Published in J Biol Chem on August 25, 1995
Neutral thiol as a proximal ligand to ferrous heme iron: implications for heme proteins that lose cysteine thiolate ligation on reduction. Proc Natl Acad Sci U S A (2003) 1.20
Spectroscopic and biochemical characterization of heme binding to yeast Dap1p and mouse PGRMC1p. Biochemistry (2005) 1.02
Ferric, not ferrous, heme activates RNA-binding protein DGCR8 for primary microRNA processing. Proc Natl Acad Sci U S A (2012) 1.02
Mechanism of Nitric Oxide Synthase Regulation: Electron Transfer and Interdomain Interactions. Coord Chem Rev (2011) 0.97
Visualizing inducible nitric-oxide synthase in living cells with a heme-binding fluorescent inhibitor. Proc Natl Acad Sci U S A (2005) 0.95
Stabilization and characterization of a heme-oxy reaction intermediate in inducible nitric-oxide synthase. J Biol Chem (2008) 0.91
Mutations in the FMN domain modulate MCD spectra of the heme site in the oxygenase domain of inducible nitric oxide synthase. J Am Chem Soc (2009) 0.90
Replacement of the axial histidine heme ligand with cysteine in nitrophorin 1: spectroscopic and crystallographic characterization. J Biol Inorg Chem (2008) 0.89
Haem insertion, dimerization and reactivation of haem-free rat neuronal nitric oxide synthase. Biochem J (1998) 0.85
Electron paramagnetic resonance characterization of tetrahydrobiopterin radical formation in bacterial nitric oxide synthase compared to mammalian nitric oxide synthase. Biophys J (2012) 0.85
Characterization of the proximal ligand in the P420 form of inducible nitric oxide synthase. J Am Chem Soc (2009) 0.83
Probing heme coordination states of inducible nitric oxide synthase with a ReI(imidazole-alkyl-nitroarginine) sensitizer-wire. J Phys Chem B (2007) 0.80
Formation of transient oxygen complexes of cytochrome p450 BM3 and nitric oxide synthase under high pressure. Biophys J (2003) 0.75
A heme-binding domain controls regulation of ATP-dependent potassium channels. Proc Natl Acad Sci U S A (2016) 0.75
Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production. J Immunol (1988) 14.21
Mammalian nitrate biosynthesis: mouse macrophages produce nitrite and nitrate in response to Escherichia coli lipopolysaccharide. Proc Natl Acad Sci U S A (1985) 7.36
Macrophage synthesis of nitrite, nitrate, and N-nitrosamines: precursors and role of the respiratory burst. Proc Natl Acad Sci U S A (1987) 5.69
Induction of nitrite/nitrate synthesis in murine macrophages by BCG infection, lymphokines, or interferon-gamma. J Immunol (1987) 5.00
Nitric oxide synthases: properties and catalytic mechanism. Annu Rev Physiol (1995) 4.12
Macrophage deactivating factor and transforming growth factors-beta 1 -beta 2 and -beta 3 inhibit induction of macrophage nitrogen oxide synthesis by IFN-gamma. J Immunol (1990) 3.55
Identification of arginine as a precursor of endothelium-derived relaxing factor. Proc Natl Acad Sci U S A (1988) 3.44
Reduced biopterin as a cofactor in the generation of nitrogen oxides by murine macrophages. J Biol Chem (1989) 3.31
Structure of nitric oxide synthase oxygenase dimer with pterin and substrate. Science (1998) 2.75
Hepatocytes produce nitrogen oxides from L-arginine in response to inflammatory products of Kupffer cells. J Exp Med (1989) 2.49
Continuous nitric oxide synthesis by inducible nitric oxide synthase in normal human airway epithelium in vivo. Proc Natl Acad Sci U S A (1995) 2.44
An L-arginine-dependent mechanism mediates Kupffer cell inhibition of hepatocyte protein synthesis in vitro. J Exp Med (1989) 2.27
The structure of nitric oxide synthase oxygenase domain and inhibitor complexes. Science (1997) 2.18
Nitric oxide synthases reveal a role for calmodulin in controlling electron transfer. Proc Natl Acad Sci U S A (1993) 2.18
Modulation of nitrogen oxide synthesis in vivo: NG-monomethyl-L-arginine inhibits endotoxin-induced nitrate/nitrate biosynthesis while promoting hepatic damage. J Leukoc Biol (1990) 2.11
