Published in J Biol Chem on June 10, 1974
Structure-activity relationships of an exotoxin of Pseudomonas aeruginosa. Infect Immun (1977) 3.63
Genetic analysis of the cell surface: association of human chromosome 5 with sensitivity to diphtheria toxin in mouse-human somatic cell hybrids. Proc Natl Acad Sci U S A (1975) 1.26
Studies on the proteins from the seeds of Croton tiglium and of Jatropha curcas. Toxic properties and inhibition of protein synthesis in vitro. Biochem J (1976) 1.14
Chimeric toxins: toxic, disulfide-linked conjugate of concanavalin A with fragment A from diphtheria toxin. Proc Natl Acad Sci U S A (1978) 1.13
Inhibition of protein synthesis in vitro by crotins and ricin. Effect on the steps of peptide chain elongation. Biochem J (1976) 1.12
Variants of hamster fibroblasts resistant to Ricinus communis toxin (ricin). Biochem J (1976) 1.09
Internalization of ricin in Chinese hamster ovary cells. Mol Cell Biol (1981) 1.01
Inhibition of human neuroblastoma DNA polymerase activities by plant lectins and toxins. Proc Natl Acad Sci U S A (1979) 1.00
Introduction of B-chain-inactivated ricin into mouse macrophages and rat Kupffer cells via their membrane Fc receptors. J Exp Med (1976) 0.88
Abrin immunotoxin: targeted cytotoxicity and intracellular trafficking pathway. PLoS One (2013) 0.88
Chinese hamster cell variants resistant to the A chain of ricin carry altered ribosome function. Mol Cell Biol (1982) 0.88
A case of abrin toxin poisoning, confirmed via quantitation of L-abrine (N-methyl-L-tryptophan) biomarker. J Med Toxicol (2014) 0.87
Dynamics of toxin and lectin receptors on a lymphoma cell line and its toxin-resistant variant using ferritin-conjugated, 125I-labeled ligand. J Cell Biol (1978) 0.84
Regulation of Caspase-3 and Bcl-2 Expression in Dalton's Lymphoma Ascites Cells by Abrin. Evid Based Complement Alternat Med (2007) 0.84
Brefeldin A inhibits the endocytosis of plasma-membrane-associated heparan sulphate proteoglycans of cultured rat ovarian granulosa cells. Biochem J (1995) 0.80
Targeting of loaded Sendai virus envelopes by covalently attached insulin molecules to virus receptor-depleted cells: fusion-mediated microinjection of ricin A and simian virus 40 DNA. Proc Natl Acad Sci U S A (1985) 0.77
Calorimetric studies on the stability of the ribosome-inactivating protein abrin II: effects of pH and ligand binding. Biochem J (1999) 0.75
Diphtheria toxin entry into cells is facilitated by low pH. J Cell Biol (1980) 4.62
Acidification of the cytosol inhibits endocytosis from coated pits. J Cell Biol (1987) 3.13
The cytotoxic activity of Shigella toxin. Evidence for catalytic inactivation of the 60 S ribosomal subunit. J Biol Chem (1981) 3.13
Shiga toxin: biochemistry, genetics, mode of action, and role in pathogenesis. Curr Top Microbiol Immunol (1992) 3.03
Mechanism of action of the toxic lectins abrin and ricin. Nature (1974) 2.83
Rapid entry of nicked diphtheria toxin into cells at low pH. Characterization of the entry process and effects of low pH on the toxin molecule. J Biol Chem (1981) 2.79
Isolation and characterization of Shigella shigae cytotoxin. J Biol Chem (1980) 2.78
Characterization of membrane translocation by anthrax protective antigen. Biochemistry (1998) 2.75
Subunit structure of Shigella cytotoxin. J Biol Chem (1981) 2.59
Entry of the toxic proteins abrin, modeccin, ricin, and diphtheria toxin into cells. II. Effect of pH, metabolic inhibitors, and ionophores and evidence for toxin penetration from endocytotic vesicles. J Biol Chem (1982) 2.32
Different biological properties of the two constituent peptide chains of ricin, a toxic protein inhibiting protein synthesis. Biochemistry (1973) 2.30
The ways of endocytosis. Int Rev Cytol (1989) 2.23
Gelonin, a new inhibitor of protein synthesis, nontoxic to intact cells. Isolation, characterization, and preparation of cytotoxic complexes with concanavalin A. J Biol Chem (1980) 2.16
Kinetics of binding of the toxic lectins abrin and ricin to surface receptors of human cells. J Biol Chem (1976) 2.12
