Published in Am J Pathol on October 01, 1985
RAS oncogenes: weaving a tumorigenic web. Nat Rev Cancer (2011) 6.45
Targeting MET in cancer: rationale and progress. Nat Rev Cancer (2012) 6.43
Stromal expression of 72 kda type IV collagenase (MMP-2) and TIMP-2 mRNAs in colorectal neoplasia. Am J Pathol (1992) 2.17
Metastatic properties and genomic amplification of the tyrosine kinase gene ACK1. Proc Natl Acad Sci U S A (2005) 1.82
Expression of H-ras correlates with metastatic potential: evidence for direct regulation of the metastatic phenotype in 10T1/2 and NIH 3T3 cells. Mol Cell Biol (1987) 1.24
Host genetics and tumour metastasis. Br J Cancer (2004) 1.17
Expression of gelatinase A and TIMP-2 mRNAs in desmoplastic fibroblasts in both mammary carcinomas and basal cell carcinomas of the skin. J Clin Pathol (1993) 1.07
Amplification and rearrangement of the Kirsten ras oncogene in virus-transformed BALB/c 3T3 cells during malignant tumor progression. Proc Natl Acad Sci U S A (1987) 1.02
Complete nucleotide and deduced amino acid sequences of human and murine preprocathepsin L. An abundant transcript induced by transformation of fibroblasts. J Clin Invest (1988) 1.02
Requirement for matrix metalloproteinase-9 (gelatinase B) expression in metastasis by murine prostate carcinoma. Am J Pathol (1998) 0.98
Identification of genes controlling metastatic behaviour. Br J Cancer (1991) 0.96
Papillary and follicular thyroid carcinomas show a different pattern of ras oncogene mutation. Br J Cancer (1989) 0.94
Cancer Stem Cells, EMT, and Developmental Pathway Activation in Pancreatic Tumors. Cancers (Basel) (2012) 0.85
Evaluation of a monoclonal antibody to ras peptide, RAP-5, claimed to bind preferentially to cells of infiltrating carcinomas. Br J Cancer (1986) 0.85
Parallel analysis of transcript and translation profiles: identification of metastasis-related signal pathways differentially regulated by drug and genetic modifications. J Proteome Res (2006) 0.83
Genetic factors and suppression of metastatic ability of v-Ha-ras-transfected rat mammary cancer cells. Proc Natl Acad Sci U S A (1992) 0.76
Molecular determinants of metastatic transformation. Environ Health Perspect (1991) 0.75
Persistence of Ha-ras-induced metastatic potential of SP1 mouse mammary tumors despite loss of the Ha-ras shuttle vector. Proc Natl Acad Sci U S A (1992) 0.75
Mechanism of activation of a human oncogene. Nature (1982) 12.09
A point mutation is responsible for the acquisition of transforming properties by the T24 human bladder carcinoma oncogene. Nature (1982) 11.92
Murine sarcoma and leukemia viruses: assay using clonal lines of contact-inhibited mouse cells. J Virol (1969) 11.78
Complete nucleotide sequences of the T24 human bladder carcinoma oncogene and its normal homologue. Nature (1983) 10.64
Amplification of N-myc in untreated human neuroblastomas correlates with advanced disease stage. Science (1984) 9.64
Monoclonal antibodies to the p21 products of the transforming gene of Harvey murine sarcoma virus and of the cellular ras gene family. J Virol (1982) 8.88
Helper-independent transformation by unintegrated Harvey sarcoma virus DNA. J Virol (1978) 7.75
A quantitative in vitro focus assay for bovine papilloma virus. Virology (1980) 7.14
Isolation of a transforming sequence from a human bladder carcinoma cell line. Cell (1982) 6.93
Activation of the T24 bladder carcinoma transforming gene is linked to a single amino acid change. Nature (1982) 6.78
Analysis of two divergent rat genomic clones homologous to the transforming gene of Harvey murine sarcoma virus. Proc Natl Acad Sci U S A (1981) 5.51
Tumorigenic transformation of mammalian cells induced by a normal human gene homologous to the oncogene of Harvey murine sarcoma virus. Nature (1982) 5.08
Transformation of rat cells by DNA of human adenovirus 5. Virology (1973) 4.85
Dual evolutionary origin for the rat genetic sequences of Harvey murine sarcoma virus. J Virol (1980) 4.63
Activation of the mouse cellular Harvey-ras gene in chemically induced benign skin papillomas. Nature (1984) 4.28
Identification of a sarcoma virus-coded phosphoprotein in nonproducer cells transformed by Kirsten or Harvey murine sarcoma virus. Virology (1979) 4.08
Biological diversity in metastatic neoplasms: origins and implications. Science (1982) 3.95
Nucleotide sequence of the p21 transforming protein of Harvey murine sarcoma virus. Science (1982) 3.55
