Published in Nature on April 30, 1981
Sigma factors from E. coli, B. subtilis, phage SP01, and phage T4 are homologous proteins. Nucleic Acids Res (1986) 7.28
Improved detection of helix-turn-helix DNA-binding motifs in protein sequences. Nucleic Acids Res (1990) 6.99
Arac/XylS family of transcriptional regulators. Microbiol Mol Biol Rev (1997) 6.56
GCN4, a eukaryotic transcriptional activator protein, binds as a dimer to target DNA. EMBO J (1987) 5.32
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Process of protein transport by the type III secretion system. Microbiol Mol Biol Rev (2004) 3.31
Patterns of lambda Int recognition in the regions of strand exchange. Cell (1983) 3.07
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Structural similarity in the DNA-binding domains of catabolite gene activator and cro repressor proteins. Proc Natl Acad Sci U S A (1982) 2.84
Bacteriophage lambda int protein recognizes two classes of sequence in the phage att site: characterization of arm-type sites. Proc Natl Acad Sci U S A (1982) 2.81
Analysis of the sequence-specific interactions between Cro repressor and operator DNA by systematic base substitution experiments. Proc Natl Acad Sci U S A (1989) 2.76
Purification and characterization of trp aporepressor. Proc Natl Acad Sci U S A (1983) 2.70
Mutational studies with the trp repressor of Escherichia coli support the helix-turn-helix model of repressor recognition of operator DNA. Proc Natl Acad Sci U S A (1985) 2.48
The tetracycline resistance determinants of RP1 and Tn1721: nucleotide sequence analysis. Nucleic Acids Res (1983) 2.40
Model of specific complex between catabolite gene activator protein and B-DNA suggested by electrostatic complementarity. Proc Natl Acad Sci U S A (1984) 2.32
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Nucleotide sequence binding specificity of the LexA repressor of Escherichia coli K-12. J Bacteriol (1985) 2.16
Nucleotide sequence of the CytR regulatory gene of E. coli K-12. Nucleic Acids Res (1986) 2.14
Nucleotide sequence of the repressor gene of the TN10 tetracycline resistance determinant. Nucleic Acids Res (1984) 2.10
Structure of the DNA-binding region of lac repressor inferred from its homology with cro repressor. Proc Natl Acad Sci U S A (1982) 2.09
Cleavage of the site-specific recombination protein gamma delta resolvase: the smaller of two fragments binds DNA specifically. Proc Natl Acad Sci U S A (1984) 2.02
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The yeast regulatory protein ADR1 binds in a zinc-dependent manner to the upstream activating sequence of ADH2. Mol Cell Biol (1988) 1.96
Regulation of the glyoxylate bypass operon: cloning and characterization of iclR. J Bacteriol (1990) 1.95
Molecular basis of DNA sequence recognition by the catabolite gene activator protein: detailed inferences from three mutations that alter DNA sequence specificity. Proc Natl Acad Sci U S A (1984) 1.94
Nucleotide sequence of the yeast regulatory gene GAL80. Nucleic Acids Res (1984) 1.91
The DNA-binding domain of the transcriptional activator protein NifA resides in its carboxy terminus, recognises the upstream activator sequences of nif promoters and can be separated from the positive control function of NifA. Nucleic Acids Res (1988) 1.89
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The primary structure of the DeoR repressor from Escherichia coli K-12. Nucleic Acids Res (1985) 1.78
Bacteriophage lambda cro mutations: effects on activity and intracellular degradation. Proc Natl Acad Sci U S A (1986) 1.77
Dominant negative mutations in the Tn10 tet repressor: evidence for use of the conserved helix-turn-helix motif in DNA binding. Proc Natl Acad Sci U S A (1985) 1.76
Two helix DNA binding motif of CAP found in lac repressor and gal repressor. Nucleic Acids Res (1982) 1.66
Regulatory regions of two transport operons under nitrogen control: nucleotide sequences. Proc Natl Acad Sci U S A (1982) 1.66
The structure of plasmid-encoded transcriptional repressor CopG unliganded and bound to its operator. EMBO J (1998) 1.64
Protein-DNA conformational changes in the crystal structure of a lambda Cro-operator complex. Proc Natl Acad Sci U S A (1990) 1.63
Isolation and characterization of the SPT2 gene, a negative regulator of Ty-controlled yeast gene expression. Mol Cell Biol (1985) 1.62
Studies on the origin-specific DNA-binding domain of simian virus 40 large T antigen. J Virol (1987) 1.56
The effect on the function of the transcriptional activator NtrC from Klebsiella pneumoniae of mutations in the DNA-recognition helix. Nucleic Acids Res (1988) 1.54
