Published in Science on September 24, 1982
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Mechanisms of cell injury by activated oxygen species. Environ Health Perspect (1994) 1.42
Regulation of intracellular calcium compartmentation: studies with isolated hepatocytes and t-butyl hydroperoxide. Proc Natl Acad Sci U S A (1982) 1.40
Cytopathic effects of Treponema denticola chymotrypsin-like proteinase on migrating and stratified epithelial cells. Infect Immun (1995) 1.37
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Calcium signaling and cytotoxicity. Environ Health Perspect (1999) 1.04
Scanning electron microscopic examination of acetaminophen-induced hepatotoxicity and congestion in mice. Am J Pathol (1983) 1.03
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Free radical mediated cell toxicity by redox cycling chemicals. Br J Cancer Suppl (1987) 0.93
H2O2-treated actin: assembly and polymer interactions with cross-linking proteins. Biophys J (1995) 0.90
Hepatocyte membrane injury and bleb formation following low dose comfrey toxicity in rats. Int J Exp Pathol (1993) 0.87
Protection of human umbilical vein endothelial cells by glycine and structurally similar amino acids against calcium and hydrogen peroxide-induced lethal cell injury. Am J Pathol (1992) 0.85
Extracellular calcium effects on cell viability and thiol homeostasis. Environ Health Perspect (1990) 0.81
Assessment of the role of calcium ion in halocarbon hepatotoxicity. Environ Health Perspect (1984) 0.81
A chemical perspective on the anthracycline antitumor antibiotics. Environ Health Perspect (1985) 0.78
The protection of hepatocyte cells from the effects of oxidative stress by treatment with vitamin E in conjunction with DTT. J Biomed Biotechnol (2010) 0.78
T-2 toxin effect on isolated perfused rat hearts. Basic Res Cardiol (1984) 0.78
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Neuronal APP accumulates in toxic membrane blebbings. J Neural Transm (Vienna) (1997) 0.77
Acute phalloidin toxicity in living hepatocytes. Evidence for a possible disturbance in membrane flow and for multiple functions for actin in the liver cell. Am J Pathol (1986) 0.76
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Leukocyte membrane bleb and pseudopod formation in hypertension. J Hum Hypertens (2010) 0.76
Determination of the lowest concentrations of aldehyde fixatives for completely fixing various cellular structures by real-time imaging and quantification. Histochem Cell Biol (2012) 0.76
Protective Effects of Proanthocyanidin on Cerulein-induced Acute Pancreatic Inflammation in Rats. Gastroenterology Res (2009) 0.75
Nucleotide sequence of bacteriophage phi X174 DNA. Nature (1977) 95.69
Oligonucleotide-directed mutagenesis of DNA fragments cloned into M13 vectors. Methods Enzymol (1983) 17.47
Oligonucleotide-directed mutagenesis: a simple method using two oligonucleotide primers and a single-stranded DNA template. DNA (1984) 14.55
The nucleotide sequence of bacteriophage phiX174. J Mol Biol (1978) 13.55
Oligonucleotide-directed mutagenesis using M13-derived vectors: an efficient and general procedure for the production of point mutations in any fragment of DNA. Nucleic Acids Res (1982) 13.52
A general method for defining restriction enzyme cleavage and recognition sites. Methods Enzymol (1980) 13.26
Sequence of the gene for iso-1-cytochrome c in Saccharomyces cerevisiae. Cell (1979) 10.86
Routine versus clinically driven laboratory monitoring of HIV antiretroviral therapy in Africa (DART): a randomised non-inferiority trial. Lancet (2009) 7.96
Mutagenesis at a specific position in a DNA sequence. J Biol Chem (1978) 7.56
Report of the Committee on the Genetic Constitution of Chromosomes 7, 8 and 9. Cytogenet Cell Genet (1985) 7.28
The specific non-symmetrical sequence recognized by restriction endonuclease MboII. J Mol Biol (1980) 6.36
Deletion mapping of sequences essential for in vivo transcription of the iso-1-cytochrome c gene. Proc Natl Acad Sci U S A (1981) 6.26
Environmental lead and children's intelligence: a systematic review of the epidemiological evidence. BMJ (1994) 5.55
The sequence of the DNAs coding for the mating-type loci of Saccharomyces cerevisiae. Cell (1981) 5.23
A position effect in the control of transcription at yeast mating type loci. Nature (1981) 5.23
The alcohol use disorder and associated disabilities interview schedule (AUDADIS): reliability of alcohol and drug modules in a clinical sample. Drug Alcohol Depend (1997) 5.10
