Phosphorylation of tyrosine 503 in the erythropoietin receptor (EpR) is essential for binding the P85 subunit of phosphatidylinositol (PI) 3-kinase and for EpR-associated PI 3-kinase activity.

PubWeight™: 1.33‹?› | Rank: Top 10%

🔗 View Article (PMID 7559499)

Published in J Biol Chem on October 06, 1995

Authors

J E Damen1, R L Cutler, H Jiao, T Yi, G Krystal

Author Affiliations

1: Terry Fox Laboratory, British Columbia Cancer Research Centre, Vancouver, Canada.

Articles citing this

Tyrosine 1101 of Tie2 is the major site of association of p85 and is required for activation of phosphatidylinositol 3-kinase and Akt. Mol Cell Biol (1998) 2.28

Erythropoietin induces activation of Stat5 through association with specific tyrosines on the receptor that are not required for a mitogenic response. Mol Cell Biol (1996) 1.86

Recombinant human erythropoietin antagonizes trastuzumab treatment of breast cancer cells via Jak2-mediated Src activation and PTEN inactivation. Cancer Cell (2010) 1.71

Direct association with and dephosphorylation of Jak2 kinase by the SH2-domain-containing protein tyrosine phosphatase SHP-1. Mol Cell Biol (1996) 1.68

The distal region and receptor tyrosines of the Epo receptor are non-essential for in vivo erythropoiesis. EMBO J (2001) 1.67

Identification of a novel pathway important for proliferation and differentiation of primary erythroid progenitors. Proc Natl Acad Sci U S A (1997) 1.57

AKT induces erythroid-cell maturation of JAK2-deficient fetal liver progenitor cells and is required for Epo regulation of erythroid-cell differentiation. Blood (2005) 1.25

Selective regulation of Bcl-XL by a Jak kinase-dependent pathway is bypassed in murine hematopoietic malignancies. Genes Dev (1998) 1.24

Functional interaction of erythropoietin and stem cell factor receptors is essential for erythroid colony formation. Proc Natl Acad Sci U S A (1997) 1.19

Cytokine rescue of p53-dependent apoptosis and cell cycle arrest is mediated by distinct Jak kinase signaling pathways. Genes Dev (1998) 1.15

Identification of K-ras as the major regulator for cytokine-dependent Akt activation in erythroid progenitors in vivo. Proc Natl Acad Sci U S A (2005) 1.12

Erythroid cells rendered erythropoietin independent by infection with Friend spleen focus-forming virus show constitutive activation of phosphatidylinositol 3-kinase and Akt kinase: involvement of insulin receptor substrate-related adapter proteins. J Virol (2000) 1.10

Acute neuroprotective synergy of erythropoietin and insulin-like growth factor I. Proc Natl Acad Sci U S A (2004) 1.08

Tissue inhibitor of metalloproteinases-1 signalling pathway leading to erythroid cell survival. Biochem J (2003) 1.07

Symmetric signaling by an asymmetric 1 erythropoietin: 2 erythropoietin receptor complex. Mol Cell (2009) 1.00

Src transduces erythropoietin-induced differentiation signals through phosphatidylinositol 3-kinase. EMBO J (2001) 0.96

The thrombopoietin receptor can mediate proliferation without activation of the Jak-STAT pathway. J Exp Med (1997) 0.92

Combination treatment for myeloproliferative neoplasms using JAK and pan-class I PI3K inhibitors. J Cell Mol Med (2013) 0.90

Oligomerization and scaffolding functions of the erythropoietin receptor cytoplasmic tail. J Biol Chem (1999) 0.89

The erythropoietin receptor: molecular structure and hematopoietic signaling pathways. J Investig Med (2011) 0.88

Absence of polycythemia in a child with a unique erythropoietin receptor mutation in a family with autosomal dominant primary polycythemia. J Clin Invest (1998) 0.86

Hematopoietic cell survival signals are elicited through non-tyrosine-containing sequences in the membrane-proximal region of the erythropoietin receptor (EPOR) by a Stat5-dependent pathway. Exp Hematol (2003) 0.84

Differential proteomic analysis of human erythroblasts undergoing apoptosis induced by epo-withdrawal. PLoS One (2012) 0.80

Dna damage-induced G(1) arrest in hematopoietic cells is overridden following phosphatidylinositol 3-kinase-dependent activation of cyclin-dependent kinase 2. Mol Cell Biol (2001) 0.78

Articles by these authors

JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin. Cell (1993) 6.04

Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav. Mol Cell Biol (1994) 5.02