Malignant transformation of early passage rodent cells by a single mutated human oncogene. Nature (1984) 3.24
Comparative biochemical properties of p21 ras molecules coded for by viral and cellular ras genes. J Virol (1982) 2.91
Metastatic heterogeneity of cells from an ultraviolet light-induced murine fibrosarcoma of recent origin. Cancer Res (1978) 2.28
Monoclonal antibodies define differential ras gene expression in malignant and benign colonic diseases. Nature (1984) 1.62
NIH/3T3 cells transfected with human tumor DNA containing activated ras oncogenes express the metastatic phenotype in nude mice. Mol Cell Biol (1985) 1.48
Oncogenes of spontaneous and chemically induced tumors. Adv Cancer Res (1982) 1.11
Oncogenes and proto-oncogenes: how do they differ? J Natl Cancer Inst (1984) 1.08
Three different activated ras genes in mouse tumours; evidence for oncogene activation during progression of a mouse lymphoma. EMBO J (1984) 1.07
Tumor implantation and invasion at metastatic sites. Int Rev Exp Pathol (1983) 1.04
Expression of the metastatic phenotype in cells transfected with human metastatic tumor DNA. Proc Natl Acad Sci U S A (1985) 1.03
Cancer metastasis is selective or random depending on the parent tumour population. Nature (1982) 0.93
In vivo isolation of a metastatic tumor cell variant involving selective and nonadaptive processes. J Natl Cancer Inst (1981) 0.85
Laser capture microdissection. Science (1996) 12.21
Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro. Proc Natl Acad Sci U S A (1986) 12.14
Mechanism of activation of a human oncogene. Nature (1982) 12.09
Mouse cells transformed by bovine papillomavirus contain only extrachromosomal viral DNA sequences. Proc Natl Acad Sci U S A (1981) 9.27
Murine leukemia virus: high-frequency activation in vitro by 5-iododeoxyuridine and 5-bromodeoxyuridine. Science (1971) 8.78
The p21 src genes of Harvey and Kirsten sarcoma viruses originate from divergent members of a family of normal vertebrate genes. Nature (1981) 8.44
Positional cloning of the gene for multiple endocrine neoplasia-type 1. Science (1997) 7.95
Helper-independent transformation by unintegrated Harvey sarcoma virus DNA. J Virol (1978) 7.75
Papillomavirus L1 major capsid protein self-assembles into virus-like particles that are highly immunogenic. Proc Natl Acad Sci U S A (1992) 7.72
A quantitative in vitro focus assay for bovine papilloma virus. Virology (1980) 7.14
Isolation and characterization of type IV procollagen, laminin, and heparan sulfate proteoglycan from the EHS sarcoma. Biochemistry (1982) 6.87
In vitro tumorigenic transformation by a defined sub-genomic fragment of bovine papilloma virus DNA. Nature (1980) 6.67
HPV16 E6 and E7 proteins cooperate to immortalize human foreskin keratinocytes. EMBO J (1989) 6.60
Tumor cell interactions with the extracellular matrix during invasion and metastasis. Annu Rev Cell Biol (1993) 6.53
Identification of a second transforming region in bovine papillomavirus DNA. Proc Natl Acad Sci U S A (1984) 5.88
Metastatic potential correlates with enzymatic degradation of basement membrane collagen. Nature (1980) 5.84
Bovine papillomavirus E2 trans-activating gene product binds to specific sites in papillomavirus DNA. Nature (1987) 5.61
Analysis of two divergent rat genomic clones homologous to the transforming gene of Harvey murine sarcoma virus. Proc Natl Acad Sci U S A (1981) 5.51
Evidence for a novel gene associated with low tumor metastatic potential. J Natl Cancer Inst (1988) 5.42
Cellular origin and role of mink cell focus-forming viruses in murine thymic lymphomas. Nature (1982) 5.23
Efficient self-assembly of human papillomavirus type 16 L1 and L1-L2 into virus-like particles. J Virol (1993) 5.12
Tumorigenic transformation of mammalian cells induced by a normal human gene homologous to the oncogene of Harvey murine sarcoma virus. Nature (1982) 5.08
Tumor invasion and metastases--role of the extracellular matrix: Rhoads Memorial Award lecture. Cancer Res (1986) 5.05
Transfection of molecularly cloned Friend murine leukemia virus DNA yields a highly leukemogenic helper-independent type C virus. J Virol (1980) 4.91
Molecular cloning of infectious integrated murine leukemia virus DNA from infected mouse cells. Proc Natl Acad Sci U S A (1980) 4.71
ACP Broadsheet no 148. July 1996. Laboratory diagnosis of malaria. J Clin Pathol (1996) 4.64
Dual evolutionary origin for the rat genetic sequences of Harvey murine sarcoma virus. J Virol (1980) 4.63
