Published in Microb Pathog on March 01, 1995
Enteric bacterial toxins: mechanisms of action and linkage to intestinal secretion. Microbiol Rev (1996) 3.46
A diffusible cytotoxin of Haemophilus ducreyi. Proc Natl Acad Sci U S A (1997) 2.89
The cell cycle-specific growth-inhibitory factor produced by Actinobacillus actinomycetemcomitans is a cytolethal distending toxin. Infect Immun (1998) 2.41
Campylobacter jejuni cytolethal distending toxin causes a G2-phase cell cycle block. Infect Immun (1998) 2.34
CdtA, CdtB, and CdtC form a tripartite complex that is required for cytolethal distending toxin activity. Infect Immun (2001) 2.13
Salmonella typhi encodes a functional cytolethal distending toxin that is delivered into host cells by a bacterial-internalization pathway. Proc Natl Acad Sci U S A (2004) 1.99
Escherichia coli cytolethal distending toxin blocks the HeLa cell cycle at the G2/M transition by preventing cdc2 protein kinase dephosphorylation and activation. Infect Immun (1997) 1.99
Cytolethal distending toxin sequence and activity in the enterohepatic pathogen Helicobacter hepaticus. Infect Immun (2000) 1.99
Identification of a cytolethal distending toxin gene locus and features of a virulence-associated region in Actinobacillus actinomycetemcomitans. Infect Immun (1999) 1.97
Examination of diarrheagenicity of cytolethal distending toxin: suckling mouse response to the products of the cdtABC genes of Shigella dysenteriae. Infect Immun (1997) 1.80
Gastroenteritis in NF-kappaB-deficient mice is produced with wild-type Camplyobacter jejuni but not with C. jejuni lacking cytolethal distending toxin despite persistent colonization with both strains. Infect Immun (2004) 1.74
Escherichia coli CdtB mediates cytolethal distending toxin cell cycle arrest. Infect Immun (2001) 1.56
Production of cytolethal distending toxins by pathogenic Escherichia coli strains isolated from human and animal sources: establishment of the existence of a new cdt variant (Type IV). J Clin Microbiol (2003) 1.54
Functional studies of the recombinant subunits of a cytolethal distending holotoxin. Cell Microbiol (2002) 1.53
The cytolethal distending toxin from the chancroid bacterium Haemophilus ducreyi induces cell-cycle arrest in the G2 phase. J Clin Invest (1999) 1.52
Controlled study of cytolethal distending toxin-producing Escherichia coli infections in Bangladeshi children. J Clin Microbiol (1996) 1.38
Interactions of Campylobacter jejuni cytolethal distending toxin subunits CdtA and CdtC with HeLa cells. Infect Immun (2003) 1.38
Effect of cytolethal distending toxin on F-actin assembly and cell division in Chinese hamster ovary cells. Infect Immun (1997) 1.27
Characterization of a Haemophilus ducreyi mutant deficient in expression of cytolethal distending toxin. Infect Immun (1999) 1.25
Cytolethal distending toxin demonstrates genotoxic activity in a yeast model. Infect Immun (2001) 1.23
Characterization of Haemophilus ducreyi cdtA, cdtB, and cdtC mutants in in vitro and in vivo systems. Infect Immun (2001) 1.17
A novel mode of action for a microbial-derived immunotoxin: the cytolethal distending toxin subunit B exhibits phosphatidylinositol 3,4,5-triphosphate phosphatase activity. J Immunol (2007) 1.16
PCR for detection of cdt-III and the relative frequencies of cytolethal distending toxin variant-producing Escherichia coli isolates from humans and cattle. J Clin Microbiol (2002) 1.13
Cholesterol-rich membrane microdomains mediate cell cycle arrest induced by Actinobacillus actinomycetemcomitans cytolethal-distending toxin. Cell Microbiol (2006) 1.11
