Published in Science on February 20, 1981
Sympathetic nerve discharge is coupled to muscle cell pH during exercise in humans. J Clin Invest (1988) 2.32
Regional cerebral blood flow during volitional breathing in man. J Physiol (1991) 1.84
The 2008 Carl Ludwig Lecture: retrotrapezoid nucleus, CO2 homeostasis, and breathing automaticity. J Appl Physiol (1985) (2008) 1.70
Epidural anaesthesia and cardiovascular responses to static exercise in man. J Physiol (1989) 1.58
Electrically induced static exercise elicits a pressor response in the decerebrate rat. J Physiol (2001) 1.46
Paraventricular hypothalamic nucleus: axonal projections to the brainstem. J Comp Neurol (2010) 1.41
Somatosensory feedback from the limbs exerts inhibitory influences on central neural drive during whole body endurance exercise. J Appl Physiol (1985) (2008) 1.35
Is the voluntary control of exercise in man necessary for the ventilatory response? J Physiol (1984) 1.32
The role of spinal cord transmission in the ventilatory response to exercise in man. J Physiol (1984) 1.24
Hyperpnoea during and immediately after exercise in man: evidence of motor cortical involvement. J Physiol (1995) 1.23
Identification of higher brain centres that may encode the cardiorespiratory response to exercise in humans. J Physiol (2001) 1.21
Central activation of autonomic effectors during mental simulation of motor actions in man. J Physiol (1993) 1.19
Defining the neurocircuitry of exercise hyperpnoea. J Physiol (2013) 1.18
Identifying cardiorespiratory neurocircuitry involved in central command during exercise in humans. J Physiol (2006) 1.15
Neural Control of Breathing and CO2 Homeostasis. Neuron (2015) 1.11
Respiratory modulation of the activity in sympathetic neurones supplying muscle, skin and pelvic organs in the cat. J Physiol (1992) 1.10
An interdependent model of central/peripheral chemoreception: evidence and implications for ventilatory control. Respir Physiol Neurobiol (2010) 1.08
Activation of the retrotrapezoid nucleus by posterior hypothalamic stimulation. J Physiol (2009) 1.07
The relevance of central command for the neural cardiovascular control of exercise. Exp Physiol (2010) 1.04
Ventilation during exercise in chronic heart failure. Basic Res Cardiol (1996) 1.01
Analysis of co-ordination between breathing and exercise rhythms in man. J Physiol (1993) 0.99
Are type III-IV muscle afferents required for a normal steady-state exercise hyperpnoea in humans? J Physiol (2013) 0.99
Influence of inspired oxygen concentration on the dynamics of the exercise hyperpnoea in man. J Physiol (1986) 0.97
Immediate changes in ventilation and respiratory pattern associated with onset and cessation of locomotion in the cat. J Physiol (1983) 0.96
Electrical stimulation of the midbrain increases heart rate and arterial blood pressure in awake humans. J Physiol (2002) 0.96
Central motor command activates sympathetic outflow to the cutaneous circulation in humans. J Physiol (1996) 0.95
Pathophysiology of human ventilatory control. Eur Respir J (2014) 0.92
New perspectives concerning feedback influences on cardiorespiratory control during rhythmic exercise and on exercise performance. J Physiol (2012) 0.92
Exercise intolerance, lactic acidosis, and abnormal cardiopulmonary regulation in exercise associated with adult skeletal muscle cytochrome c oxidase deficiency. J Clin Invest (1989) 0.91
Respiratory-related activation of human abdominal muscles during exercise. J Physiol (2002) 0.89
Specific neural substrate linking respiration to locomotion. Proc Natl Acad Sci U S A (2011) 0.88
Ventilatory responses to muscle metaboreflex activation in chronic obstructive pulmonary disease. J Physiol (2016) 0.87
