| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
MK0787 (N-formimidoyl thienamycin): evaluation of in vitro and in vivo activities.
|
Antimicrob Agents Chemother
|
1980
|
9.02
|
|
2
|
The mechanism of action of fosfomycin (phosphonomycin).
|
Ann N Y Acad Sci
|
1974
|
7.21
|
|
3
|
Metabolism of thienamycin and related carbapenem antibiotics by the renal dipeptidase, dehydropeptidase.
|
Antimicrob Agents Chemother
|
1982
|
5.83
|
|
4
|
Thienamycin: development of imipenen-cilastatin.
|
J Antimicrob Chemother
|
1983
|
5.52
|
|
5
|
Evaluation of the echinocandin antifungal MK-0991 (L-743,872): efficacies in mouse models of disseminated aspergillosis, candidiasis, and cryptococcosis.
|
Antimicrob Agents Chemother
|
1997
|
4.87
|
|
6
|
Urinary recovery of N-formimidoyl thienamycin (MK0787) as affected by coadministration of N-formimidoyl thienamycin dehydropeptidase inhibitors.
|
Antimicrob Agents Chemother
|
1983
|
4.25
|
|
7
|
Cephamycins, a new family of beta-lactam antibiotics. IV. In vivo studies.
|
Antimicrob Agents Chemother
|
1972
|
2.88
|
|
8
|
Preliminary animal pharmacokinetics of the parenteral antifungal agent MK-0991 (L-743,872).
|
Antimicrob Agents Chemother
|
1997
|
2.73
|
|
9
|
Evaluation of water-soluble pneumocandin analogs L-733560, L-705589, and L-731373 with mouse models of disseminated aspergillosis, candidiasis, and cryptococcosis.
|
Antimicrob Agents Chemother
|
1995
|
2.62
|
|
10
|
In vitro evaluation of the pneumocandin antifungal agent L-733560, a new water-soluble hybrid of L-705589 and L-731373.
|
Antimicrob Agents Chemother
|
1995
|
2.37
|
|
11
|
beta-Lactam antibiotic-induced release of free endotoxin: in vitro comparison of penicillin-binding protein (PBP) 2-specific imipenem and PBP 3-specific ceftazidime.
|
J Infect Dis
|
1992
|
2.27
|
|
12
|
In vivo activity and pharmacokinetic evaluation of a novel long-acting carbapenem antibiotic, MK-826 (L-749,345).
|
Antimicrob Agents Chemother
|
1998
|
2.13
|
|
13
|
Antibacterial activity of imipenem: the first thienamycin antibiotic.
|
Rev Infect Dis
|
1985
|
2.00
|
|
14
|
Carbapenems, a new class of beta-lactam antibiotics. Discovery and development of imipenem/cilastatin.
|
Am J Med
|
1985
|
1.90
|
|
15
|
Pharmacokinetics of L-749,345, a long-acting carbapenem antibiotic, in primates.
|
Antimicrob Agents Chemother
|
1997
|
1.80
|
|
16
|
In vitro activities of the potent, broad-spectrum carbapenem MK-0826 (L-749,345) against broad-spectrum beta-lactamase-and extended-spectrum beta-lactamase-producing Klebsiella pneumoniae and Escherichia coli clinical isolates.
|
Antimicrob Agents Chemother
|
1999
|
1.57
|
|
17
|
Phosphonomycin. V. Evaluation in mice.
|
Antimicrob Agents Chemother (Bethesda)
|
1969
|
1.38
|
|
18
|
Synthesis, stability, and biological evaluation of water-soluble prodrugs of a new echinocandin lipopeptide. Discovery of a potential clinical agent for the treatment of systemic candidiasis and Pneumocystis carinii pneumonia (PCP).
|
J Med Chem
|
1992
|
1.31
|
|
19
|
Pharmacokinetics in nonhuman primates of a prototype carbapenem active against methicillin-resistant Staphylococcus aureus.
|
Antimicrob Agents Chemother
|
1996
|
0.92
|
|
20
|
Effects of antibiotic therapy on Pseudomonas aeruginosa-induced lung injury in a rat model.
|
Antimicrob Agents Chemother
|
1999
|
0.92
|
|
21
|
Letter: New antibacterial agent via photofluorination of a bacterial cell wall constituent.