Cytolethal distending toxin-induced cell cycle arrest of lymphocytes is dependent upon recognition and binding to cholesterol. J Biol Chem (2009) 1.10
Cytolethal distending toxin (CDT)-negative Campylobacter jejuni strains and anti-CDT neutralizing antibodies are induced during human infection but not during colonization in chickens. Infect Immun (2005) 1.08
Cytolethal distending toxin genes in Campylobacter jejuni and Campylobacter coli isolates: detection and analysis by PCR. J Clin Microbiol (1999) 1.08
Cytolethal distending toxin from Shiga toxin-producing Escherichia coli O157 causes irreversible G2/M arrest, inhibition of proliferation, and death of human endothelial cells. Infect Immun (2005) 1.07
Variation of loop sequence alters stability of cytolethal distending toxin (CDT): crystal structure of CDT from Actinobacillus actinomycetemcomitans. Protein Sci (2006) 1.04
Prevalence of cytolethal distending toxin production in periodontopathogenic bacteria. J Clin Microbiol (2003) 1.03
Detection of cytolethal distending toxin activity and cdt genes in Actinobacillus actinomycetemcomitans isolates from geographically diverse populations. Oral Microbiol Immunol (2002) 0.97
Association of cytolethal distending toxin locus cdtB with enteropathogenic Escherichia coli isolated from patients with acute diarrhea in Calcutta, India. J Clin Microbiol (2003) 0.96
Resistance of human periodontal ligament fibroblasts to the cytolethal distending toxin of Actinobacillus actinomycetemcomitans. J Periodontol (2005) 0.95
Exposure of lymphocytes to high doses of Actinobacillus actinomycetemcomitans cytolethal distending toxin induces rapid onset of apoptosis-mediated DNA fragmentation. Infect Immun (2006) 0.94
Diversity and impact of prokaryotic toxins on aquatic environments: a review. Toxins (Basel) (2010) 0.94
Role of intrachain disulfides in the activities of the CdtA and CdtC subunits of the cytolethal distending toxin of Actinobacillus actinomycetemcomitans. Infect Immun (2006) 0.93
Cholesterol depletion reduces entry of Campylobacter jejuni cytolethal distending toxin and attenuates intoxication of host cells. Infect Immun (2011) 0.91
Biogenesis of the Actinobacillus actinomycetemcomitans cytolethal distending toxin holotoxin. Infect Immun (2006) 0.90
Blockade of the PI-3K signalling pathway by the Aggregatibacter actinomycetemcomitans cytolethal distending toxin induces macrophages to synthesize and secrete pro-inflammatory cytokines. Cell Microbiol (2014) 0.90
Kinetics of KB and HEp-2 cell responses to an invasive, cytolethal distending toxin-producing strain of Actinobacillus actinomycetemcomitans. Oral Microbiol Immunol (2002) 0.89
Introns in the cytolethal distending toxin gene of Actinobacillus actinomycetemcomitans. J Bacteriol (2005) 0.89
Role of bacteria in carcinogenesis, with special reference to carcinoma of the gallbladder. World J Gastroenterol (2010) 0.88
Patterns of variations in Escherichia coli strains that produce cytolethal distending toxin. Infect Immun (2004) 0.87
Cellular interactions of the cytolethal distending toxins from Escherichia coli and Haemophilus ducreyi. J Biol Chem (2013) 0.84
Inhibition of mast cell degranulation by a chimeric toxin containing a novel phosphatidylinositol-3,4,5-triphosphate phosphatase. Mol Immunol (2010) 0.83
Impact of cholesterol on disease progression. Biomedicine (Taipei) (2015) 0.83
Stability and infectivity of cytolethal distending toxin type V gene-carrying bacteriophages in a water mesocosm and under different inactivation conditions. Appl Environ Microbiol (2012) 0.80
Occurrence of genes encoding enterotoxins in uropathogenic Escherichia coli isolates. Braz J Microbiol (2015) 0.80