The distal transcription signals of the herpesvirus tk gene share a common hexanucleotide control sequence. Cell (1984) 5.10
Four mating-type genes control sexual differentiation in the fission yeast. EMBO J (1988) 5.00
Site-specific mutagenesis using synthetic oligodeoxyribonucleotide primers: II. In vitro selection of mutant DNA. Gene (1979) 4.99
The DNA sequence and analysis of human chromosome 6. Nature (2003) 4.75
Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing. Nature (2000) 4.68
Requirement for the homeobox gene Hb9 in the consolidation of motor neuron identity. Neuron (1999) 4.68
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Work system design for patient safety: the SEIPS model. Qual Saf Health Care (2006) 4.21
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Glutamate-induced neuronal death: a succession of necrosis or apoptosis depending on mitochondrial function. Neuron (1995) 4.07
Diabetes-associated sustained activation of the transcription factor nuclear factor-kappaB. Diabetes (2001) 3.83
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Isolation and sequence of the gene for iso-2-cytochrome c in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1980) 3.62
Phenobarbital-induced synthesis of the microsomal drug-metabolizing enzyme system and its relationship to the proliferation of endoplasmic membranes. A morphological and biochemical study. J Cell Biol (1965) 3.55
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Identification and isolation of the yeast cytochrome c gene. Cell (1978) 3.39
The mapping and sequence determination of the single site in phiX174am3 replicative form DNA cleaved by restriction endonuclease Pst I. FEBS Lett (1976) 3.31
Calcium-activated DNA fragmentation kills immature thymocytes. FASEB J (1989) 3.26
Prostate Testing for Cancer and Treatment (ProtecT) feasibility study. Health Technol Assess (2003) 3.25
Mutations in ATP2A2, encoding a Ca2+ pump, cause Darier disease. Nat Genet (1999) 3.25
Mutations of the yeast SUP4 tRNATyr locus: transcription of the mutant genes in vitro. Cell (1980) 3.24
Molecular cloning and characterization of protective outer membrane protein P.69 from Bordetella pertussis. Proc Natl Acad Sci U S A (1989) 3.13
The base-pairing specificity of cellulose-pdT9. Nucleic Acids Res (1975) 3.11
The Epstein-Barr virus BMLF1 promoter contains an enhancer element that is responsive to the BZLF1 and BRLF1 transactivators. J Virol (1989) 3.11
In vitro mutation analysis of the mating-type locus in yeast. Cell (1981) 3.09
Glucocorticoids activate a suicide process in thymocytes through an elevation of cytosolic Ca2+ concentration. Arch Biochem Biophys (1989) 3.07
Isolation and use of liver cells. Methods Enzymol (1978) 3.06
Site-specific mutagenesis using synthetic oligodeoxyribonucleotide primers: I. Optimum conditions and minimum ologodeoxyribonucleotide length. Gene (1979) 3.05
Triggering and modulation of apoptosis by oxidative stress. Free Radic Biol Med (2000) 2.98
Loss of heterozygosity on chromosome 16p13.3 in hamartomas from tuberous sclerosis patients. Nat Genet (1994) 2.93
Characterization of a short, cis-acting DNA sequence which conveys cell cycle stage-dependent transcription in Saccharomyces cerevisiae. Mol Cell Biol (1991) 2.91
Multisystem involvement in chronic liver disease. Studies on the incidence and pathogenesis. Am J Med (1973) 2.88
Nucleotide sequence of the yeast alcohol dehydrogenase II gene. J Biol Chem (1983) 2.82
The metabolism of menadione (2-methyl-1,4-naphthoquinone) by isolated hepatocytes. A study of the implications of oxidative stress in intact cells. J Biol Chem (1982) 2.81
Structure of the 3' hairpin termini of four rodent parvovirus genomes: nucleotide sequence homology at origins of DNA replication. Cell (1979) 2.78
In vitro mutagenesis. Annu Rev Genet (1985) 2.72
Constitutive expression of a c-myb cDNA blocks Friend murine erythroleukemia cell differentiation. Mol Cell Biol (1988) 2.70
Hormone replacement therapy and breast cancer: what are the facts? Med J Aust (1995) 2.66
Cellular signalling in programmed cell death (apoptosis). Immunol Today (1990) 2.64
Redesigning enzyme structure by site-directed mutagenesis: tyrosyl tRNA synthetase and ATP binding. Nature (1982) 2.63
Apoptosis: a basic biological phenomenon with wide-ranging implications in human disease. J Intern Med (2005) 2.62
Primary sequence and immunological characterization of beta-subunit of high conductance Ca(2+)-activated K+ channel from smooth muscle. J Biol Chem (1994) 2.62
