PubRank

H Ginsburg

Author PubWeight™ 166.64‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 The in vitro differentiation of mast cells. Cultures of cells from immunized mouse lymph nodes and thoracic duct lymph on fibroblast monolayers. J Cell Biol 1967 3.14
2 Destruction of mouse and rat embryo cells in tissue culture by lymph node cells from unsensitized rats. J Cell Physiol 1965 2.44
3 Identification of the acidic compartment of Plasmodium falciparum-infected human erythrocytes as the target of the antimalarial drug chloroquine. EMBO J 1984 2.11
4 Graft versus host reaction in tissue culture. I. Lysis of monolayers of embryo mouse cells from strains differing in the H-2 histocompatibility locus by rat lymphocytes sensitized in vitro. Immunology 1968 2.04
5 Characterization of permeation pathways appearing in the host membrane of Plasmodium falciparum infected red blood cells. Mol Biochem Parasitol 1985 1.94
6 Graft reaction in tissue culture. II. Quantification of the lytic action on mouse fibroblasts by rat lymphocytes sensitized on mouse embryo monolayers. Immunology 1969 1.93
7 Characterization of permeation pathways in the plasma membrane of human erythrocytes infected with early stages of Plasmodium falciparum: association with parasite development. J Cell Physiol 1985 1.91
8 Impairment of macrophage functions after ingestion of Plasmodium falciparum-infected erythrocytes or isolated malarial pigment. J Exp Med 1992 1.78
9 The permeation of organic acids through lecithin bilayers. Resemblance to diffusion in polymers. Biochim Biophys Acta 1975 1.76
10 An assay of malaria parasite invasion into human erythrocytes. The effects of chemical and enzymatic modification of erythrocyte membrane components. Biochim Biophys Acta 1983 1.63
11 Susceptibility of human malaria parasites to chloroquine is pH dependent. Proc Natl Acad Sci U S A 1985 1.62
12 Optimisation of flow cytometric measurement of parasitaemia in plasmodium-infected mice. Int J Parasitol 2000 1.61
13 DNA sequence analysis of a 5.27-kb direct repeat occurring adjacent to the regions of S-episome homology in maize mitochondria. EMBO J 1986 1.59
14 Extensive transformation of lymphocytes by a mycoplasma organism. Nat New Biol 1973 1.58
15 Transport of uridine in human red blood cells. Demonstration of a simple carrier-mediated process. J Gen Physiol 1977 1.58
16 Uptake of [3H]chloroquine by drug-sensitive and -resistant strains of the human malaria parasite Plasmodium falciparum. Biochem Pharmacol 1986 1.53
17 Lymphocyte activation by various Mycoplasma strains and species. Infect Immun 1977 1.52
18 Mathematical modelling of the chemotherapy of Plasmodium falciparum malaria with artesunate: postulation of 'dormancy', a partial cytostatic effect of the drug, and its implication for treatment regimens. Parasitology 2000 1.50
19 Differentiation and activity of mast cells following immunization in cultures of lymph-node cells. Immunology 1978 1.46
20 Effects of chloroquine on the feeding mechanism of the intraerythrocytic human malarial parasite Plasmodium falciparum. J Protozool 1984 1.46
21 New permeability pathways induced in membranes of Plasmodium falciparum infected erythrocytes. Mol Biochem Parasitol 1983 1.45
22 Sequence analysis of the maize mitochondrial 26 S rRNA gene and flanking regions. Plasmid 1984 1.45
23 Cellular uptake of chloroquine is dependent on binding to ferriprotoporphyrin IX and is independent of NHE activity in Plasmodium falciparum. J Cell Biol 1999 1.44
24 Analysis of plant root electropotentials. J Theor Biol 1972 1.39
25 Isolation and characterization of an operator-constitutive mutation in the recA gene of E. coli K-12. Mol Gen Genet 1982 1.37
26 Metabolic interconnection between the human malarial parasite Plasmodium falciparum and its host erythrocyte. Regulation of ATP levels by means of an adenylate translocator and adenylate kinase. J Biol Chem 1989 1.34
27 Model for iso-osmotic water flow in plant roots. J Theor Biol 1971 1.33
