Published in J Steroid Biochem Mol Biol on June 01, 1995
The molecular mechanisms underlying the pharmacological actions of ER modulators: implications for new drug discovery in breast cancer. Curr Opin Pharmacol (2010) 1.21
Research resource: Transcriptional profiling in a cellular model of breast cancer reveals functional and mechanistic differences between clinically relevant SERM and between SERM/estrogen complexes. Mol Endocrinol (2012) 1.04
The estrogen receptor beta-isoform (ERbeta) of the human estrogen receptor modulates ERalpha transcriptional activity and is a key regulator of the cellular response to estrogens and antiestrogens. Endocrinology (1999) 3.67
Cloning and expression of full-length cDNA encoding human vitamin D receptor. Proc Natl Acad Sci U S A (1988) 3.53
Human progesterone receptor A form is a cell- and promoter-specific repressor of human progesterone receptor B function. Mol Endocrinol (1993) 2.89
Molecular cloning of complementary DNA encoding the avian receptor for vitamin D. Science (1987) 2.71
Human estrogen receptor transactivational capacity is determined by both cellular and promoter context and mediated by two functionally distinct intramolecular regions. Mol Endocrinol (1994) 2.62
The human estrogen receptor-alpha is a ubiquitinated protein whose stability is affected differentially by agonists, antagonists, and selective estrogen receptor modulators. J Biol Chem (2001) 2.45
The mechanism of RU486 antagonism is dependent on the conformation of the carboxy-terminal tail of the human progesterone receptor. Cell (1992) 2.37
Bisphenol A interacts with the estrogen receptor alpha in a distinct manner from estradiol. Mol Cell Endocrinol (1998) 2.18
Dissection of the LXXLL nuclear receptor-coactivator interaction motif using combinatorial peptide libraries: discovery of peptide antagonists of estrogen receptors alpha and beta. Mol Cell Biol (1999) 2.13
Variant human breast tumor estrogen receptor with constitutive transcriptional activity. Cancer Res (1991) 1.92
Peptide antagonists of the human estrogen receptor. Science (1999) 1.86
The opposing transcriptional activities of the two isoforms of the human progesterone receptor are due to differential cofactor binding. Mol Cell Biol (2000) 1.83
Identification of a new subclass of Alu DNA repeats which can function as estrogen receptor-dependent transcriptional enhancers. J Biol Chem (1995) 1.78
Evaluation of chemicals with endocrine modulating activity in a yeast-based steroid hormone receptor gene transcription assay. Toxicol Appl Pharmacol (1997) 1.75
Estrogen levels in childhood determined by an ultrasensitive recombinant cell bioassay. J Clin Invest (1994) 1.72
Modulation of estrogen receptor-alpha transcriptional activity by the coactivator PGC-1. J Biol Chem (2000) 1.70
Yeast RSP5 and its human homolog hRPF1 potentiate hormone-dependent activation of transcription by human progesterone and glucocorticoid receptors. Mol Cell Biol (1996) 1.70
Rsp5 ubiquitin-protein ligase mediates DNA damage-induced degradation of the large subunit of RNA polymerase II in Saccharomyces cerevisiae. Mol Cell Biol (1999) 1.66
Evaluation of a recombinant yeast cell estrogen screening assay. Environ Health Perspect (1997) 1.65
The nuclear corepressors NCoR and SMRT are key regulators of both ligand- and 8-bromo-cyclic AMP-dependent transcriptional activity of the human progesterone receptor. Mol Cell Biol (1998) 1.61
Analysis of repetitive sequence elements containing tRNA-like sequences. Nucleic Acids Res (1985) 1.53
Comparative analyses of mechanistic differences among antiestrogens. Endocrinology (1999) 1.52
Estrogen receptor (ER) modulators each induce distinct conformational changes in ER alpha and ER beta. Proc Natl Acad Sci U S A (1999) 1.52
The A and B isoforms of the human progesterone receptor operate through distinct signaling pathways within target cells. Mol Cell Biol (1994) 1.48