Treatment decision-making at the end of life: a survey of Australian doctors' attitudes towards patients' wishes and euthanasia. Med J Aust (1996) 2.59
Oligonucleotide-directed mutagenesis: a simple method using two oligonucleotide primers and a single-stranded DNA template. Methods Enzymol (1987) 2.59
DNA sequences of two yeast promoter-up mutants. Nature (1983) 2.50
Regional gene assignment of human porphobilinogen deaminase and esterase A4 to chromosome 11q23 leads to 11qter. Proc Natl Acad Sci U S A (1981) 2.50
How white and African Americans view their health and social problems. Different experiences, different expectations. JAMA (1995) 2.48
Psychiatric Research Interview for Substance and Mental Disorders (PRISM): reliability for substance abusers. Am J Psychiatry (1996) 2.47
Nucleotide sequence of salmon testes and salmon liver cytoplasmic initiator tRNA. Cell (1975) 2.46
Cryptosporidiosis in hospital patients with gastroenteritis. Am J Trop Med Hyg (1983) 2.45
The role of emotionality and regulation in children's social functioning: a longitudinal study. Child Dev (1995) 2.43
The DNA sequence and biological annotation of human chromosome 1. Nature (2006) 2.42
Conversion of topoisomerase I cleavage complexes on the leading strand of ribosomal DNA into 5'-phosphorylated DNA double-strand breaks by replication runoff. Mol Cell Biol (2000) 2.41
CPP32/apopain is a key interleukin 1 beta converting enzyme-like protease involved in Fas-mediated apoptosis. J Biol Chem (1996) 2.40
Presence of a pre-apoptotic complex of pro-caspase-3, Hsp60 and Hsp10 in the mitochondrial fraction of jurkat cells. EMBO J (1999) 2.36
Transcription initiation of the Saccharomyces cerevisiae iso-1-cytochrome c gene. Multiple, independent T-A-T-A sequences. J Mol Biol (1986) 2.36
Substrate-induced synthesis of the hydroxylating enzyme system of liver microsomes. Fed Proc (1966) 2.36
Structure of the Saccharomyces cerevisiae HO gene and analysis of its upstream regulatory region. Mol Cell Biol (1986) 2.36
The sequence of a region of bacteriophage phiX174 DNA coding for parts of genes A and B. J Mol Biol (1977) 2.33
Cloning of several cDNA segments coding for human liver proteins. EMBO J (1983) 2.32
Evidence of activity-dependent withdrawal of corticospinal projections during human development. Neurology (2001) 2.32
The relations of emotionality and regulation to dispositional and situational empathy-related responding. J Pers Soc Psychol (1994) 2.31
The 3' terminal sequence of chicken ovalbumin messenger RNA and its comparison with other messenger RNA molecules. J Mol Biol (1976) 2.29
Effects of ligand activation of peroxisome proliferator-activated receptor gamma in human prostate cancer. Proc Natl Acad Sci U S A (2000) 2.23
Detection of herpesvirus DNA in the large intestine of patients with ulcerative colitis and Crohn's disease using the nested polymerase chain reaction. J Med Virol (1992) 2.22
International Morquio A Registry: clinical manifestation and natural course of Morquio A disease. J Inherit Metab Dis (2007) 2.21
Mutagenesis of Fujinami sarcoma virus: evidence that tyrosine phosphorylation of P130gag-fps modulates its biological activity. Cell (1984) 2.18
Laparoscopic total mesorectal excision (TME) for rectal cancer surgery: long-term outcomes. Surg Endosc (2003) 2.18
Role of Ca2+ in toxic cell killing. Trends Pharmacol Sci (1989) 2.17
Macrophage migration inhibitory factor in rheumatoid arthritis: evidence of proinflammatory function and regulation by glucocorticoids. Arthritis Rheum (1999) 2.17
Sequence and nitrate regulation of the Arabidopsis thaliana mRNA encoding nitrate reductase, a metalloflavoprotein with three functional domains. Proc Natl Acad Sci U S A (1988) 2.12
Uncoupling Phosphorylation in Spinach Chloroplasts by Absence of Cations. Plant Physiol (1962) 2.12
Identification of functional regions in the transforming protein of Fujinami sarcoma virus by in-phase insertion mutagenesis. Cell (1984) 2.12
Multicystic, peritoneal mesothelioma: a report with electron microscopy of a case mimicking intra-abdominal cystic hygroma (lymphangioma). Cancer (1979) 2.11
Thiopurine withdrawal during sustained clinical remission in inflammatory bowel disease: relapse and recapture rates, with predictive factors in 237 patients. Aliment Pharmacol Ther (2014) 2.11
Characterization of transposable element-associated mutations that alter yeast alcohol dehydrogenase II expression. Mol Cell Biol (1983) 2.09