Published in Invest Ophthalmol Vis Sci on December 01, 1993
The pivotal role of the complement system in aging and age-related macular degeneration: hypothesis re-visited. Prog Retin Eye Res (2009) 3.40
Membrane cofactor protein is a receptor for adenoviruses associated with epidemic keratoconjunctivitis. J Virol (2004) 1.77
The role of complement system in ocular diseases including uveitis and macular degeneration. Mol Immunol (2007) 1.37
Chronic low level complement activation within the eye is controlled by intraocular complement regulatory proteins. Invest Ophthalmol Vis Sci (2000) 1.27
Oxidative stress and the regulation of complement activation in human glaucoma. Invest Ophthalmol Vis Sci (2010) 1.21
Xenotransplantation--the future of corneal transplantation? Cornea (2011) 1.10
Complement regulatory activity of normal human intraocular fluid is mediated by MCP, DAF, and CD59. Invest Ophthalmol Vis Sci (2000) 1.07
Immune escape mechanisms of intraocular tumors. Prog Retin Eye Res (2009) 1.07
The role of complement in ocular pathology. Semin Immunopathol (2008) 1.07
Pathogenesis of acanthamoeba keratitis. Ocul Surf (2010) 1.05
Sub-lytic C5b-9 induces functional changes in retinal pigment epithelial cells consistent with age-related macular degeneration. Eye (Lond) (2011) 1.04
CD59 blocks not only the insertion of C9 into MAC but inhibits ion channel formation by homologous C5b-8 as well as C5b-9. J Physiol (2002) 1.02
Immune privilege of corneal allografts. Ocul Immunol Inflamm (2010) 1.01
Initial in vitro investigation of the human immune response to corneal cells from genetically engineered pigs. Invest Ophthalmol Vis Sci (2011) 1.01
Alternate serotype adenovector provides long-term therapeutic gene expression in the eye. Mol Vis (2008) 0.98
Complement gene expression and regulation in mouse retina and retinal pigment epithelium/choroid. Mol Vis (2011) 0.98
Corneal transplantation and immune privilege. Int Rev Immunol (2013) 0.91
Ocular immune privilege and ocular melanoma: parallel universes or immunological plagiarism? Front Immunol (2012) 0.90
Decay accelerating factor is essential for successful corneal engraftment. Am J Transplant (2010) 0.87
Tears contain the complement regulator CD59 as well as decay-accelerating factor (DAF). Clin Exp Immunol (2001) 0.86
Complement factor H deficiency results in decreased neuroretinal expression of Cd59a in aged mice. Invest Ophthalmol Vis Sci (2012) 0.85
Complement regulatory protein CD46 protects against choroidal neovascularization in mice. Am J Pathol (2014) 0.83
Blockage of complement regulators in the conjunctiva and within the eye leads to massive inflammation and iritis. Immunology (2001) 0.82
Cornea: Window to Ocular Immunology. Curr Immunol Rev (2011) 0.81
Ocular Immune Privilege and Transplantation. Front Immunol (2016) 0.80
Immunology of Corneal Allografts: Insights from Animal Models. J Clin Exp Ophthalmol (2015) 0.79
Alloimmunity and Tolerance in Corneal Transplantation. J Immunol (2016) 0.79
Induction of interleukin-6 in human retinal epithelial cells by an attenuated Herpes simplex virus vector requires viral replication and NFkappaB activation. Exp Eye Res (2007) 0.77
Enhanced expression of the complement factor H mRNA in proliferating human RPE cells. Graefes Arch Clin Exp Ophthalmol (2010) 0.77
[The complement system and its possible role in the pathogenesis of age-related macular degeneration (AMD)]. Ophthalmologe (2005) 0.77
Can innate and autoimmune reactivity forecast early and advance stages of age-related macular degeneration? Autoimmun Rev (2017) 0.76
Cell death and the immune response: a lesson from the privileged. J Clin Immunol (1997) 0.76
High-risk corneal allografts: A therapeutic challenge. World J Transplant (2016) 0.75
Passive immunization with Pneumovax® 23 and pneumolysin in combination with vancomycin for pneumococcal endophthalmitis. BMC Ophthalmol (2013) 0.75
Retinal Pre-Conditioning by CD59a Knockout Protects against Light-Induced Photoreceptor Degeneration. PLoS One (2016) 0.75
Membrane cofactor protein (MCP or CD46): newest member of the regulators of complement activation gene cluster. Annu Rev Immunol (1991) 4.27
Decay-accelerating factor: biochemistry, molecular biology, and function. Annu Rev Immunol (1989) 3.20
