Biosynthesis of 24,25-epoxycholesterol from squalene 2,3;22,23-dioxide.

PubWeight™: 1.14‹?› | Rank: Top 10%

🔗 View Article (PMID 7451488)

Published in J Biol Chem on February 10, 1981

Authors

J A Nelson, S R Steckbeck, T A Spencer

Articles citing this

Sterol upregulation of human CETP expression in vitro and in transgenic mice by an LXR element. J Clin Invest (2000) 2.10

Oxysterol-binding protein and vesicle-associated membrane protein-associated protein are required for sterol-dependent activation of the ceramide transport protein. Mol Biol Cell (2006) 1.77

Characterization of the Saccharomyces cerevisiae ERG27 gene encoding the 3-keto reductase involved in C-4 sterol demethylation. Proc Natl Acad Sci U S A (1999) 1.07

Targeted lipidomic analysis of oxysterols in the embryonic central nervous system. Mol Biosyst (2009) 0.96

Oxysterols and their cellular effectors. Biomolecules (2012) 0.92

Synthesis of the oxysterol, 24(S), 25-epoxycholesterol, parallels cholesterol production and may protect against cellular accumulation of newly-synthesized cholesterol. Lipids Health Dis (2007) 0.88

Oxysterols in the brain of the cholesterol 24-hydroxylase knockout mouse. Biochem Biophys Res Commun (2014) 0.87

Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1. J Lipid Res (2014) 0.82

Regulation of 3-hydroxy-3-methylglutaryl-CoA reductase mRNA contents in human hepatoma cell line Hep G2 by distinct classes of mevalonate-derived metabolites. Biochem J (1988) 0.82

Regulation of CYP3A4 and CYP2B6 expression by liver X receptor agonists. Biochem Pharmacol (2007) 0.81

24S,25-Epoxycholesterol in mouse and rat brain. Biochem Biophys Res Commun (2014) 0.77

The biosynthetic pathway of the nonsugar, high-intensity sweetener mogroside V from Siraitia grosvenorii. Proc Natl Acad Sci U S A (2016) 0.77

Interactions of oxidosqualene cyclase (Erg7p) with 3-keto reductase (Erg27p) and other enzymes of sterol biosynthesis in yeast. Biochim Biophys Acta (2009) 0.77

Nuclear hormone receptors put immunity on sterols. Eur J Immunol (2015) 0.76

Cholesterol Metabolism and Prostate Cancer Lethality. Cancer Res (2016) 0.75

The good side of cholesterol: A requirement for maintenance of intestinal integrity. J Lipid Res (2017) 0.75

Articles by these authors

Antiviral pressure exerted by HIV-1-specific cytotoxic T lymphocytes (CTLs) during primary infection demonstrated by rapid selection of CTL escape virus. Nat Med (1997) 12.08

Cellular localization of human immunodeficiency virus infection within the brains of acquired immune deficiency syndrome patients. Proc Natl Acad Sci U S A (1986) 8.45

Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway. J Biol Chem (1997) 4.81

Promoter-specific trans activation and repression by human cytomegalovirus immediate-early proteins involves common and unique protein domains. J Virol (1990) 4.24

Cerebrospinal fluid human immunodeficiency virus type 1 RNA levels are elevated in neurocognitively impaired individuals with acquired immunodeficiency syndrome. HIV Neurobehavioral Research Center Group. Ann Neurol (1997) 4.17

Characterization of V3 sequence heterogeneity in subtype C human immunodeficiency virus type 1 isolates from Malawi: underrepresentation of X4 variants. J Virol (1999) 4.16

Reactivation of latent human cytomegalovirus by allogeneic stimulation of blood cells from healthy donors. Cell (1997) 3.99

Regulated expression of early and late RNAs and proteins from the human cytomegalovirus immediate-early gene region. J Virol (1989) 3.98

Detection of human cytomegalovirus in peripheral blood lymphocytes in a natural infection. Science (1985) 3.69

BEACHES: an observational system for assessing children's eating and physical activity behaviors and associated events. J Appl Behav Anal (1991) 3.61