Electrostatic potential molecular surfaces. Proc Natl Acad Sci U S A (1982) 1.53
Interaction of nuclear proteins with muscle-specific regulatory sequences of the human cardiac alpha-actin promoter. Mol Cell Biol (1988) 1.50
Regulation of the penicillinase genes of Bacillus licheniformis: interaction of the pen repressor with its operators. J Bacteriol (1988) 1.44
Viral proteomics. Microbiol Mol Biol Rev (2007) 1.43
Separate sites for binding and nicking of bacteriophage lambda DNA by terminase. Proc Natl Acad Sci U S A (1983) 1.39
NH2-terminal arm of phage lambda repressor contributes energy and specificity to repressor binding and determines the effects of operator mutations. Proc Natl Acad Sci U S A (1985) 1.36
Thermodynamics of Cro protein-DNA interactions. Proc Natl Acad Sci U S A (1992) 1.35
Two-dimensional 1H NMR study of the lambda operator site OL1: a sequential assignment strategy and its application. Proc Natl Acad Sci U S A (1984) 1.34
Primary structure of phage mu transposase: homology to mu repressor. Proc Natl Acad Sci U S A (1985) 1.30
Probing the sequence-specific interaction of the cyclic AMP receptor protein with DNA by site-directed mutagenesis. Biochem J (1987) 1.29
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Adenoviral protein VII packages intracellular viral DNA throughout the early phase of infection. EMBO J (1986) 1.28
Cocrystals of the DNA-binding domain of phage 434 repressor and a synthetic phage 434 operator. Proc Natl Acad Sci U S A (1984) 1.24
Transition metal ion activation of DNA binding by the diphtheria tox repressor requires the formation of stable homodimers. Proc Natl Acad Sci U S A (1995) 1.24
Structural aspects of protein-DNA recognition. Biochem J (1991) 1.21
DNA bending induced by Cro protein binding as demonstrated by gel electrophoresis. Proc Natl Acad Sci U S A (1991) 1.20
Sequence-specific interaction of the Salmonella Hin recombinase in both major and minor grooves of DNA. EMBO J (1992) 1.19
The plasmid-encoded urease gene cluster of the family Enterobacteriaceae is positively regulated by UreR, a member of the AraC family of transcriptional activators. J Bacteriol (1993) 1.19
Tn10 tet operator mutations affecting Tet repressor recognition. Nucleic Acids Res (1986) 1.18
The amino-terminal domain of LexA repressor is alpha-helical but differs from canonical helix-turn-helix proteins: a two-dimensional 1H NMR study. Proc Natl Acad Sci U S A (1989) 1.14
The three-dimensional structure of the seed storage protein phaseolin at 3 A resolution. EMBO J (1990) 1.14
Structure of wild-type and mutant repressors and of the control region of the rbt operon of Klebsiella aerogenes. EMBO J (1985) 1.10
Protein-protein interactions directing resolvase site-specific recombination: a structure-function analysis. EMBO J (1993) 1.10
How Cro and lambda-repressor distinguish between operators: the structural basis underlying a genetic switch. Proc Natl Acad Sci U S A (1998) 1.07
Crystal structure of an engineered Cro monomer bound nonspecifically to DNA: possible implications for nonspecific binding by the wild-type protein. Protein Sci (1998) 1.06
Equilibrium dissociation and unfolding of the dimeric human papillomavirus strain-16 E2 DNA-binding domain. Protein Sci (1996) 1.06
Integron integrase binds to bulged hairpin DNA. Nucleic Acids Res (2004) 1.04
The polypeptide fold of the globular domain of histone H5 in solution. A study using nuclear magnetic resonance, distance geometry and restrained molecular dynamics. EMBO J (1987) 1.02
DNA-directed oligomerization of the monomeric Ner repressor from the Mu-like bacteriophage D108. EMBO J (1989) 1.02
A model for catabolite activator protein binding to supercoiled DNA. Proc Natl Acad Sci U S A (1982) 1.00
Altered DNA contacts made by a mutant AraC protein. Nucleic Acids Res (1985) 0.98
The chemistry of regulation of genes and other things. J Biol Chem (2014) 0.96
Altered Cro repressors from engineered mutagenesis of a synthetic cro gene. Proc Natl Acad Sci U S A (1985) 0.95
Lac repressor with the helix-turn-helix motif of lambda cro binds to lac operator. EMBO J (1992) 0.95
Secondary structure of the lac repressor DNA-binding domain by two-dimensional 1H nuclear magnetic resonance in solution. Proc Natl Acad Sci U S A (1983) 0.95
Sequence-dependent contribution of distal binding domains to CAP protein-DNA binding affinity. Nucleic Acids Res (1991) 0.94
