Published in J Physiol on January 01, 1995
Reduced pH and chloride levels in exhaled breath condensate of patients with chronic cough. Thorax (2004) 2.36
Interganglionic segregation of distinct vagal afferent fibre phenotypes in guinea-pig airways. J Physiol (1996) 1.70
Expression of taste receptors in solitary chemosensory cells of rodent airways. BMC Pulm Med (2011) 1.38
Differential effects of airway afferent nerve subtypes on cough and respiration in anesthetized guinea pigs. Am J Physiol Regul Integr Comp Physiol (2008) 1.04
Bronchoconstriction triggered by breathing hot humid air in patients with asthma: role of cholinergic reflex. Am J Respir Crit Care Med (2012) 1.03
Central regulation of the cough reflex: therapeutic implications. Pulm Pharmacol Ther (2009) 1.02
Activation of large conductance potassium channels inhibits the afferent and efferent function of airway sensory nerves in the guinea pig. J Clin Invest (1997) 1.02
Pharmacology of airway afferent nerve activity. Respir Res (2001) 0.97
TRPM8 is a neuronal osmosensor that regulates eye blinking in mice. Nat Commun (2015) 0.86
Molecular signaling and targets from itch: lessons for cough. Cough (2013) 0.81
Bronchoconstriction induced by hyperventilation with humidified hot air: role of TRPV1-expressing airway afferents. J Appl Physiol (1985) (2009) 0.80
Pathophysiology of bronchoconstriction: role of oxidatively damaged DNA repair. Curr Opin Allergy Clin Immunol (2016) 0.78
Targeting peripheral afferent nerve terminals for cough and dyspnea. Curr Opin Pharmacol (2011) 0.76
Protective effect of inhaled furosemide on allergen-induced early and late asthmatic reactions. N Engl J Med (1989) 3.12
The response of laryngeal afferent fibres to mechanical and chemical stimuli. J Physiol (1974) 2.50
Afferent neural pathways in cough and reflex bronchoconstriction. J Appl Physiol (1985) (1988) 2.23
Alteration in osmolarity of inhaled aerosols cause bronchoconstriction and cough, but absence of a permeant anion causes cough alone. Am Rev Respir Dis (1984) 2.05
Prevention of exercise-induced bronchoconstriction by inhaled frusemide. Lancet (1988) 1.71
Inhibition of chloride secretion by furosemide in canine tracheal epithelium. J Membr Biol (1983) 1.67
Mechanism of cough and bronchoconstriction induced by distilled water aerosol. Am Rev Respir Dis (1983) 1.66
Effect of inhaled furosemide on metabisulfite- and methacholine-induced bronchoconstriction and nasal potential difference in asthmatic subjects. Am Rev Respir Dis (1990) 1.57
An in vitro study of the properties of single vagal afferents innervating guinea-pig airways. J Physiol (1993) 1.44
Inhaled furosemide inhibits cough induced by low chloride content solutions but not by capsaicin. Am Rev Respir Dis (1990) 1.31
Cough and bronchoconstriction mediated by capsaicin-sensitive sensory neurons in the guinea-pig. Pulm Pharmacol (1988) 1.30
Hypertonic saline increases vascular permeability in the rat trachea by producing neurogenic inflammation. J Clin Invest (1990) 1.27
Effect of inhaled furosemide and bumetanide on adenosine 5'-monophosphate- and sodium metabisulfite-induced bronchoconstriction in asthmatic subjects. Am Rev Respir Dis (1991) 1.23
The (Na+-K+-Cl-) co-transport system. Clin Sci (Lond) (1986) 1.16
Chemical specificity of a laryngeal apneic reflex in puppies. J Appl Physiol Respir Environ Exerc Physiol (1982) 1.14
Effects of aerosol-applied capsaicin, histamine and prostaglandin E2 on airway sensory receptors of anaesthetized cats. J Physiol (1993) 1.07
Inhibition by furosemide of inflammatory mediators from lung fragments. N Engl J Med (1991) 1.07
Chemical specificity of coughing in man. Clin Sci (Lond) (1986) 1.04
Loop diuretics inhibit cholinergic and noncholinergic nerves in guinea pig airways. Am Rev Respir Dis (1991) 1.03
Vagal afferent and reflex responses to changes in surface osmolarity in lower airways of dogs. J Appl Physiol (1985) (1992) 0.99
Hyperosmolarity as the stimulus to asthma induced by hyperventilation? J Allergy Clin Immunol (1986) 0.95
Inhaled furosemide prevents both the bronchoconstriction and the increase in neutrophil chemotactic activity induced by ultrasonic "fog" of distilled water in asthmatics. Am Rev Respir Dis (1991) 0.92
Diuretics and asthma. Thorax (1993) 0.86
Laryngeal afferent activity and reflexes in the guinea pig. Respir Physiol (1991) 0.85
Effect of hypo- and hyper-osmolarity on basophil histamine release. Clin Allergy (1986) 0.83
Effect of frusemide on cough responses to chloride-deficient solution in normal and mild asthmatic subjects. Eur Respir J (1993) 0.83