Mutations at the murine motheaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene. Cell (1993) 4.06

Targeted disruption of SHIP leads to hemopoietic perturbations, lung pathology, and a shortened life span. Genes Dev (1998) 3.40

Recruitment of tyrosine phosphatase HCP by the killer cell inhibitor receptor. Immunity (1996) 3.33

Structure of the murine Jak2 protein-tyrosine kinase and its role in interleukin 3 signal transduction. Proc Natl Acad Sci U S A (1993) 2.88

The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase. Proc Natl Acad Sci U S A (1996) 2.68

Monomeric IgE stimulates signaling pathways in mast cells that lead to cytokine production and cell survival. Immunity (2001) 2.11

Expression of Thy-1 on human hematopoietic progenitor cells. J Exp Med (1993) 2.09

Dissected nucleus-independent chemical shift analysis of pi-aromaticity and antiaromaticity. Org Lett (2001) 2.01

The src homology 2-containing inositol phosphatase (SHIP) is the gatekeeper of mast cell degranulation. Proc Natl Acad Sci U S A (1998) 1.98

Genetic analysis of non-insulin dependent diabetes mellitus in the GK rat. Nat Genet (1996) 1.96

Tyrosine 343 in the erythropoietin receptor positively regulates erythropoietin-induced cell proliferation and Stat5 activation. EMBO J (1995) 1.87

Hematopoietic cell phosphatase associates with the interleukin-3 (IL-3) receptor beta chain and down-regulates IL-3-induced tyrosine phosphorylation and mitogenesis. Mol Cell Biol (1993) 1.86

Sodium stibogluconate is a potent inhibitor of protein tyrosine phosphatases and augments cytokine responses in hemopoietic cell lines. J Immunol (2001) 1.73

Direct association with and dephosphorylation of Jak2 kinase by the SH2-domain-containing protein tyrosine phosphatase SHP-1. Mol Cell Biol (1996) 1.68

Comprehensive microRNA expression profiling of the hematopoietic hierarchy. Proc Natl Acad Sci U S A (2010) 1.67

Multiple cytokines induce the tyrosine phosphorylation of Shc and its association with Grb2 in hemopoietic cells. J Biol Chem (1993) 1.60

Erythropoietin stimulates the tyrosine phosphorylation of Shc and its association with Grb2 and a 145-Kd tyrosine phosphorylated protein. Blood (1993) 1.60

Expression of a novel form of Tec kinase in hematopoietic cells and mapping of the gene to chromosome 5 near Kit. Oncogene (1993) 1.58

Small cell carcinomas of the lung express the Bcl-2 protein. Am J Pathol (1994) 1.53

A novel phosphotyrosine motif with a critical amino acid at position -2 for the SH2 domain-mediated activation of the tyrosine phosphatase SHP-1. J Biol Chem (1997) 1.50

Quantitation and detection of isotypes of anti-SS-B antibodies by ELISA and Farr assays using affinity purified antigens. An approach to the investigation of Sjögren's syndrome and systemic lupus erythematosus. Arthritis Rheum (1983) 1.48

The protein tyrosine kinase ZAP-70 can associate with the SH2 domain of proto-Vav. J Biol Chem (1994) 1.45

A dual role for Src homology 2 domain-containing inositol-5-phosphatase (SHIP) in immunity: aberrant development and enhanced function of b lymphocytes in ship -/- mice. J Exp Med (2000) 1.42

Scavenging capacity of berry crops on superoxide radicals, hydrogen peroxide, hydroxyl radicals, and singlet oxygen. J Agric Food Chem (2000) 1.38

Multiple cytokines stimulate the binding of a common 145-kilodalton protein to Shc at the Grb2 recognition site of Shc. Mol Cell Biol (1994) 1.35

The Src homology 2 (SH2) domain of SH2-containing inositol phosphatase (SHIP) is essential for tyrosine phosphorylation of SHIP, its association with Shc, and its induction of apoptosis. J Biol Chem (1997) 1.35

Regulated transcription of the genomes of defective virions and temperature-sensitive mutants of reovirus. J Virol (1976) 1.34

Steel factor stimulates the tyrosine phosphorylation of the proto-oncogene product, p95vav, in human hemopoietic cells. J Biol Chem (1992) 1.34

Protein-tyrosine phosphatase Shp-1 is a negative regulator of IL-4- and IL-13-dependent signal transduction. J Biol Chem (1998) 1.34

