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P Agre

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Top papers

Rank Title Journal Year PubWeight™‹?›
1 Appearance of water channels in Xenopus oocytes expressing red cell CHIP28 protein. Science 1992 9.09
2 Structural determinants of water permeation through aquaporin-1. Nature 2000 7.66
3 Specialized membrane domains for water transport in glial cells: high-resolution immunogold cytochemistry of aquaporin-4 in rat brain. J Neurosci 1997 5.68
4 Reconstitution of functional water channels in liposomes containing purified red cell CHIP28 protein. Biochemistry 1992 3.84
5 Identification, purification, and partial characterization of a novel Mr 28,000 integral membrane protein from erythrocytes and renal tubules. J Biol Chem 1988 3.83
6 The mercury-sensitive residue at cysteine 189 in the CHIP28 water channel. J Biol Chem 1993 3.80
7 Isolation of the cDNA for erythrocyte integral membrane protein of 28 kilodaltons: member of an ancient channel family. Proc Natl Acad Sci U S A 1991 3.69
8 Cellular and molecular biology of the aquaporin water channels. Annu Rev Biochem 1999 3.65
9 CHIP28 water channels are localized in constitutively water-permeable segments of the nephron. J Cell Biol 1993 3.50
10 Distribution of the aquaporin CHIP in secretory and resorptive epithelia and capillary endothelia. Proc Natl Acad Sci U S A 1993 3.46
11 Molecular characterization of an aquaporin cDNA from brain: candidate osmoreceptor and regulator of water balance. Proc Natl Acad Sci U S A 1994 3.20
12 Direct immunogold labeling of aquaporin-4 in square arrays of astrocyte and ependymocyte plasma membranes in rat brain and spinal cord. Proc Natl Acad Sci U S A 1998 2.99
13 Syntrophin-dependent expression and localization of Aquaporin-4 water channel protein. Proc Natl Acad Sci U S A 2001 2.88
14 Erythrocyte Mr 28,000 transmembrane protein exists as a multisubunit oligomer similar to channel proteins. J Biol Chem 1991 2.70
15 Molecular structure of the water channel through aquaporin CHIP. The hourglass model. J Biol Chem 1994 2.65
16 Reconstitution and functional comparison of purified GlpF and AqpZ, the glycerol and water channels from Escherichia coli. Proc Natl Acad Sci U S A 2001 2.28
17 The three-dimensional structure of aquaporin-1. Nature 1997 2.28
18 Pathophysiology of the aquaporin water channels. Annu Rev Physiol 1996 2.25
19 Aquaporins: water channel proteins of plant and animal cells. Trends Biochem Sci 1994 2.22
20 Rapid gating and anion permeability of an intracellular aquaporin. Nature 1999 2.17
21 Aquaporins in complex tissues. II. Subcellular distribution in respiratory and glandular tissues of rat. Am J Physiol 1997 2.15
22 Aquaporin-4 water channel protein in the rat retina and optic nerve: polarized expression in Müller cells and fibrous astrocytes. J Neurosci 1998 2.11
23 Defective cellular trafficking of lacrimal gland aquaporin-5 in Sjögren's syndrome. Lancet 2001 2.10
24 Mutations in aquaporin-1 in phenotypically normal humans without functional CHIP water channels. Science 1994 2.09
25 Heterotetrameric composition of aquaporin-4 water channels. Biochemistry 1999 2.05
26 Molecular cloning and characterization of an aquaporin cDNA from salivary, lacrimal, and respiratory tissues. J Biol Chem 1995 2.02
27 Functional reconstitution and characterization of AqpZ, the E. coli water channel protein. J Mol Biol 1999 1.99
28 Partial deficiency of erythrocyte spectrin in hereditary spherocytosis. Nature 1985 1.81
29 Cancer-related patient education: an overview of the last decade of evaluation and research. Oncol Nurs Forum 2001 1.79
30 Aquaporins: a family of water channel proteins. Am J Physiol 1993 1.76
31 Increased fluid secretion after adenoviral-mediated transfer of the aquaporin-1 cDNA to irradiated rat salivary glands. Proc Natl Acad Sci U S A 1997 1.76
32 Reductions of erythrocyte membrane viscoelastic coefficients reflect spectrin deficiencies in hereditary spherocytosis. J Clin Invest 1988 1.75
33 Functional impairment of lens aquaporin in two families with dominantly inherited cataracts. Hum Mol Genet 2000 1.73
34 Developmental gene expression and tissue distribution of the CHIP28 water-channel protein. Proc Natl Acad Sci U S A 1993 1.68
35 Water channel properties of major intrinsic protein of lens. J Biol Chem 1995 1.64