Origin of mink cytopathic focus-forming (MCF) viruses:comparison with ecotropic and xenotropic murine leukemia virus genomes. Virology (1981) 4.62
Guanosine triphosphatase activating protein (GAP) interacts with the p21 ras effector binding domain. Science (1988) 4.58
Virus-specific transcription in bovine papillomavirus-transformed mouse cells. Virology (1982) 4.52
Qualitative and quantitative studies of AKR-type murine leukemia virus sequences in mouse DNA. Cold Spring Harb Symp Quant Biol (1975) 4.49
The p21 ras C-terminus is required for transformation and membrane association. Nature (1984) 4.43
Reverse phase protein microarrays which capture disease progression show activation of pro-survival pathways at the cancer invasion front. Oncogene (2001) 4.40
Intravascular origin of metastasis from the proliferation of endothelium-attached tumor cells: a new model for metastasis. Nat Med (2000) 4.36
Harvey murine sarcoma virus p21 ras protein: biological and biochemical significance of the cysteine nearest the carboxy terminus. EMBO J (1984) 4.28
Structure of endogenous murine leukemia virus DNA in mouse genomes. Proc Natl Acad Sci U S A (1980) 4.24
Genomes of murine leukemia viruses isolated from wild mice. J Virol (1981) 4.24
Immunization with viruslike particles from cottontail rabbit papillomavirus (CRPV) can protect against experimental CRPV infection. J Virol (1995) 4.14
Long terminal repeat of murine retroviral DNAs: sequence analysis, host-proviral junctions, and preintegration site. J Virol (1982) 4.06
E5 open reading frame of bovine papillomavirus type 1 encodes a transforming gene. J Virol (1986) 4.04
Quantitative relationships of intravascular tumor cells, tumor vessels, and pulmonary metastases following tumor implantation. Cancer Res (1974) 3.96
A virus-like particle enzyme-linked immunosorbent assay detects serum antibodies in a majority of women infected with human papillomavirus type 16. J Natl Cancer Inst (1994) 3.95
Epidermal-growth-factor-dependent transformation by a human EGF receptor proto-oncogene. Science (1987) 3.93
Laser capture microdissection: molecular analysis of tissue. Science (1997) 3.93
Molecular cloning of the Harvey sarcoma virus closed circular DNA intermediates: initial structural and biological characterization. J Virol (1979) 3.90
Tumor invasion and the extracellular matrix. Lab Invest (1983) 3.81
X-ray unit for general practitioners. Br Med J (1968) 3.78
Reduced Nm23/Awd protein in tumour metastasis and aberrant Drosophila development. Nature (1989) 3.75
High-resolution serum proteomic features for ovarian cancer detection. Endocr Relat Cancer (2004) 3.75
General mechanisms of metastasis. Cancer (1997) 3.71
In vitro generation and type-specific neutralization of a human papillomavirus type 16 virion pseudotype. J Virol (1996) 3.66
Virus infection of murine teratocarcinoma stem cell lines. Cell (1977) 3.54
Definitive evidence that the murine C-type virus inducing locus Akv-1 is viral genetic material. Proc Natl Acad Sci U S A (1975) 3.51
Human genome contains four genes homologous to transforming genes of Harvey and Kirsten murine sarcoma viruses. Proc Natl Acad Sci U S A (1982) 3.48
The significance of hematogenous tumor cell clumps in the metastatic process. Cancer Res (1976) 3.47
Laminin receptor on human breast carcinoma cells. Proc Natl Acad Sci U S A (1983) 3.32
Abnormal regulation of mammalian p21ras contributes to malignant tumor growth in von Recklinghausen (type 1) neurofibromatosis. Cell (1992) 3.30
Safety and immunogenicity trial in adult volunteers of a human papillomavirus 16 L1 virus-like particle vaccine. J Natl Cancer Inst (2001) 3.28
Characterization of a human colon/lung carcinoma oncogene. Nature (1983) 3.26
Reduced tumor incidence, metastatic potential, and cytokine responsiveness of nm23-transfected melanoma cells. Cell (1991) 3.21
Altered levels of laminin receptor mRNA in various human carcinoma cells that have different abilities to bind laminin. Proc Natl Acad Sci U S A (1986) 3.21
Identification of the protein encoded by the E6 transforming gene of bovine papillomavirus. Science (1985) 3.21
The transforming function of bovine papillomavirus DNA. Proc Natl Acad Sci U S A (1983) 3.19
Biochemical interactions of tumor cells with the basement membrane. Annu Rev Biochem (1986) 3.06
Isolation of a tumor cell laminin receptor. Biochem Biophys Res Commun (1983) 3.05