28 Mathematical modelling of the within-host dynamics of Plasmodium falciparum. Parasitology 2000 1.33
29 Diffusion within egg lecithin bilayers resembles that within soft polymers. J Gen Physiol 1978 1.32
30 Heme degradation in the presence of glutathione. A proposed mechanism to account for the high levels of non-heme iron found in the membranes of hemoglobinopathic red blood cells. J Biol Chem 1995 1.28
31 The mitochondrion of Plasmodium falciparum visualized by rhodamine 123 fluorescence. J Protozool 1985 1.27
32 Cell survival, UV-reactivation and induction of prophage lambda in Escherichia coli K12 overproducing RecA protein. Mol Gen Genet 1982 1.27
33 The malaria parasite supplies glutathione to its host cell--investigation of glutathione transport and metabolism in human erythrocytes infected with Plasmodium falciparum. Eur J Biochem 1997 1.26
34 Biophysical analysis of novel transport pathways induced in red blood cell membranes. J Membr Biol 1987 1.21
35 Origin of reactive oxygen species in erythrocytes infected with Plasmodium falciparum. Mol Biochem Parasitol 1993 1.20
36 Digestion of the host erythrocyte by malaria parasites is the primary target for quinoline-containing antimalarials. Biochem Pharmacol 1986 1.20
37 Alterations in membrane permeability of malaria-infected human erythrocytes are related to the growth stage of the parasite. Biochim Biophys Acta 1982 1.18
38 On the mode of action of phlorizin as an antimalarial agent in in vitro cultures of Plasmodium falciparum. Biochem Pharmacol 1987 1.18
39 Phagocytosis of Plasmodium falciparum-infected human red blood cells by human monocytes: involvement of immune and nonimmune determinants and dependence on parasite developmental stage. Blood 1992 1.17
40 Aggregation and transformation of rat lymphocytes on rat embryo monolayers. J Cell Biol 1968 1.17
41 Mitogenic activity of Mycoplasma pulmonis. I. Stimulation of rat B and T lymphocytes. Immunology 1979 1.15
42 Modelling the chloroquine chemotherapy of falciparum malaria: the value of spacing a split dose. Parasitology 1998 1.15
43 Kinetic analysis of a graft reaction induced in cell culture. Immunology 1969 1.14
44 Activation of B lymphocytes by mycoplasma mitogen(s). Immunology 1978 1.14
45 Mathematical modelling of malaria chemotherapy: combining artesunate and mefloquine. Parasitology 2002 1.13
46 Potent antimalarial activity of clotrimazole in in vitro cultures of Plasmodium falciparum. Proc Natl Acad Sci U S A 2000 1.12
47 The development of hypersensitive lymphocytes in cell culture. J Exp Med 1971 1.11
48 Antimalarial activities of dermaseptin S4 derivatives. Antimicrob Agents Chemother 2000 1.10
49 Mast cell growth on fibroblast monolayers: two-cell entities. Immunology 1982 1.10
50 Absence of alpha-ketoglutarate dehydrogenase activity and presence of CO2-fixing activity in Plasmodium falciparum grown in vitro in human erythrocytes. J Protozool 1984 1.10
51 Current concepts and new ideas on the mechanism of action of quinoline-containing antimalarials. Biochem Pharmacol 1987 1.10
52 Graft reaction in tissue culture. 3. Effect of phytohaemagglutinin. Immunology 1969 1.09
53 Effects of mitochondrial inhibitors on intraerythrocytic Plasmodium falciparum in in vitro cultures. J Protozool 1986 1.09
54 Ethnopharmacology and malaria: new hypothetical leads or old efficient antimalarials? Int J Parasitol 2007 1.08
55 Erythrocyte stages of Plasmodium falciparum exhibit a high nitric oxide synthase (NOS) activity and release an NOS-inducing soluble factor. J Exp Med 1995 1.06
56 The fate of ferriprotorphyrin IX in malaria infected erythrocytes in conjunction with the mode of action of antimalarial drugs. Mol Biochem Parasitol 1999 1.05
57 Mouse heparin proteoglycan. Synthesis by mast cell-fibroblast monolayers during lymphocyte-dependent mast cell proliferation. J Biol Chem 1982 1.04
58 Mode of antimalarial effect of methylene blue and some of its analogues on Plasmodium falciparum in culture and their inhibition of P. vinckei petteri and P. yoelii nigeriensis in vivo. Biochem Pharmacol 1996 1.03