36 Aquaporin-1 water channels in short and long loop descending thin limbs and in descending vasa recta in rat kidney. Am J Physiol 1995 1.59
37 Aquaporins in complex tissues: distribution of aquaporins 1-5 in human and rat eye. Am J Physiol 1998 1.59
38 Keratinocyte growth factor modulates alveolar epithelial cell phenotype in vitro: expression of aquaporin 5. Am J Respir Cell Mol Biol 1998 1.59
39 The human AQP4 gene: definition of the locus encoding two water channel polypeptides in brain. Proc Natl Acad Sci U S A 1996 1.58
40 Molecular cloning and characterization of AqpZ, a water channel from Escherichia coli. J Biol Chem 1995 1.56
41 Aquaporin-6: An intracellular vesicle water channel protein in renal epithelia. Proc Natl Acad Sci U S A 1999 1.52
42 Membrane topology of aquaporin CHIP. Analysis of functional epitope-scanning mutants by vectorial proteolysis. J Biol Chem 1994 1.47
43 Aquaporin-1 water channel protein in lung: ontogeny, steroid-induced expression, and distribution in rat. J Clin Invest 1996 1.46
44 Biologically active two-dimensional crystals of aquaporin CHIP. J Biol Chem 1994 1.45
45 Linkage of dominant hereditary spherocytosis to the gene for the erythrocyte membrane-skeleton protein ankyrin. N Engl J Med 1990 1.45
46 Ultrastructure, pharmacologic inhibition, and transport selectivity of aquaporin channel-forming integral protein in proteoliposomes. Biochemistry 1994 1.44
47 Two-dimensional iodopeptide mapping demonstrates that erythrocyte Rh D, c, and E polypeptides are structurally homologous but nonidentical. Blood 1988 1.42
48 Highly selective water channel activity measured by voltage clamp: analysis of planar lipid bilayers reconstituted with purified AqpZ. Proc Natl Acad Sci U S A 2001 1.42
49 Deficient red-cell spectrin in severe, recessively inherited spherocytosis. N Engl J Med 1982 1.40
50 Abnormal distribution of aquaporin-5 water channel protein in salivary glands from Sjögren's syndrome patients. Lab Invest 2001 1.40
51 High resolution AFM topographs of the Escherichia coli water channel aquaporin Z. EMBO J 1999 1.34
52 Aquaporins in complex tissues. I. Developmental patterns in respiratory and glandular tissues of rat. Am J Physiol 1997 1.33
53 Polymorphism in the Mr 32,000 Rh protein purified from Rh(D)-positive and -negative erythrocytes. Proc Natl Acad Sci U S A 1988 1.30
54 Secretin promotes osmotic water transport in rat cholangiocytes by increasing aquaporin-1 water channels in plasma membrane. Evidence for a secretin-induced vesicular translocation of aquaporin-1. J Biol Chem 1997 1.30
55 Defective urinary-concentrating ability due to a complete deficiency of aquaporin-1. N Engl J Med 2001 1.29
56 Aquaporins in Saccharomyces. Genetic and functional distinctions between laboratory and wild-type strains. J Biol Chem 1998 1.26
57 Aqp1 expression in erythroleukemia cells: genetic regulation of glucocorticoid and chemical induction. Am J Physiol 1997 1.26
58 Functional analysis of aquaporin-1 deficient red cells. The Colton-null phenotype. J Biol Chem 1996 1.26
59 Aquaporins in health and disease. Mol Med Today 2000 1.24
60 Inheritance pattern and clinical response to splenectomy as a reflection of erythrocyte spectrin deficiency in hereditary spherocytosis. N Engl J Med 1986 1.24
61 Altered ubiquitination and stability of aquaporin-1 in hypertonic stress. Proc Natl Acad Sci U S A 2001 1.24
62 The human aquaporin-CHIP gene. Structure, organization, and chromosomal localization. J Biol Chem 1993 1.23
63 Mutant forms of spectrin alpha-subunits in hereditary elliptocytosis. J Clin Invest 1987 1.22
64 The aquaporin family of water channels in kidney. Kidney Int 1995 1.22
65 Regulation of the Escherichia coli water channel gene aqpZ. Proc Natl Acad Sci U S A 1998 1.22
66 The three-dimensional structure of human erythrocyte aquaporin CHIP. EMBO J 1994 1.21
67 Ontogeny of water transport in rat brain: postnatal expression of the aquaporin-4 water channel. Eur J Neurosci 1999 1.20
68 Water and ion permeation of aquaporin-1 in planar lipid bilayers. Major differences in structural determinants and stoichiometry. J Biol Chem 2001 1.19
69 Hypertonic induction of aquaporin-5 expression through an ERK-dependent pathway. J Biol Chem 2000 1.19
70 The importance of aquaporin water channel protein structures. EMBO J 2000 1.18
