PubRank

T Friedmann

Author PubWeight™ 217.79‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 The nucleotide sequence of bacteriophage phiX174. J Mol Biol 1978 13.55
2 Vesicular stomatitis virus G glycoprotein pseudotyped retroviral vectors: concentration to very high titer and efficient gene transfer into mammalian and nonmammalian cells. Proc Natl Acad Sci U S A 1993 9.17
3 Base sequence studies of 300 nucleotide renatured repeated human DNA clones. J Mol Biol 1981 7.94
4 Partial nucleotide sequence of the 300-nucleotide interspersed repeated human DNA sequences. Nature 1980 7.92
5 Isolation and characterization of a full-length expressible cDNA for human hypoxanthine phosphoribosyl transferase. Proc Natl Acad Sci U S A 1983 5.50
6 Generation of high-titer pseudotyped retroviral vectors with very broad host range. Methods Cell Biol 1994 5.17
7 A general method for the generation of high-titer, pantropic retroviral vectors: highly efficient infection of primary hepatocytes. Proc Natl Acad Sci U S A 1994 4.86
8 Suppression of the neoplastic phenotype by replacement of the RB gene in human cancer cells. Science 1988 4.54
9 The nucleotide sequence and genome organization of the polyoma early region: extensive nucleotide and amino acid homology with SV40. Cell 1979 4.23
10 Base-specific reactions useful for DNA sequencing: methylene blue--sensitized photooxidation of guanine and osmium tetraoxide modification of thymine. Nucleic Acids Res 1978 4.20
11 Mutation near the polyoma DNA replication origin permits productive infection of F9 embryonal carcinoma cells. Cell 1981 3.61
12 Methylation of the hypoxanthine phosphoribosyltransferase locus on the human X chromosome: implications for X-chromosome inactivation. Proc Natl Acad Sci U S A 1984 3.53
13 Isolation of a genomic clone partially encoding human hypoxanthine phosphoribosyltransferase. Proc Natl Acad Sci U S A 1982 3.49
14 A transmissible retrovirus expressing human hypoxanthine phosphoribosyltransferase (HPRT): gene transfer into cells obtained from humans deficient in HPRT. Proc Natl Acad Sci U S A 1983 3.31
15 Amino acid sequence homology between polyoma and SV40 tumour antigens deduced from nucleotide sequences. Nature 1978 3.11
16 Pseudotype formation of murine leukemia virus with the G protein of vesicular stomatitis virus. J Virol 1991 3.03
17 Expression of a retrovirus encoding human HPRT in mice. Science 1984 2.48
18 Nucleotide sequence and genetic organization of the polyoma late region: features common to the polyoma early region and SV40. Cell 1979 2.44
19 Rapid concentration and purification of polyoma virus and SV40 with polyethylene glycol. Virology 1970 2.37
20 Primary structure of Torpedo californica acetylcholinesterase deduced from its cDNA sequence. Nature 1986 2.32
21 Human retinoblastoma susceptibility gene: genomic organization and analysis of heterozygous intragenic deletion mutants. Proc Natl Acad Sci U S A 1988 2.22
22 Nucleotide sequence studies of polyoma DNA. The Hpa II 3/5 junction to the Hpa II 4/Hae III 18 junction, encoding the origin of DNA replication and the 5' end of the early region. J Biol Chem 1978 2.19
23 Analysis of transcription of the human Alu family ubiquitous repeating element by eukaryotic RNA polymerase III. Nucleic Acids Res 1981 2.18
24 Integration and germ-line transmission of a pseudotyped retroviral vector in zebrafish. Science 1994 2.16
25 Factors affecting long-term stability of Moloney murine leukemia virus-based vectors. Virology 1989 1.97
26 Gene expression from transcriptionally disabled retroviral vectors. Proc Natl Acad Sci U S A 1987 1.89
27 Analysis of the p53 gene and its expression in human glioblastoma cells. Cancer Res 1994 1.84
28 Cytotoxicity of a replication-defective mutant of herpes simplex virus type 1. J Virol 1992 1.79
29 Gene therapy for human genetic disease? Science 1972 1.79
30 Nucleotide sequences at the termini of phi 29 DNA. Proc Natl Acad Sci U S A 1981 1.76
