Published in Exp Cell Res on April 01, 1980
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Genomic cloning and characterization of a ricin gene from Ricinus communis. Nucleic Acids Res (1985) 1.61
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Role of arginine 180 and glutamic acid 177 of ricin toxin A chain in enzymatic inactivation of ribosomes. Mol Cell Biol (1990) 1.31
Selection and characterization of ricin toxin A-chain mutations in Saccharomyces cerevisiae. Mol Cell Biol (1989) 1.30
Role of glutamic acid 177 of the ricin toxin A chain in enzymatic inactivation of ribosomes. Mol Cell Biol (1989) 1.29
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Pilot phase IB clinical trial of an alhydrogel-adsorbed recombinant ricin vaccine. Clin Vaccine Immunol (2012) 1.12
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Selective cytotoxicity against human tumour cells by a vindesine-monoclonal antibody conjugate. Br J Cancer (1983) 1.02
Characterization of immunotoxins active against ovarian cancer cell lines. J Clin Invest (1985) 0.95
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Role of the mannose receptor (CD206) in innate immunity to ricin toxin. Toxins (Basel) (2011) 0.87
Temporary inhibition of Moloney-murine sarcoma virus (M-MSV) induced-tumours by adoptive transfer of ricin-treated T-lymphocytes. Br J Cancer (1987) 0.84
Fragment-based identification of determinants of conformational and spectroscopic change at the ricin active site. BMC Struct Biol (2007) 0.82
Recombinant TAT-gelonin fusion toxin: synthesis and characterization of heparin/protamine-regulated cell transduction. J Biomed Mater Res A (2014) 0.79
Adapting yeast as model to study ricin toxin a uptake and trafficking. Toxins (Basel) (2011) 0.78
Design of an EGFR-targeting toxin for photochemical delivery: in vitro and in vivo selectivity and efficacy. Oncogene (2015) 0.78
Persistence of Botulinum neurotoxin inactivation of nerve function. Curr Top Microbiol Immunol (2013) 0.78
Vinyldeoxyadenosine in a sarcin-ricin RNA loop and its binding to ricin toxin a-chain. Biochemistry (2007) 0.78
Complete suppression of in vivo growth of human leukemia cells by specific immunotoxins: nude mouse models. Proc Natl Acad Sci U S A (1987) 0.77
Synergistic antitumor activity from two-stage delivery of targeted toxins and endosome-disrupting nanoparticles. Biomacromolecules (2013) 0.77
Intraneural OX7-saporin for neuroma-in-continuity in a rat model. Eur J Orthop Surg Traumatol (2012) 0.77
Recombinant ricin toxin A chain cytotoxicity against carcinoembryonic antigen expressing tumour cells mediated by a bispecific monoclonal antibody and its potentiation by ricin toxin B chain. Br J Cancer (1991) 0.76
Reporter assay for endo/lysosomal escape of toxin-based therapeutics. Toxins (Basel) (2014) 0.76
Getting across the cell membrane: an overview for small molecules, peptides, and proteins. Methods Mol Biol (2015) 0.76
Drug-targeting by monoclonal antibodies. Br J Cancer (1987) 0.76
Carboxylic ionophores enhance the cytotoxic potency of ligand- and antibody-delivered ricin A chain. J Exp Med (1984) 0.76
Expression and purification of cysteine introduced recombinant saporin. Protein Expr Purif (2007) 0.76
Immunotoxin Therapy for Lung Cancer. Chin Med J (Engl) (2017) 0.75
Diphtheria toxin entry into cells is facilitated by low pH. J Cell Biol (1980) 4.62
Acidification of the cytosol inhibits endocytosis from coated pits. J Cell Biol (1987) 3.13
The cytotoxic activity of Shigella toxin. Evidence for catalytic inactivation of the 60 S ribosomal subunit. J Biol Chem (1981) 3.13
Shiga toxin: biochemistry, genetics, mode of action, and role in pathogenesis. Curr Top Microbiol Immunol (1992) 3.03
Mechanism of action of the toxic lectins abrin and ricin. Nature (1974) 2.83
Rapid entry of nicked diphtheria toxin into cells at low pH. Characterization of the entry process and effects of low pH on the toxin molecule. J Biol Chem (1981) 2.79
Isolation and characterization of Shigella shigae cytotoxin. J Biol Chem (1980) 2.78
Characterization of membrane translocation by anthrax protective antigen. Biochemistry (1998) 2.75
Subunit structure of Shigella cytotoxin. J Biol Chem (1981) 2.59
