Published in Blood on December 01, 1995
Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis. Proc Natl Acad Sci U S A (1996) 6.29
Chromosome translocations and covert leukemic clones are generated during normal fetal development. Proc Natl Acad Sci U S A (2002) 2.58
The United Kingdom Childhood Cancer Study: objectives, materials and methods. UK Childhood Cancer Study Investigators. Br J Cancer (2000) 2.37
Identification of a nuclear matrix targeting signal in the leukemia and bone-related AML/CBF-alpha transcription factors. Proc Natl Acad Sci U S A (1997) 2.06
The t(8;21) fusion product, AML-1-ETO, associates with C/EBP-alpha, inhibits C/EBP-alpha-dependent transcription, and blocks granulocytic differentiation. Mol Cell Biol (1998) 1.98
The t(12;21) translocation converts AML-1B from an activator to a repressor of transcription. Mol Cell Biol (1996) 1.75
Auto-inhibition and partner proteins, core-binding factor beta (CBFbeta) and Ets-1, modulate DNA binding by CBFalpha2 (AML1). Mol Cell Biol (2000) 1.58
Both TEL and AML-1 contribute repression domains to the t(12;21) fusion protein. Mol Cell Biol (1999) 1.53
TEL-AML1 transgenic zebrafish model of precursor B cell acute lymphoblastic leukemia. Proc Natl Acad Sci U S A (2006) 1.53
Fetal origins of the TEL-AML1 fusion gene in identical twins with leukemia. Proc Natl Acad Sci U S A (1998) 1.50
Prospective analysis of TEL/AML1-positive patients treated on Dana-Farber Cancer Institute Consortium Protocol 95-01. Blood (2006) 1.28
TEL, a putative tumor suppressor, modulates cell growth and cell morphology of ras-transformed cells while repressing the transcription of stromelysin-1. Mol Cell Biol (2000) 1.24
The t(1;12)(q21;p13) translocation of human acute myeloblastic leukemia results in a TEL-ARNT fusion. Proc Natl Acad Sci U S A (2000) 1.19
Modeling the evolution of ETV6-RUNX1-induced B-cell precursor acute lymphoblastic leukemia in mice. Blood (2011) 1.16
The TEL-AML1 leukemia fusion gene dysregulates the TGF-beta pathway in early B lineage progenitor cells. J Clin Invest (2009) 1.15
Human AML1/MDS1/EVI1 fusion protein induces an acute myelogenous leukemia (AML) in mice: a model for human AML. Proc Natl Acad Sci U S A (2000) 1.14
Molecular mechanisms of ETS transcription factor-mediated tumorigenesis. Crit Rev Biochem Mol Biol (2013) 1.08
The PEBP2betaMYH11 fusion created by Inv(16)(p13;q22) in myeloid leukemia impairs neutrophil maturation and contributes to granulocytic dysplasia. Proc Natl Acad Sci U S A (1998) 1.07
The leukemogenic t(8;21) fusion protein AML1-ETO controls rRNA genes and associates with nucleolar-organizing regions at mitotic chromosomes. J Cell Sci (2008) 1.06
The novel ETS factor TEL2 cooperates with Myc in B lymphomagenesis. Mol Cell Biol (2005) 1.04
Genomic and proteomic biomarkers for cancer: a multitude of opportunities. Biochim Biophys Acta (2009) 1.03
Clonal origins of ETV6-RUNX1⁺ acute lymphoblastic leukemia: studies in monozygotic twins. Leukemia (2014) 0.97
ETS-core binding factor: a common composite motif in antigen receptor gene enhancers. Mol Cell Biol (1998) 0.95
Functional characterization of ETV6 and ETV6/CBFA2 in the regulation of the MCSFR proximal promoter. Proc Natl Acad Sci U S A (1997) 0.95
Genetic studies of a cluster of acute lymphoblastic leukemia cases in Churchill County, Nevada. Environ Health Perspect (2007) 0.94
Molecular pathophysiology of myelodysplastic syndromes. Annu Rev Pathol (2012) 0.94
Prospective analysis of TEL gene rearrangements in childhood acute lymphoblastic leukemia: a Children's Oncology Group study. J Clin Oncol (2008) 0.93
Core-binding factor influences the disease specificity of Moloney murine leukemia virus. J Virol (1999) 0.93
A genome-scale in vivo loss-of-function screen identifies Phf6 as a lineage-specific regulator of leukemia cell growth. Genes Dev (2015) 0.91
Cytotoxic T cell response against the chimeric ETV6-AML1 protein in childhood acute lymphoblastic leukemia. J Clin Invest (1998) 0.90
Presence of clone-specific markers at birth in children with acute lymphoblastic leukaemia. Br J Cancer (2002) 0.89