Seven-day recall and other physical activity self-reports in children and adolescents. Med Sci Sports Exerc (1993) 3.57

Widespread presence of histologically occult cytomegalovirus. Hum Pathol (1984) 3.45

Dendritic injury is a pathological substrate for human immunodeficiency virus-related cognitive disorders. HNRC Group. The HIV Neurobehavioral Research Center. Ann Neurol (1997) 3.38

Human cytomegalovirus US3 impairs transport and maturation of major histocompatibility complex class I heavy chains. Proc Natl Acad Sci U S A (1996) 3.17

Human cytomegalovirus productively infects primary differentiated macrophages. J Virol (1991) 3.16

Predominant immediate-early transcripts of human cytomegalovirus AD 169. J Virol (1984) 3.15

Long-term infection and transformation of dermal microvascular endothelial cells by human herpesvirus 8. J Virol (1999) 3.02

The human cytomegalovirus chemokine receptor US28 mediates vascular smooth muscle cell migration. Cell (1999) 2.97

Fine mapping of an immunodominant domain in the transmembrane glycoprotein of human immunodeficiency virus. J Virol (1987) 2.97

Correlates of physical activity at home in Mexican-American and Anglo-American preschool children. Health Psychol (1993) 2.74

Empiric antimicrobial therapy of domestically acquired acute diarrhea in urban adults. Arch Intern Med (1990) 2.45

The enhancer domain of the human cytomegalovirus major immediate-early promoter determines cell type-specific expression in transgenic mice. J Virol (1996) 2.37

ACAT-2, a second mammalian acyl-CoA:cholesterol acyltransferase. Its cloning, expression, and characterization. J Biol Chem (1998) 2.13

Cytomegalovirus US2 destroys two components of the MHC class II pathway, preventing recognition by CD4+ T cells. Nat Med (1999) 2.08

Blood-brain barrier tight junction disruption in human immunodeficiency virus-1 encephalitis. Am J Pathol (1999) 2.07

Transcriptional regulation of the human cytomegalovirus major immediate-early gene is associated with induction of DNase I-hypersensitive sites. Mol Cell Biol (1986) 2.05

Neurocognitive impairment is an independent risk factor for death in HIV infection. San Diego HIV Neurobehavioral Research Center Group. Arch Neurol (1997) 2.00

Human immunodeficiency virus infection of bone marrow endothelium reduces induction of stromal hematopoietic growth factors. Blood (1996) 1.98

HIV-1 infection in a man homozygous for CCR5 delta 32. Lancet (1997) 1.95

Localization of cytomegalovirus proteins and genome during fulminant central nervous system infection in an AIDS patient. J Neuropathol Exp Neurol (1986) 1.94

The human cytomegalovirus IE86 protein can block cell cycle progression after inducing transition into the S phase of permissive cells. J Virol (2000) 1.92

Do pathogens accelerate atherosclerosis? J Nutr (2001) 1.91

Diagnosis of AIDS by using a 12-amino acid peptide representing an immunodominant epitope of the human immunodeficiency virus. J Infect Dis (1987) 1.91

Serial magnetic resonance imaging of experimental atherosclerosis detects lesion fine structure, progression and complications in vivo. Nat Med (1995) 1.90

Transformation of NIH 3T3 cells with cloned fragments of human cytomegalovirus strain AD169. J Virol (1982) 1.88

Analysis of methotrexate in human plasma by high-pressure liquid chromatography with fluorescence detection. Cancer Res (1977) 1.87

Human cytomegalovirus IE86 protein interacts with promoter-bound TATA-binding protein via a specific region distinct from the autorepression domain. J Virol (1993) 1.82

Coexpression of truncated human cytomegalovirus gH with the UL115 gene product or the truncated human fibroblast growth factor receptor results in transport of gH to the cell surface. Virology (1993) 1.81

Television's influence on children's diet and physical activity. J Dev Behav Pediatr (1989) 1.77

Radiographic findings of the National Cooperative Crohn's Disease Study. Gastroenterology (1979) 1.77

