Published in J Biol Chem on September 10, 1982
Monoclonal antibodies distinguish phosphorylated and nonphosphorylated forms of neurofilaments in situ. Proc Natl Acad Sci U S A (1983) 6.14
Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death. Proc Natl Acad Sci U S A (1996) 4.16
Aberrant neurofilament phosphorylation in Alzheimer disease. Proc Natl Acad Sci U S A (1985) 2.96
The human mid-size neurofilament subunit: a repeated protein sequence and the relationship of its gene to the intermediate filament gene family. EMBO J (1987) 2.72
Microtubule-associated protein 2: monoclonal antibodies demonstrate the selective incorporation of certain epitopes into Alzheimer neurofibrillary tangles. Proc Natl Acad Sci U S A (1984) 2.22
Recognition of tau epitopes by anti-neurofilament antibodies that bind to Alzheimer neurofibrillary tangles. Proc Natl Acad Sci U S A (1987) 1.96
Neurofilaments and orthograde transport are reduced in ventral root axons of transgenic mice that express human SOD1 with a G93A mutation. J Cell Biol (1997) 1.95
Role of phosphorylation on the structural dynamics and function of types III and IV intermediate filaments. Exp Cell Res (2007) 1.52
Biochemical and immunological analyses of cytoskeletal domains of neurons. J Cell Biol (1986) 1.49
Characterization of dominant and recessive assembly-defective mutations in mouse neurofilament NF-M. J Cell Biol (1990) 1.45
NF-M is an essential target for the myelin-directed "outside-in" signaling cascade that mediates radial axonal growth. J Cell Biol (2003) 1.41
Glutamate slows axonal transport of neurofilaments in transfected neurons. J Cell Biol (2000) 1.33
Alzheimer neurofibrillary tangles contain phosphorylated and hidden neurofilament epitopes. J Neurol Neurosurg Psychiatry (1986) 1.27
440-kD ankyrinB: structure of the major developmentally regulated domain and selective localization in unmyelinated axons. J Cell Biol (1993) 1.22
Neurofilament-dependent radial growth of motor axons and axonal organization of neurofilaments does not require the neurofilament heavy subunit (NF-H) or its phosphorylation. J Cell Biol (1998) 1.16
Axonal outgrowth and dendritic plasticity in the cortical peri-infarct area after experimental stroke. Stroke (2012) 1.15
Molecular cloning and primary structure of human glial fibrillary acidic protein. Proc Natl Acad Sci U S A (1989) 1.14
Disruption of the NF-H gene increases axonal microtubule content and velocity of neurofilament transport: relief of axonopathy resulting from the toxin beta,beta'-iminodipropionitrile. J Cell Biol (1998) 1.14
The transport and assembly of the axonal cytoskeleton. J Cell Biol (1989) 1.14
A monoclonal antibody that cross-reacts with phosphorylated epitopes on two microtubule-associated proteins and two neurofilament polypeptides. Proc Natl Acad Sci U S A (1986) 1.13
Gene replacement in mice reveals that the heavily phosphorylated tail of neurofilament heavy subunit does not affect axonal caliber or the transit of cargoes in slow axonal transport. J Cell Biol (2002) 1.11
Expression of NF-L and NF-M in fibroblasts reveals coassembly of neurofilament and vimentin subunits. J Cell Biol (1989) 1.10
The neurofilament middle molecular mass subunit carboxyl-terminal tail domains is essential for the radial growth and cytoskeletal architecture of axons but not for regulating neurofilament transport rate. J Cell Biol (2003) 1.07
Differential brain expression of the Alzheimer's amyloid precursor protein. EMBO J (1989) 1.06
An immunocytochemical comparison of cytoskeletal proteins in aluminum-induced and Alzheimer-type neurofibrillary tangles. Acta Neuropathol (1986) 1.04
Phosphorylation of highly conserved neurofilament medium KSP repeats is not required for myelin-dependent radial axonal growth. J Neurosci (2009) 1.04
Neurofilaments from ox spinal nerves. Isolation, disassembly, reassembly and cross-linking properties. Biochem J (1983) 1.02