71 Human red cell aquaporin CHIP. I. Molecular characterization of ABH and Colton blood group antigens. J Clin Invest 1994 1.15
72 Secretin induces the apical insertion of aquaporin-1 water channels in rat cholangiocytes. Am J Physiol 1999 1.15
73 Expression of multiple water channel activities in Xenopus oocytes injected with mRNA from rat kidney. J Gen Physiol 1993 1.14
74 Quantification of Aquaporin-CHIP water channel protein in microdissected renal tubules by fluorescence-based ELISA. J Clin Invest 1995 1.13
75 Aquaporin-1 water channel expression in human kidney. J Am Soc Nephrol 1997 1.09
76 Alteration of the erythrocyte membrane skeletal ultrastructure in hereditary spherocytosis, hereditary elliptocytosis, and pyropoikilocytosis. Blood 1990 1.09
77 Surface topographies at subnanometer-resolution reveal asymmetry and sidedness of aquaporin-1. J Mol Biol 1996 1.08
78 Sequence and exon-intron organization of the DNA encoding the alpha I domain of human spectrin. Application to the study of mutations causing hereditary elliptocytosis. J Clin Invest 1989 1.08
79 Evidence that aquaporin-1 mediates NaCl-induced water flux across descending vasa recta. Am J Physiol 1997 1.08
80 A molecular defect in two families with hemolytic poikilocytic anemia: reduction of high affinity membrane binding sites for ankyrin. J Clin Invest 1981 1.07
81 Adenovirus-mediated expression of aquaporin-5 in epithelial cells. J Biol Chem 1996 1.06
82 Progress on the structure and function of aquaporin 1. J Struct Biol 1998 1.06
83 Concurrent expression of erythroid and renal aquaporin CHIP and appearance of water channel activity in perinatal rats. J Clin Invest 1993 1.06
84 The mouse aquaporin-1 gene. Genomics 1995 1.05
85 The aquaporin family of water channel proteins in clinical medicine. Medicine (Baltimore) 1997 1.05
86 Regulation and dysregulation of aquaporins in water balance disorders. J Intern Med 2007 1.05
87 Structure of the water channel AqpZ from Escherichia coli revealed by electron crystallography. J Mol Biol 1999 1.03
88 Localization of aquaporin CHIP in the human eye: implications in the pathogenesis of glaucoma and other disorders of ocular fluid balance. Invest Ophthalmol Vis Sci 1994 1.03
89 Differential control of band 3 lateral and rotational mobility in intact red cells. J Clin Invest 1994 1.03
90 Expression of aquaporins-1 and -2 during nephrogenesis and in autosomal dominant polycystic kidney disease. Am J Physiol 1996 1.02
91 The human Aquaporin-5 gene. Molecular characterization and chromosomal localization. J Biol Chem 1996 1.00
92 Cholangiocytes express the aquaporin CHIP and transport water via a channel-mediated mechanism. Proc Natl Acad Sci U S A 1994 0.99
93 Effects of microtubule disruption on endocytosis, membrane recycling and polarized distribution of Aquaporin-1 and gp330 in proximal tubule cells. Eur J Cell Biol 1995 0.98
94 Membrane dynamics of the water transport protein aquaporin-1 in intact human red cells. Biophys J 1999 0.97
95 The structure of aquaporin-1 at 4.5-A resolution reveals short alpha-helices in the center of the monomer. J Struct Biol 1999 0.97
96 A new face of the Rhesus antigen. Nat Genet 2000 0.97
97 Distinct variants of erythrocyte protein 4.1 inherited in linkage with elliptocytosis and Rh type in three white families. Blood 1988 0.96
98 Aquaporins in Saccharomyces: Characterization of a second functional water channel protein. Proc Natl Acad Sci U S A 2001 0.96
99 Hourglass pore-forming domains restrict aquaporin-1 tetramer assembly. Biochemistry 1999 0.96
100 The 3.7 A projection map of the glycerol facilitator GlpF: a variant of the aquaporin tetramer. EMBO Rep 2000 0.94
101 Association between human erythrocyte calmodulin and the cytoplasmic surface of human erythrocyte membranes. J Biol Chem 1983 0.94
102 Aquaporin in Candida: characterization of a functional water channel protein. Yeast 2001 0.93
103 The aquaporin-Z water channel gene of Escherichia coli: structure, organization and phylogeny. Biol Cell 1997 0.92
104 Projection map of aquaporin-1 determined by electron crystallography. Nat Struct Biol 1995 0.92
105 Visualization of AqpZ-mediated water permeability in Escherichia coli by cryoelectron microscopy. J Bacteriol 1999 0.92
