Lack of beta 1 integrin gene in embryonic stem cells affects morphology, adhesion, and migration but not integration into the inner cell mass of blastocysts.

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Published in J Cell Biol on March 01, 1995

Authors

R Fässler1, M Pfaff, J Murphy, A A Noegel, S Johansson, R Timpl, R Albrecht

Author Affiliations

1: Max-Planck-Institute for Biochemistry, Martinsried, Germany.

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Language comprehension in ape and child. Monogr Soc Res Child Dev (1993) 2.38

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Preparation and use in immunohistology of antibodies specific for type I and type III collagen and procollagen. J Immunol Methods (1976) 2.28

Appearance and distribution of collagens and laminin in the early mouse embryo. Dev Biol (1980) 2.27

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Structure, development, and molecular pathology of basement membranes. Int Rev Exp Pathol (1986) 2.25

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The strength of the menisci of the knee as it relates to their fine structure. J Bone Joint Surg Br (1970) 2.02

The production of specific antibodies to native collagens with the chain compositions, (alpha1(I))3, (alpha1(II))3, and (alpha1(I))2alpha 2. J Immunol (1974) 2.02

Prospective long-term study of vagus nerve stimulation for the treatment of refractory seizures. Epilepsia (2000) 2.02

Arg-Gly-Asp constrained within cyclic pentapeptides. Strong and selective inhibitors of cell adhesion to vitronectin and laminin fragment P1. FEBS Lett (1991) 2.02

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Treatment of patients with symptomless left ventricular dysfunction after myocardial infarction. Lancet (1988) 1.98

Simultaneous synthesis of types I and III collagen by fibroblasts in culture. Proc Natl Acad Sci U S A (1976) 1.97

Impact of inflammation on epigenetic DNA methylation - a novel risk factor for cardiovascular disease? J Intern Med (2007) 1.97

Macromolecular structure of basement membrane collagens. FEBS Lett (1981) 1.96

Folding mechanism of the triple helix in type-III collagen and type-III pN-collagen. Role of disulfide bridges and peptide bond isomerization. Eur J Biochem (1980) 1.96

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Adhesion, growth, and matrix production by fibroblasts on laminin substrates. J Cell Biol (1983) 1.91

Biosynthesis of two subunits of type IV procollagen and of other basement membrane proteins by a human tumor cell line. Eur J Biochem (1980) 1.90

Cessation of smoking after myocardial infarction. Effects on mortality after 10 years. Br Heart J (1983) 1.90

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Summary of FDA antibody-mediated rejection workshop. Am J Transplant (2011) 1.87

Radioimmunoassay for type III procollagen peptide and its application to human liver disease. Eur J Clin Invest (1979) 1.87

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