Published in J Mol Biol on October 25, 1978
Pattern recognition in nucleic acid sequences. I. A general method for finding local homologies and symmetries. Nucleic Acids Res (1982) 28.51
Comparison of initiation of protein synthesis in procaryotes, eucaryotes, and organelles. Microbiol Rev (1983) 24.58
Rapid evolution of animal mitochondrial DNA. Proc Natl Acad Sci U S A (1979) 22.76
Polymorphism in mitochondrial DNA of humans as revealed by restriction endonuclease analysis. Proc Natl Acad Sci U S A (1980) 14.06
Characterization of translational initiation sites in E. coli. Nucleic Acids Res (1982) 11.91
Genotypic identification of rickettsiae and estimation of intraspecies sequence divergence for portions of two rickettsial genes. J Bacteriol (1991) 9.65
Maternal inheritance of human mitochondrial DNA. Proc Natl Acad Sci U S A (1980) 9.48
Method to determine the reading frame of a protein from the purine/pyrimidine genome sequence and its possible evolutionary justification. Proc Natl Acad Sci U S A (1981) 7.00
The inverted repeat as a recognizable structural feature in supercoiled DNA molecules. Proc Natl Acad Sci U S A (1980) 6.83
The pitch of chromatin DNA is reflected in its nucleotide sequence. Proc Natl Acad Sci U S A (1980) 5.88
Los Alamos sequence analysis package for nucleic acids and proteins. Nucleic Acids Res (1982) 5.48
Depurination causes mutations in SOS-induced cells. Proc Natl Acad Sci U S A (1981) 5.19
Generating a synthetic genome by whole genome assembly: phiX174 bacteriophage from synthetic oligonucleotides. Proc Natl Acad Sci U S A (2003) 5.10
Bacteriophage lysis: mechanism and regulation. Microbiol Rev (1992) 4.95
Nucleotide sequence divergence and functional constraint in mRNA evolution. Proc Natl Acad Sci U S A (1980) 4.71
Some rules in the ordering of nucleotides in the DNA. Nucleic Acids Res (1980) 4.56
A primer on metagenomics. PLoS Comput Biol (2010) 4.40
The ribosome binding sites recognized by E. coli ribosomes have regions with signal character in both the leader and protein coding segments. Nucleic Acids Res (1980) 3.74
Assignment of the chloramphenicol resistance gene to mitochondrial deoxyribonucleic acid and analysis of its expression in cultured human cells. Mol Cell Biol (1981) 3.71
Isolation and sequence of the gene for iso-2-cytochrome c in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1980) 3.62
New map of bacteriophage lambda DNA. J Virol (1980) 3.21
Short-insert libraries as a method of problem solving in genome sequencing. Genome Res (1998) 2.99
Infidelity of DNA synthesis associated with bypass of apurinic sites. Proc Natl Acad Sci U S A (1983) 2.95
Epstein-Barr virus DNA XII. A variable region of the Epstein-Barr virus genome is included in the P3HR-1 deletion. J Virol (1982) 2.70
An Escherichia coli replication protein that recognizes a unique sequence within a hairpin region in phi X174 DNA. Proc Natl Acad Sci U S A (1980) 2.67
A type II restriction endonuclease with an eight nucleotide specificity from Streptomyces fimbriatus. Nucleic Acids Res (1984) 2.64
DNA of Epstein-Barr virus. V. Direct repeats of the ends of Epstein-Barr virus DNA. J Virol (1979) 2.63
Repetitive DNA of Candida albicans: nuclear and mitochondrial components. J Bacteriol (1984) 2.52
Clonal inheritance of the pattern of DNA methylation in mouse cells. Proc Natl Acad Sci U S A (1982) 2.52
Unique primed start of phage phi X174 DNA replication and mobility of the primosome in a direction opposite chain synthesis. Proc Natl Acad Sci U S A (1981) 2.44
Atomic structure of single-stranded DNA bacteriophage phi X174 and its functional implications. Nature (1992) 2.44
Transcripts of the adeno-associated virus genome: mapping of the major RNAs. J Virol (1980) 2.42
Fidelity of replication of phage phi X174 DNA by DNA polymerase III holoenzyme: spontaneous mutation by misincorporation. Proc Natl Acad Sci U S A (1979) 2.31