59 Lysis of target cell monolayers by lymphocytes stimulated with pokeweed mitogen. Transplantation 1971 1.03
60 Effects of red blood cell potassium and hypertonicity on the growth of Plasmodium falciparum in culture. Z Parasitenkd 1986 1.03
61 Kinetic characterization of Na+/H+ antiport of Plasmodium falciparum membrane. J Cell Physiol 1993 1.02
62 Transport of lactate in Plasmodium falciparum-infected human erythrocytes. J Cell Physiol 1991 1.02
63 Hexose-monophosphate shunt activity in intact Plasmodium falciparum-infected erythrocytes and in free parasites. Mol Biochem Parasitol 1994 1.01
64 Functional characterization of anion transport system isolated from human erythrocyte membranes. J Biol Chem 1977 1.00
65 Effects of mitochondrial protein synthesis inhibitors on the incorporation of isoleucine into Plasmodium falciparum in vitro. J Protozool 1984 0.98
66 Graft reaction in tissue culture by normal rat lymphocytes. Transplant Proc 1969 0.98
67 Mitogenic activity of Mycoplasma pulmonis. II. Studies on the biochemical nature of the mitogenic factor. Eur J Immunol 1979 0.97
68 The function of the delayed sensitivity reaction as revealed in the graft reaction culture. Adv Cancer Res 1970 0.97
69 Kinetics of inhibition of glutathione-mediated degradation of ferriprotoporphyrin IX by antimalarial drugs. Biochem Pharmacol 1999 0.96
70 Hemoglobin denaturation and iron release in acidified red blood cell lysate--a possible source of iron for intraerythrocytic malaria parasites. Exp Parasitol 1993 0.96
71 Antiplasmodial activity of lauryl-lysine oligomers. Antimicrob Agents Chemother 2007 0.96
72 Antimalarial effects of C18 fatty acids on Plasmodium falciparum in culture and on Plasmodium vinckei petteri and Plasmodium yoelii nigeriensis in vivo. Exp Parasitol 1995 0.95
73 Effects of L-asparaginase on lymphocyte-target cell reactions in vitro. Nature 1970 0.95
74 Chronotherapy of malaria: an approach to malaria chemotherapy. Parasitol Today 1991 0.94
75 Kinetic modelling of the response of Plasmodium falciparum to chloroquine and its experimental testing in vitro. Implications for mechanism of action of and resistance to the drug. Biochem Pharmacol 1990 0.94
76 Covalent modification of the permeability pathways induced in the human erythrocyte membrane by the malarial parasite Plasmodium falciparum. J Cell Physiol 1987 0.94
77 Degranulation capacity of cultured mast cells in the presence of histamine releaser. Nature 1979 0.92
78 Chloroquine inhibits the degradation of endocytic vesicles in human malaria parasites. Cell Biol Int Rep 1983 0.92
79 Mycoplasma neurolyticum: a potent mitogen for rat B lymphocytes. Eur J Immunol 1979 0.92
80 Reduced microbicidal and anti-tumour activities of human monocytes after ingestion of Plasmodium falciparum-infected red blood cells. Parasite Immunol 1993 0.92
81 In vitro generation of memory lymphocytes reactive to transplantation antigens. J Exp Med 1974 0.90
82 The effect of ferriprotoporphyrin IX and chloroquine on phospholipid monolayers and the possible implications to antimalarial activity. Biochim Biophys Acta 1983 0.90
83 The treatment of Plasmodium falciparum-infected erythrocytes with chloroquine leads to accumulation of ferriprotoporphyrin IX bound to particular parasite proteins and to the inhibition of the parasite's 6-phosphogluconate dehydrogenase. Parasite 2003 0.90
84 Calcium transport and compartment analysis of free and exchangeable calcium in Plasmodium falciparum-infected red blood cells. J Protozool 1992 0.89
85 Experimental conditions for testing the inhibitory activity of chloroquine on the formation of beta-hematin. Exp Parasitol 2000 0.88
86 The status of zinc in malaria (Plasmodium falciparum) infected human red blood cells: stage dependent accumulation, compartmentation and effect of dipicolinate. Biochim Biophys Acta 1986 0.88
87 Anion transport inhibitors as suppressors of Plasmodium falciparum growth in in vitro cultures. Mol Pharmacol 1983 0.88