Retrograde transport of mutant ricin to the endoplasmic reticulum with subsequent translocation to cytosol. Proc Natl Acad Sci U S A (1997) 2.08
Mechanism of entry into the cytosol of poliovirus type 1: requirement for low pH. J Cell Biol (1984) 2.05
Endocytosis from coated pits of Shiga toxin: a glycolipid-binding protein from Shigella dysenteriae 1. J Cell Biol (1989) 2.02
Isolation and comparison of galactose-binding lectins from Abrus precatorius and Ricinus communis. J Biol Chem (1974) 1.96
Estimation of the amount of internalized ricin that reaches the trans-Golgi network. J Cell Biol (1988) 1.90
Routing of internalized ricin and ricin conjugates to the Golgi complex. J Cell Biol (1986) 1.90
Interaction of Shigella shigae cytotoxin with receptors on sensitive and insensitive cells. J Recept Res (1980) 1.76
Effect of temperature on the uptake, excretion and degradation of abrin and ricin by HeLa cells. Exp Cell Res (1979) 1.74
Entry of lethal doses of abrin, ricin and modeccin into the cytosol of HeLa cells. Exp Cell Res (1980) 1.69
Dependence of ricin toxicity on translocation of the toxin A-chain from the endoplasmic reticulum to the cytosol. J Biol Chem (1999) 1.69
How protein toxins enter and kill cells. Cancer Treat Res (1988) 1.63
Ricin - a potent inhibitor of protein synthesis. FEBS Lett (1972) 1.60
Animal toxicity of Shigella dysenteriae cytotoxin: evidence that the neurotoxic, enterotoxic, and cytotoxic activities are due to one toxin. J Immunol (1983) 1.60
Ribosome inactivation by the toxic lectins abrin and ricin. Kinetics of the enzymic activity of the toxin A-chains. Eur J Biochem (1975) 1.54
Nude rat model for studying metastasis of human tumor cells to bone and bone marrow. J Natl Cancer Inst (1990) 1.53
Effect of reduced endocytosis induced by hypotonic shock and potassium depletion on the infection of Hep 2 cells by picornaviruses. J Cell Physiol (1987) 1.52
Dual mode of signal transduction by externally added acidic fibroblast growth factor. Cell (1994) 1.49
Treatment of abrin and ricin with -mercaptoethanol opposite effects on their toxicity in mice and their ability to inhibit protein synthesis in a cell-free system. FEBS Lett (1972) 1.48
Isolation and properties of abrin: a toxic protein inhibiting protein synthesis. Evidence for different biological functions of its two constituent-peptide chains. Eur J Biochem (1973) 1.44
Studies on the structure and properties of the lectins from Abrus precatorius and Ricinus communis. Biochim Biophys Acta (1975) 1.43
On the current management of osteosarcoma. A critical evaluation and a proposal for a modified treatment strategy. Eur J Cancer (1997) 1.42
Requirements for entry of poliovirus RNA into cells at low pH. EMBO J (1984) 1.41
Entry of the toxic proteins abrin, modeccin, ricin, and diphtheria toxin into cells. I. Requirement for calcium. J Biol Chem (1982) 1.35
Pathways involved in fluid phase and adsorptive endocytosis in neuroblastoma. J Cell Biol (1980) 1.33
Membrane translocation of diphtheria toxin fragment A exploits early to late endosome trafficking machinery. Mol Microbiol (1997) 1.33
A chimeric toxin to study the role of the 21 kDa GTP binding protein rho in the control of actin microfilament assembly. EMBO J (1993) 1.31
Inhibitory effect of ammonium chloride and chloroquine on the entry of the toxic lectin modeccin into HeLa cells. Biochem Biophys Res Commun (1979) 1.30
Low pH-induced release of diphtheria toxin A-fragment in Vero cells. Biochemical evidence for transfer to the cytosol. J Biol Chem (1988) 1.29
Different pH requirements for entry of the two picornaviruses, human rhinovirus 2 and murine encephalomyocarditis virus. Virology (1984) 1.29
Extrapulmonary, tissue-specific metastasis formation in nude mice injected with FEMX-I human melanoma cells. Cancer Res (1988) 1.29
Chimeric toxins. Pharmacol Ther (1981) 1.25
Modeccin--a plant toxin inhibiting protein synthesis. Biochem Biophys Res Commun (1977) 1.21
