Published in Genes Dev on November 01, 1995
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BMP4 is essential for lens induction in the mouse embryo. Genes Dev (1998) 2.62
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A novel dominant negative mutation of OTX2 associated with combined pituitary hormone deficiency. J Clin Endocrinol Metab (2008) 0.99
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A symphony of inner ear developmental control genes. BMC Genet (2010) 0.97
Deletion of Otx2 in GnRH neurons results in a mouse model of hypogonadotropic hypogonadism. Mol Endocrinol (2011) 0.97
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Expression of the homeobox genes OTX2 and OTX1 in the early developing human brain. J Histochem Cytochem (2010) 0.96
Mature middle and inner ears express Chd7 and exhibit distinctive pathologies in a mouse model of CHARGE syndrome. Hear Res (2011) 0.95
A rare de novo nonsense mutation in OTX2 causes early onset retinal dystrophy and pituitary dysfunction. Mol Vis (2009) 0.95
SOX9, through interaction with microphthalmia-associated transcription factor (MITF) and OTX2, regulates BEST1 expression in the retinal pigment epithelium. J Biol Chem (2010) 0.95
Genome-scale proteome quantification by DEEP SEQ mass spectrometry. Nat Commun (2013) 0.94
Otx2 induction of the gonadotropin-releasing hormone promoter is modulated by direct interactions with Grg co-repressors. J Biol Chem (2009) 0.93
BEST1 expression in the retinal pigment epithelium is modulated by OTX family members. Hum Mol Genet (2008) 0.93
LHX2 is necessary for the maintenance of optic identity and for the progression of optic morphogenesis. J Neurosci (2013) 0.92
Developmental genetic evidence for a monophyletic origin of the bilaterian brain. Philos Trans R Soc Lond B Biol Sci (2001) 0.92
Developmental studies of the lamprey and hierarchical evolutionary steps towards the acquisition of the jaw. J Anat (2005) 0.91
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Dynamic gene expression is required for anterior regionalization in a spider. Proc Natl Acad Sci U S A (2009) 0.91
Otx2 ChIP-seq reveals unique and redundant functions in the mature mouse retina. PLoS One (2014) 0.90
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Otx1 and Otx2 in the development and evolution of the mammalian brain. EMBO J (1998) 0.89
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Genetic and physical interaction of Meis2, Pax3 and Pax7 during dorsal midbrain development. BMC Dev Biol (2012) 0.88
Evolutionary conservation of otd/Otx2 transcription factor action: a genome-wide microarray analysis in Drosophila. Genome Biol (2002) 0.87
Immunocytochemical analyses and targeted gene disruption of GTPBP1. Mol Cell Biol (2000) 0.87
Acetylated YY1 regulates Otx2 expression in anterior neuroectoderm at two cis-sites 90 kb apart. EMBO J (2007) 0.86
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CRISPR/Cas9-based generation of knockdown mice by intronic insertion of artificial microRNA using longer single-stranded DNA. Sci Rep (2015) 0.85
Transcriptional selectors, masters, and combinatorial codes: regulatory principles of neural subtype specification. Wiley Interdiscip Rev Dev Biol (2015) 0.85
Differentiation of human epidermal neural crest stem cells (hEPI-NCSC) into virtually homogenous populations of dopaminergic neurons. Stem Cell Rev (2014) 0.84
Neonatal lethality, dwarfism, and abnormal brain development in Dmbx1 mutant mice. Mol Cell Biol (2004) 0.84
OTX2 duplication is implicated in hemifacial microsomia. PLoS One (2014) 0.84
Otocephaly-Dysgnathia Complex: Description of Four Cases and Confirmation of the Role of OTX2. Mol Syndromol (2013) 0.84
Neuronal developmental gene and miRNA signatures induced by histone deacetylase inhibitors in human embryonic stem cells. Cell Death Dis (2015) 0.83
Aberrant Otx2 expression enhances migration and induces ectopic proliferation of hindbrain neuronal progenitor cells. PLoS One (2012) 0.83
A novel loss-of-function mutation in OTX2 in a patient with anophthalmia and isolated growth hormone deficiency. Hum Genet (2010) 0.83
Gene dosage of Otx2 is important for fertility in male mice. Mol Cell Endocrinol (2013) 0.82
The expression of twisted gastrulation in postnatal mouse brain and functional implications. Neuroscience (2010) 0.82
Otx2 is involved in the regional specification of the developing retinal pigment epithelium by preventing the expression of sox2 and fgf8, factors that induce neural retina differentiation. PLoS One (2012) 0.81
Functional Interplay between Dopaminergic and Serotonergic Neuronal Systems during Development and Adulthood. ACS Chem Neurosci (2015) 0.81
Conserved roles of ems/Emx and otd/Otx genes in olfactory and visual system development in Drosophila and mouse. Open Biol (2013) 0.81
Regenerative therapy for retinal disorders. J Ophthalmic Vis Res (2010) 0.81
Occupancy of tissue-specific cis-regulatory modules by Otx2 and TLE/Groucho for embryonic head specification. Nat Commun (2014) 0.81
Thyroid hormone and retinoic acid interact to regulate zebrafish craniofacial neural crest development. Dev Biol (2012) 0.80
Genetic and phenotypic analysis of Tcm, a mutation affecting early eye development. Mamm Genome (2005) 0.80
The Bicoid class homeodomain factors ceh-36/OTX and unc-30/PITX cooperate in C. elegans embryonic progenitor cells to regulate robust development. PLoS Genet (2015) 0.80
Genetics of Combined Pituitary Hormone Deficiency: Roadmap into the Genome Era. Endocr Rev (2016) 0.80
Stem and progenitor cell dysfunction in human trisomies. EMBO Rep (2014) 0.79
Von Hippel-Lindau protein in the RPE is essential for normal ocular growth and vascular development. Development (2012) 0.79
Deletion of OTX2 in neural ectoderm delays anterior pituitary development. Hum Mol Genet (2014) 0.78
Homeobox genes in the rodent pineal gland: roles in development and phenotype maintenance. Neurochem Res (2012) 0.78
OTX2 exhibits cell-context-dependent effects on cellular and molecular properties of human embryonic neural precursors and medulloblastoma cells. Dis Model Mech (2015) 0.78
Xenopus Xotx2 and Drosophila otd share similar activities in anterior patterning of the frog embryo. Dev Genes Evol (2006) 0.77
A specific box switches the cell fate determining activity of XOTX2 and XOTX5b in the Xenopus retina. Neural Dev (2007) 0.77
Taspase1-dependent TFIIA cleavage coordinates head morphogenesis by limiting Cdkn2a locus transcription. J Clin Invest (2015) 0.76
Non-trisomic homeobox gene expression during craniofacial development in the Ts65Dn mouse model of Down syndrome. Am J Med Genet A (2013) 0.76
Strain-specific modifier genes governing craniofacial phenotypes. Birth Defects Res A Clin Mol Teratol (2012) 0.76
Conserved genetic pathways associated with microphthalmia, anophthalmia, and coloboma. Birth Defects Res C Embryo Today (2015) 0.76
Otx genes in evolution: are they involved in instructing the vertebrate brain morphology? J Anat (2001) 0.75
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