Estrogen-induced activation of mitogen-activated protein kinase requires mobilization of intracellular calcium. Proc Natl Acad Sci U S A (1999) 1.46
Vitamin D receptor interaction with specific DNA requires a nuclear protein and 1,25-dihydroxyvitamin D3. Proc Natl Acad Sci U S A (1990) 1.42
Circumventing tamoxifen resistance in breast cancers using antiestrogens that induce unique conformational changes in the estrogen receptor. Cancer Res (2001) 1.38
Inhibition of estrogen receptor action by a naturally occurring variant in human breast tumors. Cancer Res (1992) 1.30
The A and B isoforms of the human progesterone receptor: two functionally different transcription factors encoded by a single gene. Recent Prog Horm Res (1999) 1.30
Differential interaction of the methoxychlor metabolite 2,2-bis-(p-hydroxyphenyl)-1,1,1-trichloroethane with estrogen receptors alpha and beta. Endocrinology (1999) 1.29
Interaction of methoxychlor and related compounds with estrogen receptor alpha and beta, and androgen receptor: structure-activity studies. Mol Pharmacol (2000) 1.28
BRCA1 expression is not directly responsive to estrogen. Oncogene (1997) 1.24
Human and rat peroxisome proliferator activated receptors (PPARs) demonstrate similar tissue distribution but different responsiveness to PPAR activators. J Steroid Biochem Mol Biol (1994) 1.24
Hormone-dependent interaction between the amino- and carboxyl-terminal domains of progesterone receptor in vitro and in vivo. Mol Endocrinol (1999) 1.23
Transactivation functions facilitate the disruption of chromatin structure by estrogen receptor derivatives in vivo. J Biol Chem (1991) 1.20
Ligand-dependent and -independent function of the transactivation regions of the human estrogen receptor in yeast. Mol Endocrinol (1992) 1.19
Enhancement of estrogen receptor transcriptional activity by the coactivator GRIP-1 highlights the role of activation function 2 in determining estrogen receptor pharmacology. J Biol Chem (1998) 1.17
Estrogenic activity of a dieldrin/toxaphene mixture in the mouse uterus, MCF-7 human breast cancer cells, and yeast-based estrogen receptor assays: no apparent synergism. Endocrinology (1997) 1.16
Antiestrogen can establish nonproductive receptor complexes and alter chromatin structure at target enhancers. Proc Natl Acad Sci U S A (1991) 1.14
Mapping and characterization of the functional domains responsible for the differential activity of the A and B isoforms of the human progesterone receptor. J Biol Chem (1997) 1.14
Expression of functional chicken oviduct progesterone receptors in yeast (Saccharomyces cerevisiae). J Biol Chem (1989) 1.11
Molecular biology of the vitamin D hormone. Recent Prog Horm Res (1988) 1.11
Development of an ER action indicator mouse for the study of estrogens, selective ER modulators (SERMs), and Xenobiotics. Endocrinology (2001) 1.10
Estrogen-related receptor alpha as a therapeutic target in cancer. Endocr Relat Cancer (2006) 1.10
Ligand-selective interactions of ER detected in living cells by fluorescence resonance energy transfer. Mol Endocrinol (2002) 1.08
Expression of human vitamin D receptor in Saccharomyces cerevisiae. Purification, properties, and generation of polyclonal antibodies. J Biol Chem (1990) 1.08
Nuclear import/export of hRPF1/Nedd4 regulates the ubiquitin-dependent degradation of its nuclear substrates. J Biol Chem (2001) 1.05
Potency of combined estrogenic pesticides. Science (1997) 1.04
Identification of the sequences within the human complement 3 promoter required for estrogen responsiveness provides insight into the mechanism of tamoxifen mixed agonist activity. Mol Endocrinol (1996) 1.02
Novel estrogen response elements identified by genetic selection in yeast are differentially responsive to estrogens and antiestrogens in mammalian cells. Mol Endocrinol (1994) 1.01
Temporally distinct and ligand-specific recruitment of nuclear receptor-interacting peptides and cofactors to subnuclear domains containing the estrogen receptor. Mol Endocrinol (2000) 0.99