Slow posttranslational modification of a neurofilament protein. J Cell Biol (1985) 0.96
Influence of the phosphorylation state of neurofilament proteins on the interactions between purified filaments in vitro. Biochem J (1988) 0.95
Effects of phosphorylation of the neurofilament L protein on filamentous structures. Cell Regul (1990) 0.94
Inhibition of Pin1 reduces glutamate-induced perikaryal accumulation of phosphorylated neurofilament-H in neurons. Mol Biol Cell (2007) 0.94
Declining phosphatases underlie aging-related hyperphosphorylation of neurofilaments. Neurobiol Aging (2009) 0.87
Expression of neurofilaments and of a titin epitope in thymic epithelial tumors. Implications for the pathogenesis of myasthenia gravis. Am J Pathol (1996) 0.87
Cloning of a cDNA encoding the rat high molecular weight neurofilament peptide (NF-H): developmental and tissue expression in the rat, and mapping of its human homologue to chromosomes 1 and 22. Proc Natl Acad Sci U S A (1989) 0.84
Properties of neurofilament protein kinase. Biochem J (1986) 0.84
Pin1-dependent prolyl isomerization modulates the stress-induced phosphorylation of high molecular weight neurofilament protein. J Biol Chem (2008) 0.84
Squid neurofilaments. Phosphorylation and Ca2+-dependent proteolysis in situ. Biochem J (1986) 0.81
Neurofilament Phosphorylation during Development and Disease: Which Came First, the Phosphorylation or the Accumulation? J Amino Acids (2012) 0.79
The C-terminal domains of NF-H and NF-M subunits maintain axonal neurofilament content by blocking turnover of the stationary neurofilament network. PLoS One (2012) 0.78
Modulation of phosphorylation of neuronal cytoskeletal proteins by neuronal depolarization. Cell Mol Neurobiol (1997) 0.77
Structure-function analysis of the glioma targeting NFL-TBS.40-63 peptide corresponding to the tubulin-binding site on the light neurofilament subunit. PLoS One (2012) 0.76
Recovery of neurofilament following early monocular deprivation. Front Syst Neurosci (2012) 0.76
Calcium and calmodulin-enhanced in vitro phosphorylation of hen brain cold-stable microtubules and spinal cord neurofilament triplet proteins after a single oral dose of tri-o-cresyl phosphate. Proc Natl Acad Sci U S A (1986) 0.75
Isolation of Intermediate Filament Proteins from Multiple Mouse Tissues to Study Aging-associated Post-translational Modifications. J Vis Exp (2017) 0.75
Preoperative chemotherapy in primary operable breast cancer: results from the European Organization for Research and Treatment of Cancer trial 10902. J Clin Oncol (2001) 5.28
Defective axonal transport in a transgenic mouse model of amyotrophic lateral sclerosis. Nature (1995) 2.83
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Impaired learning and LTP in mice expressing the carboxy terminus of the Alzheimer amyloid precursor protein. Nature (1997) 2.44
Progressive neuronopathy in transgenic mice expressing the human neurofilament heavy gene: a mouse model of amyotrophic lateral sclerosis. Cell (1993) 2.42
Delayed maturation of regenerating myelinated axons in mice lacking neurofilaments. Exp Neurol (1997) 2.11
The structure of a human neurofilament gene (NF-L): a unique exon-intron organization in the intermediate filament gene family. Biochim Biophys Acta (1987) 2.10
Deregulation of Cdk5 in a mouse model of ALS: toxicity alleviated by perikaryal neurofilament inclusions. Neuron (2001) 1.68
The distribution of phosphorylation sites among identified proteolytic fragments of mammalian neurofilaments. J Biol Chem (1983) 1.68
Electron microscope and experimental investigations of the neurofilamentous network in Deiters' neurons. Relationship with the cell surface and nuclear pores. J Cell Biol (1974) 1.60
An improved CAT assay for promoter analysis in either transgenic mice or tissue culture cells. DNA Cell Biol (1992) 1.59