Non-thermal modification of heat-loss responses during exercise in humans. Eur J Appl Physiol (2010) 0.86
Ventilation and cardiac output during the onset of exercise, and during voluntary hyperventilation, in humans. J Physiol (1986) 0.85
Sound stabilizes locomotor-respiratory coupling and reduces energy cost. PLoS One (2012) 0.83
Proton detection and breathing regulation by the retrotrapezoid nucleus. J Physiol (2016) 0.83
The control of ventilation is dissociated from locomotion during walking in sheep. J Physiol (2004) 0.82
Lack of importance of respiratory muscle load in ventilatory regulation during heavy exercise in humans. J Physiol (1996) 0.81
Relationship between effort sense and ventilatory response to intense exercise performed with reduced muscle glycogen. Eur J Appl Physiol (2011) 0.81
Neural correlates of motor vigour and motor urgency during exercise. Sports Med (2013) 0.80
Remote control of respiratory neural network by spinal locomotor generators. PLoS One (2014) 0.79
Contributions of Central Command and Muscle Feedback to Sympathetic Nerve Activity in Contracting Human Skeletal Muscle. Front Physiol (2016) 0.78
Stride frequency and ventilation at constant carbon dioxide output. Br J Sports Med (1985) 0.78
Metaboreflex control of the heart. J Physiol (2010) 0.78
Tendon vibration attenuates superficial venous vessel response of the resting limb during static arm exercise. J Physiol Anthropol (2012) 0.78
Reciprocal functional interactions between the brainstem and the lower spinal cord. Front Neurosci (2014) 0.78
Effects of sodium bicarbonate ingestion on EMG, effort sense and ventilatory response during intense exercise and subsequent active recovery. Eur J Appl Physiol (2010) 0.76
Immediate ventilatory response to sudden changes in venous return in humans. J Physiol (1986) 0.75
Reciprocal functional interactions between the respiration/circulation center, the upper spinal cord, and the trigeminal system. Transl Neurosci (2015) 0.75
Sciatic nerve stimulation activates the retrotrapezoid nucleus in anesthetized rats. J Neurophysiol (2016) 0.75
Dynamic Characteristics of Ventilatory and Gas Exchange during Sinusoidal Walking in Humans. PLoS One (2017) 0.75
Murine hypothalamic destruction with vascular cell apoptosis subsequent to combined administration of human papilloma virus vaccine and pertussis toxin. Sci Rep (2016) 0.75
Metaboreflex activation delays heart rate recovery after aerobic exercise in never-treated hypertensive men. J Physiol (2016) 0.75
Insomnia with sleep apnea: a new syndrome. Science (1973) 2.62
Sleep apnea in eight children. Pediatrics (1976) 2.60
Effect of ischemia on responses of group III and IV afferents to contraction. J Appl Physiol Respir Environ Exerc Physiol (1984) 2.00
Prolonged stimulation of respiration by endogenous central serotonin. Respir Physiol (1980) 1.91
Stimulation by central command of locomotion, respiration and circulation during exercise. Respir Physiol (1985) 1.83
Prolonged stimulation of respiration by a new central neural mechanism. Respir Physiol (1980) 1.79
Multiple molecular penumbras after focal cerebral ischemia. J Cereb Blood Flow Metab (2000) 1.67
Input-output relationships of central neural circuits involved in respiration in cats. J Physiol (1981) 1.63
Relationship between phrenic nerve activity and ventilation. Am J Physiol (1971) 1.60
Hypoxia-induced protein binding to O2-responsive sequences on the tyrosine hydroxylase gene. J Biol Chem (1995) 1.57
Hypoxia and electrical stimulation of the carotid sinus nerve induce Fos-like immunoreactivity within catecholaminergic and serotoninergic neurons of the rat brainstem. J Comp Neurol (1994) 1.56
Selective activation of p38alpha and p38gamma by hypoxia. Role in regulation of cyclin D1 by hypoxia in PC12 cells. J Biol Chem (1999) 1.47