31 The organization of the human HPRT gene. Nucleic Acids Res 1986 1.75
32 Structure of the heterogeneous L-S junction region of human cytomegalovirus strain AD169 DNA. J Virol 1984 1.73
33 Structural roles of polyoma virus proteins. J Virol 1972 1.67
34 The nucleotide sequence and restriction enzyme sites of the polyoma genome. Nucleic Acids Res 1980 1.67
35 Elements in the long terminal repeat of murine retroviruses enhance stable transformation by thymidine kinase gene. Nucleic Acids Res 1983 1.63
36 Variable stability of a selectable provirus after retroviral vector gene transfer into human cells. Mol Cell Biol 1986 1.62
37 In vitro reassembly of shell-like particles from disrupted polyoma virus. Proc Natl Acad Sci U S A 1971 1.58
38 Improved cell survival by the reduction of immediate-early gene expression in replication-defective mutants of herpes simplex virus type 1 but not by mutation of the virion host shutoff function. J Virol 1994 1.52
39 Isolation of a herpes simplex virus type 1 mutant deleted for the essential UL42 gene and characterization of its null phenotype. J Virol 1991 1.43
40 Grafting genetically modified cells to the damaged brain: restorative effects of NGF expression. Science 1988 1.42
41 Retroviral vector-mediated gene transfer into human hematopoietic progenitor cells. Science 1985 1.39
42 Expression of retrovirally transduced genes in primary cultures of adult rat hepatocytes. Proc Natl Acad Sci U S A 1987 1.31
43 Long-term transgene expression from genetically modified hepatocytes grafted to the rat liver. New Biol 1992 1.28
44 Nucleotide sequence at polyoma VP1 mRNA splice sites. J Virol 1981 1.27
45 In vitro cell-free conversion of noninfectious Moloney retrovirus particles to an infectious form by the addition of the vesicular stomatitis virus surrogate envelope G protein. J Virol 1998 1.26
46 Dopamine deficiency in a genetic mouse model of Lesch-Nyhan disease. J Neurosci 1994 1.22
47 Generation of packaging cell lines for pseudotyped retroviral vectors of the G protein of vesicular stomatitis virus by using a modified tetracycline inducible system. Proc Natl Acad Sci U S A 1996 1.21
48 Cystinosis. Combined clinical staff conference at the National Institutes of Health. Ann Intern Med 1968 1.20
49 Rapid nucleotide sequencing of DNA. Am J Hum Genet 1979 1.19
50 Inducible gene expression by retrovirus-mediated transfer of a modified tetracycline-regulated system. J Virol 1996 1.17
51 Enhanced levels of lipoperoxides in low density lipoprotein incubated with murine fibroblast expressing high levels of human 15-lipoxygenase. J Biol Chem 1995 1.17
52 Noninfectious virus-like particles produced by Moloney murine leukemia virus-based retrovirus packaging cells deficient in viral envelope become infectious in the presence of lipofection reagents. Proc Natl Acad Sci U S A 1997 1.15
53 Genetic economy of polyoma virus: capsid proteins are cleavage products of same viral gene. Proc Natl Acad Sci U S A 1974 1.15
54 Efficient gene expression in mammalian cells from a dicistronic transcriptional unit in an improved retroviral vector. Gene 1991 1.14
55 Grafting fibroblasts genetically modified to produce L-dopa in a rat model of Parkinson disease. Proc Natl Acad Sci U S A 1989 1.11
56 Effect of host modification and age on airway epithelial gene transfer mediated by a murine leukemia virus-derived vector. J Virol 1998 1.10
57 Prenatal diagnosis of genetic disease. Sci Am 1971 1.07
58 Dose-related analgesic effects of flupirtine. Br J Clin Pharmacol 1991 1.07
59 Partial phenotypic correction of human Lesch-Nyhan (hypoxanthine-guanine phosphoribosyltransferase-deficient) lymphoblasts with a transmissible retroviral vector. J Biol Chem 1984 1.05
60 Structural proteins of polyoma virus: proteolytic degradation of virion proteins by exogenous and by virion-associated proteases. J Virol 1976 1.05
61 Regions of the polyoma genome coding for T antigens. Nucleic Acids Res 1979 1.03
