Published in Cell on September 23, 1994
Is the Exhaled Nitric Oxide in Infants a Predictive Marker of Asthma ? (NOnourisson) | NCT01239199
Nitric oxide and peroxynitrite in health and disease. Physiol Rev (2007) 15.49
Nitric oxide synthases: structure, function and inhibition. Biochem J (2001) 9.73
An official ATS clinical practice guideline: interpretation of exhaled nitric oxide levels (FENO) for clinical applications. Am J Respir Crit Care Med (2011) 5.53
Nitric oxide regulates exocytosis by S-nitrosylation of N-ethylmaleimide-sensitive factor. Cell (2003) 4.55
Predominant role of endothelial nitric oxide synthase in vascular endothelial growth factor-induced angiogenesis and vascular permeability. Proc Natl Acad Sci U S A (2001) 3.88
Nitric oxide synthases: which, where, how, and why? J Clin Invest (1997) 3.81
Role of oxidants in microbial pathophysiology. Clin Microbiol Rev (1997) 3.78
Inducible nitric oxide is essential for host control of persistent but not acute infection with the intracellular pathogen Toxoplasma gondii. J Exp Med (1997) 3.62
Mice lacking inducible nitric oxide synthase are not resistant to lipopolysaccharide-induced death. Proc Natl Acad Sci U S A (1995) 3.53
Nitric oxide synthase generates superoxide and nitric oxide in arginine-depleted cells leading to peroxynitrite-mediated cellular injury. Proc Natl Acad Sci U S A (1996) 3.29
A hypoxia-responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter. J Exp Med (1995) 2.88
Syntrophin mutation associated with long QT syndrome through activation of the nNOS-SCN5A macromolecular complex. Proc Natl Acad Sci U S A (2008) 2.79
Superoxide and peroxynitrite generation from inducible nitric oxide synthase in macrophages. Proc Natl Acad Sci U S A (1997) 2.47
Immunopathology of tuberculosis: roles of macrophages and monocytes. Infect Immun (1996) 2.41
Innate immunity in Arabidopsis thaliana: lipopolysaccharides activate nitric oxide synthase (NOS) and induce defense genes. Proc Natl Acad Sci U S A (2004) 2.40
A stress surveillance system based on calcium and nitric oxide in marine diatoms. PLoS Biol (2006) 2.40
Intestinal epithelial responses to enteric pathogens: effects on the tight junction barrier, ion transport, and inflammation. Gut (2003) 2.37
Hypotension and reduced nitric oxide-elicited vasorelaxation in transgenic mice overexpressing endothelial nitric oxide synthase. J Clin Invest (1998) 2.36
Tetrahydrobiopterin restores endothelial function in hypercholesterolemia. J Clin Invest (1997) 2.27
Specificity of a third kind: reactive oxygen and nitrogen intermediates in cell signaling. J Clin Invest (2003) 2.15
No .NO from NO synthase. Proc Natl Acad Sci U S A (1996) 2.14
Sensitizing soluble guanylyl cyclase to become a highly CO-sensitive enzyme. EMBO J (1996) 2.13
Cysteine-mediated redox signaling: chemistry, biology, and tools for discovery. Chem Rev (2013) 2.02
Heterozygous deficiency of hypoxia-inducible factor-2alpha protects mice against pulmonary hypertension and right ventricular dysfunction during prolonged hypoxia. J Clin Invest (2003) 2.00
Canadian Thoracic Society 2012 guideline update: diagnosis and management of asthma in preschoolers, children and adults. Can Respir J (2012) 1.96
Inhibition of NF-kappaB DNA binding by nitric oxide. Nucleic Acids Res (1996) 1.94
Theiler's virus infection: a model for multiple sclerosis. Clin Microbiol Rev (2004) 1.92
Role of nitric oxide in parasitic infections. Microbiol Rev (1995) 1.91
A novel mechanism of action of tetracyclines: effects on nitric oxide synthases. Proc Natl Acad Sci U S A (1996) 1.90
A role for nitric oxide in muscle repair: nitric oxide-mediated activation of muscle satellite cells. Mol Biol Cell (2000) 1.75
Macrophages in resistance to candidiasis. Microbiol Mol Biol Rev (1997) 1.74
Nitric oxide negatively regulates c-Jun N-terminal kinase/stress-activated protein kinase by means of S-nitrosylation. Proc Natl Acad Sci U S A (2000) 1.70
Nitric oxide-induced p53 accumulation and regulation of inducible nitric oxide synthase expression by wild-type p53. Proc Natl Acad Sci U S A (1996) 1.68