Higher blood flow and circulating NO products offset high-altitude hypoxia among Tibetans. Proc Natl Acad Sci U S A (2007) 2.07
Macrophage nitric oxide synthase subunits. Purification, characterization, and role of prosthetic groups and substrate in regulating their association into a dimeric enzyme. J Biol Chem (1993) 1.91
Inhibition of tumor cell ribonucleotide reductase by macrophage-derived nitric oxide. J Exp Med (1991) 1.83
Proteomic method identifies proteins nitrated in vivo during inflammatory challenge. Proc Natl Acad Sci U S A (2001) 1.77
Multiple cytokines are required to induce hepatocyte nitric oxide production and inhibit total protein synthesis. Ann Surg (1990) 1.74
Macrophage and endothelial cell nitric oxide synthesis: cell-type selective inhibition by NG-aminoarginine, NG-nitroarginine and NG-methylarginine. Biochem Biophys Res Commun (1990) 1.72
L-citrulline production from L-arginine by macrophage nitric oxide synthase. The ureido oxygen derives from dioxygen. J Biol Chem (1990) 1.70
Calmodulin controls neuronal nitric-oxide synthase by a dual mechanism. Activation of intra- and interdomain electron transfer. J Biol Chem (1994) 1.70
Calmodulin activates intersubunit electron transfer in the neuronal nitric-oxide synthase dimer. J Biol Chem (2001) 1.68
Inducible cytosolic enzyme activity for the production of nitrogen oxides from L-arginine in hepatocytes. Biochem Biophys Res Commun (1990) 1.67
Spectral characterization of brain and macrophage nitric oxide synthases. Cytochrome P-450-like hemeproteins that contain a flavin semiquinone radical. J Biol Chem (1992) 1.66
Nitric oxide synthesis in the lung. Regulation by oxygen through a kinetic mechanism. J Clin Invest (1998) 1.60
Nitrosation of amines by stimulated macrophages. Carcinogenesis (1987) 1.59
Expression of human inducible nitric oxide synthase in a tetrahydrobiopterin (H4B)-deficient cell line: H4B promotes assembly of enzyme subunits into an active dimer. Proc Natl Acad Sci U S A (1995) 1.56
Effect of exogenous and endogenous nitric oxide on mitochondrial respiration of rat hepatocytes. Am J Physiol (1991) 1.54
Spectroscopic investigations of ferric cytochrome P-450-CAM ligand complexes. Identification of the ligand trans to cysteinate in the native enzyme. J Biol Chem (1982) 1.51
Nitric oxide and nitric oxide-generating compounds inhibit hepatocyte protein synthesis. FASEB J (1991) 1.48
Arginine conversion to nitroxide by tetrahydrobiopterin-free neuronal nitric-oxide synthase. Implications for mechanism. J Biol Chem (2000) 1.41
Ischemic injury to mitochondrial electron transport in the aging heart: damage to the iron-sulfur protein subunit of electron transport complex III. Arch Biochem Biophys (2001) 1.41
Structural and functional effects of apolar mutations of the distal valine in myoglobin. J Mol Biol (1995) 1.37
The effect of quaternary structure on the kinetics of conformational changes and nanosecond geminate rebinding of carbon monoxide to hemoglobin. Proc Natl Acad Sci U S A (1988) 1.36
Interaction between caveolin-1 and the reductase domain of endothelial nitric-oxide synthase. Consequences for catalysis. J Biol Chem (1998) 1.36
The iron-proximal histidine linkage and protein control of oxygen binding in hemoglobin. A transient Raman study. J Biol Chem (1983) 1.35
Synergistic cooperation between T cell lymphokines for induction of the nitric oxide synthase gene in murine peritoneal macrophages. J Immunol (1993) 1.34
Macrophage NO synthase: characterization of isolated oxygenase and reductase domains reveals a head-to-head subunit interaction. Biochemistry (1995) 1.32
Structural factors governing azide and cyanide binding to mammalian metmyoglobins. J Biol Chem (1994) 1.31
Characterization of the inducible nitric oxide synthase oxygenase domain identifies a 49 amino acid segment required for subunit dimerization and tetrahydrobiopterin interaction. Biochemistry (1997) 1.30