88 Adenomyoma arising in a meckel diverticulum: case report and review of the literature. Pediatr Dev Pathol 2000 0.88
89 Specific adherence of in vitro differentiated lymphocytes to target cells. J Exp Med 1972 0.88
90 Correlation of erythrocyte and plasma levels of zinc, copper, and iron with evidence of metastatic spread in cancer patients. Cancer 1985 0.87
91 Mast cell differentiation depends on T cells and granule synthesis on fibroblasts. Immunology 1983 0.87
92 The pharmacokinetics of chloroquine in healthy and Plasmodium chabaudi-infected mice: implications for chronotherapy. Parasite 1994 0.87
93 Role of internal domains of glycophorin in Plasmodium falciparum invasion of human erythrocytes. Infect Immun 1983 0.87
94 A non-radiolabelled ferriprotoporphyrin IX biomineralisation inhibition test for the high throughput screening of antimalarial compounds. Exp Parasitol 2002 0.87
95 Selectivity properties of pores induced in host erythrocyte membrane by Plasmodium falciparum. Effect of parasite maturation. Biochim Biophys Acta 1986 0.87
96 Transglutaminase in Plasmodium parasites: activity and putative role in oocysts and blood stages. Mol Biochem Parasitol 2001 0.86
97 Erythrophagocytosis in malaria: Host defence or menace to the macrophage? Parasitol Today 1991 0.86
98 Lysis and necrosis: analysis of two cytotoxic phenomena mediated by lymphocytes. Isr J Med Sci 1976 0.86
99 Effects of cinnamic acid derivatives on in vitro growth of Plasmodium falciparum and on the permeability of the membrane of malaria-infected erythrocytes. Antimicrob Agents Chemother 1992 0.85
100 Facilitated transport of di- and trinitrophenolate ions across lipid membranes by valinomycin and nonactin. Biochim Biophys Acta 1976 0.85
101 Zero-trans and infinite-cis uptake of galactose in human erythrocytes. Biochim Biophys Acta 1975 0.85
102 Effects of temperature on the transport of galactose in human erythrocytes. J Physiol 1978 0.84
103 Enhancement of mast cell differentiation in vitro by T cell factor(s). Int Arch Allergy Appl Immunol 1981 0.84
104 Interactions of hemin, antimalarial drugs and hemin-antimalarial complexes with phospholipid monolayers. Chem Phys Lipids 1984 0.84
105 Compartment analysis of ATP in malaria-infected erythrocytes. Biochem Int 1988 0.83
106 Graft reaction in cell culture. Isr J Med Sci 1969 0.83
107 Cycles of transformation and differentiation of lymphocytes in vitro. Transplant Proc 1971 0.82
108 Transport and trafficking in the malaria-infected erythrocyte. Parasitol Today 1999 0.82
109 Permselectivity changes in malaria (Plasmodium falciparum) infected human red blood cell membranes. J Cell Physiol 1983 0.82
110 Plasmodium vinckei vinckei, P. v. lentum and P. yoelii yoelii: chronobiology of the asexual cycle in the blood. Parasite 1994 0.81
111 Oriented reconstitution of red cell membrane proteins and assessment of their transmembrane disposition by immunoquenching of fluorescence. Biochim Biophys Acta 1985 0.81
112 Experimental modifications of the circadian rythm of Plasmodium vinckei petteri following cryopreservation; probable resistance of the merozoïte to thawing. C R Acad Sci III 1988 0.81
113 Evidence from electron paramagnetic resonance for function-related conformation changes in the anion-transport protein of human erythrocytes. Eur J Biochem 1981 0.81
114 The malarial pigment in rat infected erythrocytes and its interaction with chloroquine. A Mössbauer effect study. J Biol Chem 1984 0.81
115 The anion-transfer system of erythrocyte membranes. N-(7-Nitrobenzofurazan-4-yl)taurine, a fluorescent substrate-analogue of the system. Biochem J 1981 0.80
116 Inhibition by anti-malarial drugs of haemoglobin denaturation and iron release in acidified red blood cell lysates--a possible mechanism of their anti-malarial effect? Parasitology 1994 0.80
117 Antimalarial properties of soy-bean fat emulsions. Int J Parasitol 1995 0.80
118 Effects of combinations of quinoline-containing antimalarials on Plasmodium falciparum in culture. Ann Trop Med Parasitol 1986 0.80
