PubRank

D R Lowy

Author PubWeight™ 375.93‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Mechanism of activation of a human oncogene. Nature 1982 12.09
2 Mouse cells transformed by bovine papillomavirus contain only extrachromosomal viral DNA sequences. Proc Natl Acad Sci U S A 1981 9.27
3 Murine leukemia virus: high-frequency activation in vitro by 5-iododeoxyuridine and 5-bromodeoxyuridine. Science 1971 8.78
4 The p21 src genes of Harvey and Kirsten sarcoma viruses originate from divergent members of a family of normal vertebrate genes. Nature 1981 8.44
5 Helper-independent transformation by unintegrated Harvey sarcoma virus DNA. J Virol 1978 7.75
6 Papillomavirus L1 major capsid protein self-assembles into virus-like particles that are highly immunogenic. Proc Natl Acad Sci U S A 1992 7.72
7 A quantitative in vitro focus assay for bovine papilloma virus. Virology 1980 7.14
8 In vitro tumorigenic transformation by a defined sub-genomic fragment of bovine papilloma virus DNA. Nature 1980 6.67
9 HPV16 E6 and E7 proteins cooperate to immortalize human foreskin keratinocytes. EMBO J 1989 6.60
10 Identification of a second transforming region in bovine papillomavirus DNA. Proc Natl Acad Sci U S A 1984 5.88
11 Bovine papillomavirus E2 trans-activating gene product binds to specific sites in papillomavirus DNA. Nature 1987 5.61
12 Analysis of two divergent rat genomic clones homologous to the transforming gene of Harvey murine sarcoma virus. Proc Natl Acad Sci U S A 1981 5.51
13 Cellular origin and role of mink cell focus-forming viruses in murine thymic lymphomas. Nature 1982 5.23
14 Efficient self-assembly of human papillomavirus type 16 L1 and L1-L2 into virus-like particles. J Virol 1993 5.12
15 Tumorigenic transformation of mammalian cells induced by a normal human gene homologous to the oncogene of Harvey murine sarcoma virus. Nature 1982 5.08
16 Transfection of molecularly cloned Friend murine leukemia virus DNA yields a highly leukemogenic helper-independent type C virus. J Virol 1980 4.91
17 Molecular cloning of infectious integrated murine leukemia virus DNA from infected mouse cells. Proc Natl Acad Sci U S A 1980 4.71
18 Dual evolutionary origin for the rat genetic sequences of Harvey murine sarcoma virus. J Virol 1980 4.63
19 Origin of mink cytopathic focus-forming (MCF) viruses:comparison with ecotropic and xenotropic murine leukemia virus genomes. Virology 1981 4.62
20 Guanosine triphosphatase activating protein (GAP) interacts with the p21 ras effector binding domain. Science 1988 4.58
21 Virus-specific transcription in bovine papillomavirus-transformed mouse cells. Virology 1982 4.52
22 Qualitative and quantitative studies of AKR-type murine leukemia virus sequences in mouse DNA. Cold Spring Harb Symp Quant Biol 1975 4.49
23 The p21 ras C-terminus is required for transformation and membrane association. Nature 1984 4.43
24 Harvey murine sarcoma virus p21 ras protein: biological and biochemical significance of the cysteine nearest the carboxy terminus. EMBO J 1984 4.28
25 Structure of endogenous murine leukemia virus DNA in mouse genomes. Proc Natl Acad Sci U S A 1980 4.24
26 Genomes of murine leukemia viruses isolated from wild mice. J Virol 1981 4.24
27 Immunization with viruslike particles from cottontail rabbit papillomavirus (CRPV) can protect against experimental CRPV infection. J Virol 1995 4.14
28 Long terminal repeat of murine retroviral DNAs: sequence analysis, host-proviral junctions, and preintegration site. J Virol 1982 4.06
29 E5 open reading frame of bovine papillomavirus type 1 encodes a transforming gene. J Virol 1986 4.04
30 A virus-like particle enzyme-linked immunosorbent assay detects serum antibodies in a majority of women infected with human papillomavirus type 16. J Natl Cancer Inst 1994 3.95
31 Epidermal-growth-factor-dependent transformation by a human EGF receptor proto-oncogene. Science 1987 3.93
32 Molecular cloning of the Harvey sarcoma virus closed circular DNA intermediates: initial structural and biological characterization. J Virol 1979 3.90
33 In vitro generation and type-specific neutralization of a human papillomavirus type 16 virion pseudotype. J Virol 1996 3.66
