Published in J Biol Chem on September 22, 1995
Familial primary pulmonary hypertension (gene PPH1) is caused by mutations in the bone morphogenetic protein receptor-II gene. Am J Hum Genet (2000) 4.42
Myostatin signals through a transforming growth factor beta-like signaling pathway to block adipogenesis. Mol Cell Biol (2003) 2.90
Distinct roles of type I bone morphogenetic protein receptors in the formation and differentiation of cartilage. Genes Dev (1997) 2.59
Differential roles for bone morphogenetic protein (BMP) receptor type IB and IA in differentiation and specification of mesenchymal precursor cells to osteoblast and adipocyte lineages. J Cell Biol (1998) 2.17
Role of TAK1 and TAB1 in BMP signaling in early Xenopus development. EMBO J (1998) 2.15
Bone morphogenetic protein receptor complexes on the surface of live cells: a new oligomerization mode for serine/threonine kinase receptors. Mol Biol Cell (2000) 2.08
The BMP signaling and in vivo bone formation. Gene (2005) 1.82
Bone morphogenetic protein and retinoic acid signaling cooperate to induce osteoblast differentiation of preadipocytes. J Cell Biol (2002) 1.58
BMP-2 antagonists emerge from alterations in the low-affinity binding epitope for receptor BMPR-II. EMBO J (2000) 1.55
Functional heterogeneity of bone morphogenetic protein receptor-II mutants found in patients with primary pulmonary hypertension. Mol Biol Cell (2002) 1.45
Bone morphogenetic protein signaling is required for maintenance of differentiated phenotype, control of proliferation, and hypertrophy in chondrocytes. J Cell Biol (1998) 1.34
BMPR1a and BMPR1b signaling exert opposing effects on gliosis after spinal cord injury. J Neurosci (2010) 1.29
Schistosoma mansoni TGF-beta receptor II: role in host ligand-induced regulation of a schistosome target gene. PLoS Pathog (2006) 1.29
Bone morphogenetic protein receptor type II C-terminus interacts with c-Src: implication for a role in pulmonary arterial hypertension. Am J Respir Cell Mol Biol (2005) 1.28
A silent H-bond can be mutationally activated for high-affinity interaction of BMP-2 and activin type IIB receptor. BMC Struct Biol (2007) 1.25
BMP signaling mediates effects of exercise on hippocampal neurogenesis and cognition in mice. PLoS One (2009) 1.14
Type III TGF-beta receptor-independent signalling of TGF-beta2 via TbetaRII-B, an alternatively spliced TGF-beta type II receptor. EMBO J (2001) 1.05
Bone morphogenetic proteins, genetics and the pathophysiology of primary pulmonary hypertension. Respir Res (2001) 0.98
Bone morphogenetic protein-4 interacts with activin and GnRH to modulate gonadotrophin secretion in LbetaT2 gonadotrophs. J Endocrinol (2008) 0.96
Bone morphogenetic protein receptors and activin receptors are highly expressed in ossified ligament tissues of patients with ossification of the posterior longitudinal ligament. Am J Pathol (1997) 0.95
Transcribed pseudogene ψPPM1K generates endogenous siRNA to suppress oncogenic cell growth in hepatocellular carcinoma. Nucleic Acids Res (2013) 0.92
Genetic analysis of punt, a type II Dpp receptor that functions throughout the Drosophila melanogaster life cycle. Genetics (1998) 0.91
Insulin-like growth factor I suppresses bone morphogenetic protein signaling in prostate cancer cells by activating mTOR signaling. Cancer Res (2010) 0.90
Interaction of Wnt Signaling with BMP/Smad Signaling during the Transition from Cell Proliferation to Myogenic Differentiation in Mouse Myoblast-Derived Cells. Int J Cell Biol (2013) 0.87
BMP4 increases the expression of TRPC and basal [Ca2+]i via the p38MAPK and ERK1/2 pathways independent of BMPRII in PASMCs. PLoS One (2014) 0.86
[Osteoinduction and -reparation]. Mund Kiefer Gesichtschir (1997) 0.86
A chimeric serine/threonine kinase receptor system reveals the potential of multiple type II receptors to cooperate with transforming growth factor-beta type I receptor. Mol Biol Cell (1997) 0.86
Functional redundancy of type II BMP receptor and type IIB activin receptor in BMP2-induced osteoblast differentiation. J Cell Physiol (2012) 0.83
Targeting BMP signalling in cardiovascular disease and anaemia. Nat Rev Cardiol (2015) 0.82
Role of BMP-4 and Its Signaling Pathways in Cultured Human Melanocytes. Int J Cell Biol (2009) 0.80