DNA sequencing: bench to bedside and beyond. Nucleic Acids Res (2007) 2.25
Structure of nonintegrated, circular Herpesvirus saimiri and Herpesvirus ateles genomes in tumor cell lines and in vitro-transformed cells. J Virol (1982) 2.23
ClaI. a new restriction endonuclease from Caryophanon latum L. Nucleic Acids Res (1981) 2.21
Hairpin-loop formation by inverted repeats in supercoiled DNA is a local and transmissible property. Nucleic Acids Res (1981) 2.16
Structure and evolution of organelle genomes. Microbiol Rev (1982) 2.11
Studies on the biological role of dna methylation; IV. Mode of methylation of DNA in E. coli cells. Nucleic Acids Res (1980) 2.04
Defined transversion mutations at a specific position in DNA using synthetic oligodeoxyribonucleotides as mutagens. Nucleic Acids Res (1979) 1.99
Estimation of phylogenetic relationships from DNA restriction patterns and selection of endonuclease cleavage sites. Proc Natl Acad Sci U S A (1982) 1.98
Template recognition sequence for RNA primer synthesis by gene 4 protein of bacteriophage T7. Proc Natl Acad Sci U S A (1981) 1.97
Key for protein coding sequences identification: computer analysis of codon strategy. Nucleic Acids Res (1982) 1.97
Interaction with nucleic acids and stimulation of the viral DNA polymerase by the herpes simplex virus type 1 major DNA-binding protein. J Virol (1984) 1.91
Cloning and mapping of the genetic determinants for microcin B17 production and immunity. J Bacteriol (1985) 1.90
UGA suppression by normal tRNA Trp in Escherichia coli: codon context effects. Nucleic Acids Res (1981) 1.82
Pattern recognition in nucleic acid sequences. II. An efficient method for finding locally stable secondary structures. Nucleic Acids Res (1982) 1.81
The rate of compensatory mutation in the DNA bacteriophage phiX174. Genetics (2005) 1.80
Second-site suppressors of a cold-sensitive prohead accessory protein of bacteriophage phi X174. Genetics (1991) 1.78
Organization of spacer DNA in chromatin. Proc Natl Acad Sci U S A (1979) 1.76
Two juxtaposed tyrosyl-OH groups participate in phi X174 gene A protein catalysed cleavage and ligation of DNA. Nucleic Acids Res (1986) 1.74
Identification and nucleotide sequences of two similar tandem direct repeats in Epstein-Barr virus DNA. J Virol (1982) 1.73
Reverse chemical mutagenesis: identification of the mutagenic lesions resulting from reactive oxygen species-mediated damage to DNA. Proc Natl Acad Sci U S A (1994) 1.69
In vitro bypass of UV-induced lesions by Escherichia coli DNA polymerase I: specificity of nucleotide incorporation. Proc Natl Acad Sci U S A (1983) 1.64
Heteroduplex formation by recA protein: polarity of strand exchanges. Proc Natl Acad Sci U S A (1981) 1.63
Molecular cloning and physical mapping of varicella-zoster virus DNA. Proc Natl Acad Sci U S A (1982) 1.60
Cleavage of single-stranded DNA by the A and A* proteins of bacteriophage phi X174. Nucleic Acids Res (1979) 1.48
Termination sites of the in vitro nick-translation reaction on DNA that had photoreacted with psoralen. Proc Natl Acad Sci U S A (1983) 1.46
Mutagenic potential of O4-methylthymine in vivo determined by an enzymatic approach to site-specific mutagenesis. Proc Natl Acad Sci U S A (1986) 1.45
Isolation and characterization of virus-specific double-stranded DNA from tissues infected by bean golden mosaic virus. Proc Natl Acad Sci U S A (1981) 1.45
Next-generation sequencing of vertebrate experimental organisms. Mamm Genome (2009) 1.42
GATC sequence and mismatch repair in Escherichia coli. EMBO J (1986) 1.42
Covalently closed circular deoxyribonucleic acids in spiroplasmas. J Bacteriol (1980) 1.41
The EcoRI restriction endonuclease with bacteriophage lambda DNA. Equilibrium binding studies. Biochem J (1980) 1.41