The Aggregatibacter actinomycetemcomitans Cytolethal Distending Toxin Active Subunit CdtB Contains a Cholesterol Recognition Sequence Required for Toxin Binding and Subunit Internalization. Infect Immun (2015) 0.80
The cytolethal distending toxin of Haemophilus ducreyi inhibits endothelial cell proliferation. Infect Immun (2002) 0.79
The Cytolethal Distending Toxin Contributes to Microbial Virulence and Disease Pathogenesis by Acting As a Tri-Perditious Toxin. Front Cell Infect Microbiol (2016) 0.78
Evolution of a self-inducible cytolethal distending toxin type V-encoding bacteriophage from Escherichia coli O157:H7 to Shigella sonnei. J Virol (2013) 0.78
Aggregatibacter actinomycetemcomitans cytolethal distending toxin activates the NLRP3 inflammasome in human macrophages, leading to the release of proinflammatory cytokines. Infect Immun (2015) 0.76
Lymphoid susceptibility to the Aggregatibacter actinomycetemcomitans cytolethal distending toxin is dependent upon baseline levels of the signaling lipid, phosphatidylinositol-3,4,5-triphosphate. Mol Oral Microbiol (2015) 0.76
Molecular Mechanisms and Potential Clinical Applications of Campylobacter jejuni Cytolethal Distending Toxin. Front Cell Infect Microbiol (2016) 0.75
Map-based comparative genomic analysis of virulent haemophilus parasuis serovars 4 and 5. J Genomics (2015) 0.75
Cytolethal Distending Toxin From Campylobacter jejuni Requires the Cytoskeleton for Toxic Activity. Jundishapur J Microbiol (2016) 0.75
A Journey of Cytolethal Distending Toxins through Cell Membranes. Front Cell Infect Microbiol (2016) 0.75
Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J Immunol (1999) 16.86
Structure of the cro repressor from bacteriophage lambda and its interaction with DNA. Nature (1981) 5.24
Site of action of a Vero toxin (VT2) from Escherichia coli O157:H7 and of Shiga toxin on eukaryotic ribosomes. RNA N-glycosidase activity of the toxins. Eur J Biochem (1988) 5.22
Emergence of a unique O3:K6 clone of Vibrio parahaemolyticus in Calcutta, India, and isolation of strains from the same clonal group from Southeast Asian travelers arriving in Japan. J Clin Microbiol (1997) 4.53
Spread of Vibrio cholerae O139 Bengal in India. J Infect Dis (1994) 3.91
Cloning and nucleotide sequencing of Vero toxin 2 variant genes from Escherichia coli O91:H21 isolated from a patient with the hemolytic uremic syndrome. Microb Pathog (1990) 3.88
DNA-binding proteins. Science (1983) 3.56
The molecular basis of DNA-protein recognition inferred from the structure of cro repressor. Nature (1982) 3.56
Immunological nonidentity of heat-labile enterotoxins from human and porcine enterotoxigenic Escherichia coli. Infect Immun (1981) 3.46
Modified Elek test for detection of heat-labile enterotoxin of enterotoxigenic Escherichia coli. J Clin Microbiol (1981) 3.37
Polymerase chain reaction for detection of the cholera enterotoxin operon of Vibrio cholerae. J Clin Microbiol (1991) 3.32
Production of cholera-like enterotoxin by a Vibrio cholerae non-O1 strain isolated from the environment. Infect Immun (1981) 3.21
Molecular epidemiologic evidence for association of thermostable direct hemolysin (TDH) and TDH-related hemolysin of Vibrio parahaemolyticus with gastroenteritis. Infect Immun (1990) 3.17
Identification of lethal toxin with the thermostable direct hemolysin produced by Vibrio parahaemolyticus, and some physicochemical properties of the purified toxin. Infect Immun (1976) 3.11
Development and evaluation of a multiplex PCR assay for rapid detection of toxigenic Vibrio cholerae O1 and O139. FEMS Immunol Med Microbiol (1998) 2.98