34 Virus infection of murine teratocarcinoma stem cell lines. Cell 1977 3.54
35 Definitive evidence that the murine C-type virus inducing locus Akv-1 is viral genetic material. Proc Natl Acad Sci U S A 1975 3.51
36 Human genome contains four genes homologous to transforming genes of Harvey and Kirsten murine sarcoma viruses. Proc Natl Acad Sci U S A 1982 3.48
37 Abnormal regulation of mammalian p21ras contributes to malignant tumor growth in von Recklinghausen (type 1) neurofibromatosis. Cell 1992 3.30
38 Safety and immunogenicity trial in adult volunteers of a human papillomavirus 16 L1 virus-like particle vaccine. J Natl Cancer Inst 2001 3.28
39 Characterization of a human colon/lung carcinoma oncogene. Nature 1983 3.26
40 Identification of the protein encoded by the E6 transforming gene of bovine papillomavirus. Science 1985 3.21
41 The transforming function of bovine papillomavirus DNA. Proc Natl Acad Sci U S A 1983 3.19
42 Mammalian and yeast ras gene products: biological function in their heterologous systems. Science 1985 3.03
43 Papillomavirus polypeptides E6 and E7 are zinc-binding proteins. J Virol 1989 3.01
44 Evidence that the AKR murine-leukemia-virus genome is complete in DNA of the high-virus AKR mouse and incomplete in the DNA of the "virus-negative" NIH mouse. Proc Natl Acad Sci U S A 1974 2.95
45 AKR murine leukemia virus genome: frequency of sequences in DNA of high-, low-, and non-virus-yielding mouse strains. Proc Natl Acad Sci U S A 1974 2.91
46 Nucleotide sequence of the 3' end of MCF 247 murine leukemia virus. J Virol 1983 2.87
47 Identification of the HPV-16 E6 protein from transformed mouse cells and human cervical carcinoma cell lines. EMBO J 1987 2.84
48 Mutational analysis of a ras catalytic domain. Mol Cell Biol 1986 2.76
49 The specific DNA recognition sequence of the bovine papillomavirus E2 protein is an E2-dependent enhancer. EMBO J 1988 2.66
50 The region of the HPV E7 oncoprotein homologous to adenovirus E1a and Sv40 large T antigen contains separate domains for Rb binding and casein kinase II phosphorylation. EMBO J 1990 2.57
51 The bovine papillomavirus E5 transforming protein can stimulate the transforming activity of EGF and CSF-1 receptors. Cell 1989 2.52
52 Neutralization of bovine papillomavirus by antibodies to L1 and L2 capsid proteins. J Virol 1994 2.52
53 Functional organization of the Harvey murine sarcoma virus genome. J Virol 1980 2.46
54 Interaction of papillomaviruses with the cell surface. J Virol 1994 2.44
55 The E7 open reading frame of human papillomavirus type 16 encodes a transforming gene. Oncogene Res 1988 2.42
56 High-risk human papillomavirus is sexually transmitted: evidence from a follow-up study of virgins starting sexual activity (intercourse). Cancer Epidemiol Biomarkers Prev 2001 2.38
57 Bovine papilloma virus-transformed cells contain multiple E2 proteins. Proc Natl Acad Sci U S A 1988 2.29
58 Papillomavirus-like particles induce acute activation of dendritic cells. J Immunol 2001 2.28
59 Restriction endonuclease mapping of ecotropic murine leukemia viral DNAs: size and sequence heterogeneity of the long terminal repeat. Virology 1981 2.25
60 Minor capsid protein of human genital papillomaviruses contains subdominant, cross-neutralizing epitopes. Virology 2000 2.25
61 A causal role for human papillomavirus in head and neck cancer. Lancet 2004 2.21
62 The papillomavirus minor capsid protein, L2, induces localization of the major capsid protein, L1, and the viral transcription/replication protein, E2, to PML oncogenic domains. J Virol 1998 2.12
63 Virus-like particles of bovine papillomavirus type 4 in prophylactic and therapeutic immunization. Virology 1996 2.08
64 Transformation by cloned Harvey murine sarcoma virus DNA: efficiency increased by long terminal repeat DNA. Science 1980 2.05
65 In vitro biological activities of the E6 and E7 genes vary among human papillomaviruses of different oncogenic potential. J Virol 1991 2.00
66 Studies of the mechanism of induction of infectious murine leukemia virus from AKR mouse embryo cell lines by 5-iododeoxyuridine and 5-bromodeoxyuridine. Virology 1973 1.98