Integrators of the cytoskeleton that stabilize microtubules. Cell (1999) 1.56
Up-regulation of protein chaperones preserves viability of cells expressing toxic Cu/Zn-superoxide dismutase mutants associated with amyotrophic lateral sclerosis. J Neurochem (1999) 1.47
Variations in diagnostic and therapeutic procedures in a multicentre, randomized clinical trial (EORTC 10853) investigating breast-conserving treatment for DCIS. Eur J Surg Oncol (2001) 1.44
Improved local control and disease-free survival after perioperative chemotherapy for early-stage breast cancer. A European Organization for Research and Treatment of Cancer Breast Cancer Cooperative Group Study. J Clin Oncol (1996) 1.42
Variants of the heavy neurofilament subunit are associated with the development of amyotrophic lateral sclerosis. Hum Mol Genet (1994) 1.42
Phosphorylation of translation initiation factor eIF-4E is induced in a ras-dependent manner during nerve growth factor-mediated PC12 cell differentiation. Mol Cell Biol (1992) 1.36
Influence of pregnancy on the outcome of breast cancer: a case-control study. Societe Francaise de Senologie et de Pathologie Mammaire Study Group. Int J Cancer (1997) 1.29
Cycling at the interface between neurodevelopment and neurodegeneration. Cell Death Differ (2002) 1.28
Cloning and developmental expression of the murine neurofilament gene family. Brain Res (1986) 1.28
Transcriptional and post-transcriptional effects of nerve growth factor on expression of the three neurofilament subunits in PC-12 cells. J Biol Chem (1988) 1.24
Absence of neurofilaments reduces the selective vulnerability of motor neurons and slows disease caused by a familial amyotrophic lateral sclerosis-linked superoxide dismutase 1 mutant. Proc Natl Acad Sci U S A (1998) 1.23
Neurofilaments in health and disease. Prog Nucleic Acid Res Mol Biol (1998) 1.22
Workplace bullying and sleep disturbances: findings from a large scale cross-sectional survey in the French working population. Sleep (2009) 1.19
Nerve growth factor activates Thy-1 and neurofilament gene transcription in rat PC12 cells. EMBO J (1986) 1.19
SOD1 mutation is associated with accumulation of neurofilaments in amyotrophic lateral sclerosis. Ann Neurol (1996) 1.19
Disruption of type IV intermediate filament network in mice lacking the neurofilament medium and heavy subunits. J Neurochem (1999) 1.18
Late onset of motor neurons in mice overexpressing wild-type peripherin. J Cell Biol (1999) 1.16
Breast-conserving therapy for Paget disease of the nipple: a prospective European Organization for Research and Treatment of Cancer study of 61 patients. Cancer (2001) 1.16
Disruption of the NF-H gene increases axonal microtubule content and velocity of neurofilament transport: relief of axonopathy resulting from the toxin beta,beta'-iminodipropionitrile. J Cell Biol (1998) 1.14
Protective effect of neurofilament heavy gene overexpression in motor neuron disease induced by mutant superoxide dismutase. Proc Natl Acad Sci U S A (1998) 1.11
Induction of proinflammatory molecules in mice with amyotrophic lateral sclerosis: no requirement for proapoptotic interleukin-1beta in neurodegeneration. Ann Neurol (2001) 1.08
Adjuvant tamoxifen in postmenopausal breast cancer: preliminary results of a randomized trial. Breast Cancer Res Treat (1986) 1.06
Improved survival after one course of perioperative chemotherapy in early breast cancer patients. long-term results from the European Organization for Research and Treatment of Cancer (EORTC) Trial 10854. Eur J Cancer (2001) 1.05
Activation of the p38MAPK cascade is associated with upregulation of TNF alpha receptors in the spinal motor neurons of mouse models of familial ALS. Mol Cell Neurosci (2005) 1.04
Nucleotide clusters in deoxyribonucleic acids. II. Investigation of methods for isolation of pyrimidine oligonucleotides. Can J Biochem (1969) 1.03