Hereditary angioedema: the clinical syndrome and its management. Ann Intern Med (1976) 3.10
Purification and characterization of a membrane protein (gp45-70) that is a cofactor for cleavage of C3b and C4b. J Exp Med (1986) 2.94
Acquired immune deficiency syndrome. Pathogenic mechanisms of ocular disease. Ophthalmology (1985) 2.89
Measles virus spread and pathogenesis in genetically modified mice. J Virol (1998) 2.84
Molecular cloning and chromosomal localization of human membrane cofactor protein (MCP). Evidence for inclusion in the multigene family of complement-regulatory proteins. J Exp Med (1988) 2.75
Receptors for immunoglobulin and complement on human alveolar macrophages. J Immunol (1975) 2.74
Membrane cofactor protein (MCP or CD46) is a cellular pilus receptor for pathogenic Neisseria. Mol Microbiol (1997) 2.67
The regulators of complement activation (RCA) gene cluster. Adv Immunol (1989) 2.63
Acquired immune deficiency syndrome. Ocular manifestations. Ophthalmology (1983) 2.63
Cloning and characterization of cDNAs encoding the complete sequence of decay-accelerating factor of human complement. Proc Natl Acad Sci U S A (1987) 2.62
Control of the complement system. Adv Immunol (1996) 2.43
Clinical experience with the surgical removal of subfoveal neovascular membranes. Short-term postoperative results. Ophthalmology (1992) 2.33
Polymorphism of human erythrocyte C3b/C4b receptor. Proc Natl Acad Sci U S A (1983) 2.30
A controlled retrospective study of ganciclovir treatment for cytomegalovirus retinopathy. Use of a standardized system for the assessment of disease outcome. UCLA CMV Retinopathy. Study Group. Arch Ophthalmol (1989) 2.25
Role of virion-associated glycosylphosphatidylinositol-linked proteins CD55 and CD59 in complement resistance of cell line-derived and primary isolates of HIV-1. J Exp Med (1995) 2.12
Human genes for three complement components that regulate the activation of C3 are tightly linked. J Exp Med (1985) 2.12
Identification of an additional class of C3-binding membrane proteins of human peripheral blood leukocytes and cell lines. Proc Natl Acad Sci U S A (1985) 2.11
Multiple isoforms of CD46 (membrane cofactor protein) serve as receptors for measles virus. Proc Natl Acad Sci U S A (1994) 2.08
Systemic capillary leak syndrome and monoclonal IgG gammopathy; studies in a sixth patient and a review of the literature. Medicine (Baltimore) (1977) 2.07
Submacular surgery for subfoveal choroidal neovascular membranes in patients with presumed ocular histoplasmosis. Arch Ophthalmol (1997) 2.01
In vivo characterization of site-directed mutations in the promoter of the herpes simplex virus type 1 latency-associated transcripts. J Gen Virol (1993) 1.93
Molecular cloning, sequencing, and expression of the 36 kDa protein present in pars planitis. Sequence homology with yeast nucleopore complex protein. Invest Ophthalmol Vis Sci (1996) 1.93
Membrane cofactor protein (CD46) is a keratinocyte receptor for the M protein of the group A streptococcus. Proc Natl Acad Sci U S A (1995) 1.86
Dissecting sites important for complement regulatory activity in membrane cofactor protein (MCP; CD46). J Biol Chem (2000) 1.84
Molecular characterization of the Ss and Slp (C4) proteins of the mouse H-2 complex: subunit composition, chain size polymorphism, and an intracellular (PRO-Ss) precursor. J Immunol (1978) 1.75
Herpes simplex virus glycoproteins gC-1 and gC-2 bind to the third component of complement and provide protection against complement-mediated neutralization of viral infectivity. J Exp Med (1987) 1.74
Membrane cofactor protein of complement is present on human fibroblast, epithelial, and endothelial cells. J Clin Invest (1989) 1.70
Evaluation of the TREX1 gene in a large multi-ancestral lupus cohort. Genes Immun (2011) 1.70
Lensectomy and vitrectomy for complicated cataract secondary to uveitis. Arch Ophthalmol (1978) 1.69
Functional properties of membrane cofactor protein of complement. Biochem J (1989) 1.68
Polymorphism of the human C3b/C4b receptor. Identification of a third allele and analysis of receptor phenotypes in families and patients with systemic lupus erythematosus. J Exp Med (1984) 1.68
Decay-accelerating factor functions as a signal transducing molecule for human T cells. J Immunol (1988) 1.67