67 Suppression of c-ras transformation by GTPase-activating protein. Nature 1990 1.96
68 Assessment of the serological relatedness of genital human papillomaviruses by hemagglutination inhibition. J Virol 1996 1.94
69 An activated Harvey ras oncogene produces benign tumours on mouse epidermal tissue. Nature 1986 1.86
70 Dispersion of the ras family of transforming genes to four different chromosomes in man. Nature 1983 1.82
71 Serologic association between human papillomavirus type 16 infection and esophageal cancer in Shaanxi Province, China. J Natl Cancer Inst 1996 1.75
72 The full-length E6 protein of human papillomavirus type 16 has transforming and trans-activating activities and cooperates with E7 to immortalize keratinocytes in culture. J Virol 1991 1.74
73 Subgenomic fragment of molecular cloned Friend murine leukemia virus DNA contains the gene(s) responsible for Friend murine leukemia virus-induced disease. J Virol 1980 1.73
74 Characterization of a human papillomavirus type 16 variant-dependent neutralizing epitope. J Virol 1997 1.66
75 Identification of bovine papillomavirus E1 mutants with increased transforming and transcriptional activity. J Virol 1989 1.64
76 Conjugation of a self-antigen to papillomavirus-like particles allows for efficient induction of protective autoantibodies. J Clin Invest 2001 1.63
77 Chimeric papillomavirus virus-like particles elicit antitumor immunity against the E7 oncoprotein in an HPV16 tumor model. Proc Natl Acad Sci U S A 1998 1.59
78 Mapping of transforming region of the Harvey murine sarcoma virus genome by using insertion-deletion mutants constructed in vitro. Proc Natl Acad Sci U S A 1980 1.56
79 Inactivation of the NF1 gene in human melanoma and neuroblastoma cell lines without impaired regulation of GTP.Ras. Proc Natl Acad Sci U S A 1993 1.55
80 Amplification and rearrangement of onc genes in mammalian species. Nature 1982 1.48
81 Interferon induces morphologic reversion with elimination of extrachromosomal viral genomes in bovine papillomavirus-transformed mouse cells. Proc Natl Acad Sci U S A 1982 1.46
82 Molecular cloning of the Harvey sarcoma virus circular DNA intermediates. II. Further structural analyses. J Virol 1980 1.45
83 Suppression of src transformation by overexpression of full-length GTPase-activating protein (GAP) or of the GAP C terminus. Mol Cell Biol 1991 1.44
84 Transformation-specific interaction of the bovine papillomavirus E5 oncoprotein with the platelet-derived growth factor receptor transmembrane domain and the epidermal growth factor receptor cytoplasmic domain. J Virol 1993 1.43
85 The Sos1 and Sos2 Ras-specific exchange factors: differences in placental expression and signaling properties. EMBO J 2000 1.38
86 Isolation of multiple mouse cDNAs with coding homology to Saccharomyces cerevisiae CDC25: identification of a region related to Bcr, Vav, Dbl and CDC24. EMBO J 1992 1.38
87 Infectious murine leukemia virus from DNA of virus-negative AKR mouse embryo cells. Proc Natl Acad Sci U S A 1978 1.37
88 Retroviruses expressing different levels of the normal epidermal growth factor receptor: biological properties and new bioassay. J Cell Biochem 1989 1.36
89 NHPV16 VLP vaccine induces human antibodies that neutralize divergent variants of HPV16. Virology 2001 1.34
90 L1 interaction domains of papillomavirus l2 necessary for viral genome encapsidation. J Virol 2001 1.34
91 Infectious papillomavirus in the vapor of warts treated with carbon dioxide laser or electrocoagulation: detection and protection. J Am Acad Dermatol 1989 1.33
92 Some implications of the activation of murine leukemia virus by halogenated pyrimidines. Proc Natl Acad Sci U S A 1972 1.33
93 Papillomavirus L1 capsids agglutinate mouse erythrocytes through a proteinaceous receptor. J Virol 1995 1.32
94 Induction of autoantibodies to mouse CCR5 with recombinant papillomavirus particles. Proc Natl Acad Sci U S A 1999 1.31
95 Harvey murine sarcoma virus: influences of coding and noncoding sequences on cell transformation in vitro and oncogenicity in vivo. J Virol 1989 1.31
96 Papillomavirus is resistant to desiccation. J Infect Dis 1997 1.30