Combined neuronal and inducible nitric oxide synthase inhibition in ovine acute lung injury. Crit Care Med (2009) 1.68
Inhibition of vesicular stomatitis virus infection by nitric oxide. J Virol (1995) 1.67
Severe malarial anemia: innate immunity and pathogenesis. Int J Biol Sci (2011) 1.65
NO mediates mural cell recruitment and vessel morphogenesis in murine melanomas and tissue-engineered blood vessels. J Clin Invest (2005) 1.65
CCR5 dictates the equilibrium of proinflammatory IL-17+ and regulatory Foxp3+ T cells in fungal infection. J Immunol (2010) 1.62
Does nitric oxide play a critical role in viral infections? J Virol (1998) 1.62
Hepatitis B virus X protein and p53 tumor suppressor interactions in the modulation of apoptosis. Proc Natl Acad Sci U S A (1997) 1.60
Expression of inducible nitric oxide synthase and nitrotyrosine in multiple sclerosis lesions. Am J Pathol (2001) 1.58
Phosphorylation of endothelial nitric-oxide synthase regulates superoxide generation from the enzyme. J Biol Chem (2008) 1.55
Increased NOS2 predicts poor survival in estrogen receptor-negative breast cancer patients. J Clin Invest (2010) 1.52
Vesicular stomatitis virus infection of the central nervous system activates both innate and acquired immunity. J Virol (1995) 1.52
The spectrum of achalasia: lessons from studies of pathophysiology and high-resolution manometry. Gastroenterology (2013) 1.51
Nitric oxide mediates N-methyl-D-aspartate receptor-induced activation of p21ras. Proc Natl Acad Sci U S A (1998) 1.51
Regulation of inducible nitric oxide synthase gene in glial cells. Antioxid Redox Signal (2006) 1.50
Nitric oxide induces CD4+CD25+ Foxp3 regulatory T cells from CD4+CD25 T cells via p53, IL-2, and OX40. Proc Natl Acad Sci U S A (2007) 1.45
beta-Chemokines enhance parasite uptake and promote nitric oxide-dependent microbiostatic activity in murine inflammatory macrophages infected with Trypanosoma cruzi. Infect Immun (1999) 1.44
Exhaled nitric oxide in paediatric asthma and cystic fibrosis. Arch Dis Child (1996) 1.42
Beneficial effects of concomitant neuronal and inducible nitric oxide synthase inhibition in ovine burn and inhalation injury. Shock (2011) 1.42
The expression and regulation of nitric oxide synthase in human osteoarthritis-affected chondrocytes: evidence for up-regulated neuronal nitric oxide synthase. J Exp Med (1995) 1.41
Molecular and biochemical characterization of dNOS: a Drosophila Ca2+/calmodulin-dependent nitric oxide synthase. Proc Natl Acad Sci U S A (1995) 1.41
Bacterial infection induces nitric oxide synthase in human neutrophils. J Clin Invest (1997) 1.40
Inhibition of Japanese encephalitis virus infection by nitric oxide: antiviral effect of nitric oxide on RNA virus replication. J Virol (1997) 1.40
Inhibition of IkappaB kinase and IkappaB phosphorylation by 15-deoxy-Delta(12,14)-prostaglandin J(2) in activated murine macrophages. Mol Cell Biol (2000) 1.39
Bcl-2 and Bcl-X(L) block thapsigargin-induced nitric oxide generation, c-Jun NH(2)-terminal kinase activity, and apoptosis. Mol Cell Biol (1999) 1.39
Serum levels of TNF-alpha, sIL-2R, IL-6, and IL-8 are increased and associated with elevated lipid peroxidation in patients with Behçet's disease. Mediators Inflamm (2002) 1.39
Role of nitric oxide in the regulation of T cell functions. Ann Rheum Dis (2006) 1.38
The role of interleukin 12 and nitric oxide in the development of spontaneous autoimmune disease in MRL/MP-lpr/lpr mice. J Exp Med (1996) 1.37
Structural basis for endothelial nitric oxide synthase binding to calmodulin. EMBO J (2003) 1.37
Transfection with the inducible nitric oxide synthase gene suppresses tumorigenicity and abrogates metastasis by K-1735 murine melanoma cells. J Exp Med (1995) 1.37
The muscle fiber type-fiber size paradox: hypertrophy or oxidative metabolism? Eur J Appl Physiol (2010) 1.36
Nitric oxide inhibits viral replication in murine myocarditis. J Clin Invest (1996) 1.36
Role of inducible nitric oxide synthase in trinitrobenzene sulphonic acid induced colitis in mice. Gut (1999) 1.35
Essential role of nitric oxide in VEGF-induced, asthma-like angiogenic, inflammatory, mucus, and physiologic responses in the lung. Proc Natl Acad Sci U S A (2006) 1.32