Electrophysiological properties of axons in mice lacking neurofilament subunit genes: disparity between conduction velocity and axon diameter in absence of NF-H. Brain Res (2000) 1.00
A prognostic score in histological node negative breast cancer. Br J Cancer (1990) 0.98
Thromboembolic complications after perioperative chemotherapy in women with early breast cancer: a European Organization for Research and Treatment of Cancer Breast Cancer Cooperative Group study. J Clin Oncol (1994) 0.97
Aberrant stress-induced phosphorylation of perikaryal neurofilaments. J Biol Chem (1996) 0.97
Characteristics of the protein kinase activity associated with rat neurofilament preparations. Biochim Biophys Acta (1983) 0.95
Neuron-specific expression of Cre recombinase during the late phase of brain development. Neurosci Res (2001) 0.95
Chemical modification of charged amino acid moieties alters the electrophoretic mobilities of neurofilament subunits on SDS/polyacrylamide gels. Eur J Biochem (1987) 0.94
Nerve growth factor enhances the synthesis, phosphorylation, and metabolic stability of neurofilament proteins in PC12 cells. J Biol Chem (1987) 0.93
Cloning of a cDNA encoding the smallest neurofilament protein from the rat. Biochim Biophys Acta (1985) 0.93
Isolation of synaptic junctional complexes of high structural integrity from rat brain. J Cell Biol (1976) 0.93
Apoptotic death of neurons exhibiting peripherin aggregates is mediated by the proinflammatory cytokine tumor necrosis factor-alpha. J Cell Biol (2001) 0.92
Extra neurofilament NF-L subunits rescue motor neuron disease caused by overexpression of the human NF-H gene in mice. J Neuropathol Exp Neurol (1999) 0.92
Oxidative stress, mutant SOD1, and neurofilament pathology in transgenic mouse models of human motor neuron disease. Lab Invest (1997) 0.92
Formation of intermediate filament protein aggregates with disparate effects in two transgenic mouse models lacking the neurofilament light subunit. J Neurosci (2000) 0.91
Altered expression of genes for amyloid and cytoskeletal proteins in Alzheimer cortex. Ann Neurol (1989) 0.91
Interactions between peripherin and neurofilaments in cultured cells: disruption of peripherin assembly by the NF-M and NF-H subunits. Biochem Cell Biol (1999) 0.91
A key role for GAP-43 in the retinotectal topographic organization. Exp Neurol (1999) 0.90
Serum hyaluronan (hyaluronic acid) in breast cancer patients. Int J Cancer (1990) 0.90
Differential vulnerability of microtubule components in cerebral ischemia. Acta Neuropathol (1990) 0.89
Okadaic acid induces the rapid and reversible disruption of the neurofilament network in rat dorsal root ganglion neurons. Biochem Biophys Res Commun (1992) 0.89
Actin-like and tubulin-like proteins in synaptic junctional complexes. Can J Biochem (1978) 0.89
Severe neuronal losses with age in the parietal cortex and ventrobasal thalamus of mice transgenic for the human NF-L neurofilament protein. J Comp Neurol (1999) 0.88
Dinucleotide repeat polymorphism at the D22S264 locus. Nucleic Acids Res (1992) 0.88
Study of proline-directed protein kinases involved in phosphorylation of the heavy neurofilament subunit. J Neurosci (1997) 0.88
Dephosphorylation of neurofilaments by exogenous phosphatases has no effect on reassembly of subunits. J Neurochem (1986) 0.88
Isolation of a zinc finger gene consistently deleted in DiGeorge syndrome. Hum Mol Genet (1993) 0.87
Neurofilaments and motor neuron disease. Trends Cell Biol (1997) 0.87
Highly purified synaptosomal membranes from rat brain. Preparation and characterization. J Biol Chem (1972) 0.87
Reduction of axonal caliber does not alleviate motor neuron disease caused by mutant superoxide dismutase 1. Proc Natl Acad Sci U S A (2000) 0.86
Nucleotide clusters in deoxyribonucleic acids. V. The pyrimidine oligonucleotides of strands r and l of bacteriophage T7 DNA. J Mol Biol (1970) 0.86
Intragenic regulatory elements contribute to transcriptional control of the neurofilament light gene. Gene (1992) 0.86