97 Positively charged termini of the L2 minor capsid protein are necessary for papillomavirus infection. J Virol 2001 1.28
98 Harvey ras induction of metastatic potential depends upon oncogene activation and the type of recipient cell. Am J Pathol 1985 1.28
99 Serologic response to human papillomavirus type 16 (HPV-16) virus-like particles in HPV-16 DNA-positive invasive cervical cancer and cervical intraepithelial neoplasia grade III patients and controls from Colombia and Spain. J Infect Dis 1995 1.27
100 Transfection of v-rasH DNA into MCF-7 human breast cancer cells bypasses dependence on estrogen for tumorigenicity. Science 1985 1.26
101 Mechanistic aspects of signaling through Ras in NIH 3T3 cells. Science 1992 1.24
102 Glucocorticoids induce focus formation and increase sarcoma viral expression in a mink cell line that contains a murine sarcoma viral genome. J Virol 1978 1.22
103 Identification of small clusters of divergent amino acids that mediate the opposing effects of ras and Krev-1. Science 1990 1.21
104 X-linked inheritance of epidermodysplasia verruciformis. Genetic and virologic studies of a kindred. Arch Dermatol 1985 1.21
105 Mutant p53 can substitute for human papillomavirus type 16 E6 in immortalization of human keratinocytes but does not have E6-associated trans-activation or transforming activity. J Virol 1992 1.18
106 Papillomavirus-like particles and HPV vaccine development. Semin Cancer Biol 1996 1.18
107 Divergent human papillomavirus type 16 variants are serologically cross-reactive. J Infect Dis 1995 1.17
108 p21-ras effector domain mutants constructed by "cassette" mutagenesis. Mol Cell Biol 1988 1.16
109 Transforming p21 ras protein: flexibility in the major variable region linking the catalytic and membrane-anchoring domains. EMBO J 1985 1.16
110 Protein modification: new clue to Ras lipid glue. Nature 1989 1.15
111 L1-specific protection from tumor challenge elicited by HPV16 virus-like particles. Virology 1998 1.15
112 Neurofibromin can inhibit Ras-dependent growth by a mechanism independent of its GTPase-accelerating function. Mol Cell Biol 1994 1.14
113 The bovine papillomavirus E5 oncogene can cooperate with ras: identification of p21 amino acids critical for transformation by c-rasH but not v-rasH. Mol Cell Biol 1991 1.13
114 Inhibition of cell growth by lovastatin is independent of ras function. Cancer Res 1991 1.12
115 Ras-specific exchange factor GRF: oligomerization through its Dbl homology domain and calcium-dependent activation of Raf. Mol Cell Biol 1999 1.12
116 p120Ras-GAP binds the DLC1 Rho-GAP tumor suppressor protein and inhibits its RhoA GTPase and growth-suppressing activities. Oncogene 2009 1.12
117 A transforming ras gene can provide an essential function ordinarily supplied by an endogenous ras gene. Mol Cell Biol 1986 1.11
118 Functional heterogeneity of proto-oncogene tyrosine kinases: the C terminus of the human epidermal growth factor receptor facilitates cell proliferation. Mol Cell Biol 1989 1.09
119 Papillomavirus-like particle vaccines. J Natl Cancer Inst Monogr 2001 1.08
120 Identification and characterization of the neurofibromatosis type 1 protein product. Proc Natl Acad Sci U S A 1991 1.08
121 Seroreactivity to human papillomavirus type 16 virus-like particles is lower in high-risk men than in high-risk women. J Infect Dis 1997 1.08
122 The conserved C-terminal domain of the bovine papillomavirus E5 oncoprotein can associate with an alpha-adaptin-like molecule: a possible link between growth factor receptors and viral transformation. Mol Cell Biol 1993 1.07
123 N terminus of Sos1 Ras exchange factor: critical roles for the Dbl and pleckstrin homology domains. Mol Cell Biol 1998 1.05
124 Mutational analysis of bovine papillomavirus E6 gene. J Virol 1989 1.05
125 Positive and negative regulation of cell proliferation by E2F-1: influence of protein level and human papillomavirus oncoproteins. Mol Cell Biol 1994 1.03
126 E-cadherin negatively regulates neoplastic growth in non-small cell lung cancer: role of Rho GTPases. Oncogene 2010 1.02
127 Functional role of GTPase-activating protein in cell transformation by pp60v-src. Mol Cell Biol 1993 1.01