Second-site suppressors of a cold-sensitive external scaffolding protein of bacteriophage phi X174. Genetics (1993) 1.40
Unique sequence arrangement of ribosomal genes in the palindromic rDNA molecule of Physarum polycephalum. Nucleic Acids Res (1979) 1.40
S1 sensitive sites in adenovirus DNA. Nucleic Acids Res (1983) 1.39
Nucleotide sequences at the phi X gene A protein cleavage site in replicative form I DNAs of bacteriophages U3, G14, and alpha 3. J Virol (1982) 1.39
Three new restriction endonucleases MaeI, MaeII and MaeIII from Methanococcus aeolicus. Nucleic Acids Res (1984) 1.39
A sequence-specific endonuclease (Xmn I) from Xanthomonas manihotis. Nucleic Acids Res (1980) 1.38
The vinyl chloride DNA derivative N2,3-ethenoguanine produces G----A transitions in Escherichia coli. Proc Natl Acad Sci U S A (1991) 1.38
RSITE: a computer program to predict the recognition sequence of a restriction enzyme. Nucleic Acids Res (1982) 1.35
Molecular characterization of a bacteriophage (Chp2) from Chlamydia psittaci. J Virol (2000) 1.34
RsaI: a new sequence-specific endonuclease activity from Rhodopseudomonas sphaeroides. J Bacteriol (1980) 1.34
Deoxyribonucleic acid adenine and cytosine methylation in Salmonella typhimurium and Salmonella typhi. J Bacteriol (1979) 1.32
Electron microscopic study of DNA complexes with proteins from the Archaebacterium Sulfolobus acidocaldarius. EMBO J (1986) 1.32
Is UAA or UGA part of the recognition signal for ribosomal initiation? Nucleic Acids Res (1979) 1.31
Role for the J-F intercistronic region of bacteriophages phi X174 and G4 in stability of mRNA. J Virol (1983) 1.30
Macroevolution by transposition: drastic modification of DNA recognition by a type I restriction enzyme following Tn5 transposition. EMBO J (1993) 1.28
Sequence specificity in aflatoxin B1--DNA interactions. Proc Natl Acad Sci U S A (1983) 1.28
The in vivo mutagenic frequency and specificity of O6-methylguanine in phi X174 replicative form DNA. Proc Natl Acad Sci U S A (1986) 1.27
Isolation of cDNA clones for the light subunit of rat liver ferritin: evidence that the light subunit is encoded by a multigene family. Proc Natl Acad Sci U S A (1983) 1.26
Polyethylene glycol derivatives of base and sequence specific DNA ligands: DNA interaction and application for base specific separation of DNA fragments by gel electrophoresis. Nucleic Acids Res (1981) 1.26
Microviridae, a family divided: isolation, characterization, and genome sequence of phiMH2K, a bacteriophage of the obligate intracellular parasitic bacterium Bdellovibrio bacteriovorus. J Bacteriol (2002) 1.24
Molecular characterisation of subgenomic single-stranded and double-stranded DNA forms isolated from plants infected with tomato golden mosaic virus. Nucleic Acids Res (1986) 1.24
Structural analysis of the Spiroplasma virus, SpV4: implications for evolutionary variation to obtain host diversity among the Microviridae. Structure (1998) 1.24
IS91 transposase is related to the rolling-circle-type replication proteins of the pUB110 family of plasmids. Nucleic Acids Res (1992) 1.24
DNA fingerprinting by sampled sequencing. Proc Natl Acad Sci U S A (1989) 1.22
Functional relationship between the J proteins of bacteriophages phi X174 and G4 during phage morphogenesis. J Bacteriol (1992) 1.21
New physical map of bacteriophage T5 DNA. J Virol (1982) 1.21
Sequence-specific endonuclease BamHI: relaxation of sequence recognition. Proc Natl Acad Sci U S A (1982) 1.19
The RFC2 gene encoding a subunit of replication factor C of Saccharomyces cerevisiae. Nucleic Acids Res (1994) 1.16
In vitro DNA replication implicates O2-ethyldeoxythymidine in transversion mutagenesis by ethylating agents. Nucleic Acids Res (1992) 1.15
Functional division and reconstruction of a plasmid replication origin: molecular dissection of the oriV of the broad-host-range plasmid RSF1010. Proc Natl Acad Sci U S A (1991) 1.14