A pair of transmembrane receptors essential for the retention and pigmentation of hair. Genesis (2012) 0.79
Differential requirement of bone morphogenetic protein receptors Ia (ALK3) and Ib (ALK6) in early embryonic patterning and neural crest development. BMC Dev Biol (2016) 0.76
Patterns of Müllerian Inhibiting Substance Type II and Candidate Type I Receptors in Epithelial Ovarian Cancer. Curr Mol Med (2016) 0.75
The transcriptional landscape of the mammalian genome. Science (2005) 37.63
Functional annotation of a full-length mouse cDNA collection. Nature (2001) 23.61
In yeast, RAS proteins are controlling elements of adenylate cyclase. Cell (1985) 11.63
Intestinal polyposis in mice with a dominant stable mutation of the beta-catenin gene. EMBO J (1999) 10.82
The genome of the social amoeba Dictyostelium discoideum. Nature (2005) 9.18
Endoscopic mucosal resection for treatment of early gastric cancer. Gut (2001) 8.70
Intracellular inactivation of the hepatitis B virus by cytotoxic T lymphocytes. Immunity (1996) 8.27
Interaction of tyrosine-based sorting signals with clathrin-associated proteins. Science (1995) 7.77
Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders. Pharmacogenetics (1996) 6.83
Similarity of protein encoded by the human c-erb-B-2 gene to epidermal growth factor receptor. Nature (1986) 6.67
Green revolution: a mutant gibberellin-synthesis gene in rice. Nature (2002) 5.84
Fcgamma receptor-mediated induction of dendritic cell maturation and major histocompatibility complex class I-restricted antigen presentation after immune complex internalization. J Exp Med (1999) 5.55
Design of a novel oral fluoropyrimidine carbamate, capecitabine, which generates 5-fluorouracil selectively in tumours by enzymes concentrated in human liver and cancer tissue. Eur J Cancer (1998) 5.40
WW domains of Nedd4 bind to the proline-rich PY motifs in the epithelial Na+ channel deleted in Liddle's syndrome. EMBO J (1996) 5.24
Isolation and characterization of yeast mutants deficient in adenylate cyclase and cAMP-dependent protein kinase. Proc Natl Acad Sci U S A (1982) 5.04
Differential regulation of mammalian period genes and circadian rhythmicity by cryptochromes 1 and 2. Proc Natl Acad Sci U S A (1999) 4.62
Genetic analysis of novel avian A(H7N9) influenza viruses isolated from patients in China, February to April 2013. Euro Surveill (2013) 4.44
Regulation of stability and function of the epithelial Na+ channel (ENaC) by ubiquitination. EMBO J (1997) 4.01
Myogenic cells derived from rat bone marrow mesenchymal stem cells exposed to 5-azacytidine. Muscle Nerve (1995) 3.84
Failure to synthesize the T cell CD3-zeta chain: structure and function of a partial T cell receptor complex. Cell (1988) 3.59
Cardiovascular anomaly, impaired actin bundling and resistance to Src-induced transformation in mice lacking p130Cas. Nat Genet (1998) 3.38
Cytotoxic T lymphocytes inhibit hepatitis B virus gene expression by a noncytolytic mechanism in transgenic mice. Proc Natl Acad Sci U S A (1994) 3.34
Selective inhibition of catalytic activity of smooth muscle myosin light chain kinase. J Biol Chem (1987) 3.20
New endoscopic treatment for intramucosal gastric tumors using an insulated-tip diathermic knife. Endoscopy (2001) 3.20
The newly synthesized selective Ca2+/calmodulin dependent protein kinase II inhibitor KN-93 reduces dopamine contents in PC12h cells. Biochem Biophys Res Commun (1991) 3.04
Primary structure, synthesis, and biological activity of rat endothelin, an endothelium-derived vasoconstrictor peptide. Proc Natl Acad Sci U S A (1988) 2.99
Crystallization and properties of p-hydroxybenzoate hydroxylase from Pseudomonas putida. J Biol Chem (1966) 2.99
Initiation of meiosis in yeast mutants defective in adenylate cyclase and cyclic AMP-dependent protein kinase. Cell (1983) 2.91
Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase. Nat Genet (1999) 2.81
Genetic analysis of the role of cAMP in yeast. Yeast (1985) 2.78
Function of the 30 kd protein of tobacco mosaic virus: involvement in cell-to-cell movement and dispensability for replication. EMBO J (1987) 2.78
Cloning and complete nucleotide sequence of the Escherichia coli glutamine permease operon (glnHPQ). Mol Gen Genet (1986) 2.73