Workplace bullying and psychotropic drug use: the mediating role of physical and mental health status. Ann Occup Hyg (2010) 0.86
Heterodimeric associations between neuronal intermediate filament proteins. J Biol Chem (1997) 0.85
A comparison of in vitro- and in vivo-phosphorylated neurofilament polypeptides. J Neurochem (1981) 0.84
A novel cdc2-related protein kinase expressed in the nervous system. J Neurochem (1997) 0.84
Altered levels and distribution of microtubule-associated proteins before disease onset in a mouse model of amyotrophic lateral sclerosis. J Neurochem (2003) 0.84
Highly purified synaptosomal membranes from rat brain. Incorporation of amino acids into membrane proteins in vitro. J Biol Chem (1972) 0.83
Reasons for non-entry of patients with DCIS of the breast into a randomised trial (EORTC 10853). Eur J Cancer (1991) 0.83
Nucleotide clusters in deoxyribonucleic acids. 3. Separation of pyrimidine isostichs according to base composition. Biochim Biophys Acta (1968) 0.83
Characterization of the cation-binding properties of porcine neurofilaments. Biochemistry (1988) 0.83
Activation of stress-activated protein kinases correlates with neurite outgrowth induced by protease inhibition in PC12 cells. J Neurochem (1999) 0.82
Neuron specificity of the neurofilament light promoter in transgenic mice requires the presence of DNA unwinding elements. J Biol Chem (1995) 0.82
Specific detection of neuronal cell bodies: in situ hybridization with a biotin-labeled neurofilament cDNA probe. J Histochem Cytochem (1986) 0.82
Chromosomal mapping of the PFTAIRE gene, Pftk1, a cdc2-related kinase expressed predominantly in the mouse nervous system. Genomics (1997) 0.82
Calcium binding to untreated and dephosphorylated porcine neurofilaments. Biochem Biophys Res Commun (1987) 0.81
Nucleotide clusters in deoxyribonucleic acids. VI. The pyrimidine oligonucleotides of strands r and l of bacteriophage lambda DNA. J Mol Biol (1970) 0.81
Both upstream and intragenic sequences of the human neurofilament light gene direct expression of lacZ in neurons of transgenic mouse embryos. J Mol Neurosci (1995) 0.81
AP-1 and Krox-24 transcription factors activate the neurofilament light gene promoter in P19 embryonal carcinoma cells. Cell Growth Differ (1994) 0.81
Intermediate filament disassembly in cultured dorsal root ganglion neurons is associated with amino-terminal head domain phosphorylation of specific subunits. J Neurochem (1998) 0.81
No requirement of alpha-internexin for nervous system development and for radial growth of axons. Brain Res Mol Brain Res (1999) 0.81
The Centre H. Becquerel studies in inflammatory non metastatic breast cancer. Combined modality approach in 178 patients. Br J Cancer (1993) 0.80
Different posttranscriptional controls for the human neurofilament light and heavy genes in transgenic mice. Brain Res Mol Brain Res (1993) 0.80
Increased phosphorylation of neurofilament subunits in PC12 cells and rat dorsal root ganglion neurons treated with N-Acetyl-Leu-Leu-norleucinal. Int J Dev Neurosci (1995) 0.79
Double-isotope studies on brain protein synthesis with ( 3 H)- and ( 14 C)leucine: a warning. Brain Res (1972) 0.79
Two forms of cytoplasmic actin in adrenal chromaffin cells. Neuroscience (1979) 0.79
Decreased neurofilament gene expression is an index of selective axonal hypotrophy in ageing. Neuroreport (1997) 0.79
Neurofilament proteins in cultured chromaffin cells. J Neurochem (1984) 0.79
Inhibition of aberrant and constitutive phosphorylation of the high-molecular-mass neurofilament subunit by CEP-1347 (KT7515), an inhibitor of the stress-activated protein kinase signaling pathway. J Neurochem (2000) 0.78
Altered ionic conductances in axons of transgenic mouse expressing the human neurofilament heavy gene: A mouse model of amyotrophic lateral sclerosis. Exp Neurol (2000) 0.78