Nuclear membrane protein LAP2beta mediates transcriptional repression alone and together with its binding partner GCL (germ-cell-less).

PubWeight™: 1.51‹?› | Rank: Top 4%

🔗 View Article (PMID 11591818)

Published in J Cell Sci on September 01, 2001

Authors

E Nili1, G S Cojocaru, Y Kalma, D Ginsberg, N G Copeland, D J Gilbert, N A Jenkins, R Berger, S Shaklai, N Amariglio, F Brok-Simoni, A J Simon, G Rechavi

Author Affiliations

1: Pediatric Hemato-Oncology Department, Division of Hematology, Chaim Sheba Medical Center, Tel-Hashomer and the Sackler School of Medicine, Tel-Aviv University, Israel.

Articles citing this

Recruitment to the nuclear periphery can alter expression of genes in human cells. PLoS Genet (2008) 3.75

Abnormal nuclear shape and impaired mechanotransduction in emerin-deficient cells. J Cell Biol (2005) 2.66

Transcription-dependent spatial arrangements of CFTR and adjacent genes in human cell nuclei. J Cell Biol (2004) 2.43

Alteration of nuclear lamin organization inhibits RNA polymerase II-dependent transcription. J Cell Biol (2002) 2.14

MAN1 and emerin have overlapping function(s) essential for chromosome segregation and cell division in Caenorhabditis elegans. Proc Natl Acad Sci U S A (2003) 1.73

Emerin caps the pointed end of actin filaments: evidence for an actin cortical network at the nuclear inner membrane. PLoS Biol (2004) 1.72

Nuclear lamins: key regulators of nuclear structure and activities. J Cell Mol Med (2009) 1.70

Lamin-binding Proteins. Cold Spring Harb Perspect Biol (2010) 1.69

Role of A-type lamins in signaling, transcription, and chromatin organization. J Cell Biol (2009) 1.68

The inner nuclear envelope as a transcription factor resting place. EMBO Rep (2007) 1.61

An emerin "proteome": purification of distinct emerin-containing complexes from HeLa cells suggests molecular basis for diverse roles including gene regulation, mRNA splicing, signaling, mechanosensing, and nuclear architecture. Biochemistry (2007) 1.48

miR-23 regulation of lamin B1 is crucial for oligodendrocyte development and myelination. Dis Model Mech (2009) 1.46

The nuclear envelope at a glance. J Cell Sci (2010) 1.38

Lamina-associated polypeptide 2alpha regulates cell cycle progression and differentiation via the retinoblastoma-E2F pathway. J Cell Biol (2006) 1.38

Gene positioning and expression. Curr Opin Cell Biol (2011) 1.26

The transcriptionally active amyloid precursor protein (APP) intracellular domain is preferentially produced from the 695 isoform of APP in a {beta}-secretase-dependent pathway. J Biol Chem (2010) 1.21

Dynamic chromatin organization during foregut development mediated by the organ selector gene PHA-4/FoxA. PLoS Genet (2010) 1.12

Mouse germ cell-less as an essential component for nuclear integrity. Mol Cell Biol (2003) 1.09

The nuclear envelope as a chromatin organizer. Nucleus (2011) 1.06

Evolvement of LEM proteins as chromatin tethers at the nuclear periphery. Biochem Soc Trans (2011) 1.04

HA95 and LAP2 beta mediate a novel chromatin-nuclear envelope interaction implicated in initiation of DNA replication. J Cell Biol (2003) 1.03

Mouse neutrophils lacking lamin B-receptor expression exhibit aberrant development and lack critical functional responses. Exp Hematol (2008) 1.02

The nuclear envelope LEM-domain protein emerin. Nucleus (2013) 0.99

Cellular mechanosensing: getting to the nucleus of it all. Prog Biophys Mol Biol (2014) 0.99

Tyrosine phosphorylation of nuclear-membrane protein emerin by Src, Abl and other kinases. J Cell Sci (2009) 0.97

The endonuclease Ankle1 requires its LEM and GIY-YIG motifs for DNA cleavage in vivo. J Cell Sci (2012) 0.97

Tissue specificity in the nuclear envelope supports its functional complexity. Nucleus (2013) 0.96

Multiple roles for emerin: implications for Emery-Dreifuss muscular dystrophy. Anat Rec A Discov Mol Cell Evol Biol (2006) 0.95

Nuclear membrane diversity: underlying tissue-specific pathologies in disease? Curr Opin Cell Biol (2015) 0.93

