Published in Carcinogenesis on March 01, 1995
Distinct genetic profiles in colorectal tumors with or without the CpG island methylator phenotype. Proc Natl Acad Sci U S A (2000) 3.65
Balancing repair and tolerance of DNA damage caused by alkylating agents. Nat Rev Cancer (2012) 2.52
Gastrin is a target of the beta-catenin/TCF-4 growth-signaling pathway in a model of intestinal polyposis. J Clin Invest (2000) 1.44
Multifaceted roles of alkyltransferase and related proteins in DNA repair, DNA damage, resistance to chemotherapy, and research tools. Chem Res Toxicol (2011) 1.30
Development of colonic neoplasia in p53 deficient mice with experimental colitis induced by dextran sulphate sodium. Gut (2004) 1.08
Epidermal growth factor receptor signaling is required for microadenoma formation in the mouse azoxymethane model of colonic carcinogenesis. Cancer Res (2007) 1.07
Elevated levels of the pro-carcinogenic adduct, O(6)-methylguanine, in normal DNA from the cancer prone regions of the large bowel. Gut (2000) 1.06
Frequent mutations of KRAS in addition to BRAF in colorectal serrated adenocarcinoma. Histopathology (2011) 1.00
Spontaneous hepatocellular carcinoma is reduced in transgenic mice overexpressing human O6- methylguanine-DNA methyltransferase. Proc Natl Acad Sci U S A (2001) 0.96
Alkylation-induced colon tumorigenesis in mice deficient in the Mgmt and Msh6 proteins. Oncogene (2008) 0.94
Both base excision repair and O6-methylguanine-DNA methyltransferase protect against methylation-induced colon carcinogenesis. Carcinogenesis (2010) 0.87
Immunohistochemical Assessment of O(6)-Methylguanine-DNA Methyltransferase (MGMT) and Its Relationship with p53 Expression in Endometrial Cancers. J Cancer Prev (2013) 0.80
Longitudinal variation in O(6)-alkylguanine DNA-alkyltransferase activity in the human colon and rectum. Br J Cancer (2002) 0.80
Fast repair of O6-ethylguanine, but not O6-methylguanine, in transcribed genes prevents mutation of H-ras in rat mammary tumorigenesis induced by ethylnitrosourea in place of methylnitrosourea. Proc Natl Acad Sci U S A (1998) 0.79
Weight loss following diet-induced obesity does not alter colon tumorigenesis in the AOM mouse model. Am J Physiol Gastrointest Liver Physiol (2016) 0.75
The proline rich domain of p53 is dispensable for MGMT-dependent DNA repair and cell survival following alkylation damage. Cell Death Differ (2017) 0.75
Hematopoietic engraftment and survival in adult recipients of umbilical-cord blood from unrelated donors. N Engl J Med (2001) 5.14
A new human prostate carcinoma cell line, 22Rv1. In Vitro Cell Dev Biol Anim (1999) 4.93
Rapid hematopoietic recovery after coinfusion of autologous-blood stem cells and culture-expanded marrow mesenchymal stem cells in advanced breast cancer patients receiving high-dose chemotherapy. J Clin Oncol (2000) 3.94
Effectiveness of influenza vaccine in health care professionals: a randomized trial. JAMA (1999) 3.71
Allogeneic mesenchymal stem cell infusion for treatment of metachromatic leukodystrophy (MLD) and Hurler syndrome (MPS-IH). Bone Marrow Transplant (2002) 3.24
Phenotypic and functional comparison of cultures of marrow-derived mesenchymal stem cells (MSCs) and stromal cells. J Cell Physiol (1998) 3.08
Prolonged granulocytopenia: the major risk factor for invasive pulmonary aspergillosis in patients with acute leukemia. Ann Intern Med (1984) 3.07
Marked inactivation of O6-alkylguanine-DNA alkyltransferase activity with protracted temozolomide schedules. Br J Cancer (2003) 2.38
The changing purpose of Prader-Willi syndrome clinical diagnostic criteria and proposed revised criteria. Pediatrics (2001) 2.37
Ex vivo expansion and subsequent infusion of human bone marrow-derived stromal progenitor cells (mesenchymal progenitor cells): implications for therapeutic use. Bone Marrow Transplant (1995) 2.35