Entry of the toxic proteins abrin, modeccin, ricin, and diphtheria toxin into cells. II. Effect of pH, metabolic inhibitors, and ionophores and evidence for toxin penetration from endocytotic vesicles. J Biol Chem (1982) 2.32
Different biological properties of the two constituent peptide chains of ricin, a toxic protein inhibiting protein synthesis. Biochemistry (1973) 2.30
The ways of endocytosis. Int Rev Cytol (1989) 2.23
Gelonin, a new inhibitor of protein synthesis, nontoxic to intact cells. Isolation, characterization, and preparation of cytotoxic complexes with concanavalin A. J Biol Chem (1980) 2.16
Kinetics of binding of the toxic lectins abrin and ricin to surface receptors of human cells. J Biol Chem (1976) 2.12
Retrograde transport of mutant ricin to the endoplasmic reticulum with subsequent translocation to cytosol. Proc Natl Acad Sci U S A (1997) 2.08
Mechanism of entry into the cytosol of poliovirus type 1: requirement for low pH. J Cell Biol (1984) 2.05
Endocytosis from coated pits of Shiga toxin: a glycolipid-binding protein from Shigella dysenteriae 1. J Cell Biol (1989) 2.02
Isolation and comparison of galactose-binding lectins from Abrus precatorius and Ricinus communis. J Biol Chem (1974) 1.96
Routing of internalized ricin and ricin conjugates to the Golgi complex. J Cell Biol (1986) 1.90
Estimation of the amount of internalized ricin that reaches the trans-Golgi network. J Cell Biol (1988) 1.90
Another case of imprinting defect in a girl with Angelman syndrome who was conceived by intracytoplasmic semen injection. Am J Hum Genet (2003) 1.86
Interaction of Shigella shigae cytotoxin with receptors on sensitive and insensitive cells. J Recept Res (1980) 1.76
Effect of temperature on the uptake, excretion and degradation of abrin and ricin by HeLa cells. Exp Cell Res (1979) 1.74
Dependence of ricin toxicity on translocation of the toxin A-chain from the endoplasmic reticulum to the cytosol. J Biol Chem (1999) 1.69
How protein toxins enter and kill cells. Cancer Treat Res (1988) 1.63
Ricin - a potent inhibitor of protein synthesis. FEBS Lett (1972) 1.60
Animal toxicity of Shigella dysenteriae cytotoxin: evidence that the neurotoxic, enterotoxic, and cytotoxic activities are due to one toxin. J Immunol (1983) 1.60
Ribosome inactivation by the toxic lectins abrin and ricin. Kinetics of the enzymic activity of the toxin A-chains. Eur J Biochem (1975) 1.54
On the toxic proteins abrin and ricin. Studies of their binding to and entry into Ehrlich ascites cells. J Biol Chem (1974) 1.54
Nude rat model for studying metastasis of human tumor cells to bone and bone marrow. J Natl Cancer Inst (1990) 1.53
Effect of reduced endocytosis induced by hypotonic shock and potassium depletion on the infection of Hep 2 cells by picornaviruses. J Cell Physiol (1987) 1.52
Dual mode of signal transduction by externally added acidic fibroblast growth factor. Cell (1994) 1.49
Treatment of abrin and ricin with -mercaptoethanol opposite effects on their toxicity in mice and their ability to inhibit protein synthesis in a cell-free system. FEBS Lett (1972) 1.48
Isolation and properties of abrin: a toxic protein inhibiting protein synthesis. Evidence for different biological functions of its two constituent-peptide chains. Eur J Biochem (1973) 1.44
Studies on the structure and properties of the lectins from Abrus precatorius and Ricinus communis. Biochim Biophys Acta (1975) 1.43
On the current management of osteosarcoma. A critical evaluation and a proposal for a modified treatment strategy. Eur J Cancer (1997) 1.42
Requirements for entry of poliovirus RNA into cells at low pH. EMBO J (1984) 1.41
Entry of the toxic proteins abrin, modeccin, ricin, and diphtheria toxin into cells. I. Requirement for calcium. J Biol Chem (1982) 1.35
Pathways involved in fluid phase and adsorptive endocytosis in neuroblastoma. J Cell Biol (1980) 1.33
Membrane translocation of diphtheria toxin fragment A exploits early to late endosome trafficking machinery. Mol Microbiol (1997) 1.33
A chimeric toxin to study the role of the 21 kDa GTP binding protein rho in the control of actin microfilament assembly. EMBO J (1993) 1.31
Inhibitory effect of ammonium chloride and chloroquine on the entry of the toxic lectin modeccin into HeLa cells. Biochem Biophys Res Commun (1979) 1.30