Vaso-occlusive retinopathy associated with antiphospholipid antibodies (lupus anticoagulant retinopathy). Ophthalmology (1989) 1.66
Immune response to immunization via the anterior chamber of the eye. I. F. lymphocyte-induced immune deviation. J Immunol (1977) 1.65
Complement factor C3 deposition and serum resistance in isogenic capsule and lipooligosaccharide sialic acid mutants of serogroup B Neisseria meningitidis. Infect Immun (1997) 1.65
Measles virus and C3 binding sites are distinct on membrane cofactor protein (CD46). Proc Natl Acad Sci U S A (1995) 1.64
Contribution of the repeating domains of membrane cofactor protein (CD46) of the complement system to ligand binding and cofactor activity. J Immunol (1991) 1.63
Bladder toxicity with chronic oral cyclophosphamide therapy in nonmalignant disease. Arthritis Rheum (1973) 1.61
Membrane cofactor protein (MCP; CD46): isoform-specific tyrosine phosphorylation. J Immunol (2000) 1.59
Immune response to immunization via the anterior chamber of the eye. II. An analysis of F1 lymphocyte-induced immune deviation. J Immunol (1978) 1.59
Human immunodeficiency virus type 1 incorporates both glycosyl phosphatidylinositol-anchored CD55 and CD59 and integral membrane CD46 at levels that protect from complement-mediated destruction. J Gen Virol (1997) 1.59
The effect of Bacillus Calmette-Guerin-induced macrophage activation on the in vivo clearance of sensitized erythrocytes. J Clin Invest (1974) 1.58
Surgical removal of a subretinal proliferating cysticercus of taeniaeformis crassiceps. Arch Ophthalmol (1997) 1.57
Distribution of membrane cofactor protein of complement on human peripheral blood cells. An altered form is found on granulocytes. Eur J Immunol (1988) 1.55
Hereditary vascular retinopathy, cerebroretinal vasculopathy, and hereditary endotheliopathy with retinopathy, nephropathy, and stroke map to a single locus on chromosome 3p21.1-p21.3. Am J Hum Genet (2001) 1.54
Studies on the in vivo effects of antibody. Interaction of IgM antibody and complement in the immune clearance and destruction of erythrocytes in man. J Clin Invest (1974) 1.54
Induction of a transient elevation in intracellular levels of adenosine-3',5'-cyclic monophosphate by chemotactic factors: an early event in human neutrophil activation. J Immunol (1980) 1.54
Endotoxin-induced uveitis in the rat is attenuated by inhibition of nitric oxide production. Invest Ophthalmol Vis Sci (1994) 1.53
Mapping of the region of complement receptor (CR) 1 required for Plasmodium falciparum rosetting and demonstration of the importance of CR1 in rosetting in field isolates. J Immunol (2000) 1.48
Structure-function relationships of complement receptor type 1. Immunol Rev (2001) 1.47
Characterization of a murine model of recurrent herpes simplex viral keratitis induced by ultraviolet B radiation. Invest Ophthalmol Vis Sci (1991) 1.47
Binding of measles virus to membrane cofactor protein (CD46): importance of disulfide bonds and N-glycans for the receptor function. J Virol (1994) 1.46
Proliferative vitreoretinopathy membranes. An immunohistochemical study. Ophthalmology (1989) 1.45
The human cell-surface glycoproteins HuLy-m5, membrane co-factor protein (MCP) of the complement system, and trophoblast leucocyte-common (TLX) antigen, are CD46. Immunology (1990) 1.45
Varicella zoster virus is a cause of the acute retinal necrosis syndrome. Ophthalmology (1986) 1.43
Structural heterogeneity of the C3b/C4b receptor (Cr 1) on human peripheral blood cells. J Exp Med (1983) 1.43
Biosynthesis and glycosylation of the human complement regulatory protein decay-accelerating factor. J Immunol (1986) 1.41
Membrane cofactor protein (MCP; CD46). Isoforms differ in protection against the classical pathway of complement. J Immunol (1996) 1.41
Efficacy and safety of the ProTek (Vifilcon A) therapeutic soft contact lens after photorefractive keratectomy. Am J Ophthalmol (1998) 1.40
Screening corneal donors for transmissible disease. Safety, resources, and reason. Arch Ophthalmol (1991) 1.40
The role of complement in the clearance of cold agglutinin-sensitized erythrocytes in man. J Clin Invest (1976) 1.40
Débridement of the pig retinal pigment epithelium in vivo. Arch Ophthalmol (1995) 1.40