Two-dimensional IR correlation spectroscopy: sequential events in the unfolding process of the lambda cro-V55C repressor protein. Proc Natl Acad Sci U S A (1999) 0.93
1H NMR study of the interaction of bacteriophage lambda Cro protein with the OR3 operator. Evidence for a change of the conformation of the OR3 operator on binding. Nucleic Acids Res (1984) 0.92
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19F-n.m.r. studies of ligand binding to 5-fluorotryptophan- and 3-fluorotyrosine-containing cyclic AMP receptor protein from Escherichia coli. Biochem J (1990) 0.90
Hydrogen bonding motifs of protein side chains: descriptions of binding of arginine and amide groups. Protein Sci (1995) 0.90
1H-NMR study of the lambda operator site OL1: assignment of the imino and adenine H2 resonances. Nucleic Acids Res (1984) 0.89
lac repressor: crystallization of intact tetramer and its complexes with inducer and operator DNA. Proc Natl Acad Sci U S A (1990) 0.89
Dynamic filtering by two-dimensional 1H NMR with application to phage lambda repressor. Proc Natl Acad Sci U S A (1984) 0.89
Detecting DNA-binding helix-turn-helix structural motifs using sequence and structure information. Nucleic Acids Res (2005) 0.87
Folding and unfolding of helix-turn-helix motifs in the gas phase. J Am Soc Mass Spectrom (2007) 0.87
Overproduction of the cyclic AMP receptor protein of Escherichia coli and expression of the engineered C-terminal DNA-binding domain. Biochem J (1986) 0.85
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Energetics of the protein-DNA-water interaction. BMC Struct Biol (2007) 0.84
Ribosomal protein L7/L12 has a helix-turn-helix motif similar to that found in DNA-binding regulatory proteins. Nucleic Acids Res (1989) 0.83
A theory of the symmetries of filamentous bacteriophages. Biophys J (1988) 0.83
The mannitol operon repressor MtlR belongs to a new class of transcription regulators in bacteria. J Biol Chem (2009) 0.83
Base sequence-specific interactions of operator DNA fragments with the lambda-cro repressor coupled with changes in their conformations. EMBO J (1987) 0.82
Solution structure and dynamics of a designed monomeric variant of the lambda Cro repressor. Protein Sci (1998) 0.82
Cytochrome c oxidase is activated by the oncoprotein Ras and is required for A549 lung adenocarcinoma growth. Mol Cancer (2012) 0.81
Crystal structure of the transcriptional repressor PagR of Bacillus anthracis. Microbiology (2009) 0.81
Molecular simulation uncovers the conformational space of the λ Cro dimer in solution. Biophys J (2011) 0.80
Structural insight into DNA binding and oligomerization of the multifunctional Cox protein of bacteriophage P2. Nucleic Acids Res (2013) 0.80
SVM based model generation for binding site prediction on helix turn helix motif type of transcription factors in eukaryotes. Bioinformation (2013) 0.77
The Cardiac Stress Response Factor Ms1 Can Bind to DNA and Has a Function in the Nucleus. PLoS One (2015) 0.75
Flanking DNA-sequences contribute to the specific binding of cI-repressor and OR1. Nucleic Acids Res (1989) 0.75
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Comparison of the predicted and observed secondary structure of T4 phage lysozyme. Biochim Biophys Acta (1975) 17.03
Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J Immunol (1999) 16.86
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Prospects for human gene therapy. Science (1984) 3.93
Spread of Vibrio cholerae O139 Bengal in India. J Infect Dis (1994) 3.91
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Production of cholera-like enterotoxin by a Vibrio cholerae non-O1 strain isolated from the environment. Infect Immun (1981) 3.21
Molecular epidemiologic evidence for association of thermostable direct hemolysin (TDH) and TDH-related hemolysin of Vibrio parahaemolyticus with gastroenteritis. Infect Immun (1990) 3.17
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Structure of bacteriophage T4 lysozyme refined at 1.7 A resolution. J Mol Biol (1987) 3.02
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Detection of the thermostable direct hemolysin gene and related DNA sequences in Vibrio parahaemolyticus and other vibrio species by the DNA colony hybridization test. Infect Immun (1985) 2.90
Escherichia coli biotin holoenzyme synthetase/bio repressor crystal structure delineates the biotin- and DNA-binding domains. Proc Natl Acad Sci U S A (1992) 2.89
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Structure of thermolysin refined at 1.6 A resolution. J Mol Biol (1982) 2.84
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