Human immunodeficiency virus infection of human brain capillary endothelial cells occurs via a CD4/galactosylceramide-independent mechanism. Proc Natl Acad Sci U S A (1993) 1.73

Glycoprotein H-related complexes of human cytomegalovirus: identification of a third protein in the gCIII complex. J Virol (1997) 1.73

Prolonged suppressive antibiotic therapy for infected orthopedic prostheses. Clin Infect Dis (1998) 1.72

Exclusive and persistent use of the entry coreceptor CXCR4 by human immunodeficiency virus type 1 from a subject homozygous for CCR5 delta32. J Virol (1998) 1.69

Direct interaction of the human cytomegalovirus IE86 protein with the cis repression signal does not preclude TBP from binding to the TATA box. J Virol (1993) 1.68

Synthetic peptide immunoassay distinguishes HIV type 1 and HIV type 2 infections. Science (1987) 1.66

Reactivation of latent human cytomegalovirus in CD14(+) monocytes is differentiation dependent. J Virol (2001) 1.65

Interferon-gamma and tumor necrosis factor-alpha specifically induce formation of cytomegalovirus-permissive monocyte-derived macrophages that are refractory to the antiviral activity of these cytokines. J Clin Invest (1997) 1.62

A discrete cis element in the human immunodeficiency virus long terminal repeat mediates synergistic trans activation by cytomegalovirus immediate-early proteins. J Virol (1991) 1.62

Interaction of the 72-kilodalton human cytomegalovirus IE1 gene product with E2F1 coincides with E2F-dependent activation of dihydrofolate reductase transcription. J Virol (1995) 1.59

Sequence homology and immunologic cross-reactivity of human cytomegalovirus with HLA-DR beta chain: a means for graft rejection and immunosuppression. J Virol (1988) 1.57

Energy and macronutrient intakes of elite figure skaters. J Am Diet Assoc (2001) 1.56

Human cytomegalovirus persistently infects aortic endothelial cells. J Virol (1998) 1.55

Aerobic and anaerobic swimming performance of individual Atlantic cod. J Exp Biol (2000) 1.55

Growth kinetics of human cytomegalovirus are altered in monocyte-derived macrophages. J Virol (1995) 1.52

Thermally induced asthma and airway drying. Am J Respir Crit Care Med (1999) 1.52

Gossypiboma--the problem of the retained surgical sponge. Radiology (1978) 1.52

An isoform variant of the cytomegalovirus immediate-early auto repressor functions as a transcriptional activator. Virology (1992) 1.51

Role of human immunodeficiency virus and cytomegalovirus in AIDS encephalitis. Am J Pathol (1988) 1.49

THE MILLER-ABBOTT TUBE AS AN ADJUNCT TO SURGERY OF SMALL INTESTINAL OBSTRUCTIONS. Ann Surg (1940) 1.49

Effects of dichlorodiphenyltrichloroethane (DDT) analogs and polychlorinated biphenyl (PCB) mixtures on 17beta-(3H)estradiol binding to rat uterine receptor. Biochem Pharmacol (1974) 1.48

T cell recognition of HIV synthetic peptides in a natural infection. J Immunol (1989) 1.47

Spatial analysis of the distribution of Ixodes dammini (Acari: Ixodidae) on white-tailed deer in Ogle County, Illinois. J Med Entomol (1992) 1.47

HIV-1 in trophoblastic and villous Hofbauer cells, and haematological precursors in eight-week fetuses. Lancet (1990) 1.45

B- and T-lymphocyte responses to an immunodominant epitope of human immunodeficiency virus. J Virol (1988) 1.42

Effect of spectral shaping and content on loudness discomfort. J Am Acad Audiol (2001) 1.42

Inflammatory cells in transplanted kidneys are infected by human cytomegalovirus. Am J Pathol (1988) 1.41

Individual variation and repeatability in aerobic and anaerobic swimming performance of European sea bass, Dicentrarchus labrax. J Exp Biol (2010) 1.39

T-cell-induced expression of human immunodeficiency virus in macrophages. J Virol (1990) 1.38

