Published in Cancer Res on September 01, 1981
Pharmacokinetics, binding and distribution of Hoechst 33342 in spheroids and murine tumours. Br J Cancer (1985) 1.47
The response to cytotoxic drugs of EMT6 cells treated either as intact or disaggregated spheroids. Br J Cancer (1985) 1.28
Evaluation of therapeutics in three-dimensional cell culture systems by MALDI imaging mass spectrometry. Anal Chem (2013) 1.05
Effect of cell density on intracellular adriamycin concentration and cytotoxicity in exponential and plateau phase EMT6 cells. Br J Cancer (1984) 1.01
Characterization of three-dimensional tissue cultures using electrical impedance spectroscopy. Biophys J (1999) 0.88
The effect of adriamycin and 4'-deoxydoxorubicin on cell survival of human lung tumour cells grown in monolayer and as spheroids. Br J Cancer (1986) 0.88
Size-dependent resistance of human tumour spheroids to photodynamic treatment. Br J Cancer (1989) 0.87
Intraperitoneal therapy in the management of ovarian carcinoma. Yale J Biol Med (1990) 0.86
The pH partition theory predicts the accumulation and toxicity of doxorubicin in normal and low-pH-adapted cells. Br J Cancer (1999) 0.86
Opioid receptor activation triggering downregulation of cAMP improves effectiveness of anti-cancer drugs in treatment of glioblastoma. Cell Cycle (2014) 0.85
Identification of a novel topoisomerase inhibitor effective in cells overexpressing drug efflux transporters. PLoS One (2009) 0.85
Inhibition of the regulation of intracellular pH: potential of 5-(N,N-hexamethylene) amiloride in tumour-selective therapy. Br J Cancer (1994) 0.84
Penetration of anticancer drugs through tumour tissue as a function of cellular packing density and interstitial fluid pressure and its modification by bortezomib. BMC Cancer (2012) 0.84
Intraperitoneal chemotherapy in the management of ovarian cancer: focus on carboplatin. Ther Clin Risk Manag (2009) 0.81
Flow cytometry-assisted Monte Carlo simulation predicts clonogenic survival of cell populations with lognormal distributions of radiopharmaceuticals and anticancer drugs. Int J Radiat Biol (2011) 0.79
A comparison of adriamycin and mAMSA. II. Studies with V79 and human tumour multicellular spheroids. Cancer Chemother Pharmacol (1987) 0.78
Intracavitary chemotherapy for malignant disease confined to body cavities. West J Med (1985) 0.75
Heterogeneity in radiation-induced DNA damage and repair in tumor and normal cells measured using the "comet" assay. Radiat Res (1990) 4.60
Intermittent blood flow in a murine tumor: radiobiological effects. Cancer Res (1987) 2.85
Radiation response of multicell spheroids--an in vitro tumour model. Curr Top Radiat Res Q (1976) 2.73
Acute hypoxia in tumors: implications for modifiers of radiation effects. Int J Radiat Oncol Biol Phys (1986) 1.84
Effects of intercellular contact on repair of radiation damage. Exp Cell Res (1972) 1.76
Use of Hoechst 33342 for cell selection from multicell systems. J Histochem Cytochem (1982) 1.72
The use of fluorescent probes to identify regions of transient perfusion in murine tumors. Int J Radiat Oncol Biol Phys (1989) 1.71
Cell selection from a murine tumour using the fluorescent probe Hoechst 33342. Br J Cancer (1985) 1.57
Cytotoxicity, Mutagenicity and DNA damage by Hoechst 33342. J Histochem Cytochem (1982) 1.56
Pharmacokinetics, binding and distribution of Hoechst 33342 in spheroids and murine tumours. Br J Cancer (1985) 1.47
The effects of nitrobenzene derivatives on oxygen utilization and radiation response of an in vitro tumor model. Radiat Res (1976) 1.45
Drug and radiation resistance in spheroids: cell contact and kinetics. Cancer Metastasis Rev (1994) 1.42
Factors influencing DNA migration from individual cells subjected to gel electrophoresis. Exp Cell Res (1992) 1.30
Gel electrophoresis of individual cells to quantify hypoxic fraction in human breast cancers. Cancer Res (1993) 1.25
Flow cytometry studies of intracellular adriamycin in single cells in vitro. Cancer Res (1981) 1.22
Comparison between pimonidazole binding, oxygen electrode measurements, and expression of endogenous hypoxia markers in cancer of the uterine cervix. Cytometry B Clin Cytom (2006) 1.20
Characterization of radiolabeled fluoromisonidazole as a probe for hypoxic cells. Radiat Res (1987) 1.18
Effects of sensitizers on cell respiration: 1. Factors influencing the effects of hypoxic cell radiosensitizers on oxygen utilization of tumour and cultured mammalian cells. Br J Cancer Suppl (1978) 1.16
Variable radiobiological responses of spheroids. Radiat Res (1980) 1.10
Chemosensitivity testing in V79 spheroids: drug delivery and cellular microenvironment. J Natl Cancer Inst (1986) 1.10