Characterization of three monoclonal antibodies to membrane co-factor protein (MCP) of the complement system and quantification of MCP by radioassay. Clin Exp Immunol (1991) 1.39
Genetic variation in glycosylation of the fourth component of murine complement. Association with hemolytic activity. J Biol Chem (1982) 1.39
Maximizing surgeon safety during excimer laser photorefractive procedures. Am J Ophthalmol (2000) 1.39
Membrane cofactor protein (CD46) protects cells from complement-mediated attack by an intrinsic mechanism. J Exp Med (1992) 1.38
Triple agent immunosuppression in serpiginous choroiditis. Ophthalmology (1991) 1.36
Decay-accelerating factor and membrane cofactor protein. Curr Top Microbiol Immunol (1990) 1.34
Sites within the complement C3b/C4b receptor important for the specificity of ligand binding. Proc Natl Acad Sci U S A (1991) 1.34
Herpes simplex virus type 2 as a cause of acute retinal necrosis syndrome in young patients. Ophthalmology (2001) 1.33
Posterior vitreous detachment with dispase. Retina (1998) 1.33
Demonstration of herpes group virus in acute retinal necrosis syndrome. Am J Ophthalmol (1986) 1.33
Polymorphism of the C3b/C4b receptor (CR1): characterization of a fourth allele. J Immunol (1985) 1.33
Improved cell surface radioiodination of macrophages. J Immunol Methods (1980) 1.30
Membrane cofactor protein: importance of N- and O-glycosylation for complement regulatory function. J Immunol (1998) 1.30
The gene encoding decay-accelerating factor (DAF) is located in the complement-regulatory locus on the long arm of chromosome 1. J Exp Med (1987) 1.29
The sensitivity of Neisseria gonorrhoeae, Chlamydia trachomatis, and herpes simplex type II to disinfection with povidone-iodine. Am J Ophthalmol (1990) 1.29
A polymorphism of the complement regulatory protein MCP (membrane cofactor protein or gp45-70). J Immunol (1987) 1.28
Chronic low level complement activation within the eye is controlled by intraocular complement regulatory proteins. Invest Ophthalmol Vis Sci (2000) 1.27
Epidemiology and diagnosis of acute conjunctivitis at an inner-city hospital. Ophthalmology (1989) 1.27
Birdshot retinochoroidopathy. Am J Ophthalmol (1980) 1.26
Membrane cofactor protein (CD46) protects cells predominantly from alternative complement pathway-mediated C3-fragment deposition and cytolysis. J Immunol (1993) 1.25
Molecular identification of Knops blood group polymorphisms found in long homologous region D of complement receptor 1. Blood (2001) 1.25
Functional domains, structural variations and pathogen interactions of MCP, DAF and CR1. Immunopharmacology (2000) 1.25
Isolation of a biologically active macrophage receptor for the third component of complement. Nature (1981) 1.24
Analysis of the functional domains of complement receptor type 1 (C3b/C4b receptor; CD35) by substitution mutagenesis. J Biol Chem (1994) 1.24
Pediatric and adolescent gynecology. I. Fundamental considerations. Gross anatomy. Ann N Y Acad Sci (1967) 1.24
Effects of corticosteroids and splenectomy on the immune clearance and destruction of erythrocytes. J Clin Invest (1973) 1.24
Purification and functional analysis of the polymorphic variants of the C3b/C4b receptor (CR1) and comparison with H, C4b-binding protein (C4bp), and decay accelerating factor (DAF). J Immunol (1985) 1.23
Voltage-sensitive potassium channels in Limulus ventral photoreceptors. J Gen Physiol (1978) 1.23
Distribution of growth factors in subfoveal neovascular membranes in age-related macular degeneration and presumed ocular histoplasmosis syndrome. Am J Ophthalmol (1995) 1.22
Decay accelerating activity of complement receptor type 1 (CD35). Two active sites are required for dissociating C5 convertases. J Biol Chem (1999) 1.22
Microassay for immunoglobulin G antibodies to Treponema pallidum with radioiodinated protein A from staphylococcus aureus: immunoglobulin G response in experimental syphilis in rabbits. Infect Immun (1978) 1.22
Diagnosis and management of hereditary angioedema (HAE). Ann Allergy (1979) 1.21
Attachment of Neisseria gonorrhoeae to the cellular pilus receptor CD46: identification of domains important for bacterial adherence. Cell Microbiol (2001) 1.21
Concurrent herpes simplex and cytomegalovirus retinitis and encephalitis in the acquired immune deficiency syndrome (AIDS). Ophthalmology (1984) 1.19