106 Molecular analysis of insertion/deletion mutations in protein 4.1 in elliptocytosis. II. Determination of molecular genetic origins of rearrangements. J Clin Invest 1990 0.91
107 Decreased membrane mechanical stability and in vivo loss of surface area reflect spectrin deficiencies in hereditary spherocytosis. J Clin Invest 1988 0.91
108 The aquaporin family of water channels in kidney: an update on physiology and pathophysiology of aquaporin-2. Kidney Int 1996 0.91
109 Rh blood group antigens: protein and gene structure. Semin Hematol 1993 0.91
110 Aquaporin-1 is expressed by vascular smooth muscle cells and mediates rapid water transport across vascular cell membranes. J Vasc Res 1999 0.91
111 Molecular analysis of insertion/deletion mutations in protein 4.1 in elliptocytosis. I. Biochemical identification of rearrangements in the spectrin/actin binding domain and functional characterizations. J Clin Invest 1990 0.90
112 Mammalian red cell membrane Rh polypeptides are selectively palmitoylated subunits of a macromolecular complex. J Biol Chem 1992 0.89
113 Reconstitution of water channel function of aquaporins 1 and 2 by expression in yeast secretory vesicles. Am J Physiol 1998 0.88
114 Aquaporin-1 and endothelial nitric oxide synthase expression in capillary endothelia of human peritoneum. Am J Physiol 1998 0.87
115 Cloning and chromosomal localization of mouse aquaporin 4: exclusion of a candidate mutant phenotype, ataxia. Genomics 1997 0.87
116 Secondary structures comparison of aquaporin-1 and bacteriorhodopsin: a Fourier transform infrared spectroscopy study of two-dimensional membrane crystals. Biophys J 1997 0.86
117 Cultured bovine corneal endothelial cells express CHIP28 water channels. Am J Physiol 1993 0.86
118 Aquaporins and ion conductance. Science 1997 0.85
119 The Rh polypeptide is a major fatty acid-acylated erythrocyte membrane protein. J Biol Chem 1988 0.85
120 Clinical disorders of the erythrocyte membrane skeleton. Hematol Pathol 1988 0.85
121 Aquaporins and the respiratory system: advice for a lung investigator. J Clin Invest 2000 0.84
122 Expression of aquaporin isoforms during human and mouse tooth development. Arch Oral Biol 2004 0.83
123 Man Is not a rodent: aquaporins in the airways. Am J Respir Cell Mol Biol 2001 0.83
124 Genomic organization and developmental expression of aquaporin-5 in lung. Chest 1997 0.82
125 Isolation of proteins related to the Rh polypeptides from nonhuman erythrocytes. J Clin Invest 1989 0.81
126 Regulation of AQP6 mRNA and protein expression in rats in response to altered acid-base or water balance. Am J Physiol Renal Physiol 2000 0.79
127 Respiratory aquaporins in lung inflammation: the night is young. Am J Respir Cell Mol Biol 2000 0.79
128 Amino-acid substitution in alpha-spectrin commonly coinherited with nondominant hereditary spherocytosis. Am J Hematol 1997 0.78
129 Biochemistry and molecular genetics of Rh antigens. Baillieres Clin Haematol 1991 0.78
130 Bepridil and cetiedil. Vasodilators which inhibit Ca2+-dependent calmodulin interactions with erythrocyte membranes. J Clin Invest 1984 0.78
131 The 6.9-A structure of GlpF: a basis for homology modeling of the glycerol channel from Escherichia coli. J Struct Biol 2000 0.77
132 The human tumor cloning assay in cancer drug development. A review. Invest New Drugs 1983 0.77
133 The distribution of erythrocyte phospholipids in hereditary spherocytosis demonstrates a minimal role for erythrocyte spectrin on phospholipid diffusion and asymmetry. Blood 1993 0.77
134 The aquaporin sidedness revisited. J Mol Biol 2000 0.76
135 Action at a distance: another lesson from the red cell. Biophys J 1994 0.76
136 Article on patient-education materials neglects literature with a general theme. Oncol Nurs Forum 1996 0.75
137 How much time do nurses spend teaching cancer patients. Patient Educ Couns 1990 0.75
138 Interactive computer technology. Cancer Pract 1994 0.75
139 What patients and their significant others need to know about breast reconstruction. Plast Surg Nurs 1996 0.75
140 Taurine and water channels are co-localized in renal tubule cells and other tissues. Immunocytochemical studies in rats. Adv Exp Med Biol 1996 0.75
141 Patient education: a multidisciplinary approach to influence patient compliance. Top Hosp Pharm Manage 1991 0.75
142 Hereditary spherocytosis. JAMA 1989 0.75