119 The susceptibility of the malarial parasite Plasmodium falciparum to quinoline-containing drugs is correlated to the lipid composition of the infected erythrocyte membranes. Biochem Pharmacol 1993 0.80
120 Chronotherapy of malaria: improved efficacy of timed chloroquine treatment of patients with Plasmodium falciparum infections. Trans R Soc Trop Med Hyg 1992 0.79
121 A method for the measurement of chloroquine uptake in erythrocytes. Anal Biochem 1980 0.79
122 Uptake of L-tryptophan by erythrocytes infected with malaria parasites (Plasmodium falciparum). Biochim Biophys Acta 1983 0.79
123 Synchronization of Plasmodium yoelii nigeriensis and P. y. killicki infection in the mouse by means of Percoll-glucose gradient stage fractionation: determination of the duration of the schizogonic cycle. Parasitol Res 1994 0.79
124 Ultrastructural aspects of the adherence to target cells of in vitro differentiated lymphocytes. Proc Soc Exp Biol Med 1975 0.79
125 Orientation of transmembrane polypeptides as revealed by antibody quenching of fluorescence. Biochim Biophys Acta 1984 0.79
126 Reconstitution of the erythrocyte anion transport system: in vitro and in vivo approaches. Ann N Y Acad Sci 1980 0.78
127 Does stem cell self renewal and progenitor cell commitment operate through an effector-memory cell mechanism? Immunol Lett 1986 0.78
128 Cure of fibroblast monolayers from murine cytomegalovirus infection: phenotypic assessment of rat lymphoid cell population developed on fibroblast monolayers. Cell Immunol 1996 0.78
129 Can biochemical properties serve as selective pressure for gene selection during inter-species and endosymbiotic lateral gene transfer? Syst Biol (Stevenage) 2006 0.78
130 A simplified microassay for serotonin: modification of the enzymatic isotopic assay. Anal Biochem 1978 0.78
131 Antimalarial drug development and new targets. Parasitol Today 2000 0.78
132 The transport of chloroquine across human erythrocyte membranes is mediated by a simple symmetric carrier. Biochim Biophys Acta 1982 0.78
133 Stage sensitivity of Plasmodium vinckei petteri to quinine, mefloquine, and pyrimethamine. J Parasitol 1995 0.78
134 Gentamicin and amikacin repress the growth of Plasmodium falciparum in culture, probably by inhibiting a parasite acid phospholipase. Life Sci 1987 0.78
135 Galactose transport in human erythrocytes. The transport mechanism is resolved into two simple asymmetric antiparallel carriers. Biochim Biophys Acta 1978 0.77
136 Growth and differentiation of cells of lymphoid origin on embryo cell monolayers. Wistar Inst Symp Monogr 1965 0.77
137 Effect of ferriprotoporphyrin IX and non-heme iron on the Ca(2+) pump of intact human red cells. J Membr Biol 2000 0.77
138 Recognition signals for phagocytic removal of favic, malaria-infected and sickled erythrocytes. Adv Exp Med Biol 1991 0.77
139 A search for natural bioactive compounds in Bolivia through a multidisciplinary approach. Part IV. Is a new haem polymerisation inhibition test pertinent for the detection of antimalarial natural products? J Ethnopharmacol 2000 0.77
140 Protonophoric effects of antimalarial drugs and alkylamines in Escherichia coli membranes. Biochim Biophys Acta 1989 0.77
141 Granular natural-killer cells develop into mucus-secreting cells. Immunol Lett 1985 0.77
142 Synthesis of chondroitin sulfate D and heparin proteoglycans in murine lymph node-derived mast cells. The dependence on fibroblasts. J Biol Chem 1990 0.77
143 Murine interleukin-2 generates glycogen-rich and mucus-secreting NK cells. Immunology 1983 0.77
144 Studies on the antimalarial mode of action of quinoline-containing drugs: time-dependence and irreversibility of drug action, and interactions with compounds that alter the function of the parasite's food vacuole. Life Sci 1991 0.77
145 Iron acquisition by Plasmodium spp. Parasitol Today 1999 0.77
146 Single or multiple localization of ADP/ATP transporter in human malarial Plasmodium falciparum. Biochem Pharmacol 1992 0.76