Mammalian and yeast ras gene products: biological function in their heterologous systems. Science (1985) 3.03
Papillomavirus polypeptides E6 and E7 are zinc-binding proteins. J Virol (1989) 3.01
Effect of plasminogen activator (urokinase), plasmin, and thrombin on glycoprotein and collagenous components of basement membrane. Cancer Res (1981) 3.00
Randomized controlled trial of the effect of the Royal College of Radiologists' guidelines on general practitioners' referrals for radiographic examination. Br J Gen Pract (1994) 2.97
Evidence that the AKR murine-leukemia-virus genome is complete in DNA of the high-virus AKR mouse and incomplete in the DNA of the "virus-negative" NIH mouse. Proc Natl Acad Sci U S A (1974) 2.95
Identification, purification, and partial sequence analysis of autotaxin, a novel motility-stimulating protein. J Biol Chem (1992) 2.93
AKR murine leukemia virus genome: frequency of sequences in DNA of high-, low-, and non-virus-yielding mouse strains. Proc Natl Acad Sci U S A (1974) 2.91
Nucleotide sequence of the 3' end of MCF 247 murine leukemia virus. J Virol (1983) 2.87
Tissue inhibitor of metalloproteinase (TIMP-2). A new member of the metalloproteinase inhibitor family. J Biol Chem (1989) 2.87
Identification of the HPV-16 E6 protein from transformed mouse cells and human cervical carcinoma cell lines. EMBO J (1987) 2.84
Detection of gene deletion in single metastatic tumour cells in lymphnode tissue by fluorescent in-situ hybridisation. Lancet (1997) 2.77
Mutational analysis of a ras catalytic domain. Mol Cell Biol (1986) 2.76
The differentiation of invasive and non-invasive Entamoeba histolytica by isoenzyme electrophoresis. Trans R Soc Trop Med Hyg (1978) 2.71
Platelet thrombospondin modulates endothelial cell adhesion, motility, and growth: a potential angiogenesis regulatory factor. J Cell Biol (1990) 2.69
The specific DNA recognition sequence of the bovine papillomavirus E2 protein is an E2-dependent enhancer. EMBO J (1988) 2.66
Laser-capture microdissection: opening the microscopic frontier to molecular analysis. Trends Genet (1998) 2.60
Immuno-LCM: laser capture microdissection of immunostained frozen sections for mRNA analysis. Am J Pathol (1999) 2.59
A microdissection technique for archival DNA analysis of specific cell populations in lesions < 1 mm in size. Am J Pathol (1995) 2.59
The region of the HPV E7 oncoprotein homologous to adenovirus E1a and Sv40 large T antigen contains separate domains for Rb binding and casein kinase II phosphorylation. EMBO J (1990) 2.57
The bovine papillomavirus E5 transforming protein can stimulate the transforming activity of EGF and CSF-1 receptors. Cell (1989) 2.52
Neutralization of bovine papillomavirus by antibodies to L1 and L2 capsid proteins. J Virol (1994) 2.52
Molecular insights into cancer invasion: strategies for prevention and intervention. Cancer Res (1995) 2.50
Role of laminin in the attachment and metastasis of murine tumor cells. Cancer Res (1982) 2.49
Functional organization of the Harvey murine sarcoma virus genome. J Virol (1980) 2.46
Interaction of papillomaviruses with the cell surface. J Virol (1994) 2.44
The E7 open reading frame of human papillomavirus type 16 encodes a transforming gene. Oncogene Res (1988) 2.42
Independent expression and cellular processing of Mr 72,000 type IV collagenase and interstitial collagenase in human tumorigenic cell lines. Cancer Res (1990) 2.40
Association of low nm23 RNA levels in human primary infiltrating ductal breast carcinomas with lymph node involvement and other histopathological indicators of high metastatic potential. Cancer Res (1989) 2.39
High-risk human papillomavirus is sexually transmitted: evidence from a follow-up study of virgins starting sexual activity (intercourse). Cancer Epidemiol Biomarkers Prev (2001) 2.38
A Drosophila gene that is homologous to a mammalian gene associated with tumor metastasis codes for a nucleoside diphosphate kinase. Cell (1990) 2.36
Bovine papilloma virus-transformed cells contain multiple E2 proteins. Proc Natl Acad Sci U S A (1988) 2.29
Tumor cell autocrine motility factor. Proc Natl Acad Sci U S A (1986) 2.28
Papillomavirus-like particles induce acute activation of dendritic cells. J Immunol (2001) 2.28
Extracellular matrix 6: role of matrix metalloproteinases in tumor invasion and metastasis. FASEB J (1993) 2.28
Preferential digestion of basement membrane collagen by an enzyme derived from a metastatic murine tumor. Proc Natl Acad Sci U S A (1979) 2.25