The pharmacokinetics of colistin in patients with cystic fibrosis. J Clin Pharmacol (2001) 2.18
CWR22: the first human prostate cancer xenograft with strongly androgen-dependent and relapsed strains both in vivo and in soft agar. Cancer Res (1996) 2.18
Carcinoembryonic antigen in human colonic aberrant crypt foci. Gastroenterology (1994) 2.09
Aberrant crypts: putative preneoplastic foci in human colonic mucosa. Cancer Res (1991) 2.06
CWR22: androgen-dependent xenograft model derived from a primary human prostatic carcinoma. Cancer Res (1994) 1.77
Human marrow-derived mesenchymal stem cells (MSCs) express hematopoietic cytokines and support long-term hematopoiesis when differentiated toward stromal and osteogenic lineages. J Hematother Stem Cell Res (2000) 1.73
Altered expression of RET proto-oncogene product in prostatic intraepithelial neoplasia and prostate cancer. J Natl Cancer Inst (1998) 1.68
Eosinophil infiltration of human colonic carcinomas as a prognostic indicator. Cancer Res (1983) 1.66
Transplantation of human prostatic carcinoma into nude mice in Matrigel. Cancer Res (1991) 1.61
Antigen detection in the diagnosis of invasive aspergillosis. Utility in controlled, blinded trials. Ann Intern Med (1983) 1.59
Bone marrow-derived mesenchymal stem cells remain host-derived despite successful hematopoietic engraftment after allogeneic transplantation in patients with lysosomal and peroxisomal storage diseases. Exp Hematol (1999) 1.55
Inhibition of the activation of Hageman factor (factor XII) and of platelet aggregation by extracts of Brugia malayi microfilariae. J Lab Clin Med (1991) 1.52
Randomized cross-over trial of progenitor-cell mobilization: high-dose cyclophosphamide plus granulocyte colony-stimulating factor (G-CSF) versus granulocyte-macrophage colony-stimulating factor plus G-CSF. J Clin Oncol (2000) 1.50
Polypharmacy in fatal clozapine-associated agranulocytosis. Lancet (1991) 1.50
Mismatch repair mutations override alkyltransferase in conferring resistance to temozolomide but not to 1,3-bis(2-chloroethyl)nitrosourea. Cancer Res (1996) 1.47
Pharmacologic disruption of base excision repair sensitizes mismatch repair-deficient and -proficient colon cancer cells to methylating agents. Clin Cancer Res (1999) 1.46
Serodiagnosis of invasive aspergillosis in patients with hematologic malignancy: validation of the Aspergillus fumigatus antigen radioimmunoassay. J Infect Dis (1987) 1.44
Perinatal correlates and neonatal outcomes of small for gestational age infants born at term gestation. Am J Obstet Gynecol (2001) 1.43
Ethanol inhibits L1-mediated neurite outgrowth in postnatal rat cerebellar granule cells. J Biol Chem (1999) 1.43
Sequential tumor biopsies in early phase clinical trials of anticancer agents for pharmacodynamic evaluation. Clin Cancer Res (2001) 1.42
Comparison of O6-alkylguanine-DNA alkyltransferase activity based on cellular DNA content in human, rat and mouse tissues. Carcinogenesis (1986) 1.40
Mesenchymal stem cells: no longer second class marrow citizens. Nat Med (1999) 1.39
Loss of fragile histidine triad expression in colorectal carcinomas and premalignant lesions. Cancer Res (2000) 1.38
The identification of monoclonality in human aberrant crypt foci. Cancer Res (1999) 1.34
O6 alkylguanine-DNA alkyltransferase activity in human myeloid cells. J Clin Invest (1985) 1.33
Antiemetic efficacy of dexamethasone therapy in patients receiving cancer chemotherapy. Arch Intern Med (1983) 1.31
Expression of E-cadherin in primary and metastatic prostate cancer. Am J Pathol (1996) 1.31
The prevention of thymic lymphomas in transgenic mice by human O6-alkylguanine-DNA alkyltransferase. Science (1993) 1.27
Isolation of super-repressor mutants in the histidine utilization system of Salmonella typhimurium. J Bacteriol (1975) 1.26