Cytogenetic and molecular predictors of outcome in acute lymphocytic leukemia: recent developments. Curr Hematol Malig Rep (2012) 0.89
Ovarian cancer has frequent loss of heterozygosity at chromosome 12p12.3-13.1 (region of TEL and Kip1 loci) and chromosome 12q23-ter: evidence for two new tumour-suppressor genes. Br J Cancer (1997) 0.87
CD10 is a marker for cycling cells with propensity to apoptosis in childhood ALL. Br J Cancer (2002) 0.83
Tel, a frequent target of leukemic translocations, induces cellular aggregation and influences expression of extracellular matrix components. Neoplasia (1999) 0.81
ETV6/RUNX1 induces reactive oxygen species and drives the accumulation of DNA damage in B cells. Neoplasia (2013) 0.81
Copy number genome alterations are associated with treatment response and outcome in relapsed childhood ETV6/RUNX1-positive acute lymphoblastic leukemia. Haematologica (2013) 0.80
Treatment of adolescent and young adults with acute lymphoblastic leukemia. Mediterr J Hematol Infect Dis (2014) 0.78
Proteomic profile of pre - B2 lymphoblasts from children with acute lymphoblastic leukemia (ALL) in relation with the translocation (12; 21). Clin Proteomics (2014) 0.77
Transcriptome sequencing reveals CHD1 as a novel fusion partner of RUNX1 in acute myeloid leukemia with t(5;21)(q21;q22). Mol Cancer (2015) 0.77
Neonatal infection with species C adenoviruses confirmed in viable cord blood lymphocytes. PLoS One (2015) 0.77
Cooperation of ETV6/RUNX1 and BCL2 enhances immunoglobulin production and accelerates glomerulonephritis in transgenic mice. Oncotarget (2016) 0.76
No chromosome arm unturned: in memory of Roland Berger 1934-2012. Leukemia (2014) 0.75
Classification of acute leukaemia: the need to incorporate cytogenetic and molecular genetic information. J Clin Pathol (1998) 0.75
The TEL-AML1 fusion protein of acute lymphoblastic leukemia modulates IRF3 activity during early B-cell differentiation. Oncogene (2015) 0.75
A new highly penetrant form of obesity due to deletions on chromosome 16p11.2. Nature (2010) 4.52
All-trans retinoic acid as a differentiation therapy for acute promyelocytic leukemia. I. Clinical results. Blood (1990) 4.36
NB4, a maturation inducible cell line with t(15;17) marker isolated from a human acute promyelocytic leukemia (M3). Blood (1991) 4.30
A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia. Science (1997) 4.29
A broadly neutralizing human monoclonal antibody against gp41 of human immunodeficiency virus type 1. AIDS Res Hum Retroviruses (1994) 3.97
Improved left ventricular mechanics from acute VDD pacing in patients with dilated cardiomyopathy and ventricular conduction delay. Circulation (1999) 3.62
A gene encoding a P-type ATPase mutated in two forms of hereditary cholestasis. Nat Genet (1998) 3.09
Correlation between immunoglobulin light chain expression and variant translocation in Burkitt's lymphoma. Nature (1982) 3.03
Mutations of ASXL1 gene in myeloproliferative neoplasms. Leukemia (2009) 2.77
Cytogenetic studies on African Burkitt's lymphoma cell lines: t(8;14), t(2;8) and t(8;22) translocations. Cancer Genet Cytogenet (1981) 2.74
Bridging Ral GTPase to Rho pathways. RLIP76, a Ral effector with CDC42/Rac GTPase-activating protein activity. J Biol Chem (1995) 2.69
HIV-1, hepatitis (A,B, and C), and measles in Romanian children. Lancet (1991) 2.63
Angiographic prevalence of high-risk coronary artery disease in patient subsets (CASS). Circulation (1981) 2.36
Chromosomal localization of the human proto-oncogene c-ets. Nature (1984) 2.35
Involvement of a human gene related to the Drosophila spen gene in the recurrent t(1;22) translocation of acute megakaryocytic leukemia. Proc Natl Acad Sci U S A (2001) 2.35
The t(12;21) of acute lymphoblastic leukemia results in a tel-AML1 gene fusion. Blood (1995) 2.30
Standardized MRD quantification in European ALL trials: proceedings of the Second International Symposium on MRD assessment in Kiel, Germany, 18-20 September 2008. Leukemia (2009) 2.30
