Published in Blood on December 01, 1995
Deconstructing sickle cell disease: reappraisal of the role of hemolysis in the development of clinical subphenotypes. Blood Rev (2006) 4.46
Markers of severe vaso-occlusive painful episode frequency in children and adolescents with sickle cell anemia. J Pediatr (2011) 1.05
Apolipoprotein A-I and serum amyloid A plasma levels are biomarkers of acute painful episodes in patients with sickle cell disease. Haematologica (2010) 0.90
Novel small molecule therapeutics for sickle cell disease: nitric oxide, carbon monoxide, nitrite, and apolipoprotein A-I. Hematology Am Soc Hematol Educ Program (2008) 0.84
Alpha thalassemia among sickle cell anaemia patients in Kampala, Uganda. Afr Health Sci (2015) 0.83
Genotypic influence of α-deletions on the phenotype of Indian sickle cell anemia patients. Korean J Hematol (2011) 0.82
Emerging point-of-care technologies for sickle cell disease screening and monitoring. Expert Rev Med Devices (2016) 0.75
Correction of sickle cell disease in transgenic mouse models by gene therapy. Science (2001) 3.25
Evidence for the multicentric origin of the sickle cell hemoglobin gene in Africa. Proc Natl Acad Sci U S A (1984) 2.86
Rosetting of Plasmodium falciparum-infected red blood cells with uninfected red blood cells enhances microvascular obstruction under flow conditions. Blood (1991) 2.18
Shear stress enhances the proteolysis of von Willebrand factor in normal plasma. Blood (1994) 2.12
Polymerase chain reaction amplification applied to the determination of beta-like globin gene cluster haplotypes. Am J Hematol (1989) 2.04
Sickle cell anemia day hospital: an approach for the management of uncomplicated painful crises. Blood (2000) 1.95
Hematologically and genetically distinct forms of sickle cell anemia in Africa. The Senegal type and the Benin type. N Engl J Med (1985) 1.90
Ligand-induced conformational dependence of hemoglobin in sickling interactios. J Mol Biol (1971) 1.89
Common haplotype dependency of high G gamma-globin gene expression and high Hb F levels in beta-thalassemia and sickle cell anemia patients. Proc Natl Acad Sci U S A (1985) 1.85
Microvascular sites and characteristics of sickle cell adhesion to vascular endothelium in shear flow conditions: pathophysiological implications. Proc Natl Acad Sci U S A (1989) 1.79
Monoclonal antibodies to alphaVbeta3 (7E3 and LM609) inhibit sickle red blood cell-endothelium interactions induced by platelet-activating factor. Blood (2000) 1.77
Membrane knobs are required for the microcirculatory obstruction induced by Plasmodium falciparum-infected erythrocytes. Proc Natl Acad Sci U S A (1985) 1.68
Impaired nitric oxide-mediated vasodilation in transgenic sickle mouse. Am J Physiol Heart Circ Physiol (2000) 1.63
Preliminary report on the use of desferrioxamine in the treatment of Plasmodium falciparum malaria. Am J Hematol (1991) 1.54
Structural bases of the inhibitory effects of hemoglobin F and hemoglobin A2 on the polymerization of hemoglobin S. Proc Natl Acad Sci U S A (1979) 1.50
Heterogeneity of red cells in the sickler: a characteristic with practical clinical and pathophysiological implications. Blood Cells (1982) 1.49
Erythrocytes in sickle cell anemia are heterogeneous in their rheological and hemodynamic characteristics. J Clin Invest (1983) 1.48
The binding of hemoglobin to haptoglobin and its relation to subunit dissociation of hemoglobin. J Biol Chem (1971) 1.44
High expression of human beta S- and alpha-globins in transgenic mice: hemoglobin composition and hematological consequences. Proc Natl Acad Sci U S A (1992) 1.42
Effect of alpha-thalassemia on sickle-cell anemia linked to the Arab-Indian haplotype in India. Am J Hematol (1997) 1.40
Plasmodium falciparum: inhibition of in vitro growth by desferrioxamine. Am J Trop Med Hyg (1982) 1.39
High expression of human beta S- and alpha-globins in transgenic mice: erythrocyte abnormalities, organ damage, and the effect of hypoxia. Proc Natl Acad Sci U S A (1992) 1.37
Structure and properties of hemoglobin C-Harlem, a human hemoglobin variant with amino acid substitutions in 2 residues of the beta-polypeptide chain. J Biol Chem (1967) 1.34
The -158 site 5' to the G gamma gene and G gamma expression. Blood (1985) 1.34
Nuclear magnetic relaxation dispersion in protein solutions. IV. Proton relaxation at the active site of carbonic anhydrase. J Biol Chem (1970) 1.32
Volume-dependent and NEM-stimulated K+,Cl- transport is elevated in oxygenated SS, SC and CC human red cells. FEBS Lett (1986) 1.32
Sickling rates of human AS red cells infected in vitro with Plasmodium falciparum malaria. Science (1978) 1.31
The hematologic characteristics of sickle cell anemia bearing the Bantu haplotype: the relationship between G gamma and HbF level. Blood (1987) 1.29
An objective sign in painful crisis in sickle cell anemia: the concomitant reduction of high density red cells. Blood (1984) 1.27
Glucose-6-phosphate dehydrogenase deficiency inhibits in vitro growth of Plasmodium falciparum. Proc Natl Acad Sci U S A (1983) 1.25
Water exchange between red cells and plasma. Measurement by nuclear magnetic relaxation. Biophys J (1975) 1.25