Aging decreases electron transport complex III activity in heart interfibrillar mitochondria by alteration of the cytochrome c binding site. J Mol Cell Cardiol (2001) 1.27
Practice variations: a challenge for physicians. JAMA (1987) 1.25
Comparative functioning of dihydro- and tetrahydropterins in supporting electron transfer, catalysis, and subunit dimerization in inducible nitric oxide synthase. Biochemistry (1998) 1.24
Intracellular assembly of inducible NO synthase is limited by nitric oxide-mediated changes in heme insertion and availability. J Biol Chem (1996) 1.24
Nitric oxide binding to the heme of neuronal nitric-oxide synthase links its activity to changes in oxygen tension. J Biol Chem (1996) 1.24
Domain swapping in inducible nitric-oxide synthase. Electron transfer occurs between flavin and heme groups located on adjacent subunits in the dimer. J Biol Chem (1998) 1.24
Stability of myoglobin: a model for the folding of heme proteins. Biochemistry (1994) 1.23
Human myeloperoxidase and thyroid peroxidase, two enzymes with separate and distinct physiological functions, are evolutionarily related members of the same gene family. Proteins (1988) 1.22
Nanosecond optical spectra of iron-cobalt hybrid hemoglobins: geminate recombination, conformational changes, and intersubunit communication. Biochemistry (1985) 1.22
Magnetic susceptibility of oxy- and carbonmonoxyhemoglobins. Proc Natl Acad Sci U S A (1984) 1.22
Role of reductase domain cluster 1 acidic residues in neuronal nitric-oxide synthase. Characterization of the FMN-FREE enzyme. J Biol Chem (1999) 1.19
Does endothelium-derived nitric oxide have a role in cytokine-induced hypotension? J Natl Cancer Inst (1990) 1.19
Sulfur donor ligand binding to ferric cytochrome P-450-CAM and myoglobin. Ultraviolet-visible absorption, magnetic circular dichroism, and electron paramagnetic resonance spectroscopic investigation of the complexes. J Biol Chem (1982) 1.18
Letter: Oxidized cytochrome P-450. Magnetic circular dichroism evidence for thiolate ligation in the substrate-bound form. Implications for the catalytic mechanism. J Am Chem Soc (1976) 1.15
Differences in three kinetic parameters underpin the unique catalytic profiles of nitric-oxide synthases I, II, and III. J Biol Chem (2001) 1.15
Stopped-flow analysis of CO and NO binding to inducible nitric oxide synthase. Biochemistry (1998) 1.14
Structural characterization of horseradish peroxidase using EXAFS spectroscopy. Evidence for Fe = O ligation in compounds I and II. J Am Chem Soc (1986) 1.14
Neuronal nitric oxide synthase self-inactivates by forming a ferrous-nitrosyl complex during aerobic catalysis. J Biol Chem (1995) 1.13
Rapid kinetic studies link tetrahydrobiopterin radical formation to heme-dioxy reduction and arginine hydroxylation in inducible nitric-oxide synthase. J Biol Chem (2001) 1.12
Structures of the N(omega)-hydroxy-L-arginine complex of inducible nitric oxide synthase oxygenase dimer with active and inactive pterins. Biochemistry (2000) 1.12
Probing the heme iron coordination structure of pressure-induced cytochrome P420cam. Biochemistry (1996) 1.11
Nitric oxide myoglobin: crystal structure and analysis of ligand geometry. Proteins (1998) 1.11
Characterization of the reductase domain of rat neuronal nitric oxide synthase generated in the methylotrophic yeast Pichia pastoris. Calmodulin response is complete within the reductase domain itself. J Biol Chem (1996) 1.10
Neuronal nitric-oxide synthase mutant (Ser-1412 --> Asp) demonstrates surprising connections between heme reduction, NO complex formation, and catalysis. J Biol Chem (2001) 1.09
A kinetic simulation model that describes catalysis and regulation in nitric-oxide synthase. J Biol Chem (2001) 1.08
Substrate specificity of NO synthases: detailed comparison of L-arginine, homo-L-arginine, their N omega-hydroxy derivatives, and N omega-hydroxynor-L-arginine. Biochemistry (1998) 1.06