Nitric oxide preferentially induces type 1 T cell differentiation by selectively up-regulating IL-12 receptor beta 2 expression via cGMP. Proc Natl Acad Sci U S A (2002) 1.31
Deletion of the Mycobacterium tuberculosis pknH gene confers a higher bacillary load during the chronic phase of infection in BALB/c mice. J Bacteriol (2005) 1.31
Innate immunity signaling: cytosolic Ca2+ elevation is linked to downstream nitric oxide generation through the action of calmodulin or a calmodulin-like protein. Plant Physiol (2008) 1.28
Expression of nitric oxide synthases and effects of L-arginine and L-NMMA on nitric oxide production and fluid transport in collagenous colitis. Gut (2001) 1.22
Cell cycle control, checkpoint mechanisms, and genotoxic stress. Environ Health Perspect (1999) 1.22
Disassociation between the in vitro and in vivo effects of nitric oxide on a neurotropic murine coronavirus. J Virol (1997) 1.22
The mode of action of aspirin-like drugs: effect on inducible nitric oxide synthase. Proc Natl Acad Sci U S A (1995) 1.22
Molecular targets of dietary polyphenols with anti-inflammatory properties. Yonsei Med J (2005) 1.21
Local nitric oxide production in viral and autoimmune diseases of the central nervous system. Proc Natl Acad Sci U S A (1995) 1.21
Direct measurement of nitric oxide generation from nitric oxide synthase. Proc Natl Acad Sci U S A (1997) 1.20
Signalling events involved in interferon-gamma-inducible macrophage nitric oxide generation. Immunology (2003) 1.19
Blockade of endogenous leukotrienes exacerbates pulmonary histoplasmosis. Infect Immun (2004) 1.19
Features of protein-protein interactions that translate into potent inhibitors: topology, surface area and affinity. Expert Rev Mol Med (2012) 1.18
Direct modulation of calmodulin targets by the neuronal calcium sensor NCS-1. Proc Natl Acad Sci U S A (1996) 1.17
S-nitrosylation at cysteine 498 of c-Src tyrosine kinase regulates nitric oxide-mediated cell invasion. J Biol Chem (2009) 1.17
The physiological expression of inducible nitric oxide synthase (iNOS) in the human colon. J Clin Pathol (2001) 1.16
Nitric oxide and cardioprotection during ischemia-reperfusion. Heart Fail Rev (2002) 1.16
Dose dependent effects of reactive oxygen and nitrogen species on the function of neuronal nitric oxide synthase. Arch Biochem Biophys (2008) 1.16
Nitric oxide production in human endothelial cells stimulated by histamine requires Ca2+ influx. Biochem J (1998) 1.15
Neuronal (type I) nitric oxide synthase regulates nuclear factor kappaB activity and immunologic (type II) nitric oxide synthase expression. Proc Natl Acad Sci U S A (1997) 1.15
Nitric oxide inhibits creatine kinase and regulates rat heart contractile reserve. Proc Natl Acad Sci U S A (1996) 1.15
Nitric oxide: a regulator of mast cell activation and mast cell-mediated inflammation. Clin Exp Immunol (2002) 1.15
Agmatine, a bioactive metabolite of arginine. Production, degradation, and functional effects in the kidney of the rat. J Clin Invest (1996) 1.15
Hypoxia induces a functionally significant and translationally efficient neuronal NO synthase mRNA variant. J Clin Invest (2005) 1.15
Expression of inducible nitric oxide synthase activity in human colon epithelial cells: modulation by T lymphocyte derived cytokines. Gut (1998) 1.15
The SPRY domain-containing SOCS box protein SPSB2 targets iNOS for proteasomal degradation. J Cell Biol (2010) 1.14
Immunotoxicity in invertebrates: measurement and ecotoxicological relevance. Ecotoxicology (2001) 1.14
Repression of SPI2 transcription by nitric oxide-producing, IFNgamma-activated macrophages promotes maturation of Salmonella phagosomes. J Exp Med (2005) 1.13
Cytokines and nitric oxide as effector molecules against parasitic infections. Philos Trans R Soc Lond B Biol Sci (1997) 1.13
Vasodilator interactions in skeletal muscle blood flow regulation. J Physiol (2012) 1.13
Up-regulation of inducible nitric oxide synthase expression in cancer-prone p53 knockout mice. Proc Natl Acad Sci U S A (1998) 1.12