Glucocorticoids manifest androgenic activity in a cell line derived from a metastatic prostate cancer. Cancer Res (2001) 0.99
Identification of a third autonomous activation domain within the human estrogen receptor. Mol Endocrinol (1997) 0.98
Inhibition of androgen receptor-dependent transcriptional activity by DDT isomers and methoxychlor in HepG2 human hepatoma cells. Toxicol Appl Pharmacol (1998) 0.98
Development of peptide antagonists that target estrogen receptor beta-coactivator interactions. Mol Endocrinol (2000) 0.96
Utilization of recombinant adenovirus and dominant negative mutants to characterize hepatocyte nuclear factor 4-regulated apolipoprotein AI and CIII expression. J Biol Chem (1997) 0.95
High level expression of a truncated chicken progesterone receptor in Escherichia coli. J Biol Chem (1990) 0.94
Dissection of the molecular mechanism of action of GW5638, a novel estrogen receptor ligand, provides insights into the role of estrogen receptor in bone. Endocrinology (1997) 0.94
Additive estrogenic activities of a binary mixture of 2',4',6'-trichloro- and 2',3',4',5'-tetrachloro-4-biphenylol. Toxicol Appl Pharmacol (1997) 0.92
Positive regulation of the vitamin D receptor by its cognate ligand in heterologous expression systems. Mol Endocrinol (1993) 0.88
Identification of an estrogen response element in the 3'-flanking region of the murine c-fos protooncogene. J Biol Chem (1992) 0.87
16 alpha-substituted analogs of the antiprogestin RU486 induce a unique conformation in the human progesterone receptor resulting in mixed agonist activity. Proc Natl Acad Sci U S A (1996) 0.86
Structural organization and regulation of the chicken estrogen receptor. Mol Endocrinol (1987) 0.84
Potentiation of progesterone receptor-mediated transcription by the immunosuppressant FK506. Biochemistry (1994) 0.82
Identification of novel steroid-response elements. Gene Expr (1992) 0.81
The novel progesterone receptor antagonists RTI 3021-012 and RTI 3021-022 exhibit complex glucocorticoid receptor antagonist activities: implications for the development of dissociated antiprogestins. Endocrinology (1999) 0.81
Assessing the infrequent oral supplementation of olanzapine long-acting injection in the treatment of schizophrenia. Eur Psychiatry (2010) 0.81
Creatine kinase activity as an indicator of unopposed estrogen action in the mouse uterus associated with anti-progesterone treatment. J Steroid Biochem Mol Biol (1994) 0.81
Modulation of progesterone receptor binding to progesterone response elements by positioned nucleosomes. Biochemistry (1992) 0.80
Structural requirements for high affinity ligand binding by estrogen receptors: a comparative analysis of truncated and full length estrogen receptors expressed in bacteria, yeast, and mammalian cells. Mol Endocrinol (1992) 0.80
The mechanism of action of steroid hormones: a new twist to an old tale. J Clin Pharmacol (1993) 0.79
Estrogen receptor-cofactor interactions as targets for novel drug discovery. Ernst Schering Res Found Workshop (2001) 0.79
Chicken progesterone receptor expressed in Saccharomyces cerevisiae is correctly phosphorylated at all four Ser-Pro phosphorylation sites. Biochemistry (1993) 0.78
A novel, highly regulated, rapidly inducible system for the expression of chicken progesterone receptor, cPRA, in Saccharomyces cerevisiae. Gene (1992) 0.77
The molecular pharmacology of ovarian steroid receptors. Vitam Horm (1996) 0.77
Cystine addiction of triple-negative breast cancer associated with EMT augmented death signaling. Oncogene (2017) 0.76
Creation of an active estrogen-responsive element by a single base change in the flanking sequence of a cellular oncogene: a possible mechanism for hormonal carcinogenesis? Mol Carcinog (1993) 0.75
Immunoselection of cDNAs to avian intestinal calcium binding protein 28K and a novel calmodulin-like protein: assessment of mRNA regulation by the vitamin D hormone. Biochemistry (1987) 0.75