Nuclear mechanics in cancer. Adv Exp Med Biol (2014) 0.88

Structural determinants for nuclear envelope localization and function of pseudorabies virus pUL34. J Virol (2011) 0.87

Outfits for different occasions: tissue-specific roles of Nuclear Envelope proteins. Curr Opin Cell Biol (2012) 0.85

Gene clusters, molecular evolution and disease: a speculation. Curr Genomics (2009) 0.85

Functional disruption of the moloney murine leukemia virus preintegration complex by vaccinia-related kinases. J Biol Chem (2010) 0.85

Chromatin states and nuclear organization in development--a view from the nuclear lamina. Genome Biol (2015) 0.84

Chromatin at the nuclear periphery and the regulation of genome functions. Histochem Cell Biol (2015) 0.83

Lamina-associated polypeptide (LAP)2α and other LEM proteins in cancer biology. Adv Exp Med Biol (2014) 0.83

Chromatin remodelling initiation during human spermiogenesis. Biol Open (2012) 0.81

Emerin in health and disease. Semin Cell Dev Biol (2013) 0.81

A-type lamins bind both hetero- and euchromatin, the latter being regulated by lamina-associated polypeptide 2 alpha. Genome Res (2016) 0.81

LAP2 is widely overexpressed in diverse digestive tract cancers and regulates motility of cancer cells. PLoS One (2012) 0.80

Embryonic and adult isoforms of XLAP2 form microdomains associated with chromatin and the nuclear envelope. Cell Tissue Res (2011) 0.80

Induction of polyploidy by nuclear fusion mechanism upon decreased expression of the nuclear envelope protein LAP2β in the human osteosarcoma cell line U2OS. Mol Cytogenet (2014) 0.79

Barrier-to-Autointegration Factor 1 (BAF/BANF1) Promotes Association of the SETD1A Histone Methyltransferase with Herpes Simplex Virus Immediate-Early Gene Promoters. MBio (2015) 0.79

GAGE cancer-germline antigens are recruited to the nuclear envelope by germ cell-less (GCL). PLoS One (2012) 0.78

Anchoring a Leviathan: How the Nuclear Membrane Tethers the Genome. Front Genet (2016) 0.77

Xenopus LAP2β protein knockdown affects location of lamin B and nucleoporins and has effect on assembly of cell nucleus and cell viability. Protoplasma (2015) 0.76

Insulin-response epigenetic activation of Egr-1 and JunB genes at the nuclear periphery by A-type lamin-associated pY19-Caveolin-2 in the inner nuclear membrane. Nucleic Acids Res (2015) 0.75

Nucleo-cytoplasmic shuttling of the endonuclease ankyrin repeats and LEM domain-containing protein 1 (Ankle1) is mediated by canonical nuclear export- and nuclear import signals. BMC Cell Biol (2016) 0.75

Tissue-specific NETs alter genome organization and regulation even in a heterologous system. Nucleus (2017) 0.75

Articles by these authors

An efficient recombination system for chromosome engineering in Escherichia coli. Proc Natl Acad Sci U S A (2000) 17.30

A highly efficient Escherichia coli-based chromosome engineering system adapted for recombinogenic targeting and subcloning of BAC DNA. Genomics (2001) 15.03

The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer. Cell (1993) 13.54

Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. Nature (1992) 12.92

Recombineering: a powerful new tool for mouse functional genomics. Nat Rev Genet (2001) 8.35

Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand. Cell (1994) 7.23

Deletions and a translocation interrupt a cloned gene at the neurofibromatosis type 1 locus. Cell (1990) 6.94

Organization, distribution, and stability of endogenous ecotropic murine leukemia virus DNA sequences in chromosomes of Mus musculus. J Virol (1982) 6.56

ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions. Neuron (1997) 6.16

TNF-alpha induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway. Cell (2000) 6.07

An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria. Neuron (1995) 6.03

Mutation of unique region of Bruton's tyrosine kinase in immunodeficient XID mice. Science (1993) 5.50

Arc, a growth factor and activity-regulated gene, encodes a novel cytoskeleton-associated protein that is enriched in neuronal dendrites. Neuron (1995) 5.43

Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo. Neuron (1996) 5.30

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo. Neuron (1996) 5.14

Binding and modulation of p53 by p300/CBP coactivators. Nature (1997) 5.12

CD40 ligand gene defects responsible for X-linked hyper-IgM syndrome. Science (1993) 5.04

Mutations at the mouse microphthalmia locus are associated with defects in a gene encoding a novel basic-helix-loop-helix-zipper protein. Cell (1993) 5.00