Detection of the thermostable direct hemolysin gene and related DNA sequences in Vibrio parahaemolyticus and other vibrio species by the DNA colony hybridization test. Infect Immun (1985) 2.90
Amino-acid sequence of a heat-stable enterotoxin produced by human enterotoxigenic Escherichia coli. Eur J Biochem (1982) 2.78
Non-O1 Vibrio cholerae hemolysin: purification, partial characterization, and immunological relatedness to El Tor hemolysin. Infect Immun (1984) 2.72
Clonal diversity among recently emerged strains of Vibrio parahaemolyticus O3:K6 associated with pandemic spread. J Clin Microbiol (1999) 2.66
Enzyme-linked immunosorbent assay to measure antibodies to purified heat-labile enterotoxins from human and porcine strains of Escherichia coli and to cholera toxin: application in serodiagnosis and seroepidemiology. J Clin Microbiol (1985) 2.66
Vibrio cholerae O139 Bengal in Bangkok. Lancet (1993) 2.64
Purification and some properties of a non-o1 Vibrio cholerae enterotoxin that is identical to cholera enterotoxin. Infect Immun (1983) 2.62
Lambda repressor recognizes the approximately 2-fold symmetric half-operator sequences asymmetrically. Proc Natl Acad Sci U S A (1989) 2.61
Isolation of a factor causing morphological changes of chinese hamster ovary cells from the culture filtrate of Vibrio parahaemolyticus. Infect Immun (1976) 2.56
Purification and partial characterization of heat-stable enterotoxin of enterotoxigenic Escherichia coli. Infect Immun (1979) 2.55
Demonstration of the cardiotoxicity of the thermostable direct hemolysin (lethal toxin) produced by Vibrio parahaemolyticus. Infect Immun (1976) 2.51
Sequential appearance of gamma/delta- and alpha/beta-bearing T cells in the peritoneal cavity during an i.p. infection with Listeria monocytogenes. Eur J Immunol (1990) 2.44
Molecular evidence of clonal Vibrio parahaemolyticus pandemic strains. Emerg Infect Dis (2001) 2.24
Detection of the thermostable direct hemolysin gene (tdh) and the thermostable direct hemolysin-related hemolysin gene (trh) of Vibrio parahaemolyticus by polymerase chain reaction. Mol Cell Probes (1992) 2.22
Synthetic ColE1 plasmids carrying genes for cell division in Escherichia coli. Plasmid (1977) 2.22
Virulence genes in environmental strains of Vibrio cholerae. Appl Environ Microbiol (2000) 2.21
Temporal shifts in traits of Vibrio cholerae strains isolated from hospitalized patients in Calcutta: a 3-year (1993 to 1995) analysis. J Clin Microbiol (1996) 2.21
Amino acid sequence of Cro regulatory protein of bacteriophage lambda. Nature (1977) 2.18
Sequence variation in the thermostable direct hemolysin-related hemolysin (trh) gene of Vibrio parahaemolyticus. Appl Environ Microbiol (1992) 2.16
Immunological methods for detection of Kanagawa phenomenon of Vibrio parahaemolyticus. J Clin Microbiol (1980) 2.15
In vitro formation of hybrid toxins between subunits of Escherichia coli heat-labile enterotoxin and those of cholera enterotoxin. Infect Immun (1981) 2.12
Economic recession and health inequalities in Japan: analysis with a national sample, 1986-2001. J Epidemiol Community Health (2008) 2.11
Structure of the DNA-binding region of lac repressor inferred from its homology with cro repressor. Proc Natl Acad Sci U S A (1982) 2.09
A nontoxic mutant of cholera toxin elicits Th2-type responses for enhanced mucosal immunity. Proc Natl Acad Sci U S A (1997) 2.07
Blockage of interleukin-6 receptor ameliorates joint disease in murine collagen-induced arthritis. Arthritis Rheum (1998) 2.01