|
Nature
|
1973
|
0.92
|
|
22
|
Phosphonomycin. 3. Evaluation in vitro.
|
Antimicrob Agents Chemother (Bethesda)
|
1969
|
0.91
|
|
23
|
Pharmacokinetics of L-671,329 in rhesus monkeys and DBA/2 mice.
|
Antimicrob Agents Chemother
|
1992
|
0.89
|
|
24
|
Evaluation of experimental therapeutics in a new mouse model of Helicobacter felis utilizing 16S rRNA polymerase chain reaction for detection.
|
Scand J Gastroenterol
|
1997
|
0.85
|
|
25
|
A sensitive and specific PCR method to detect Helicobacter felis in a conventional mouse model.
|
Clin Diagn Lab Immunol
|
1996
|
0.84
|
|
26
|
Reduced immunotoxicity and preservation of antibacterial activity in a releasable side-chain carbapenem antibiotic.
|
Science
|
1999
|
0.80
|
|
27
|
Oxidative and defluorinative metabolism of fludalanine, 2-2H-3-fluoro-D-alanine.
|
Drug Metab Dispos
|
1987
|
0.80
|
|
28
|
Influence of antibiotic class and concentration on the percentage of release of lipopolysaccharide from Escherichia coli.
|
J Infect Dis
|
1994
|
0.78
|
|
29
|
Use of acetylacetone to prepare a prodrug of cycloserine.
|
J Med Chem
|
1980
|
0.75
|
|
30
|
[A so-called coumarin necrosis in a child].
|
Monatsschr Kinderheilkd
|
1973
|
0.75
|
|
31
|
In vivo evaluation of three acid-stable azalide compounds, L-701,677, L-708,299 and L-708,365 compared to erythromycin, azithromycin and clarithromycin.
|
J Antibiot (Tokyo)
|
1995
|
0.75
|
|
32
|
Antibacterial chemotherapy tests. II. Influence of route and number of treatments on in vivo effectiveness of streptomycin and tetracycline and influence on resistance to rechallenge.
|
Antimicrob Agents Chemother (Bethesda)
|
1966
|
0.75
|
|
33
|
Quantitative variations in beta-lactam antibiotic released endotoxin from Pseudomonas aeruginosa: in-vivo relevance.
|
Prog Clin Biol Res
|
1995
|
0.75
|
|
34
|
[Abdominal neoplasms in childhood].
|
Med Klin
|
1973
|
0.75
|
|
35
|
[Clinical trials with mercapto polycytidylic acid in the treatment of acute childhood leukemia (author's transl)].
|
Klin Padiatr
|
1979
|
0.75
|
|
36
|
[Interstitial pneumonia in children with malignancies during cytotoxic therapie. Clinical picture, analysis of promoting factors, and detailed discussion of etiology (author's transl)].
|
Klin Padiatr
|
1978
|
0.75
|
|
37
|
[Herpesvirus diseases in children with acute leukosis. Treatment with cytosine-arabinoside].
|
Fortschr Med
|
1974
|
0.75
|
|
38
|
[Varicella-zoster-immunoglobulin as a safe prophylaxis of varicella (author's transl)].
|
Monatsschr Kinderheilkd
|
1982
|
0.75
|
|
39
|
[An ophthalmologic image databank on the Internet].
|
Ophthalmologe
|
1998
|
0.75
|
|
40
|
[Selection of resistant variants by broad spectrum beta-lactam antibiotics: to what extent is there cross resistance between imipenem and other beta-lactam antibiotics?].
|
Immun Infekt
|
1986
|
0.75
|
|
41
|
[Prevention of cytomegalic inclusion disease in leukemia patients with a cytomegalovirus hyperimmune globulin preparation].
|
Klin Padiatr
|
1989
|
0.75
|
|
42
|
[Interstitial pneumonia in children on cystostatic treatment for malignant systematic disease (author's transl)].
|
Rontgenblatter
|
1975
|
0.75
|
|
43
|
[Febrile course of subcutaneous fat necrosis of the newborn with severe generalized manifestations].
|
Z Kinderheilkd
|
1968
|
0.75
|
|
44
|
[Harmonizing of tomography pictures].
|
Rontgenblatter
|
1973
|
0.75
|
|
45
|
[Prevention of varicella in children on immunosuppressive therapy (author's transl)].
|
Klin Padiatr
|
1980
|
0.75
|