Detection of etoposide resistance by measuring DNA damage in individual Chinese hamster cells. J Natl Cancer Inst (1990) 1.09
Growth and cellular characteristics of multicell spheroids. Recent Results Cancer Res (1984) 1.07
Detection of hypoxic cells in a murine tumor with the use of the comet assay. J Natl Cancer Inst (1992) 1.05
Fluorescent nitroheterocycles for identifying hypoxic cells. Cancer Res (1983) 1.04
Intermittent blood flow in the KHT sarcoma--flow cytometry studies using Hoechst 33342. Br J Cancer (1990) 1.04
Effects of sensitizers on cell respiration: III. The effects of hypoxic cell radiosensitizers on oxidative metabolism and the radiation response of an in vitro tumour model. Br J Cancer Suppl (1978) 1.03
Hypoxic cells in an in vitro tumour model. Int J Radiat Biol Relat Stud Phys Chem Med (1973) 1.02
Cell killing, radiosensitization and cell cycle redistribution induced by chronic hypoxia. Int J Radiat Oncol Biol Phys (1984) 1.01
Effects of hyperthermia on the cycling, noncycling, and hypoxic cells of irradiated and unirradiated multicell spheroids. Radiat Res (1978) 0.99
Measurements of relative biological effectiveness of the 70 MeV proton beam at TRIUMF using Chinese hamster V79 cells and the high-precision cell sorter assay. Radiat Res (1996) 0.98
Activation of radiosensitizers by hypoxic cells. Br J Cancer Suppl (1978) 0.98
Use of a cell sorter for assays of cell clonogenicity. Cancer Res (1986) 0.97
Analysis of DNA damage in individual cells. Methods Cell Biol (2001) 0.97
Radioprotection by WR-2721 in vitro at low oxygen tensions: implications for its mechanisms of action. Br J Cancer (1983) 0.96
Hypoxic fractions measured in murine tumors and normal tissues using the comet assay. Int J Radiat Oncol Biol Phys (1994) 0.95
Radiosensitization of hypoxic cells of an in vitro tumor model by respiratory inhibitors. Radiat Res (1977) 0.94
Isolation of cell subpopulations from in vitro tumor models according to sedimentation velocity. Cancer Res (1975) 0.94
Comparison between the comet assay and pimonidazole binding for measuring tumour hypoxia. Br J Cancer (2000) 0.93
The comet assay in clinical practice. Acta Oncol (1999) 0.93
Letter: Modification of the radiation response of an in vitro tumour model by control of cellular respiration. Int J Radiat Biol Relat Stud Phys Chem Med (1974) 0.92
Characterization of a carbocyanine derivative as a fluorescent penetration probe. Cytometry (1987) 0.92
The radiosensitizing and toxic effects of RSU-1069 on hypoxic cells in a murine tumor. Int J Radiat Oncol Biol Phys (1986) 0.90
Oxygen enhancement ratio in V79 spheroids. Radiat Res (1983) 0.90
Adriamycin: a possible indirect radiosensitizer of hypoxic tumor cells. Radiology (1976) 0.87
Evidence for intermittent radiobiological hypoxia in experimental tumour systems. Biomed Biochim Acta (1989) 0.86
Growth and radiation survival characteristics of V79-171b Chinese hamster cells: a possible influence of intercellular contact. Radiat Res (1973) 0.86
Interaction of etoposide and cisplatin in an in vitro tumor model. Cancer Treat Rep (1987) 0.86
Cell cycle kinetics in an in vitro tumor model. Cell Tissue Kinet (1976) 0.85
Apoptosis: an indicator of radiosensitivity in vitro? Int J Radiat Biol (1997) 0.85
Cure, regression and cell survival: a comparison of common radiobiological endpoints using an in vitro tumour model. Br J Radiol (1975) 0.84
Radiation-induced DNA damage in V79 spheroids and monolayers. Radiat Res (1979) 0.83
Repair and reoxygenation following irradiation of an in vitro tumor model. Int J Radiat Oncol Biol Phys (1977) 0.83
Detection of subpopulations resistant to DNA-damaging agents in spheroids and murine tumours. Mutat Res (1997) 0.83
Cell contact as a possible contribution to radiation resistance of some tumours. Br J Radiol (1972) 0.83
Irradiation of multi-cell spheroids with fast neutrons versus X-rays: a qualitative difference in sub-lethal damage repair capacity or kinetics. Int J Radiat Biol Relat Stud Phys Chem Med (1976) 0.82
Cell kinetics and repopulation mechanisms during multifraction irradiation of spheroids. Radiother Oncol (1998) 0.82
Dependence of the radiation response of an in vitro tumor model on cell cycle effects. Cancer Res (1973) 0.82
The comet assay: a new method to examine heterogeneity associated with solid tumors. Nat Med (1998) 0.81
Effect of intercellular contact on DNA conformation, radiation-induced DNA damage, and mutation in Chinese hamster V79 cells. Radiat Res (1985) 0.81
Calibration of flow cytometry detector systems. Cytometry (1981) 0.81