Genome of Bacillus subtilis Bacteriophage SPP1: Structure and Nucleotide Sequence of pac, the Origin of DNA Packaging. J Virol (1982) 1.14
Site specific mutagenesis: insertion of single noncomplementary nucleotides at specified sites by error-directed DNA polymerization. Nucleic Acids Res (1984) 1.13
Stability of bacteriophage phi X174-specific mRNA in vivo. J Virol (1981) 1.13
uvrA and recA mutations inhibit a site-specific transition produced by a single O6-methylguanine in gene G of bacteriophage phi X174. Proc Natl Acad Sci U S A (1985) 1.11
A vaccinia virus DNase preparation which cross-links superhelical DNA. J Virol (1985) 1.10
Sequence landscapes. Nucleic Acids Res (1986) 1.10
DNA sequencing with chain-terminating inhibitors. Proc Natl Acad Sci U S A (1977) 790.54
Nucleotide sequence of bacteriophage phi X174 DNA. Nature (1977) 95.69
A rapid method for determining sequences in DNA by primed synthesis with DNA polymerase. J Mol Biol (1975) 90.35
Cloning in single-stranded bacteriophage as an aid to rapid DNA sequencing. J Mol Biol (1980) 61.16
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature (1998) 60.62
Nucleotide and amino acid sequences of gene G of omegaX174. J Mol Biol (1976) 57.73
Sequence and organization of the human mitochondrial genome. Nature (1981) 57.39
Life with 6000 genes. Science (1996) 41.51
The use of thin acrylamide gels for DNA sequencing. FEBS Lett (1978) 40.52
The minimal gene complement of Mycoplasma genitalium. Science (1995) 32.41
A two-dimensional fractionation procedure for radioactive nucleotides. J Mol Biol (1965) 20.83
Nucleotide sequence of bacteriophage lambda DNA. J Mol Biol (1982) 19.80
Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2). Nature (2002) 19.35
Oligonucleotide-directed mutagenesis of DNA fragments cloned into M13 vectors. Methods Enzymol (1983) 17.47
The genome sequence of the food-borne pathogen Campylobacter jejuni reveals hypervariable sequences. Nature (2000) 17.14
Analysis of the protein-coding content of the sequence of human cytomegalovirus strain AD169. Curr Top Microbiol Immunol (1990) 16.31
Complete genome sequence of a multiple drug resistant Salmonella enterica serovar Typhi CT18. Nature (2001) 15.44
Chromatography of 32P-labelled oligonucleotides on thin layers of DEAE-cellulose. Eur J Biochem (1969) 15.21
Oligonucleotide-directed mutagenesis: a simple method using two oligonucleotide primers and a single-stranded DNA template. DNA (1984) 14.55
Genome sequence of Yersinia pestis, the causative agent of plague. Nature (2001) 14.36
The genome sequence of Schizosaccharomyces pombe. Nature (2002) 14.26
Oligonucleotide-directed mutagenesis using M13-derived vectors: an efficient and general procedure for the production of point mutations in any fragment of DNA. Nucleic Acids Res (1982) 13.52
A general method for defining restriction enzyme cleavage and recognition sites. Methods Enzymol (1980) 13.26
Massive gene decay in the leprosy bacillus. Nature (2001) 11.98
The availability of the acetyl derivatives of lysine for growth. Biochem J (1943) 11.78
Complete sequence of bovine mitochondrial DNA. Conserved features of the mammalian mitochondrial genome. J Mol Biol (1982) 11.71
The free amino groups of haemoglobins. Biochem J (1948) 10.93
Sequence of the gene for iso-1-cytochrome c in Saccharomyces cerevisiae. Cell (1979) 10.86
Nucleotide sequence of bacteriophage G4 DNA. Nature (1978) 10.46
Complete DNA sequence of a serogroup A strain of Neisseria meningitidis Z2491. Nature (2000) 9.86
Specific cleavage analysis of mammalian mitochondrial DNA. Proc Natl Acad Sci U S A (1975) 9.65
Vesicular stomatitis virus G glycoprotein pseudotyped retroviral vectors: concentration to very high titer and efficient gene transfer into mammalian and nonmammalian cells. Proc Natl Acad Sci U S A (1993) 9.17