147 The modulatory effect of membrane viscosity on structural and functional properties of the anion exchange protein of human erythrocytes. Membr Biochem 1986 0.76
148 Effects of lysosomotropic detergents on the human malarial parasite Plasmodium falciparum in in vitro culture. Biochem Pharmacol 1989 0.76
149 Zero-trans and equilibrium-exchange efflux and infinite-trans uptake of galactose by human erythrocytes. Biochim Biophys Acta 1975 0.76
150 Hydrophobic interactions in Plasmodium falciparum invasion into human erythrocytes. Mol Biochem Parasitol 1984 0.76
151 Na+/H+ antiporter, chloroquine uptake and drug resistance: inconsistencies in a newly proposed model. Parasitol Today 1999 0.76
152 Chronotherapy of malaria: identification of drug-sensitive stage of parasite and timing of drug delivery for improved therapy. Ann Parasitol Hum Comp 1991 0.76
153 On uridine transport in human red blood cells. J Gen Physiol 1977 0.75
154 Inhibition of malaria parasite invasion of human erythrocytes by a lymphocyte membrane polypeptide. Infect Immun 1987 0.75
155 The Plasmodium digestive vacuole and drug choice. Parasitol Today 1996 0.75
156 Chloroquine as intercalator: should this hypothesis be revived? Parasitol Today 1990 0.75
157 The modulating effect of human chorionic gonadotropin on lymphocyte blastogenesis. Am J Obstet Gynecol 1977 0.75
158 On the use of single-cell fluorescence imaging for the measurement of intracellular ion concentrations. Parasitol Today 2000 0.75
159 How Plasmodium secures nutrients: new targets for drugs? Parasitol Today 1994 0.75
160 Characterisation of the morphogenetic course and secretion of two different types of mucoid material by granulated metrial gland/lymphokine-activated killer cells. J Anat 1995 0.75
161 Elevation of erythrocyte zinc- and free protoporphyrins with metastatic spread in cancer patients. Eur J Cancer Clin Oncol 1986 0.75
162 Antimalarial drugs inhibit the phagocytosis of erythrocytes infected with Plasmodium falciparum. Trans R Soc Trop Med Hyg 1996 0.75
163 Effects of mode of presentation and number of categories on estimates of proportion by 4-year-olds. Percept Mot Skills 1968 0.75
164 Childhood victimization: desensitization effects in the later lifespan. Child Psychiatry Hum Dev 1989 0.75
165 [Fetal infection and impaired weight increase during gestation of mycoplasma infected rats]. Harefuah 1978 0.75
166 Proceedings: Time lapse cinematography of lymphocyte transformation of lytic interaction of blast cells with target fibroblasts. Isr J Med Sci 1975 0.75
167 Some effects of trinitrocresolate and valinomycin on Na and K transport across thin lipid bilayer membranes: a steady-state analysis with simultaneous tracer and electrical measurements. J Membr Biol 1978 0.75
168 Biochemistry of Plasmodium on the Web. Parasitol Today 2000 0.75
169 Effect of anti-theta serum on target cell lysis produced by lymphocytes stimulated with pokeweed mitogen. Transplantation 1973 0.75
170 Functional incorporation of the human erythrocyte chloride exchange system into plasma membranes of Friend erythroleukemic cells by Sendai virus-induced cell fusion. Exp Cell Res 1980 0.75
171 Fusion of liposomes with planar lipid bilayers. Biochim Biophys Acta 1980 0.75
172 Plasmodium falciparum: elimination of fungal and bacterial contamination from in vitro culture. Ann Trop Med Parasitol 1984 0.75
173 Effect of plasma lipoproteins on cholesterol accumulation in macrophages: comparison of lipoproteins from normal and homozygous familial hypercholesterolemic subjects. Atherosclerosis 1987 0.75
174 Direct fluorometric determination of erythrocyte free and zinc protoporphyrins in health and disease. Clin Biochem 1985 0.75
175 The strength of non-conservation. J Exp Child Psychol 1966 0.75
176 Effects of instructions and class contrast on children's and adolescents' similarity judgments. Percept Mot Skills 1967 0.75
177 Degranulation of in vitro differentiated mast cells stimulated by two monoclonal IgE specificities. Eur J Immunol 1987 0.75