Identification of BTG2, an antiproliferative p53-dependent component of the DNA damage cellular response pathway. Nat Genet (1996) 2.26
[4 cases of trisomy for the short arm of chromosome 9. Individualization of a new morbid entity]. Ann Genet (1970) 2.23
Interferon-gamma production by Listeria monocytogenes-specific T cells active in cellular antibacterial immunity. Eur J Immunol (1983) 2.06
Hyperinsulinism in short-chain L-3-hydroxyacyl-CoA dehydrogenase deficiency reveals the importance of beta-oxidation in insulin secretion. J Clin Invest (2001) 2.01
Prophylactic anticoagulation with enoxaparin: Is the subcutaneous route appropriate in the critically ill? Crit Care Med (2003) 1.87
Two distinct mechanisms for the SCL gene activation in the t(1;14) translocation of T-cell leukemias. Genes Chromosomes Cancer (1990) 1.85
Chido and Rodgers blood groups are distinct antigenic components of human complement C4. Nature (1978) 1.85
Identification of class-mu glutathione transferase genes GSTM1-GSTM5 on human chromosome 1p13. Am J Hum Genet (1993) 1.83
Intrapleural tetracycline for the prevention of recurrent spontaneous pneumothorax. Results of a Department of Veterans Affairs cooperative study. JAMA (1990) 1.79
A new congenital dysmegakaryopoietic thrombocytopenia (Paris-Trousseau) associated with giant platelet alpha-granules and chromosome 11 deletion at 11q23. Blood (1995) 1.78
Presence of an allelic EcoRI restriction fragment of the c-mos locus in leukocyte and tumor cell DNAs of breast cancer patients. Proc Natl Acad Sci U S A (1985) 1.77
[Auditory processing disorders : Consensus statement by the German Society for Phoniatry and Paedaudiology]. HNO (2007) 1.75
Mutations of IDH1 and IDH2 genes in early and accelerated phases of myelodysplastic syndromes and MDS/myeloproliferative neoplasms. Leukemia (2010) 1.75
Analysis of the pattern of initiation of sustained ventricular arrhythmias in patients with implantable defibrillators. J Cardiovasc Electrophysiol (2000) 1.73
Improved reliability of lymphoma diagnostics via PCR-based clonality testing: report of the BIOMED-2 Concerted Action BHM4-CT98-3936. Leukemia (2006) 1.72
The BCMA gene, preferentially expressed during B lymphoid maturation, is bidirectionally transcribed. Nucleic Acids Res (1994) 1.72
Detection of 11 germline inactivating TP53 mutations and absence of TP63 and HCHK2 mutations in 17 French families with Li-Fraumeni or Li-Fraumeni-like syndrome. J Med Genet (2001) 1.70
SETBP1 mutations in 658 patients with myelodysplastic syndromes, chronic myelomonocytic leukemia and secondary acute myeloid leukemias. Leukemia (2013) 1.65
Prenatal and early postnatal treatment in 3-phosphoglycerate-dehydrogenase deficiency. Lancet (2004) 1.64
Smoking and mental illness. Pharmacol Biochem Behav (2001) 1.63
FIC1, the protein affected in two forms of hereditary cholestasis, is localized in the cholangiocyte and the canalicular membrane of the hepatocyte. J Hepatol (2001) 1.60
EuroClonality/BIOMED-2 guidelines for interpretation and reporting of Ig/TCR clonality testing in suspected lymphoproliferations. Leukemia (2012) 1.60
CALM-AF10+ T-ALL expression profiles are characterized by overexpression of HOXA and BMI1 oncogenes. Leukemia (2005) 1.59
DNMT3B mutations and DNA methylation defect define two types of ICF syndrome. Hum Mutat (2005) 1.59
A review of the research on general health status indexes. Med Care (1975) 1.58
MECP2 mutations account for most cases of typical forms of Rett syndrome. Hum Mol Genet (2000) 1.58
Decrease of the lymphoproliferative response to varicella-zoster virus antigen in the aged. Infect Immun (1981) 1.57
Self-induced correction of the genetic defect in tyrosinemia type I. J Clin Invest (1994) 1.57
Age of bed v, olduvai gorge, Tanzania. Science (1968) 1.54
A topological and functional model of epitopes on the structural glycoprotein of tick-borne encephalitis virus defined by monoclonal antibodies. Virology (1983) 1.53
Demonstration of IgA polioantibody in saliva, duodenal fluid and urine. Nature (1967) 1.53