Different pH requirements for entry of the two picornaviruses, human rhinovirus 2 and murine encephalomyocarditis virus. Virology (1984) 1.29
Extrapulmonary, tissue-specific metastasis formation in nude mice injected with FEMX-I human melanoma cells. Cancer Res (1988) 1.29
Low pH-induced release of diphtheria toxin A-fragment in Vero cells. Biochemical evidence for transfer to the cytosol. J Biol Chem (1988) 1.29
Chimeric toxins. Pharmacol Ther (1981) 1.25
Modeccin--a plant toxin inhibiting protein synthesis. Biochem Biophys Res Commun (1977) 1.21
A new experimental metastasis model in athymic nude mice, the human malignant melanoma LOX. Int J Cancer (1988) 1.21
In vitro sensitivity of human melanoma xenografts to cytotoxic drugs. Correlation with in vivo chemosensitivity. Int J Cancer (1980) 1.19
Effect of potassium depletion of Hep 2 cells on intracellular pH and on chloride uptake by anion antiport. J Cell Physiol (1987) 1.19
Peptides fused to the amino-terminal end of diphtheria toxin are translocated to the cytosol. J Cell Biol (1991) 1.18
Toxic and nontoxic lectins from Abrus precatorius. Methods Enzymol (1978) 1.18
Purification and characterization of the highly toxic lectin modeccin. J Biol Chem (1978) 1.17
Insertion of diphtheria toxin B-fragment into the plasma membrane at low pH. Characterization and topology of inserted regions. J Biol Chem (1991) 1.15
Requirement of specific receptors for efficient translocation of diphtheria toxin A fragment across the plasma membrane. J Biol Chem (1988) 1.13
Lectins from Abrus precatorius and Ricinus communis. II. Hybrid toxins and their interaction with chain-specific antibodies. J Immunol (1974) 1.13
Inhibition of membrane translocation of diphtheria toxin A-fragment by internal disulfide bridges. J Biol Chem (1994) 1.13
Diphtheria toxin at low pH depolarizes the membrane, increases the membrane conductance and induces a new type of ion channel in Vero cells. EMBO J (1994) 1.12
Ability of inhibitors of glycosylation and protein synthesis to sensitize cells to abrin, ricin, Shigella toxin, and Pseudomonas toxin. Cancer Res (1986) 1.11
Binding, uptake and degradation of the toxic proteins abrin and ricin by toxin-resistant cell variants. Eur J Biochem (1978) 1.11
Replacement of negative by positive charges in the presumed membrane-inserted part of diphtheria toxin B fragment. Effect on membrane translocation and on formation of cation channels. J Biol Chem (1992) 1.11
Translation of enzymically decapped messenger RNA. Eur J Biochem (1977) 1.11
Toxicity, distribution and elimination of the cancerostatic lectins abrin and ricin after parenteral injection into mice. Br J Cancer (1976) 1.11
Comparison of two soft-agar methods for assaying chemosensitivity of human tumours in vitro: malignant melanomas. Br J Cancer (1981) 1.10
Ricin and ricinus agglutinin, toxic lectins from castor bean. Methods Enzymol (1978) 1.09
Diphtheria toxin-induced channels in Vero cells selective for monovalent cations. J Biol Chem (1988) 1.09
Delivery of internalized ricin from endosomes to cisternal Golgi elements is a discontinuous, temperature-sensitive process. Exp Cell Res (1987) 1.09
Mapping of the locus for cholestasis-lymphedema syndrome (Aagenaes syndrome) to a 6.6-cM interval on chromosome 15q. Am J Hum Genet (2000) 1.09
Characteristics of a cell line established from a patient with multiple osteosarcoma, appearing 13 years after treatment for bilateral retinoblastoma. Int J Cancer (1986) 1.09
A human melanoma cell line established from xenograft in athymic mice. Br J Cancer (1980) 1.08
Evidence that diphtheria toxin and modeccin enter the cytosol from different vesicular compartments. J Cell Biol (1984) 1.08
On the mechanism of protein-synthesis inhibition by abrin and ricin. Inhibition of the GTP-hydrolysis site on the 60-S ribosomal subunit. Eur J Biochem (1975) 1.07
Rates of different steps involved in the inhibition of protein synthesis by the toxic lectins abrin and ricin. J Biol Chem (1976) 1.06
Entry of Shigella dysenteriae toxin into HeLa cells. Infect Immun (1983) 1.06
Inhibitory effect of abrin and ricin on the growth of transplantable murine tumors and of abrin on human cancers in nude mice. Cancer Res (1977) 1.05
Effect of potassium depletion of cells on their sensitivity to diphtheria toxin and pseudomonas toxin. J Cell Physiol (1985) 1.05