Specific fragments of phi X174 deoxyribonucleic acid produced by a restriction enzyme from Haemophilus aegyptius, endonuclease Z. J Virol (1972) 8.22
Routine versus clinically driven laboratory monitoring of HIV antiretroviral therapy in Africa (DART): a randomised non-inferiority trial. Lancet (2009) 7.96
Base sequence studies of 300 nucleotide renatured repeated human DNA clones. J Mol Biol (1981) 7.94
Partial nucleotide sequence of the 300-nucleotide interspersed repeated human DNA sequences. Nature (1980) 7.92
Mutagenesis at a specific position in a DNA sequence. J Biol Chem (1978) 7.56
Report of the Committee on the Genetic Constitution of Chromosomes 7, 8 and 9. Cytogenet Cell Genet (1985) 7.28
The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing. J Biol Chem (1991) 7.22
Use of DNA polymerase I primed by a synthetic oligonucleotide to determine a nucleotide sequence in phage fl DNA. Proc Natl Acad Sci U S A (1973) 7.11
The sequence of 5 s ribosomal ribonucleic acid. J Mol Biol (1968) 6.47
A different genetic code in human mitochondria. Nature (1979) 6.41
The specific non-symmetrical sequence recognized by restriction endonuclease MboII. J Mol Biol (1980) 6.36
E-CELL: software environment for whole-cell simulation. Bioinformatics (1999) 6.29
Deletion mapping of sequences essential for in vivo transcription of the iso-1-cytochrome c gene. Proc Natl Acad Sci U S A (1981) 6.26
Sequence of a repressor-binding site in the DNA of bacteriophage lamda. Nature (1974) 6.22
Determination of nucleotide sequences in DNA. Science (1981) 6.02
Identification of clones that encode chicken tropomyosin by direct immunological screening of a cDNA expression library. Proc Natl Acad Sci U S A (1983) 6.00
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Molecular mechanisms of variation in influenza viruses. Nature (1982) 5.54
Isolation and characterization of a full-length expressible cDNA for human hypoxanthine phosphoribosyl transferase. Proc Natl Acad Sci U S A (1983) 5.50
Analysis of the complete DNA sequence of murine cytomegalovirus. J Virol (1996) 5.44
The sequence of the DNAs coding for the mating-type loci of Saccharomyces cerevisiae. Cell (1981) 5.23
A position effect in the control of transcription at yeast mating type loci. Nature (1981) 5.23
Generation of high-titer pseudotyped retroviral vectors with very broad host range. Methods Cell Biol (1994) 5.17
Complete mutagenesis of the HIV-1 protease. Nature (1989) 5.16
A heparin-binding growth factor secreted by macrophage-like cells that is related to EGF. Science (1991) 5.14
Nucleotide sequence of a bovine clone encoding the angiogenic protein, basic fibroblast growth factor. Science (1986) 5.12
The distal transcription signals of the herpesvirus tk gene share a common hexanucleotide control sequence. Cell (1984) 5.10
The alcohol use disorder and associated disabilities interview schedule (AUDADIS): reliability of alcohol and drug modules in a clinical sample. Drug Alcohol Depend (1997) 5.10
Four mating-type genes control sexual differentiation in the fission yeast. EMBO J (1988) 5.00
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A general method for the generation of high-titer, pantropic retroviral vectors: highly efficient infection of primary hepatocytes. Proc Natl Acad Sci U S A (1994) 4.86
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The DNA sequence and analysis of human chromosome 6. Nature (2003) 4.75
Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing. Nature (2000) 4.68
Requirement for the homeobox gene Hb9 in the consolidation of motor neuron identity. Neuron (1999) 4.68
Suppression of the neoplastic phenotype by replacement of the RB gene in human cancer cells. Science (1988) 4.54
Maternal inheritance of mammalian mitochondrial DNA. Nature (1974) 4.46
Overlapping genes in bacteriophage phiX174. Nature (1976) 4.35