DNA-dependent protein kinase (Ku protein-p350 complex) assembles on double-stranded DNA. Proc Natl Acad Sci U S A (1994) 2.01
Thermostable direct hemolysin of Vibrio parahaemolyticus. Pharmacol Ther (1982) 2.01
Expanding multiple antibiotic resistance among clinical strains of Vibrio cholerae isolated from 1992-7 in Calcutta, India. Epidemiol Infect (2000) 1.96
Molecular analysis of non-O1, non-O139 Vibrio cholerae associated with an unusual upsurge in the incidence of cholera-like disease in Calcutta, India. J Clin Microbiol (1998) 1.94
Isolation of special antibodies which react only with homologous enterotoxins from Vibrio cholerae and Enterotoxigenic Escherichia coli. Infect Immun (1981) 1.94
Evidence that a non-O1 Vibrio cholerae produces enterotoxin that is similar but not identical to cholera enterotoxin. Infect Immun (1983) 1.93
Ribosomes from Escherichia coli merodiplods heterozygous for resistance to streptomycin and to spectinomycin. J Mol Biol (1968) 1.92
Purification and some properties of a Vero toxin from Escherichia coli O157:H7 that is immunologically unrelated to Shiga toxin. Microb Pathog (1987) 1.90
Existence of two distinct hemolysins in Vibrio parahaemolyticus. Infect Immun (1974) 1.90
Further evaluation of the Biken test (modified Elek test) for detection of enterotoxigenic Escherichia coli producing heat-labile enterotoxin and application of the test to sampling of heat-stable enterotoxin. J Clin Microbiol (1982) 1.89
The complete sequence of botulinum neurotoxin type A and comparison with other clostridial neurotoxins. J Biol Chem (1990) 1.86
Kinetic studies on Cro repressor-operator DNA interaction. J Mol Biol (1987) 1.85
Amino acid sequence of a heat-stable enterotoxin isolated from enterotoxigenic Escherichia coli strain 18D. FEBS Lett (1983) 1.85
Detection of various variant verotoxin genes in Escherichia coli by polymerase chain reaction. Microbiol Immunol (1993) 1.84
Structure and gene expression of the E. coli Mn-superoxide dismutase gene. Nucleic Acids Res (1986) 1.83
Detection of urovirulence factors in Escherichia coli by multiplex polymerase chain reaction. FEMS Immunol Med Microbiol (1995) 1.83
Examination of diarrheagenicity of cytolethal distending toxin: suckling mouse response to the products of the cdtABC genes of Shigella dysenteriae. Infect Immun (1997) 1.80
Virulence patterns of Vibrio cholerae non-O1 strains isolated from hospitalised patients with acute diarrhoea in Calcutta, India. J Med Microbiol (1993) 1.80
A thermolabile direct hemolysin of Vibrio parahaemolyticus. Biken J (1969) 1.80
Cro regulatory protein specified by bacteriophage lambda. Structure, DNA-binding, and repression of RNA synthesis. J Biol Chem (1977) 1.78
Effect of heat (Arrhenius effect) on crude hemolysin of Vibrio parahaemolyticus. Infect Immun (1972) 1.78
Purification and some properties of a Vero toxin from a human strain of Escherichia coli that is immunologically related to Shiga-like toxin II (VT2). Microb Pathog (1989) 1.78
Long-term effect of tacrolimus therapy in patients with refractory ulcerative colitis. Aliment Pharmacol Ther (2008) 1.77
The O139 serogroup of Vibrio cholerae comprises diverse clones of epidemic and nonepidemic strains derived from multiple V. cholerae O1 or non-O1 progenitors. J Infect Dis (2000) 1.76
Characterization of VPI pathogenicity island and CTXphi prophage in environmental strains of Vibrio cholerae. J Bacteriol (2001) 1.76
Nucleotide sequence of Clostridium botulinum C1 neurotoxin. Nucleic Acids Res (1990) 1.74
Cutting edge: generation of IL-18 receptor-deficient mice: evidence for IL-1 receptor-related protein as an essential IL-18 binding receptor. J Immunol (1999) 1.69