62 Grafting genetically modified cells into the rat brain: characteristics of E. coli beta-galactosidase as a reporter gene. Brain Res Mol Brain Res 1989 1.03
63 Functional analysis of brain dopamine systems in a genetic mouse model of Lesch-Nyhan syndrome. J Pharmacol Exp Ther 1992 1.03
64 Adenovirus vector infection of chronic lymphocytic leukemia B cells. Blood 1996 1.02
65 Modulation of cell proliferation and gene expression by a p53-estrogen receptor hybrid protein. Proc Natl Acad Sci U S A 1993 1.01
66 Effects of gene transfer into cultured CNS neurons with a replication-defective herpes simplex virus type 1 vector. Brain Res Mol Brain Res 1992 1.00
67 Limited bidirectional activity of two housekeeping gene promoters: human HPRT and PGK. Gene 1990 1.00
68 Pantropic retroviral vector-mediated gene transfer, integration, and expression in cultured newt limb cells. Dev Biol 1994 1.00
69 Efficient in vivo transduction of the neonatal mouse liver with pseudotyped retroviral vectors. Gene Ther 1995 1.00
70 Influence of age and strain on striatal dopamine loss in a genetic mouse model of Lesch-Nyhan disease. J Neurochem 1999 1.00
71 Relative quantitative assay of the biological activity of interferon messenger ribonucleic acid. J Gen Virol 1975 0.97
72 Brain purines in a genetic mouse model of Lesch-Nyhan disease. J Neurochem 1993 0.96
73 Association of murine leukemia virus pol with virions, independent of Gag-Pol expression. J Virol 1999 0.96
74 Nucleotide sequence of the F protein coding region of bacteriophage phiX174 and the amino acid sequence of its product. J Mol Biol 1978 0.96
75 Direct gene transfer to the liver with herpes simplex virus type 1 vectors: transient production of physiologically relevant levels of circulating factor IX. New Biol 1992 0.95
76 Post-transcriptional regulation of retroviral vector-transduced low density lipoprotein receptor activity. J Lipid Res 1990 0.94
77 Separable mechanisms of attachment and cell uptake during retrovirus infection. J Virol 2000 0.94
78 Circulating human or canine factor IX from retrovirally transduced primary myoblasts and established myoblast cell lines grafted into murine skeletal muscle. Somat Cell Mol Genet 1992 0.93
79 Nucleotide sequence changes in polyoma ts-a mutants: correlation with protein structure. J Virol 1981 0.93
80 Suppression of acute lymphoblastic leukemia by the human wild-type p53 gene. Cancer Res 1992 0.93
81 The disaggregation of Tamm Horsfall mucroprotein by acetic acid. Biochim Biophys Acta 1966 0.92
82 Efficient infection of a human T-cell line and of human primary peripheral blood leukocytes with a pseudotyped retrovirus vector. Proc Natl Acad Sci U S A 1996 0.92
83 Characterization of the dopamine defect in primary cultures of dopaminergic neurons from hypoxanthine phosphoribosyltransferase knockout mice. Mol Ther 2000 0.90
84 Enhanced gene transfer with fusogenic liposomes containing vesicular stomatitis virus G glycoprotein. J Virol 1998 0.90
85 Further characterization of the subunit of Tamm-Horsfall mucoprotein. Biochim Biophys Acta 1966 0.89
86 Amphetamine-induced behavioral phenotype in a hypoxanthine-guanine phosphoribosyltransferase-deficient mouse model of Lesch-Nyhan syndrome. Behav Neurosci 1991 0.89
87 Efficient expression of retroviral vector-transduced human low density lipoprotein (LDL) receptor in LDL receptor-deficient rabbit fibroblasts in vitro. Proc Natl Acad Sci U S A 1988 0.87
88 Localization of hypoxanthine-guanine phosphoribosyltransferase mRNA in the mouse brain by in situ hybridization. Mol Cell Neurosci 1992 0.86
89 Primary structure of acetylcholinesterase: implications for regulation and function. Fed Proc 1986 0.86
90 Highly potent novel opioid receptor agonist in the 14-alkoxymetopon series. Eur J Pharmacol 1993 0.86
91 Virion proteins of polyoma temperature-sensitive mutants: late mutants. Cold Spring Harb Symp Quant Biol 1975 0.86