The Caltrac accelerometer as a physical activity monitor for school-age children. Med Sci Sports Exerc (1990) 1.38

Effects of genital tract inflammation on human immunodeficiency virus type 1 V3 populations in blood and semen. J Virol (2000) 1.38

A novel mechanism for persistence of human cytomegalovirus in macrophages. J Virol (1996) 1.37

Structure of the transforming region of human cytomegalovirus AD169. J Virol (1984) 1.35

Small fragments of herpesvirus DNA with transforming activity contain insertion sequence-like structures. Proc Natl Acad Sci U S A (1984) 1.34

Acceptability of self-collection of specimens for HPV DNA testing in an urban population. J Womens Health (Larchmt) (2005) 1.30

Steady-state plasma membrane expression of human cytomegalovirus gB is determined by the phosphorylation state of Ser900. J Virol (1998) 1.29

Site-specific inhibition of RNA polymerase II preinitiation complex assembly by human cytomegalovirus IE86 protein. J Virol (1993) 1.28

Systemic gene therapy of murine melanoma using tissue specific expression of the HSVtk gene involves an immune component. Cancer Res (1994) 1.27

Mechanisms of cytomegalovirus-accelerated vascular disease: induction of paracrine factors that promote angiogenesis and wound healing. Curr Top Microbiol Immunol (2008) 1.27

Developmental analysis of the cytomegalovirus enhancer in transgenic animals. J Virol (1996) 1.27

A protein-based therapeutic for human cytomegalovirus infection. Proc Natl Acad Sci U S A (2000) 1.23

Mechanisms of action of 6-thioguanine, 6-mercaptopurine, and 8-azaguanine. Cancer Res (1975) 1.23

Human cytomegalovirus infection of caco-2 cells occurs at the basolateral membrane and is differentiation state dependent. J Virol (1999) 1.23

European Lyme borreliosis: 231 culture-confirmed cases involving patients with erythema migrans. Clin Infect Dis (1996) 1.23

24,25-Epoxysterol metabolism in cultured mammalian cells and repression of 3-hydroxy-3-methylglutaryl-CoA reductase. J Biol Chem (1986) 1.21

Enhancement of RNA polymerase II initiation complexes by a novel DNA control domain downstream from the cap site of the cytomegalovirus major immediate-early promoter. J Virol (1991) 1.20

Anglo- and Mexican-American preschoolers at home and at recess: activity patterns and environmental influences. J Dev Behav Pediatr (1992) 1.18

Human immunodeficiency virus (HIV) and JC virus in acquired immune deficiency syndrome (AIDS) patients with progressive multifocal leukoencephalopathy. Acta Neuropathol (1988) 1.16

Differential role of long terminal repeat control elements for the regulation of basal and Tat-mediated transcription of the human immunodeficiency virus in stimulated and unstimulated primary human macrophages. J Virol (1994) 1.16

Key regulatory oxysterols in liver: analysis as delta4-3-ketone derivatives by HPLC and response to physiological perturbations. J Lipid Res (2001) 1.15

Reliability of interviewers using the Seven-Day Physical Activity Recall. Res Q Exerc Sport (1990) 1.14

Function-structure studies and identification of three enzyme domains involved in the catalytic activity in rat hepatic squalene synthase. J Biol Chem (1998) 1.14

24(S),25-Epoxycholesterol. Evidence consistent with a role in the regulation of hepatic cholesterogenesis. J Biol Chem (1985) 1.14

Increased purine nucleotides in adenosine deaminase-deficient lymphocytes. J Pediatr (1977) 1.13

Cultured human brain capillary endothelial cells are permissive for infection by human cytomegalovirus. Virology (1990) 1.13

Infant-feeding practices and adiposity in 4-y-old Anglo- and Mexican-Americans. Am J Clin Nutr (1992) 1.13

In vitro susceptibility of Borrelia burgdorferi to 11 antimicrobial agents. Antimicrob Agents Chemother (1993) 1.12

Peak shift as a function of multiple schedules of reinforcement. J Exp Anal Behav (1974) 1.12