Chimeras of nitric-oxide synthase types I and III establish fundamental correlates between heme reduction, heme-NO complex formation, and catalytic activity. J Biol Chem (2001) 1.06
The ferrous-dioxy complex of neuronal nitric oxide synthase. Divergent effects of L-arginine and tetrahydrobiopterin on its stability. J Biol Chem (1997) 1.05
N-terminal domain swapping and metal ion binding in nitric oxide synthase dimerization. EMBO J (1999) 1.05
The C331A mutant of neuronal nitric-oxide synthase is defective in arginine binding. J Biol Chem (1998) 1.04
Tetrahydrobiopterin-deficient nitric oxide synthase has a modified heme environment and forms a cytochrome P-420 analogue. Biochemistry (1995) 1.04
Heme-heme oxygenase complex: structure and properties of the catalytic site from resonance Raman scattering. Biochemistry (1994) 1.03
Heme coordination and structure of the catalytic site in nitric oxide synthase. J Biol Chem (1993) 1.02
Inducible nitric oxide synthase: role of the N-terminal beta-hairpin hook and pterin-binding segment in dimerization and tetrahydrobiopterin interaction. EMBO J (1999) 1.01
Heme-heme oxygenase complex. Structure of the catalytic site and its implication for oxygen activation. J Biol Chem (1994) 1.01
Mutagenesis of acidic residues in the oxygenase domain of inducible nitric-oxide synthase identifies a glutamate involved in arginine binding. Biochemistry (1997) 1.01
Tryptophan 409 controls the activity of neuronal nitric-oxide synthase by regulating nitric oxide feedback inhibition. J Biol Chem (1999) 1.00
Formation of low spin complexes of ferric cytochrome P-450-CAM with anionic ligands. Spin state and ligand affinity comparison to myoglobin. J Biol Chem (1982) 1.00
Heme iron reduction and catalysis by a nitric oxide synthase heterodimer containing one reductase and two oxygenase domains. J Biol Chem (1996) 1.00
The diverse spectroscopic properties of ferrous cytochrome P-450-CAM ligand complexes. J Biol Chem (1983) 1.00
Regulation of the properties of the heme-NO complexes in nitric-oxide synthase by hydrogen bonding to the proximal cysteine. J Biol Chem (2001) 1.00
X-ray absorption spectroscopic studies of high valent iron porphyrins. Horseradish peroxidase compounds I and II and synthetic models. J Biol Chem (1983) 1.00
L-arginine and calmodulin regulation of the heme iron reactivity in neuronal nitric oxide synthase. J Biol Chem (1994) 1.00
Histidine-132 does not stabilize a distal water ligand and is not an important residue for the enzyme activity in heme oxygenase-1. Biochemistry (1997) 0.99
Heme degradation as catalyzed by a recombinant bacterial heme oxygenase (Hmu O) from Corynebacterium diphtheriae. J Biol Chem (1999) 0.99
Alteration of axial coordination by protein engineering in myoglobin. Bisimidazole ligation in the His64-->Val/Val68-->His double mutant. J Biol Chem (1995) 0.99
Single crystal EPR of myoglobin nitroxide. Freezing-induced reversible changes in the molecular orientation of the ligand. J Biol Chem (1981) 0.98
Heme coordination of NO in NO synthase. Proc Natl Acad Sci U S A (1994) 0.97
A proximal tryptophan in NO synthase controls activity by a novel mechanism. J Inorg Biochem (2001) 0.97
High-level expression of mouse inducible nitric oxide synthase in Escherichia coli requires coexpression with calmodulin. Biochem Biophys Res Commun (1996) 0.97
Substrate binding and calmodulin binding to endothelial nitric oxide synthase coregulate its enzymatic activity. Nitric Oxide (1997) 0.97
Tetrahydrobiopterin binding to macrophage inducible nitric oxide synthase: heme spin shift and dimer stabilization by the potent pterin antagonist 4-amino-tetrahydrobiopterin. Biochemistry (1997) 0.97
Nitric oxide-generated P420 nitric oxide synthase: characterization and roles for tetrahydrobiopterin and substrate in protecting against or reversing the P420 conversion. Biochemistry (1999) 0.96
Demonstration that histidine 25, but not 132, is the axial heme ligand in rat heme oxygenase-1. Arch Biochem Biophys (1995) 0.96