Inducible nitric oxide synthase: a little bit of good in all of us. Gut (2000) 1.12
Heat-shock protein 90 augments neuronal nitric oxide synthase activity by enhancing Ca2+/calmodulin binding. Biochem J (2001) 1.12
Nitric oxide and macrophage function. Annu Rev Immunol (1997) 12.77
Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase. Cell (1995) 7.13
Regulation of biosynthesis of nitric oxide. J Biol Chem (1994) 4.82
Inhibition of viral replication by interferon-gamma-induced nitric oxide synthase. Science (1993) 4.80
Inducible nitric oxide synthase in pulmonary alveolar macrophages from patients with tuberculosis. J Exp Med (1996) 3.74
Mechanisms of suppression of macrophage nitric oxide release by transforming growth factor beta. J Exp Med (1993) 3.06
Suppression of arthritis by an inhibitor of nitric oxide synthase. J Exp Med (1993) 2.98
Calmodulin is a subunit of nitric oxide synthase from macrophages. J Exp Med (1992) 2.55
Role of interferon regulatory factor 1 in induction of nitric oxide synthase. J Exp Med (1994) 2.35
Alkyl hydroperoxide reductase subunit C (AhpC) protects bacterial and human cells against reactive nitrogen intermediates. Mol Cell (1998) 1.92
Novel triterpenoids suppress inducible nitric oxide synthase (iNOS) and inducible cyclooxygenase (COX-2) in mouse macrophages. Cancer Res (1998) 1.80
Mechanism of suppression of nitric oxide synthase expression by interleukin-4 in primary mouse macrophages. J Leukoc Biol (1994) 1.45
Vesicle membrane association of nitric oxide synthase in primary mouse macrophages. J Immunol (1995) 1.38
Transfection with the inducible nitric oxide synthase gene suppresses tumorigenicity and abrogates metastasis by K-1735 murine melanoma cells. J Exp Med (1995) 1.37
Inducible nitric oxide synthase in tangle-bearing neurons of patients with Alzheimer's disease. J Exp Med (1996) 1.25
Spermidine synthase of Escherichia coli: localization of the speE gene. Proc Natl Acad Sci U S A (1986) 1.09
Transcription and translation of inducible nitric oxide synthase in the pancreas of prediabetic BB rats. FEBS Lett (1993) 1.03
Albumin inhibits neutrophil spreading and hydrogen peroxide release by blocking the shedding of CD43 (sialophorin, leukosialin). J Cell Biol (1993) 1.00
Traces of bacterial lipopolysaccharide suppress IFN-gamma-induced nitric oxide synthase gene expression in primary mouse macrophages. J Immunol (1993) 0.97
Inducible nitric oxide synthase: identification of amino acid residues essential for dimerization and binding of tetrahydrobiopterin. Proc Natl Acad Sci U S A (1995) 0.94
Macrophages derived from C3H/HeJ (Lpsd) mice respond to bacterial lipopolysaccharide by activating NF-kappa B. J Leukoc Biol (1995) 0.94
The presence of an active S-adenosylmethionine decarboxylase gene increases the growth defect observed in Saccharomyces cerevisiae mutants unable to synthesize putrescine, spermidine, and spermine. J Bacteriol (1994) 0.83
The anti-histamine effect of acupuncture. Zhen Ci Yan Jiu (1985) 0.78
Induction of MRP1 and gamma-glutamylcysteine synthetase gene expression by interleukin 1beta is mediated by nitric oxide-related signalings in human colorectal cancer cells. J Cell Physiol (2000) 0.77
S-adenosylmethionine decarboxylase from Escherichia coli and from Saccharomyces cerevisiae: cloning and overexpression of the genes. Adv Exp Med Biol (1988) 0.77
Inhibition by estrogen of autofeedback regulation of prolactin secretion. Life Sci (1984) 0.76
Relationship between effect of acupuncture on prolactin secretion and central catecholamine and R-aminobutyric acid. Zhen Ci Yan Jiu (1989) 0.75
Endocrinological basis of acupuncture. Am J Chin Med (1981) 0.75
Effect of acupuncture on prolactin secretion of lactating rats. Zhen Ci Yan Jiu (1986) 0.75
Reduced tuberoinfundibular dopaminergic neuronal function in rats with in situ prolactin-secreting pituitary tumors. Neuroendocrinology (1984) 0.75
[An experimental study of inhibition on lactation in fluorosis rats]. Sheng Li Xue Bao (1991) 0.75
Studies on the effect of electroacupuncture on prolactin secretion and the relative specificity of acupoints in rats. Zhen Ci Yan Jiu (1988) 0.75