Telomeric 22q13 deletions resulting from rings, simple deletions, and translocations: cytogenetic, molecular, and clinical analyses of 32 new observations. J Med Genet (2003) 1.52
Transforming properties of chimeric TEL-JAK proteins in Ba/F3 cells. Blood (2000) 1.52
Differential effects of exercise training intensity on blood pressure and cardiovascular responses to stress in borderline hypertensive humans. J Hypertens (1996) 1.51
Nuclear membrane protein LAP2beta mediates transcriptional repression alone and together with its binding partner GCL (germ-cell-less). J Cell Sci (2001) 1.51
A human homologue of the Drosophila melanogaster diaphanous gene is disrupted in a patient with premature ovarian failure: evidence for conserved function in oogenesis and implications for human sterility. Am J Hum Genet (1998) 1.50
Clinical Pharmacogenetics Implementation Consortium guidelines for HLA-B genotype and carbamazepine dosing. Clin Pharmacol Ther (2013) 1.49
A novel class of zinc finger/leucine zipper genes identified from the molecular cloning of the t(10;11) translocation in acute leukemia. Blood (1995) 1.48
Large daily fluctuations in plasma tyrosine in treated patients with phenylketonuria. Am J Clin Nutr (1996) 1.47
AF6q21, a novel partner of the MLL gene in t(6;11)(q21;q23), defines a forkhead transcriptional factor subfamily. Blood (1997) 1.47
Molecular basis of 11q23 rearrangements in hematopoietic malignant proliferations. Genes Chromosomes Cancer (1995) 1.46
A new gene, BCM, on chromosome 16 is fused to the interleukin 2 gene by a t(4;16)(q26;p13) translocation in a malignant T cell lymphoma. EMBO J (1992) 1.46
The human type II collagen gene (COL2A1) assigned to 12q14.3. Ann Hum Genet (1986) 1.44
A new recurrent and specific cryptic translocation, t(5;14)(q35;q32), is associated with expression of the Hox11L2 gene in T acute lymphoblastic leukemia. Leukemia (2001) 1.43
A t(8;14)(q24;q11) translocation in a T-cell leukemia (L1-ALL) with c-myc and TcR-alpha chain locus rearrangements. Int J Cancer (1986) 1.43
Upper keratinocytes of psoriatic skin lesions express high levels of NAP-1/IL-8 mRNA in situ. J Invest Dermatol (1991) 1.43
A review of nearly two decades in an autologous blood programme: The rise and fall of activity. Transfus Med (2006) 1.42
[Auditory processing and perception disorders--diagnostics. Guidelines of the German Society of Phoniatrics and Pedaudiology]. HNO (2010) 1.42
[The Dr phenotype: a study of threee cases with a ring D chromosome]. Ann Genet (1968) 1.41
Maternal 3-methylglutaconic aciduria associated with abnormalities in offspring. Lancet (1996) 1.40
Does pH paper accurately reflect gastric pH? Crit Care Med (1990) 1.39
Two site-specific deletions and t(1;14) translocation restricted to human T-cell acute leukemias disrupt the 5' part of the tal-1 gene. Oncogene (1991) 1.39
SF3B1 mutations in myelodysplastic syndromes: clinical associations and prognostic implications. Leukemia (2011) 1.38
Measles vaccination in early infancy. Lancet (1990) 1.38
Association of the H-Y male antigen with beta2-microglobulin on human lymphoid and differentiated mouse teratocarcinoma cell lines. J Exp Med (1978) 1.38
Genomic organization and partial duplication of the human alpha7 neuronal nicotinic acetylcholine receptor gene (CHRNA7). Genomics (1998) 1.36
Rearrangements of the retinoic acid receptor alpha and promyelocytic leukemia zinc finger genes resulting from t(11;17)(q23;q21) in a patient with acute promyelocytic leukemia. J Clin Invest (1993) 1.36
Report of the Committee on Chromosome Rearrangements in Neoplasia and on Fragile Sites. Cytogenet Cell Genet (1985) 1.36
Enhancement of Epstein-Barr virus membrane protein (LMP) expression by serum, TPA, or n-butyrate in latently infected Raji cells. Virology (1987) 1.35
Activating mutation in the TSLPR gene in B-cell precursor lymphoblastic leukemia. Leukemia (2009) 1.33
Hereditary tyrosinemia type I. Self-induced correction of the fumarylacetoacetase defect. J Clin Invest (1993) 1.32
Pure de-novo 5 Mb duplication at Xp11.22-p11.23 in a male: phenotypic and molecular characterization. J Hum Genet (2006) 1.31