Depolarization and stimulation of neurons in nucleus tractus solitarii by carbon dioxide does not require chemical synaptic input. Neuroscience (1990) 1.46
Relationship between respiratory nerve and muscle activity and muscle force output. J Appl Physiol (1975) 1.43
Servo control of end-tidal CO2 in paralyzed animals. J Appl Physiol Respir Environ Exerc Physiol (1978) 1.42
CO2 decreases membrane conductance and depolarizes neurons in the nucleus tractus solitarii. Exp Brain Res (1989) 1.37
Effects of static and rhythmic twitch contractions on the discharge of group III and IV muscle afferents. Cardiovasc Res (1984) 1.37
Sleep apnea syndrome due to upper airway obstruction: a review of 25 cases. Arch Intern Med (1977) 1.36
Hypoxia increases rate of transcription and stability of tyrosine hydroxylase mRNA in pheochromocytoma (PC12) cells. J Biol Chem (1994) 1.36
The importance of timing on the respiratory effects of intermittent carotid body chemoreceptor stimulation. J Physiol (1972) 1.32
Regulation of tyrosine hydroxylase gene expression in the rat carotid body by hypoxia. J Neurochem (1992) 1.32
Selective inhibition of a slow-inactivating voltage-dependent K+ channel in rat PC12 cells by hypoxia. J Physiol (1997) 1.31
Membrane depolarization in PC-12 cells during hypoxia is regulated by an O2-sensitive K+ current. Am J Physiol (1996) 1.30
Sleep apnea syndrome. Can it induce hemodynamic changes? West J Med (1975) 1.29
The nephrotic syndrome: a complication of massive obesity. Ann Intern Med (1974) 1.26
Central neural respiratory stimulatory effect of active respiration. J Appl Physiol (1974) 1.21
Role of ventrolateral medulla in regulation of respiratory and cardiovascular systems. J Appl Physiol (1985) (1986) 1.19
Left ventricular failure secondary to chronic pulmonary disease. Am J Med (1968) 1.17
Chronic hypoxia enhances adenosine release in rat PC12 cells by altering adenosine metabolism and membrane transport. J Neurochem (2000) 1.17
EPAS1 trans-activation during hypoxia requires p42/p44 MAPK. J Biol Chem (1999) 1.14
Respiratory responses to medullary hydrogen ion changes in cats: different effects of respiratory and metabolic acidoses. J Physiol (1985) 1.14
The importance of timing on the respiratory effects of intermittent carotid sinus nerve stimulation. J Physiol (1972) 1.14
Posthyperventilation breathing: different effects of active and passive hyperventilation. J Appl Physiol (1973) 1.12
Hypoxia activates Akt and induces phosphorylation of GSK-3 in PC12 cells. Cell Signal (2001) 1.11
Fos-like protein is induced in neurons of the medulla oblongata after stimulation of the carotid sinus nerve in awake and anesthetized rats. Brain Res (1991) 1.10
Antagonism by theophylline of respiratory inhibition induced by adenosine. J Appl Physiol (1985) (1985) 1.07
Hypoxia induces phosphorylation of the cyclic AMP response element-binding protein by a novel signaling mechanism. J Biol Chem (1998) 1.06
Central neural respiratory drive and afterdischarge. Respir Physiol (1980) 1.05
O2-sensitive K+ channels: role of the Kv1.2 -subunit in mediating the hypoxic response. J Physiol (2000) 1.05
Hypoxia stimulates binding of a cytoplasmic protein to a pyrimidine-rich sequence in the 3'-untranslated region of rat tyrosine hydroxylase mRNA. J Biol Chem (1994) 1.05
Respiratory myoclonus (Leeuwenhoek's disease). N Engl J Med (1973) 1.04
Hypoxia-induced regulation of MAPK phosphatase-1 as identified by subtractive suppression hybridization and cDNA microarray analysis. J Biol Chem (2001) 1.03
Central regulation of respiration by endogenous neurotransmitters and neuromodulators. Annu Rev Physiol (1981) 1.02
Development of short-term potentiation of respiration. Respir Physiol (1991) 1.02