Developmental defects of lymphoid cells in Jak3 kinase-deficient mice. Immunity (1995) 2.70
lefty-1 is required for left-right determination as a regulator of lefty-2 and nodal. Cell (1998) 2.63
Interferon gamma production by natural killer (NK) cells and NK1.1+ T cells upon NKR-P1 cross-linking. J Exp Med (1996) 2.62
Two distinct pathways of specific killing revealed by perforin mutant cytotoxic T lymphocytes. Immunity (1994) 2.61
Functionally related motor neuron pool and muscle sensory afferent subtypes defined by coordinate ETS gene expression. Cell (1998) 2.57
Temperature-induced A-B intersite charge transfer in an A-site-ordered LaCu(3)Fe(4)O(12) perovskite. Nature (2009) 2.57
An extracellular poly(3-hydroxybutyrate) depolymerase from Alcaligenes faecalis. Eur J Biochem (1982) 2.49
Control of cell division in Saccharomyces cerevisiae mutants defective in adenylate cyclase and cAMP-dependent protein kinase. Exp Cell Res (1983) 2.48
Reconstitution of functionally active ribosomes from inactive subparticles and proteins. Proc Natl Acad Sci U S A (1966) 2.41
Liver tumor promotion by the cyanobacterial cyclic peptide toxin microcystin-LR. J Cancer Res Clin Oncol (1992) 2.40
Mu1B, a novel adaptor medium chain expressed in polarized epithelial cells. FEBS Lett (1999) 2.37
Benzo[a]pyrene carcinogenicity is lost in mice lacking the aryl hydrocarbon receptor. Proc Natl Acad Sci U S A (2000) 2.36
The Fc receptor gamma-chain and the tyrosine kinase Syk are essential for activation of mouse platelets by collagen. EMBO J (1997) 2.34
Detection of hepatitis C virus by polymerase chain reaction and response to interferon-alpha therapy: relationship to genotypes of hepatitis C virus. Hepatology (1992) 2.31
FcgammaRI (CD64) contributes substantially to severity of arthritis, hypersensitivity responses, and protection from bacterial infection. Immunity (2002) 2.31
Quantitative isolation of total glycosphingolipids from animal cells. J Lipid Res (1971) 2.29
Antigen-specific suppressive factor produced by a transplantable I-J bearing T-cell hybridoma. Nature (1979) 2.28
Induction of thymidine phosphorylase activity and enhancement of capecitabine efficacy by taxol/taxotere in human cancer xenografts. Clin Cancer Res (1998) 2.22
The medium subunits of adaptor complexes recognize distinct but overlapping sets of tyrosine-based sorting signals. J Biol Chem (1998) 2.21
Involvement of p38 mitogen-activated protein kinase signaling pathway in osteoclastogenesis mediated by receptor activator of NF-kappa B ligand (RANKL). J Biol Chem (2000) 2.18
Characterization and cloning of a receptor for BMP-2 and BMP-4 from NIH 3T3 cells. Mol Cell Biol (1994) 2.16
Neoadjuvant chemotherapy with weekly carboplatin and paclitaxel for locally advanced cervical carcinoma. Int J Gynecol Cancer (2007) 2.12
Specific antigen-Ia activation of transfected human T cells expressing murine Ti alpha beta-human T3 receptor complexes. Nature (1987) 2.11
Identification of the structural gene and nonsense alleles for adenylate cyclase in Saccharomyces cerevisiae. J Bacteriol (1984) 2.09
Mercury and cadmium resistances mediated by the penicillinase plasmid in Staphylococcus aureus. J Bacteriol (1974) 2.09
Cutting edge: the mouse NK cell-associated antigen recognized by DX5 monoclonal antibody is CD49b (alpha 2 integrin, very late antigen-2). J Immunol (2001) 2.09
Influence of dentition status on physical disability, mental impairment, and mortality in institutionalized elderly people. J Dent Res (2001) 2.06
Identification of alpha-fodrin as a candidate autoantigen in primary Sjögren's syndrome. Science (1997) 2.06
Class I-restricted cytotoxic T lymphocytes are directly cytopathic for their target cells in vivo. J Immunol (1994) 2.05
Induction of osteogenic differentiation by hedgehog proteins. Biochem Biophys Res Commun (1997) 2.05
Cyclic AMP may not be involved in catabolite repression in Saccharomyes cerevisiae: evidence from mutants capable of utilizing it as an adenine source. J Bacteriol (1982) 2.05
Heat shock response of Saccharomyces cerevisiae mutants altered in cyclic AMP-dependent protein phosphorylation. Mol Cell Biol (1987) 2.05
Molecular cloning and characterization of a cDNA encoding the gibberellin biosynthetic enzyme ent-kaurene synthase B from pumpkin (Cucurbita maxima L.). Plant J (1996) 2.04