92 Retrovirol gene transfer in Xenopus cell lines and embryos. In Vitro Cell Dev Biol Anim 1996 0.86
93 Activity of the simian virus 40 early promoter-enhancer in herpes simplex virus type 1 vectors is dependent on its position, the infected cell type, and the presence of Vmw175. J Virol 1991 0.86
94 Concepts and strategies for human gene therapy. Eur J Biochem 1992 0.85
95 A mutation increasing the size of the polyoma virion proteins, VP2 and VP3. Virology 1981 0.85
96 Grafting genetically modified cells to the brain: possibilities for the future. Neuroscience 1987 0.85
97 Gene transfer into the carotid artery using an adventitial collar: comparison of the effectiveness of the plasmid-liposome complexes, retroviruses, pseudotyped retroviruses, and adenoviruses. Hum Gene Ther 1997 0.84
98 Epitope insertion into the human hypoxanthine phosphoribosyltransferase protein and detection of the mutant protein by an anti-peptide antibody. Gene 1987 0.83
99 Evidence against the existence of guanosine and inosine kinases in human fibroblasts in tissue culture. Exp Cell Res 1969 0.83
100 Organization of T antigens in the polyoma virus genome. Cold Spring Harb Symp Quant Biol 1980 0.82
101 Animal models of Lesch-Nyhan syndrome. Brain Res Bull 1990 0.82
102 Single cell monitoring of growth arrest and morphological changes induced by transfer of wild-type p53 alleles to glioblastoma cells. Proc Natl Acad Sci U S A 1995 0.80
103 Gene transfer into rat airway epithelial cells using retroviral vectors. Somat Cell Mol Genet 1991 0.79
104 Spinal interaction between the highly selective μ agonist DAMGO and several δ opioid receptor ligands in naive and morphine-tolerant mice. Brain Res Bull 2012 0.79
105 Mechanisms of action of the p53 tumor suppressor and prospects for cancer gene therapy by reconstitution of p53 function. Ann N Y Acad Sci 1994 0.79
106 VSV-G envelope glycoprotein forms complexes with plasmid DNA and MLV retrovirus-like particles in cell-free conditions and enhances DNA transfection. Mol Ther 2001 0.79
107 High efficiency retroviral-mediated gene transduction into CD34+ cells purified from peripheral blood of breast cancer patients primed with chemotherapy and granulocyte-macrophage colony-stimulating factor. Hum Gene Ther 1994 0.79
108 Bone marrow transplantation in Lesch-Nyhan disease. Adv Exp Med Biol 1986 0.78
109 The promise and overpromise of human gene therapy. Gene Ther 1994 0.78
110 Gene expression from a transcriptionally disabled retroviral vector. Cold Spring Harb Symp Quant Biol 1986 0.78
111 Direct evidence that eseroline possesses morphine-like effects. Eur J Pharmacol 1982 0.78
112 High-efficiency gene transfer into cells. Methods Enzymol 1987 0.78
113 Serotonin reuptake inhibitors fluoxetine and citalopram relax intestinal smooth muscle. Can J Physiol Pharmacol 2001 0.78
114 Transduction of a drug-sensitive toxic gene into human leukemia cell lines with a novel retroviral vector. Proc Soc Exp Biol Med 1993 0.78
115 Effects of choline and quiescence on Drosophila choline acetyltransferase expression and acetylcholine production by transduced rat fibroblasts. J Neurochem 1992 0.78
116 Study of the analgesic effects of galanthamine, a cholinesterase inhibitor. Arch Int Pharmacodyn Ther 1983 0.77
117 Transduction of foreign regulatory sequences by a replication-defective herpes simplex virus type 1: the rat neuron-specific enolase promoter. Virus Res 1995 0.77
118 Simplified plasmid rescue of host sequences adjacent to integrated proviruses. Gene 1996 0.77
119 The incorporation of [3H]leucine into protein by tetraphenylboron- and citrate-dispersed rat liver parenchymal cells. Biochim Biophys Acta 1967 0.77
120 Wild-type p53 suppresses the malignant phenotype in breast cancer cells containing mutant p53 alleles. Anticancer Res 1994 0.77
121 Gene therapy techniques. Curr Opin Biotechnol 1991 0.76
122 The bioseparation needs for tomorrow. Trends Biotechnol 2001 0.76