Antigenic difference between polar montrichous and peritrichous flagella of Vibrio parahaemolyticus. J Bacteriol (1974) 1.69
Emergence of a restricted bioserovar of Vibrio parahaemolyticus as the predominant cause of Vibrio-associated gastroenteritis on the West Coast of the United States and Mexico. J Clin Microbiol (1989) 1.68
Studies of the metabolism and distribution of fibrinogen in healthy men with autologous 125-I-labeled fibrinogen. J Clin Invest (1966) 1.64
Protein-DNA conformational changes in the crystal structure of a lambda Cro-operator complex. Proc Natl Acad Sci U S A (1990) 1.63
Hyperbaric oxygen reduces infarct volume in rats by increasing oxygen supply to the ischemic periphery. Crit Care Med (2000) 1.62
Mutants in the ADP-ribosyltransferase cleft of cholera toxin lack diarrheagenicity but retain adjuvanticity. J Exp Med (1997) 1.61
Development of a highly sensitive bead-ELISA to detect bacterial protein toxins. Microbiol Immunol (1988) 1.61
The evolution of genomic imprinting. Genetics (1996) 1.59
Essential structure for full enterotoxigenic activity of heat-stable enterotoxin produced by enterotoxigenic Escherichia coli. FEBS Lett (1985) 1.57
Cholera toxin production by the El Tor variant of Vibrio cholerae O1 compared to prototype El Tor and classical biotypes. J Clin Microbiol (2010) 1.56
Evidence for insertion sequence-mediated spread of the thermostable direct hemolysin gene among Vibrio species. J Bacteriol (1991) 1.55
Activation of Helicobacter pylori VacA toxin by alkaline or acid conditions increases its binding to a 250-kDa receptor protein-tyrosine phosphatase beta. J Biol Chem (1999) 1.54
Purification and properties of a DNA-binding protein with characteristics expected for the Cro protein of bacteriophage lambda, a repressor essential for lytic growth. Proc Natl Acad Sci U S A (1976) 1.54
Clonal dissemination of Vibrio parahaemolyticus displaying similar DNA fingerprint but belonging to two different serovars (O3:K6 and O4:K68) in Thailand and India. Epidemiol Infect (2000) 1.54
Survey of in vitro susceptibilities of Vibrio cholerae O1 and O139 to antimicrobial agents. Antimicrob Agents Chemother (1995) 1.54
Two sporadic cases of Liddle's syndrome caused by De novo ENaC mutations. Am J Kidney Dis (2001) 1.52
Synthetic ColE1 Plasmids carrying genes for penicillin-binding proteins in Escherichia coli. Plasmid (1981) 1.52
Case report: Occurrence of hepatocellular carcinoma 4.5 years after successful treatment with virus clearance for chronic hepatitis C. J Gastroenterol Hepatol (1999) 1.51
Traditional medicine in Turkey X. Folk medicine in Central Anatolia. J Ethnopharmacol (2001) 1.50
Spontaneous regression of hepatocellular carcinoma and review of literature. J Gastroenterol Hepatol (2000) 1.50
Resurgence of Vibrio cholerae O139 Bengal with altered antibiogram in Calcutta, India. Lancet (1996) 1.49
MicroRNA-21 induces resistance to the anti-tumour effect of interferon-α/5-fluorouracil in hepatocellular carcinoma cells. Br J Cancer (2010) 1.48
Purification and some properties of Shiga-like toxin from Escherichia coli O157:H7 that is immunologically identical to Shiga toxin. Microb Pathog (1987) 1.47
Argyrophilic proteins of the nucleolar organizer region in acute leukemias and its relation to the S-phase fraction of leukemic cells. Acta Haematol (1992) 1.46
Demonstration of a temperature-dependent inactivating factor of the thermostable direct hemolysin in Vibrio parahaemolyticus. Infect Immun (1974) 1.46
A 1.2-A snapshot of the final step of bacterial cell wall biosynthesis. Proc Natl Acad Sci U S A (2001) 1.46