Aberrant crypts correlate with tumor incidence in F344 rats treated with azoxymethane and phytate. Carcinogenesis (1992) 1.25
Characterization of MLH1 and MSH2 DNA mismatch repair proteins in cell lines of the NCI anticancer drug screen. Cancer Chemother Pharmacol (2000) 1.23
Granulocyte colony-stimulating factor for clozapine-induced agranulocytosis. Lancet (1992) 1.21
O6-benzylguanine: a clinical trial establishing the biochemical modulatory dose in tumor tissue for alkyltransferase-directed DNA repair. Cancer Res (1999) 1.21
Beta-catenin expression is altered in human colonic aberrant crypt foci. Cancer Res (2001) 1.17
Maternal tobacco smoke exposure and persistent pulmonary hypertension of the newborn. Environ Health Perspect (1997) 1.15
Methoxyamine potentiates DNA single strand breaks and double strand breaks induced by temozolomide in colon cancer cells. Mutat Res (2001) 1.15
Temozolomide: the effect of once- and twice-a-day dosing on tumor tissue levels of the DNA repair protein O(6)-alkylguanine-DNA-alkyltransferase. Clin Cancer Res (2001) 1.12
LacZ and interleukin-3 expression in vivo after retroviral transduction of marrow-derived human osteogenic mesenchymal progenitors. Hum Gene Ther (1997) 1.11
Gestational age-dependent changes in circulating hematopoietic stem cells in newborn infants. J Lab Clin Med (1989) 1.10
Eradication of neuroblastoma cells in vitro by monoclonal antibody and human complement: method for purging autologous bone marrow. Cancer Res (1985) 1.10
Prospective study of one- vs two-unit umbilical cord blood transplantation following reduced intensity conditioning in adults with hematological malignancies. Bone Marrow Transplant (2011) 1.09
Aberrant P-cadherin expression is an early event in hyperplastic and dysplastic transformation in the colon. Gut (2002) 1.08
Bacterial lacZ gene as a highly sensitive marker to detect micrometastasis formation during tumor progression. Cancer Res (1990) 1.06
Aberrant crypts in human colonic mucosa: putative preneoplastic lesions. J Cell Biochem Suppl (1992) 1.04
Systemic deficits in transporter for antigen presentation (TAP)-1 or proteasome subunit LMP2 have little or no effect on tumor incidence. Int J Cancer (2001) 1.02
Role of fiberoptic bronchoscopy in the diagnosis of invasive pulmonary aspergillosis in patients with acute leukemia. Am J Med (1984) 1.01
Pulmonary cavitation and massive hemoptysis in invasive pulmonary aspergillosis. Influence of bone marrow recovery in patients with acute leukemia. Am Rev Respir Dis (1985) 1.00
Identification and quantification of ureaplasmas colonizing the respiratory tract and assessment of their role in the development of chronic lung disease in preterm infants. Pediatr Infect Dis J (2001) 1.00
Phase I clinical and pharmacokinetic study of rebeccamycin analog NSC 655649 given daily for five consecutive days. J Clin Oncol (2001) 0.98
Clozapine--deciphering the risks. N Engl J Med (1993) 0.98
Human CD34+ hematopoietic progenitors have low, cytokine-unresponsive O6-alkylguanine-DNA alkyltransferase and are sensitive to O6-benzylguanine plus BCNU. Blood (1996) 0.98
Characterization of the P140K, PVP(138-140)MLK, and G156A O6-methylguanine-DNA methyltransferase mutants: implications for drug resistance gene therapy. Hum Gene Ther (1999) 0.97
Human bone marrow-derived mesenchymal (stromal) progenitor cells (MPCs) cannot be recovered from peripheral blood progenitor cell collections. J Hematother (1997) 0.97
Identification of dysplasia in human colonic aberrant crypt foci. Am J Pathol (1997) 0.97
Retroviral transduction and expression of the human alkyltransferase cDNA provides nitrosourea resistance to hematopoietic cells. Blood (1995) 0.96
Limiting numbers of G156A O(6)-methylguanine-DNA methyltransferase-transduced marrow progenitors repopulate nonmyeloablated mice after drug selection. Blood (2000) 0.96
