug metabolism is caused by disturbances in thiol and calcium ion homeostasis.
|
Science
|
1982
|
1.41
|
|
4
|
Regulation of intracellular calcium compartmentation: studies with isolated hepatocytes and t-butyl hydroperoxide.
|
Proc Natl Acad Sci U S A
|
1982
|
1.40
|
|
5
|
Menadione-induced bleb formation in hepatocytes is associated with the oxidation of thiol groups in actin.
|
Arch Biochem Biophys
|
1988
|
1.21
|
|
6
|
Toxic injury to isolated hepatocytes is not dependent on extracellular calcium.
|
Science
|
1981
|
1.14
|
|
7
|
Formation and reduction of glutathione-protein mixed disulfides during oxidative stress. A study with isolated hepatocytes and menadione (2-methyl-1,4-naphthoquinone).
|
Biochem Pharmacol
|
1987
|
1.12
|
|
8
|
Metabolism of hydrogen peroxide in isolated hepatocytes: relative contributions of catalase and glutathione peroxidase in decomposition of endogenously generated H2O2.
|
Arch Biochem Biophys
|
1981
|
1.10
|
|
9
|
Detoxification reactions in isolated hepatocytes. Role of glutathione peroxidase, catalase, and formaldehyde dehydrogenase in reactions relating to N-demethylation by the cytochrome P-450 system.
|
J Biol Chem
|
1978
|
1.10
|
|
10
|
The toxicity of acetaminophen and N-acetyl-p-benzoquinone imine in isolated hepatocytes is associated with thiol depletion and increased cytosolic Ca2+.
|
J Biol Chem
|
1985
|
1.10
|
|
11
|
Fatty acid interaction with the hydroxylating enzyme system of rat liver microsomes.
|
Eur J Biochem
|
1969
|
1.07
|
|
12
|
The measurement of lipid peroxidation in isolated hepatocytes.
|
Biochem Pharmacol
|
1982
|
1.03
|
|
13
|
Interaction of menadione (2-methyl-1,4-naphthoquinone) with glutathione.
|
Chem Biol Interact
|
1985
|
1.01
|
|
14
|
Fatty acid inducible cy tochrome P-454 of rat kidney cortex microsomes.
|
Biochem Biophys Res Commun
|
1970
|
0.99
|
|
15
|
Cytosolic-free Ca2+ and cell killing in hepatoma 1c1c7 cells exposed to chemical anoxia.
|
FASEB J
|
1989
|
0.99
|
|
16
|
Potentiation of oxidative cell injury in hepatocytes which have accumulated Ca2+.
|
J Biol Chem
|
1984
|
0.97
|
|
17
|
Metabolic activation and hepatotoxicity. Effect of cysteine, N-acetylcysteine, and methionine on glutathione biosynthesis and bromobenzene toxicity in isolated rat hepatocytes.
|
Arch Biochem Biophys
|
1979
|
0.91
|
|
18
|
A comparative study on the effects of phenobarbital and 3,4-benzpyrene on the hydroxylating enzyme system of rat-liver microsomes.
|
Chem Biol Interact
|
1969
|
0.91
|
|
19
|
Increase in cytosolic Ca2+ concentration during t-butyl hydroperoxide metabolism by isolated hepatocytes involves NADPH oxidation and mobilization of intracellular Ca2+ stores.
|
FEBS Lett
|
1984
|
0.90
|
|
20
|
Induction of DNA damage by menadione (2-methyl-1,4-naphthoquinone) in primary cultures of rat hepatocytes.
|
Biochem Pharmacol
|
1984
|
0.89
|
|
21
|
Cytoskeletal alterations in human platelets exposed to oxidative stress are mediated by oxidative and Ca2+-dependent mechanisms.
|
Arch Biochem Biophys
|
1989
|
0.87
|
|
22
|
Oxidative stress-induced plasma membrane blebbing and cytoskeletal alterations in normal and cancer cells.
|
Ann N Y Acad Sci
|
1988
|
0.84
|
|
23
|
Effects of oxidative stress caused by hyperoxia and diquat. A study in isolated hepatocytes.
|
Free Radic Res Commun
|
1986
|
0.84
|
|
24
|
Modulation of cellular glutathione and protein thiol status during quinone metabolism.
|
Methods Enzymol
|
1990
|
0.84
|
|
25
|
Turnover and functions of glutathione studied with isolated hepatic and renal cells.
|
Fed Proc
|
1983
|
0.83
|
|
26
|
The role of lipid peroxidation in the toxicity of foreign compounds to liver cells.