Plasmodium falciparum: enhanced gametocyte formation in vitro in reticulocyte-rich blood. Exp Parasitol (1999) 1.24
SC erythrocytes have an abnormally high intracellular hemoglobin concentration. Pathophysiological consequences. J Clin Invest (1982) 1.18
Transgenic mice expressing human fetal globin are protected from malaria by a novel mechanism. Blood (1998) 1.18
In vivo demonstration of red cell-endothelial interaction, sickling and altered microvascular response to oxygen in the sickle transgenic mouse. J Clin Invest (1995) 1.15
Water exchange across red cell membranes: II. Measurements by nuclear magnetic resonance T1, T2, and T12 hybrid relaxation. The effects of osmolarity, cell volume, and medium. J Membr Biol (1978) 1.14
The effect of beta 73 Asn on the interactions of sickling hemoglobins. Biochim Biophys Acta (1970) 1.14
Effect of magnetic susceptibility on nuclear magnetic resonance signals arising from red cells: a warning. Biochemistry (1983) 1.14
Genetic epidemiology of the beta s gene. Baillieres Clin Haematol (1992) 1.14
Second generation knockout sickle mice: the effect of HbF. Blood (2001) 1.14
Gender and haplotype effects upon hematological manifestations of adult sickle cell anemia. Am J Hematol (1995) 1.13
Beta-chain contact sites in the haemoglobin S polymer. Nature (1980) 1.13
Proteolytic cleavage of recombinant type 2A von Willebrand factor mutants R834W and R834Q: inhibition by doxycycline and by monoclonal antibody VP-1. Blood (1997) 1.12
A second generation transgenic mouse model expressing both hemoglobin S (HbS) and HbS-Antilles results in increased phenotypic severity. Blood (1995) 1.12
Cerebral malaria in mice: demonstration of cytoadherence of infected red blood cells and microrheologic correlates. Am J Trop Med Hyg (1994) 1.11
Volume-stimulated, Cl(-)-dependent K+ efflux is highly expressed in young human red cells containing normal hemoglobin or HbS. J Membr Biol (1987) 1.10
Vaso-occlusion by sickle cells: evidence for selective trapping of dense red cells. Blood (1986) 1.09
On the mechanism for the red-cell accumulation of mefloquine, an antimalarial drug. Biochim Biophys Acta (1984) 1.09
Glutathione stability and oxidative stress in P. falciparum infection in vitro: responses of normal and G6PD deficient cells. Biochem Biophys Res Commun (1982) 1.09
Multimeric composition of endothelial cell-derived von Willebrand factor. Blood (1989) 1.09
Molecular cloning of human protein 4.2: a major component of the erythrocyte membrane. Proc Natl Acad Sci U S A (1990) 1.08
Spectrum of beta thalassemia mutations and their linkage to beta-globin gene haplotypes in the Indo-Mauritians. Am J Hematol (2000) 1.08
Sulfhemoglobinemia. Clinical and molecular aspects. N Engl J Med (1984) 1.08
Deoxygenation inhibits the volume-stimulated, Cl(-)-dependent K+ efflux in SS and young AA cells: a cytosolic Mg2+ modulation. Blood (1987) 1.07
The binding of hemoglobin to membranes of normal and sickle erythrocytes. Biochim Biophys Acta (1975) 1.07
Oxidation of spectrin and deformability defects in diabetic erythrocytes. Diabetes (1991) 1.07
The pathophysiology of vascular obstruction in the sickle syndromes. Blood Rev (1996) 1.06
The sickle gene polymorphism in North Africa. Blood (1981) 1.06
Accuracy of pulse oximetry in sickle cell disease. Am J Respir Crit Care Med (1999) 1.06
An increased Bohr effect in sickle cell anemia. Blood (1979) 1.06
Sickle gene. Its origin and diffusion from West Africa. J Clin Invest (1981) 1.06
Relation between structure and function in Hemoglobin Chesapeake. Biochemistry (1967) 1.04
Transgenic mice expressing human sickle hemoglobin are partially resistant to rodent malaria. Blood (1993) 1.04
Renal nitric oxide synthases in transgenic sickle cell mice. Kidney Int (1996) 1.04
HbS-oman heterozygote: a new dominant sickle syndrome. Blood (1998) 1.03
The effect of deoxygenation on red cell density: significance for the pathophysiology of sickle cell anemia. Blood (1982) 1.03
Sickle erythrocyte-endothelial interactions in microcirculation: the role of von Willebrand factor and implications for vasoocclusion. Blood (1993) 1.03
The Senegal DNA haplotype is associated with the amelioration of anemia in African-American sickle cell anemia patients. Blood (1991) 1.02
Some aspects of the pathophysiology of homozygous Hb CC erythrocytes. J Clin Invest (1981) 1.02
Microvascular hemodynamics and in vivo evidence for the role of intercellular adhesion molecule-1 in the sequestration of infected red blood cells in a mouse model of lethal malaria. Am J Trop Med Hyg (1998) 1.02
Effect of alkylureas on the polymerization of hemoglobin S. Proc Natl Acad Sci U S A (1974) 1.02
Growth of Plasmodium falciparum in human erythrocytes containing abnormal membrane proteins. Proc Natl Acad Sci U S A (1990) 1.02
Acute priapism associated with the use of sildenafil in a patient with sickle cell trait. Blood (2000) 1.01
The percentage of dense red cells does not predict incidence of sickle cell painful crisis. Blood (1986) 1.01
The high molecular weight form of endothelial cell von Willebrand factor is released by the regulated pathway. Br J Haematol (1991) 0.99