Structure, function and tissue forms of the C-terminal globular domain of collagen XVIII containing the angiogenesis inhibitor endostatin.

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Published in EMBO J on August 03, 1998

Authors

T Sasaki1, N Fukai, K Mann, W Göhring, B R Olsen, R Timpl

Author Affiliations

1: Max-Planck-Institut für Biochemie, Martinsried, Germany.

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Serotonergic dysfunction, negative mood states, and response to alcohol. Alcohol Clin Exp Res (2001) 1.85

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