Disabled-2 (Dab2) is an SH3 domain-binding partner of Grb2. Oncogene (1998) 1.30

Recruitment of SH2-containing protein tyrosine phosphatase SHP-1 to the interleukin 2 receptor; loss of SHP-1 expression in human T-lymphotropic virus type I-transformed T cells. Proc Natl Acad Sci U S A (1998) 1.30

SHIP, a new player in cytokine-induced signalling. Leukemia (1997) 1.28

Negative signaling in B lymphocytes induces tyrosine phosphorylation of the 145-kDa inositol polyphosphate 5-phosphatase, SHIP. J Immunol (1996) 1.26

Targeted disruption of SHIP leads to Steel factor-induced degranulation of mast cells. EMBO J (1998) 1.25

A simple microassay for erythropoietin based on 3H-thymidine incorporation into spleen cells from phenylhydrazine treated mice. Exp Hematol (1983) 1.24

Inhibition of antigen-induced T cell response and antibody-induced NK cell cytotoxicity by NKG2A: association of NKG2A with SHP-1 and SHP-2 protein-tyrosine phosphatases. Eur J Immunol (1998) 1.22

Phosphatidylinositol 3-kinase associates, via its Src homology 2 domains, with the activated erythropoietin receptor. Blood (1993) 1.22

Evidence for a glycoprotein in reovirus. Virology (1976) 1.21

Hck tyrosine kinase activity modulates tumor necrosis factor production by murine macrophages. J Exp Med (1993) 1.20

Evidence for phosphoproteins in reovirus. Virology (1975) 1.20

Shc interaction with Src homology 2 domain containing inositol phosphatase (SHIP) in vivo requires the Shc-phosphotyrosine binding domain and two specific phosphotyrosines on SHIP. J Biol Chem (1997) 1.19

Engagement of Gab1 and Gab2 in erythropoietin signaling. J Biol Chem (1999) 1.17

Tec kinase associates with c-kit and is tyrosine phosphorylated and activated following stem cell factor binding. Mol Cell Biol (1994) 1.15

Association of the interferon-dependent tyrosine kinase Tyk-2 with the hematopoietic cell phosphatase. J Biol Chem (1995) 1.15

Altered responsiveness to chemokines due to targeted disruption of SHIP. J Clin Invest (1999) 1.14

Selective digestion of mouse metaphase chromosomes. Chromosoma (1978) 1.13

Small hepatocellular carcinoma in patients with chronic liver damage: prospective comparison of detection with dynamic MR imaging and helical CT of the whole liver. Radiology (1996) 1.11

The carboxyl terminus of the granulocyte colony-stimulating factor receptor, truncated in patients with severe congenital neutropenia/acute myeloid leukemia, is required for SH2-containing phosphatase-1 suppression of Stat activation. J Immunol (2001) 1.10

G1 cell cycle arrest and apoptosis are induced in NIH 3T3 cells by KN-93, an inhibitor of CaMK-II (the multifunctional Ca2+/CaM kinase). Cell Growth Differ (1995) 1.10

Macrophages from motheaten and viable motheaten mutant mice show increased proliferative responses to GM-CSF: detection of potential HCP substrates in GM-CSF signal transduction. Exp Hematol (1997) 1.10

Partial characterization of a novel stromal cell-derived pre-B-cell growth factor active on normal and immortalized pre-B cells. Exp Hematol (1988) 1.10

Phosphatidylinositol 3,4,5-trisphosphate regulates Ca(2+) entry via btk in platelets and megakaryocytes without increasing phospholipase C activity. EMBO J (2000) 1.10

Contribution of both STAT and SRF/TCF to c-fos promoter activation by granulocyte-macrophage colony-stimulating factor. Blood (1996) 1.09

Interleukin-3, GM-CSF, and TPA induce distinct phosphorylation events in an interleukin 3-dependent multipotential cell line. Blood (1989) 1.09

Transitions in histone variants of the male pronucleus following fertilization and evidence for a maternal store of cleavage-stage histones in the sera urchin egg. Dev Biol (1981) 1.08

Differential association of phosphatases with hematopoietic co-receptors bearing immunoreceptor tyrosine-based inhibition motifs. Eur J Immunol (1997) 1.07

Interleukin-3 stimulates the tyrosine phosphorylation of the 140-kilodalton interleukin-3 receptor. J Biol Chem (1989) 1.06

SLP-76 is a direct substrate of SHP-1 recruited to killer cell inhibitory receptors. J Biol Chem (1998) 1.06

The role of SHIP in cytokine-induced signaling. Rev Physiol Biochem Pharmacol (2003) 1.06