|
Biochem Pharmacol
|
1983
|
0.82
|
|
27
|
Formation and efflux of glutathione disulfide studied in isolated rat hepatocytes.
|
FEBS Lett
|
1981
|
0.81
|
|
28
|
Alterations in thiol and calcium-ion homoeostasis during hydroperoxide and drug metabolism in hepatocytes.
|
Biochem Soc Trans
|
1984
|
0.81
|
|
29
|
Inhibition of ATP-dependent microsomal Ca2+ sequestration during oxidative stress and its prevention by glutathione.
|
J Biol Chem
|
1983
|
0.81
|
|
30
|
Cellular defense mechanisms against toxic substances.
|
Arch Toxicol Suppl
|
1986
|
0.80
|
|
31
|
Metabolic activation and hepatotoxicity. Metabolism of bromobenzene in isolated hypatocytes.
|
Arch Biochem Biophys
|
1978
|
0.80
|
|
32
|
On the role of thiol groups in the inhibition of liver microsomal Ca2+ sequestration by toxic agents.
|
Biochem Pharmacol
|
1985
|
0.80
|
|
33
|
Detection and measurement of drug-induced oxygen radical formation.
|
Methods Enzymol
|
1984
|
0.80
|
|
34
|
Drug-stimulated H2O2 formation in hepatocytes. Possible toxicological implications.
|
Adv Exp Med Biol
|
1981
|
0.80
|
|
35
|
Intracellular Ca2+ chelators prevent DNA damage and protect hepatoma 1C1C7 cells from quinone-induced cell killing.
|
Free Radic Res Commun
|
1990
|
0.80
|
|
36
|
The role of oxidative processes in the cytotoxicity of substituted 1,4-naphthoquinones in isolated hepatocytes.
|
Arch Biochem Biophys
|
1986
|
0.79
|
|
37
|
Isolated rat hepatocytes as an experimental tool in the study of cell injury. Effect of anoxia.
|
Forensic Sci
|
1977
|
0.78
|
|
38
|
Oxidation of glutathione by free radical intermediates formed during peroxidase-catalyzed N-demethylation reactions.
|
FEBS Lett
|
1983
|
0.78
|
|
39
|
Alterations in inositol phosphate production during oxidative stress in isolated hepatocytes.
|
J Biol Chem
|
1987
|
0.77
|
|
40
|
The cytochrome P-450-containing mono-oxygenase system of rat kidney cortex microsomes.
|
Drug Metab Dispos
|
1974
|
0.76
|
|
41
|
Biotransformation of bromobenzene to reactive metabolites by isolated hepatocytes.
|
Adv Exp Med Biol
|
1981
|
0.76
|
|
42
|
Detection of oxygen radicals during reperfusion of intestinal cells in vitro.
|
Free Radic Biol Med
|
1989
|
0.76
|
|
43
|
Cellular metabolism of arsenocholine.
|
J Appl Toxicol
|
1988
|
0.75
|
|
44
|
The mechanism of bromobenzene-induced cytotoxicity studied with isolated hepatocytes.
|
Arch Toxicol
|
1980
|
0.75
|
|
45
|
Cytochrome P-450-product complexes produced by amphetamine derivatives: a comparative study with isolated liver microsomes and hepatocytes.
|
Acta Pharmacol Toxicol (Copenh)
|
1977
|
0.75
|
|
46
|
Drug biotransformation and hepatotoxicity. Studies with bromobenzene in isolated hepatocytes.
|
Arch Toxicol Suppl
|
1978
|
0.75
|
|
47
|
Quality control of metoprolol extended-release formulations in the presence of ethanol.
|
Pharmeur Bio Sci Notes
|
2010
|
0.75
|
|
48
|
The influence of inducers on drug-metabolizing enzyme activity and on formation of reactive drug metabolites in the liver.
|
Ciba Found Symp
|
1980
|
0.75
|
|
49
|
The mechanism of pentachlorobutadienyl-glutathione nephrotoxicity studied with isolated rat renal epithelial cells.
|
Arch Biochem Biophys
|
1986
|
0.75
|
|
50
|
Induction of microsomal aryl hydrocarbon (3,4-benzo(alpha)pyrene) hydroxylase and cytochrome P-450K in rat kidney cortex. II. Interactions with the induced hemoprotein.
|
Arch Biochem Biophys
|
1973
|
0.75
|
|
51
|
The inhibition of the mitochondrial NADH oxidase by alprenolol and the protective effect of cytochrome P-450.
|
Acta Pharmacol Toxicol (Copenh)
|
1975
|
0.75
|
|
52
|
In vitro studies of mechanisms of cytotoxicity.
|
Food Chem Toxicol
|
1987
|
0.75
|