128 Regulated and constitutive activity by CDC25Mm (GRF), a Ras-specific exchange factor. Mol Cell Biol 1993 1.00
129 Successive steps in the process of immortalization identified by transfer of separate bovine papillomavirus genes into rat fibroblasts. Proc Natl Acad Sci U S A 1989 0.98
130 Papillomavirus-like particle based vaccines: cervical cancer and beyond. Expert Opin Biol Ther 2001 0.96
131 The Ras-specific exchange factors mouse Sos1 (mSos1) and mSos2 are regulated differently: mSos2 contains ubiquitination signals absent in mSos1. Mol Cell Biol 1997 0.96
132 The ras gene family. Cancer Surv 1986 0.96
133 Molecular properties of a gag- pol- env+ murine leukemia virus from cultured AKR lymphoma cells. J Virol 1982 0.95
134 Adenylate cyclase activity of NIH 3T3 cells morphologically transformed by ras genes. FEBS Lett 1986 0.94
135 Inhibition of murine leukemia virus replication by poly(vinyluracil) and poly(vinyladenine). Proc Natl Acad Sci U S A 1973 0.94
136 Early enhancement of calcium currents by H-ras oncoproteins injected into Hermissenda neurons. Science 1990 0.92
137 Seroreactivity to HPV16 virus-like particles as a marker for cervical cancer risk in high-risk populations. Int J Cancer 1996 0.92
138 The biological activity of the human epidermal growth factor receptor is positively regulated by its C-terminal tyrosines. Oncogene 1991 0.92
139 Transfected human beta-polymerase promoter contains a ras-responsive element. Mol Cell Biol 1990 0.90
140 Interaction of interferon with chick embryo cells. Arch Gesamte Virusforsch 1967 0.90
141 Sequential modification of serines 621 and 624 in the Raf-1 carboxyl terminus produces alterations in its electrophoretic mobility. J Biol Chem 1997 0.87
142 A highly efficient retroviral vector allows detection of the transforming activity of the human c-fps/fes proto-oncogene. J Virol 1989 0.87
143 Re: Cervical carcinoma and human papillomavirus: on the road to preventing a major human cancer. J Natl Cancer Inst 2001 0.86
144 Tumorigenic transformation of NIH 3T3 cells by the autocrine synthesis of transforming growth factor alpha. New Biol 1991 0.86
145 A ras effector domain mutant which is temperature sensitive for cellular transformation: interactions with GTPase-activating protein and NF-1. Mol Cell Biol 1991 0.85
146 Response of warts in epidermodysplasia verruciformis to treatment with systemic and intralesional alpha interferon. J Am Acad Dermatol 1984 0.84
147 Heterogeneous amino acids in Ras and Rap1A specifying sensitivity to GAP proteins. Science 1991 0.84
148 Carcinogenesis: a fifty-year historical perspective. J Invest Dermatol 1989 0.83
149 Rasp21 sequences opposite the nucleotide binding pocket are required for GRF-mediated nucleotide release. Oncogene 1996 0.79
150 Early regulation of membrane excitability by ras oncogene proteins. Biophys J 1990 0.79
151 Proto-oncogene activation in lung cancer. N Engl J Med 1988 0.78
152 Further genetic localization of the transforming sequences of the p21 v-ras gene of Harvey murine sarcoma virus. J Virol 1984 0.77
153 Selective potentiation of c-fps/fes transforming activity by a phosphatase inhibitor. Oncogene Res 1990 0.76
154 Correction to Lancet Oncol 2015; 16: e227. Primary endpoints for future prophylactic human papillomavirus vaccine trials: towards infection and immunobridging. Lancet Oncol 2015 0.76
155 TGF alpha enhances locomotion of cultured human keratinocytes. J Invest Dermatol 1993 0.75
156 Expression and detection of endogenous mouse C-type RNA viruses. In Vitro 1975 0.75
157 Oncogenes are here to stay. J Invest Dermatol 1985 0.75
158 Tumor viruses, oncogenes, and human cancer. J Am Acad Dermatol 1984 0.75
159 A survey of physicians' awareness of drug costs. J Med Educ 1972 0.75
160 In vitro transformation by bovine papillomavirus. J Invest Dermatol 1984 0.75
161 Structure and infectivity of integrated murine leukemia virus DNA. Cold Spring Harb Symp Quant Biol 1980 0.75
162 Infections by human papillomavirus (warts). Am J Dermatopathol 1982 0.75
163 Nonmelanoma skin cancer, melanomas, warts, and viral oncogenesis. J Am Acad Dermatol 1984 0.75