Interleukin-3 induces the association of the inositol 5-phosphatase SHIP with SHP2. J Biol Chem (1997) 1.04

Purification of a multipotential colony-stimulating factor from pokeweed mitogen-stimulated mouse spleen cell conditioned medium. J Biol Chem (1985) 1.03

Dopamine D1 and N-methyl-D-aspartate receptors and extracellular signal-regulated kinase mediate neuronal morphological changes induced by repeated cocaine administration. Neuroscience (2010) 1.03

Pulmonary alveolar proteinosis is a disease of decreased availability of GM-CSF rather than an intrinsic cellular defect. Clin Immunol (2000) 1.02

Identification of the interleukin-3 receptor using an iodinatable, cleavable, photoreactive cross-linking agent. J Biol Chem (1986) 1.02

SHIP's C-terminus is essential for its hydrolysis of PIP3 and inhibition of mast cell degranulation. Blood (2001) 1.01

Two continuous spectrophotometric assays for methionine aminopeptidase. Anal Biochem (2000) 1.01

Role of Src homology 2-containing-inositol 5'-phosphatase (SHIP) in mast cells and macrophages. Biochem Soc Trans (2003) 1.00

Tyrosine 425 within the activated erythropoietin receptor binds Syp, reduces the erythropoietin required for Syp tyrosine phosphorylation, and promotes mitogenesis. Blood (1996) 1.00

Multiple forms of uridine kinase in normal and neoplastic rat liver. Biochem J (1971) 0.99

Initial evaluation of the use of USPIO cell labeling and noninvasive MR monitoring of human tissue-engineered vascular grafts in vivo. FASEB J (2008) 0.99

Cloning and characterization of human SHIP, the 145-kD inositol 5-phosphatase that associates with SHC after cytokine stimulation. Blood (1996) 0.99

Activation of multiple hemopoietic growth factor genes in Abelson virus-transformed myeloid cells. Exp Hematol (1988) 0.98

A sensitive method for estimating the carbohydrate content of glycoproteins. Anal Biochem (1976) 0.98

Detection and isolation of the erythropoietin receptor using biotinylated erythropoietin. Blood (1990) 0.98

Synthesis and antibacterial activity of peptide deformylase inhibitors. Biochemistry (2000) 0.98

p27KIP1 deletions in childhood acute lymphoblastic leukemia. Neoplasia (1999) 0.97

The safety and efficacy of live attenuated influenza vaccine in young children with asthma or prior wheezing. Eur J Clin Microbiol Infect Dis (2012) 0.97

Renal proximal tubular AT2 receptor: signaling and transport. J Am Soc Nephrol (1999) 0.97

c-myc expression correlates with suppression of c-kit protooncogene expression in small cell lung cancer cell lines. Cancer Res (1993) 0.97

Erythropoietin-induced tyrosine phosphorylations in a high erythropoietin receptor-expressing lymphoid cell line. Blood (1992) 0.97

Regulation of phosphatidylinositol 3,4,5-trisphosphate 5'-phosphatase activity by insulin. J Biol Chem (1996) 0.96

T cells infiltrating non-Hodgkin's B cell lymphomas show altered tyrosine phosphorylation pattern even though T cell receptor/CD3-associated kinases are present. J Immunol (1995) 0.96

The role of SHIP1 in macrophage programming and activation. Biochem Soc Trans (2004) 0.96

Upstream organization of and multiple transcripts from the human folylpoly-gamma-glutamate synthetase gene. J Biol Chem (1995) 0.95

Deficiency of SHP-1 protein-tyrosine phosphatase activity results in heightened osteoclast function and decreased bone density. Am J Pathol (1999) 0.94

The acenes: is there a relationship between aromatic stabilization and reactivity? Org Lett (2001) 0.93

Erythropoietin and interleukin-3 induce distinct events in erythropoietin receptor-expressing BA/F3 cells. Blood (1995) 0.93

Multiple forms of the SH2-containing inositol phosphatase, SHIP, are generated by C-terminal truncation. Blood (1998) 0.93

Ligand-induced phosphorylation of the murine interleukin 3 receptor signals its cleavage. Proc Natl Acad Sci U S A (1992) 0.93

A methotrexate insensitive variant of folate reductase present in two lines of methotrexate-resistant L5178Y cells. Eur J Cancer (1980) 0.92

Selective stimulation by mouse spleen cell conditioned medium of human eosinophil colony formation. Blood (1983) 0.92

The role of SHIP in growth factor induced signalling. Prog Biophys Mol Biol (1999) 0.91