123 Implantation of genetically engineered cells to the brain. Prog Brain Res 1988 0.76
124 Differentiation of PC12 cells by infection with an HSV-1 vector expressing nerve growth factor. Gene Ther 1995 0.76
125 Polybrene increases the efficiency of gene transfer by lipofection. Gene Ther 1998 0.76
126 Replication-defective recombinant herpes simplex virus vectors. Methods Cell Biol 1994 0.76
127 Provirus-anchored long-range (PAL) mapping of mammalian genomes. Genomics 1993 0.76
128 Autocrine differentiation of PC12 cells mediated by retroviral vectors. Dev Neurosci 1990 0.76
129 The future for gene therapy--a reevaluation. Ann N Y Acad Sci 1976 0.76
130 Lessons from Nuremberg: ethical and social responsibilities for health care professionals, health care organizations, and medical journals. JAMA 1997 0.75
131 Knock-in and knock-out. Transgenes, Development and Disease: A Keystone Symposium sponsored by Genentech and Immunex, Tamarron, CO, USA, January 12-18, 1991. New Biol 1991 0.75
132 Viral vectors do the DNA shuffle. Nat Biotechnol 2000 0.75
133 Gene therapy. Am J Dis Child 1993 0.75
134 Gene therapy in the CNS: intracerebral grafting of genetically modified cells. Prog Brain Res 1990 0.75
135 [Structure-activity relationship of synthetic and semisynthetic opioid agonists and antagonists]. Acta Pharm Hung 1993 0.75
136 Scientific and policy progress toward gene therapy. Bioessays 1985 0.75
137 Circulatory, respiratory and antitussive effects of azidomorphine and related substances. Arch Int Pharmacodyn Ther 1974 0.75
138 Gene therapy and the brain. Br Med Bull 1995 0.75
139 Genetics. Science 1978 0.75
140 Insertion of hypoxanthine phosphoribosyltransferase cDNA into human bone marrow cells by a retrovirus. Adv Exp Med Biol 1986 0.75
141 The importance of position six in the ring C of morphine in modulation of agonist/antagonist interaction with multiple opiate receptors. Acta Physiol Hung 1990 0.75
142 Comparison of the opioid activity of CAM and kappa agonists. NIDA Res Monogr 1986 0.75
143 The role of calcium in the reactivation of reduced Taka-amylase. J Biol Chem 1967 0.75
144 Mast-cell disease in children. Report of eleven cases. Br J Dermatol 1967 0.75
145 Comparison of biological activities of enkephalin analogues in isolated organs. Pol J Pharmacol Pharm 1982 0.75
146 Grafting genetically modified cells to the brain: conceptual and technical issues. Prog Brain Res 1990 0.75
147 Activity index of frog heart ventricle cells. Analysis of the correlation between resting potential and activity of the sodium-carrier system in the frog heart by means of celluline and adrenaline. Acta Physiol Acad Sci Hung 1968 0.75
148 Swimming behavior of X and Y human sperm. Differentiation 1984 0.75
149 Adult mammalian hepatocyte as target cell for retroviral gene transfer: a model for gene therapy. Somat Cell Mol Genet 1987 0.75
150 Bone marrow transplantation does not ameliorate the neurologic symptoms in mice deficient in hypoxanthine guanine phosphoribosyl transferase (HPRT). Metab Brain Dis 1999 0.75
151 Approaches to gene therapy in disorders of purine metabolism. Rheum Dis Clin North Am 1988 0.75
152 Rigor in gene therapy studies. Gene Ther 1995 0.75
153 "The innate constitutional vigor of black youth". Pediatrics 1972 0.75
154 Effect of amniotic fluid on cationic lipid mediated transfection and retroviral infection. Gene Ther 1996 0.75
155 Effects of structural modifications of N-CPM-normorphine derivatives on agonist and antagonist activities in isolated organs. Acta Biol Hung 2003 0.75
156 The structure of Tamm-Horsfall mucoprotein in fibrocystic disease. J Lab Clin Med 1967 0.75
157 Recombination between a herpes simplex virus type 1 vector deleted for immediate early gene 3 and the infected cell genome. J Gen Virol 1992 0.75
158 Reactions of morphine derivatives with phenyliodo(III)diacetate (PIDA): synthesis of new morphine analogues. Curr Med Chem 2001 0.75