The enhanced radiation response of in vitro tumor models to insulin. Int J Radiat Oncol Biol Phys (1979) 0.80
The response of hypoxic cells in SCCVII murine tumors to treatment with cisplatin and x rays. Int J Radiat Oncol Biol Phys (1991) 0.80
Use of the comet assay for assessment of drug resistance and its modulation in vivo. Br J Cancer (1998) 0.80
DNA conformation of Chinese hamster V79 cells and sensitivity to ionizing radiation. Radiat Res (1986) 0.80
Radiosensitization by nifuroxime of the hypoxic cells in an in vitro tumour model. Int J Radiat Biol Relat Stud Phys Chem Med (1972) 0.80
Comparison between the binding of [3H]misonidazole and AF-2 in Chinese hamster V79 spheroids. Radiat Res (1986) 0.80
Cytotoxicity of RSU 1069 in spheroids and murine tumors. Int J Radiat Oncol Biol Phys (1987) 0.80
Roles of thiols in cellular radiosensitivity. Int J Radiat Oncol Biol Phys (1984) 0.80
Development of apoptosis and polyploidy in human lymphoblast cells as a function of position in the cell cycle at the time of irradiation. Radiat Res (1996) 0.79
The radiation response of asynchronous cells at low dose: evidence of substructure. Radiat Res (1991) 0.78
Development of tetraploidy in V79 spheroids. In Vitro (1982) 0.78
Etoposide sensitivity and topoisomerase II activity in Chinese hamster V79 monolayers and small spheroids. Int J Radiat Biol (1991) 0.78
Substructure in the radiation survival response at low dose in cells of human tumor cell lines. Radiat Res (1996) 0.78
Potentiation of CCNU toxicity by AF-2 in V79 spheroids: implications for mechanisms of chemosensitization. Int J Radiat Oncol Biol Phys (1986) 0.77
Potentiation of radiation lethality by hyperthermia in a tumor model: effects of sequence, degree, and duration of heating. Int J Radiat Oncol Biol Phys (1978) 0.77
Misonidazole binding in SCCVII tumors in relation to the tumor blood supply. Int J Radiat Oncol Biol Phys (1989) 0.77
The enhanced radiation response of an in vitro tumour model by cyanide released from hydrolysed amygdalin. Int J Radiat Biol Relat Stud Phys Chem Med (1978) 0.77
DNA strand breakage in Chinese hamster V79 cells caused by low levels of incorporated [3H] and [14C]thymidine. Int J Radiat Biol Relat Stud Phys Chem Med (1987) 0.77
Repopulation characteristics and cell kinetic parameters resulting from multi-fraction irradiation of xenograft tumors in SCID mice. Int J Radiat Oncol Biol Phys (1999) 0.77
Radiation-resistant tumor cells may be more sensitive in vitro. Cancer Res (1972) 0.76
Repair during multifraction exposures: spheroids versus monolayers. Br J Cancer Suppl (1984) 0.76
Penetration of AF-2 and 4NQO into multicell spheroids. Environ Mutagen (1983) 0.76
Effects of lucanthone on Chinese hamster V-79 cells. I. Interaction with radiation in monolayers and spheroids. Int J Radiat Oncol Biol Phys (1980) 0.76
Cellular oxygen utilization and radiation response of V-79 spheroids. Adv Exp Med Biol (1983) 0.76
Effects of sensitizers on cell respiration: II. The effects of hypoxic cell sensitizers on oxygen utilization in cellular and chemical models. Br J Cancer Suppl (1978) 0.75
Nitropyrrole radiosensitizers: structure function relationships. Br J Cancer Suppl (1978) 0.75
Drug-induced alterations in tumour perfusion yield increases in tumour cell radiosensitivity. Br J Cancer (2001) 0.75
The biological activity of cisplatin and dibromodulcitol in combination therapy. Br J Cancer (1995) 0.75
Flow cytometry techniques for studying cellular thiols. Radiat Res (1983) 0.75
Radiosensitization of hypoxic cells at low doses. Int J Radiat Oncol Biol Phys (1986) 0.75
The oxygen enhancement ratio for high energy neutrons. Br J Radiol (1980) 0.75
Fast neutron effects on multicell spheroids. Br J Radiol (1977) 0.75
Survival at low dose in asynchronous and partially synchronized Chinese hamster V79-171 cells. Radiat Res (1993) 0.75
Cell kinetics and repopulation parameters of irradiated xenograft tumours in SCID mice: comparison of two dose-fractionation regimens. Eur J Cancer (1999) 0.75
Effects of lucanthone on Chinese hamster V-79 cells. II. Damage to DNA. Int J Radiat Oncol Biol Phys (1980) 0.75
Low dose-rate irradiation of multicell spheroids. Int J Radiat Oncol Biol Phys (1979) 0.75
Radiation studies with spheroids. Recent Results Cancer Res (1984) 0.75
Respiration-induced oxygen gradients in cultured mammalian cells. Int J Radiat Biol (1990) 0.75
Characterization of the uptake and toxicity of a fluorescent thiol reagent. Cytometry (1983) 0.75
On the mechanism for enhancement of tumor radiation to hyperbaric oxygen in sodium pentobarbital anesthetized rodents. Adv Exp Med Biol (1984) 0.75