The Dictyostelium developmental cDNA project: generation and analysis of expressed sequence tags from the first-finger stage of development. DNA Res (1998) 2.03
Domain-specific mutations in TGFB1 result in Camurati-Engelmann disease. Nat Genet (2000) 2.02
Human soluble IL-6 receptor: its detection and enhanced release by HIV infection. J Immunol (1992) 1.99
Spondyloarthropathies in Japan: nationwide questionnaire survey performed by the Japan Ankylosing Spondylitis Society. J Rheumatol (2001) 1.99
The fine structure of the horizontal cells in some vertebrate retinae. Cold Spring Harb Symp Quant Biol (1965) 1.98
Visualization of substrate binding and translocation by the ATP-dependent protease, ClpXP. Mol Cell (2000) 1.98
Studies on erythrocyte glycolysis. I. Determination of the glycolytic intermediates in human erythrocytes. J Biochem (1965) 1.97
Fas-mediated cytotoxicity by freshly isolated natural killer cells. J Exp Med (1995) 1.97
Intramembranous fine deposit disease associated with collagen disorders: a new morphological entity? Virchows Arch A Pathol Anat Histopathol (1992) 1.97
Fluorescent leprosy antibody absorption (FLA-ABS) test for detecting subclinical infection with Mycobacterium leprae. Int J Lepr Other Mycobact Dis (1980) 1.97
Aortic arch malformations and ventricular septal defect in mice deficient in endothelin-1. J Clin Invest (1995) 1.95
Abdominal ultrasonography for the diagnosis of strangulation in small bowel obstruction. Br J Surg (1994) 1.95
Tyrosine phosphorylation controls internalization of CTLA-4 by regulating its interaction with clathrin-associated adaptor complex AP-2. Immunity (1997) 1.94
Pitx2, a bicoid-type homeobox gene, is involved in a lefty-signaling pathway in determination of left-right asymmetry. Cell (1998) 1.93
The mesenchymal factor, FGF10, initiates and maintains the outgrowth of the chick limb bud through interaction with FGF8, an apical ectodermal factor. Development (1997) 1.92
High incidence of ultraviolet-B-or chemical-carcinogen-induced skin tumours in mice lacking the xeroderma pigmentosum group A gene. Nature (1995) 1.91
Mammalian achaete-scute homolog 1 is transiently expressed by spatially restricted subsets of early neuroepithelial and neural crest cells. Genes Dev (1991) 1.90
Characterization of a new avian-like influenza A virus from horses in China. Virology (1992) 1.90
Structure and functional analysis of a marine bacterial carotenoid biosynthesis gene cluster and astaxanthin biosynthetic pathway proposed at the gene level. J Bacteriol (1995) 1.90
The metabolic topography of parkinsonism. J Cereb Blood Flow Metab (1994) 1.89
Calpain-dependent proteolytic cleavage of the p35 cyclin-dependent kinase 5 activator to p25. J Biol Chem (2000) 1.89
Cell-specific expression of RANTES, MCP-1, and MIP-1alpha by lower airway epithelial cells and eosinophils infected with respiratory syncytial virus. J Virol (1998) 1.88
Resistance of Fc receptor- deficient mice to fatal glomerulonephritis. J Clin Invest (1998) 1.88
Cyclosporin in idiopathic glomerular disease associated with the nephrotic syndrome : workshop recommendations. Kidney Int (2007) 1.86
gp180, a host cell glycoprotein that binds duck hepatitis B virus particles, is encoded by a member of the carboxypeptidase gene family. J Biol Chem (1995) 1.83
Age-related changes in the subsets and functions of human T lymphocytes. J Immunol (1978) 1.82
X-ray irradiation induces thymidine phosphorylase and enhances the efficacy of capecitabine (Xeloda) in human cancer xenografts. Clin Cancer Res (1999) 1.81
A mutation in the Pax-6 gene in rat small eye is associated with impaired migration of midbrain crest cells. Nat Genet (1993) 1.81
Giant hydronephrosis due to a ureteral stone, and elevated serum levels of CA 19-9. Intern Med (1999) 1.80
Oxidative stress by tumor-derived macrophages suppresses the expression of CD3 zeta chain of T-cell receptor complex and antigen-specific T-cell responses. Proc Natl Acad Sci U S A (1996) 1.79
A mouse model of a human multiple GIST family with KIT-Asp820Tyr mutation generated by a knock-in strategy. J Pathol (2008) 1.78
The role of macrophages in diabetic glomerulosclerosis. Am J Kidney Dis (1993) 1.77