A new experimental metastasis model in athymic nude mice, the human malignant melanoma LOX. Int J Cancer (1988) 1.21
In vitro sensitivity of human melanoma xenografts to cytotoxic drugs. Correlation with in vivo chemosensitivity. Int J Cancer (1980) 1.19
Effect of potassium depletion of Hep 2 cells on intracellular pH and on chloride uptake by anion antiport. J Cell Physiol (1987) 1.19
Peptides fused to the amino-terminal end of diphtheria toxin are translocated to the cytosol. J Cell Biol (1991) 1.18
Toxic and nontoxic lectins from Abrus precatorius. Methods Enzymol (1978) 1.18
Purification and characterization of the highly toxic lectin modeccin. J Biol Chem (1978) 1.17
Insertion of diphtheria toxin B-fragment into the plasma membrane at low pH. Characterization and topology of inserted regions. J Biol Chem (1991) 1.15
Requirement of specific receptors for efficient translocation of diphtheria toxin A fragment across the plasma membrane. J Biol Chem (1988) 1.13
Inhibition of membrane translocation of diphtheria toxin A-fragment by internal disulfide bridges. J Biol Chem (1994) 1.13
Lectins from Abrus precatorius and Ricinus communis. II. Hybrid toxins and their interaction with chain-specific antibodies. J Immunol (1974) 1.13
Diphtheria toxin at low pH depolarizes the membrane, increases the membrane conductance and induces a new type of ion channel in Vero cells. EMBO J (1994) 1.12
Ability of inhibitors of glycosylation and protein synthesis to sensitize cells to abrin, ricin, Shigella toxin, and Pseudomonas toxin. Cancer Res (1986) 1.11
Binding, uptake and degradation of the toxic proteins abrin and ricin by toxin-resistant cell variants. Eur J Biochem (1978) 1.11
Replacement of negative by positive charges in the presumed membrane-inserted part of diphtheria toxin B fragment. Effect on membrane translocation and on formation of cation channels. J Biol Chem (1992) 1.11
Translation of enzymically decapped messenger RNA. Eur J Biochem (1977) 1.11
Toxicity, distribution and elimination of the cancerostatic lectins abrin and ricin after parenteral injection into mice. Br J Cancer (1976) 1.11
Comparison of two soft-agar methods for assaying chemosensitivity of human tumours in vitro: malignant melanomas. Br J Cancer (1981) 1.10
Diphtheria toxin-induced channels in Vero cells selective for monovalent cations. J Biol Chem (1988) 1.09
Ricin and ricinus agglutinin, toxic lectins from castor bean. Methods Enzymol (1978) 1.09
Delivery of internalized ricin from endosomes to cisternal Golgi elements is a discontinuous, temperature-sensitive process. Exp Cell Res (1987) 1.09
Characteristics of a cell line established from a patient with multiple osteosarcoma, appearing 13 years after treatment for bilateral retinoblastoma. Int J Cancer (1986) 1.09
Evidence that diphtheria toxin and modeccin enter the cytosol from different vesicular compartments. J Cell Biol (1984) 1.08
A human melanoma cell line established from xenograft in athymic mice. Br J Cancer (1980) 1.08
On the mechanism of protein-synthesis inhibition by abrin and ricin. Inhibition of the GTP-hydrolysis site on the 60-S ribosomal subunit. Eur J Biochem (1975) 1.07
Rates of different steps involved in the inhibition of protein synthesis by the toxic lectins abrin and ricin. J Biol Chem (1976) 1.06
Entry of Shigella dysenteriae toxin into HeLa cells. Infect Immun (1983) 1.06
Effect of potassium depletion of cells on their sensitivity to diphtheria toxin and pseudomonas toxin. J Cell Physiol (1985) 1.05
Inhibitory effect of abrin and ricin on the growth of transplantable murine tumors and of abrin on human cancers in nude mice. Cancer Res (1977) 1.05
Role of processing and intracellular transport for optimal toxicity of Shiga toxin and toxin mutants. Exp Cell Res (1995) 1.04
Colony growth and chemosensitivity in vitro of human melanoma biopsies. Relationship to clinical parameters. Int J Cancer (1982) 1.04
Tight folding of acidic fibroblast growth factor prevents its translocation to the cytosol with diphtheria toxin as vector. EMBO J (1992) 1.04