Comparison of the inactivation of mammalian and bacterial O6-alkylguanine-DNA alkyltransferases by O6-benzylguanine and O6-methylguanine. Carcinogenesis (1991) 0.95
Increase in nitrosourea resistance in mammalian cells by retrovirally mediated gene transfer of bacterial O6-alkylguanine-DNA alkyltransferase. Cancer Res (1989) 0.94
Retroviral transduction of a mutant methylguanine DNA methyltransferase gene into human CD34 cells confers resistance to O6-benzylguanine plus 1,3-bis(2-chloroethyl)-1-nitrosourea. Proc Natl Acad Sci U S A (1996) 0.92
Separation of tumor cells by density gradient centrifugation: recent work with human tumors and a discussion of the kind of quantitation needed in cell separation experiments. Biophys Chem (1976) 0.92
Centrifugal elutriation (counterstreaming centrifugation) of cells. Cell Biophys (1979) 0.92
Evidence for genomic instability in human colonic aberrant crypt foci. Oncogene (1996) 0.91
Regulation of the hut operons of Salmonella typhimurium and Klebsiella aerogenes by the heterologous hut repressors. J Bacteriol (1975) 0.91
Enzyme activities in prostatic carcinoma related to Gleason grades. Cancer Res (1985) 0.91
Inducible nitric oxide synthase (iNOS) is expressed similarly in multiple aberrant crypt foci and colorectal tumors from the same patients. Cancer Res (2001) 0.91
Paroxetine pharmacokinetics in depressed children and adolescents. J Am Acad Child Adolesc Psychiatry (1999) 0.91
Rapid repair of O6-methylguanine-DNA adducts protects transgenic mice from N-methylnitrosourea-induced thymic lymphomas. Cancer Res (1994) 0.91
Infections in children with cancer: a continued need for the comprehensive physical examination. J Pediatr Hematol Oncol (2000) 0.91
A randomized trial of the Vein Viewer versus standard technique for placement of peripherally inserted central catheters (PICCs) in neonates. J Perinatol (2011) 0.90
DNA repair modulates the vulnerability of the developing brain to alkylating agents. DNA Repair (Amst) (2009) 0.90
Removal of uracil by uracil DNA glycosylase limits pemetrexed cytotoxicity: overriding the limit with methoxyamine to inhibit base excision repair. Cell Death Dis (2012) 0.90
Prospective evaluation of a Candida antigen detection test for invasive candidiasis in immunocompromised adult patients with cancer. Am J Med (1989) 0.90
Pediatric renal biopsy: should this procedure be performed in an outpatient setting? Pediatr Nephrol (1998) 0.90
Placental lesions associated with cerebral palsy and neurologic impairment following term birth. Arch Pathol Lab Med (2000) 0.90
Prostate cancer and other xenografts from cells in peripheral blood of patients. Cancer Res (2000) 0.89
Invasive pulmonary aspergillosis and acute leukemia. Limitations in the diagnostic utility of the air crescent sign. Radiology (1985) 0.89
5'-nucleotidase activity in prostatic carcinoma and benign prostatic hyperplasia. Cancer Res (1989) 0.89
MMTV promoter hypomethylation is linked to spontaneous and MNU associated c-neu expression and mammary carcinogenesis in MMTV c-neu transgenic mice. Oncogene (2001) 0.89
Carmustine and streptozocin in refractory melanoma: an attempt at modulation of O-alkylguanine-DNA-alkyltransferase. Clin Cancer Res (1996) 0.89
A novel approach to the characterization of whole prostate pathology in glycol methacrylate. Am J Pathol (1994) 0.89
Separation of lymphocytes and mast cells from the Furth transplantable mast cell tumor in an isokinetic gradient of Ficoll in tissue culture medium. Cancer Res (1977) 0.89
Cell fractionation of large bowel cancer. Cancer (1977) 0.88
Tissue concentrations of prostate-specific antigen in prostatic carcinoma and benign prostatic hyperplasia. Int J Cancer (1991) 0.88
Activity of temozolomide against human tumor colony-forming units. Clin Cancer Res (1997) 0.88