Respiratory-associated rhythmic firing of midbrain neurones in cats: relation to level of respiratory drive. J Physiol (1991) 1.01
Respiratory-associated thalamic activity is related to level of respiratory drive. Respir Physiol (1992) 1.00
Resetting of mammalian respiratory rhythm: existence of a phase singularity. Am J Physiol (1986) 1.00
Relationship of thoracic volume and airway occlusion pressure: muscular effects. J Appl Physiol Respir Environ Exerc Physiol (1977) 0.99
Suprapontine control of respiration. Respir Physiol (1998) 0.98
Respiratory effects of a long-acting analog of adenosine. Brain Res (1984) 0.98
Hypoxia regulates glutamate metabolism and membrane transport in rat PC12 cells. J Neurochem (2001) 0.98
Neural respiratory and circulatory interaction during chemoreceptor stimulation and cooling of ventral medulla in cats. J Physiol (1986) 0.98
Central nervous system and chemoreceptor factors in control of breathing. Chest (1978) 0.98
Stimulation of raphe (obscurus) nucleus causes long-term potentiation of phrenic nerve activity in cat. J Physiol (1986) 0.98
Central respiratory effects of carbon dioxide, and carotid sinus nerve and muscle afferents. J Physiol (1980) 0.97
Increasing gracilis muscle interstitial potassium concentrations stimulate group III and IV afferents. J Appl Physiol (1985) (1985) 0.97
Input-output relationships of the central respiratory controller during peripheral muscle stimulation in cats. J Physiol (1982) 0.97
Adenosine modulates hypoxia-induced responses in rat PC12 cells via the A2A receptor. J Physiol (1998) 0.96
Spinal inhibition of phrenic motoneurones by stimulation of afferents from peripheral muscles. J Physiol (1981) 0.96
Pressor reflex evoked by muscular contraction: contributions by neuraxis levels. J Appl Physiol (1985) (1985) 0.96
Prolonged inhibition of respiration following acute hypoxia in glomectomized cats. Respir Physiol (1984) 0.96
Naloxone enhances respiratory output in cats. J Appl Physiol Respir Environ Exerc Physiol (1979) 0.96
Identification of diencephalic and brainstem cardiorespiratory areas activated during exercise. Brain Res (1996) 0.96
In vitro responses of caudal hypothalamic neurons to hypoxia and hypercapnia. Neuroscience (1992) 0.96
Respiratory effects of carbon dioxide-induced changes of medullary extracellular fluid pH in cats. J Physiol (1984) 0.95
Oscillations of medullary extracellular fluid pH caused by breathing. Respir Physiol (1984) 0.94
Responding to hypoxia: lessons from a model cell line. Sci STKE (2002) 0.94
Gene expression and function of adenosine A(2A) receptor in the rat carotid body. Am J Physiol Lung Cell Mol Physiol (2000) 0.91
Mechanism of respiratory effects of methylxanthines. Respir Physiol (1983) 0.91
Progesterone stimulates respiration through a central nervous system steroid receptor-mediated mechanism in cat. Proc Natl Acad Sci U S A (1987) 0.90
Subthreshold central neural respiratory activity and afterdischarge. Respir Physiol (1980) 0.90
Discharge patterns of somatosensitive neurons in the nucleus tractus solitarius of the cat. Neuroscience (2005) 0.89
Emergency replacement of valves in endocarditis. Am Heart J (1967) 0.89
Lack of effect of vagal afferent input on central neural respiratory afterdischarge. J Appl Physiol Respir Environ Exerc Physiol (1978) 0.89
The Fowler breathholding study revisited: continuous rating of respiratory sensation. Respir Physiol (1994) 0.88
Stimulation of expression for the adenosine A2A receptor gene by hypoxia in PC12 cells. A potential role in cell protection. J Biol Chem (1999) 0.88
In vivo release of serotonin in cat dorsal vagal complex and cervical ventral horn induced by electrical stimulation of the medullary raphe nuclei. Brain Res (1990) 0.88