Dilute (d) coat colour mutation of DBA/2J mice is associated with the site of integration of an ecotropic MuLV genome. Nature (1981) 4.77

Co-expression of multiple transgenes in mouse CNS: a comparison of strategies. Biomol Eng (2001) 4.64

Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins. Neuron (1997) 4.49

Id proteins Id1 and Id2 selectively inhibit DNA binding by one class of helix-loop-helix proteins. Mol Cell Biol (1991) 4.42

All-trans retinoic acid as a differentiation therapy for acute promyelocytic leukemia. I. Clinical results. Blood (1990) 4.36

Crx, a novel Otx-like paired-homeodomain protein, binds to and transactivates photoreceptor cell-specific genes. Neuron (1997) 4.33

NB4, a maturation inducible cell line with t(15;17) marker isolated from a human acute promyelocytic leukemia (M3). Blood (1991) 4.30

Structure, localization and transcriptional properties of two classes of retinoic acid receptor alpha fusion proteins in acute promyelocytic leukemia (APL): structural similarities with a new family of oncoproteins. EMBO J (1992) 4.30

A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia. Science (1997) 4.29

A genetic linkage map of the mouse: current applications and future prospects. Science (1993) 4.24

Induction of apoptosis by the mouse Nedd2 gene, which encodes a protein similar to the product of the Caenorhabditis elegans cell death gene ced-3 and the mammalian IL-1 beta-converting enzyme. Genes Dev (1994) 4.19

Development and applications of a molecular genetic linkage map of the mouse genome. Trends Genet (1991) 4.17

The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H mice. Nat Genet (1998) 4.06

Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin. Hum Mol Genet (1999) 4.06

Limb alterations in brachypodism mice due to mutations in a new member of the TGF beta-superfamily. Nature (1994) 3.99

A broadly neutralizing human monoclonal antibody against gp41 of human immunodeficiency virus type 1. AIDS Res Hum Retroviruses (1994) 3.97

Novel myosin heavy chain encoded by murine dilute coat colour locus. Nature (1991) 3.95

Six3, a murine homologue of the sine oculis gene, demarcates the most anterior border of the developing neural plate and is expressed during eye development. Development (1995) 3.90

A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors. EMBO J (1995) 3.78

Retroviral activation of a novel gene encoding a zinc finger protein in IL-3-dependent myeloid leukemia cell lines. Cell (1988) 3.75

The promise of comparative genomics in mammals. Science (1999) 3.67

The cDNA structure, expression, and chromosomal assignment of the mouse Fas antigen. J Immunol (1992) 3.66

Excision of the DBA ecotropic provirus in dilute coat-color revertants of mice occurs by homologous recombination involving the viral LTRs. Cell (1983) 3.66

Improved left ventricular mechanics from acute VDD pacing in patients with dilated cardiomyopathy and ventricular conduction delay. Circulation (1999) 3.62

Cloning of the murine thymic stromal lymphopoietin (TSLP) receptor: Formation of a functional heteromeric complex requires interleukin 7 receptor. J Exp Med (2000) 3.51

Comparative anchor tagged sequences (CATS) for integrative mapping of mammalian genomes. Nat Genet (1997) 3.47

microphthalmia, a critical factor in melanocyte development, defines a discrete transcription factor family. Genes Dev (1994) 3.44

The mouse waved-2 phenotype results from a point mutation in the EGF receptor tyrosine kinase. Genes Dev (1994) 3.42

Targeted disruption of the neurofibromatosis type-1 gene leads to developmental abnormalities in heart and various neural crest-derived tissues. Genes Dev (1994) 3.40

The mouse Snell's waltzer deafness gene encodes an unconventional myosin required for structural integrity of inner ear hair cells. Nat Genet (1995) 3.40

Loss of alleles at loci on human chromosome 11 during genesis of Wilms' tumour. Nature (1984) 3.37

Identification of a minimal transforming domain of p53: negative dominance through abrogation of sequence-specific DNA binding. Mol Cell Biol (1992) 3.37

The laminin alpha chains: expression, developmental transitions, and chromosomal locations of alpha1-5, identification of heterotrimeric laminins 8-11, and cloning of a novel alpha3 isoform. J Cell Biol (1997) 3.34

Cooperative activation of Hoxa and Pbx1-related genes in murine myeloid leukaemias. Nat Genet (1996) 3.32

DNA microarrays identification of primary and secondary target genes regulated by p53. Oncogene (2001) 3.28