Local cellular and humoral responses to antigenic and distilled water challenge in subjects with allergic rhinitis. Am Rev Respir Dis (1988) 0.82
Effect of furosemide on the response of laryngeal receptors to low-chloride solutions. Eur Respir J (1993) 0.81
Issues in exercise-induced asthma. J Allergy Clin Immunol (1985) 0.81
Effect of frusemide on bradykinin- and capsaicin-induced contraction of the guinea-pig trachea. Eur Respir J (1993) 0.80
A new NK1 receptor antagonist (CP-99,994) prevents the increase in tracheal vascular permeability produced by hypertonic saline. J Pharmacol Exp Ther (1993) 0.78
Afferent innervation and receptors of the canine extrathoracic trachea. Respir Physiol (1992) 0.78
Global strategy for asthma management and prevention: GINA executive summary. Eur Respir J (2008) 10.08
Effect of inhaled formoterol and budesonide on exacerbations of asthma. Formoterol and Corticosteroids Establishing Therapy (FACET) International Study Group. N Engl J Med (1997) 8.48
Differences in interleukin-8 and tumor necrosis factor-alpha in induced sputum from patients with chronic obstructive pulmonary disease or asthma. Am J Respir Crit Care Med (1996) 5.53
Low dose inhaled budesonide and formoterol in mild persistent asthma: the OPTIMA randomized trial. Am J Respir Crit Care Med (2001) 5.47
Increased nitric oxide in exhaled air of asthmatic patients. Lancet (1994) 5.39
Outcomes for COPD pharmacological trials: from lung function to biomarkers. Eur Respir J (2008) 5.38
Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response. Lancet (2001) 5.25
Exhaled breath condensate: methodological recommendations and unresolved questions. Eur Respir J (2005) 5.24
Anti-inflammatory actions of glucocorticoids: molecular mechanisms. Clin Sci (Lond) (1998) 4.31
Addition of leukotriene antagonists to therapy in chronic persistent asthma: a randomised double-blind placebo-controlled trial. Lancet (2001) 3.48
Neutrophilic inflammation in severe persistent asthma. Am J Respir Crit Care Med (1999) 3.44
Asthma as an axon reflex. Lancet (1986) 3.26
Single-dose slow-release aminophylline at night prevents nocturnal asthma. Lancet (1982) 3.21
Exhaled markers of pulmonary disease. Am J Respir Crit Care Med (2001) 3.14
Glucocorticoid receptor recruitment of histone deacetylase 2 inhibits interleukin-1beta-induced histone H4 acetylation on lysines 8 and 12. Mol Cell Biol (2000) 3.13
Neural control of human airways in health and disease. Am Rev Respir Dis (1986) 2.97
Exhaled and nasal nitric oxide measurements: recommendations. The European Respiratory Society Task Force. Eur Respir J (1997) 2.79
Effects of inhaled and oral glucocorticoids on inflammatory indices in asthma and COPD. Am J Respir Crit Care Med (1997) 2.77
Correlation between exhaled nitric oxide, sputum eosinophils, and methacholine responsiveness in patients with mild asthma. Thorax (1998) 2.71
Exacerbations of chronic obstructive pulmonary disease. Eur Respir J (2007) 2.65
Bradykinin-induced bronchoconstriction in humans. Mode of action. Am Rev Respir Dis (1987) 2.64
Cytokines in asthma. Thorax (1999) 2.64
Synaptic mechanisms in the substantia nigra. J Pharm Pharmacol (1976) 2.54
Antagonism of 5-hydroxytryptamine by LSD 25 in the central nervous system: a possible neuronal basis for the actions of LSD 25. Br J Pharmacol (1970) 2.49
Effects of inhaled platelet activating factor on pulmonary function and bronchial responsiveness in man. Lancet (1986) 2.41
Changes in sputum eosinophils predict loss of asthma control. Am J Respir Crit Care Med (2000) 2.33
Tolerance to the nonbronchodilator effects of inhaled beta 2-agonists in asthma. N Engl J Med (1992) 2.32
Inhaled glucocorticoids decrease nitric oxide in exhaled air of asthmatic patients. Am J Respir Crit Care Med (1996) 2.32
Acute and chronic effects of cigarette smoking on exhaled nitric oxide. Am J Respir Crit Care Med (1995) 2.28
Circulating catecholamines in exercise and hyperventilation induced asthma. Thorax (1981) 2.22
Exhaled carbon monoxide in childhood asthma. J Pediatr (1999) 2.19
Activation and localization of transcription factor, nuclear factor-kappaB, in asthma. Am J Respir Crit Care Med (1998) 2.19
Cigarette smoking reduces histone deacetylase 2 expression, enhances cytokine expression, and inhibits glucocorticoid actions in alveolar macrophages. FASEB J (2001) 2.18
Parameters associated with persistent airflow obstruction in chronic severe asthma. Eur Respir J (2004) 2.18
STAT4 activation in smokers and patients with chronic obstructive pulmonary disease. Eur Respir J (2004) 2.06
Increased expression of nuclear factor-kappaB in bronchial biopsies from smokers and patients with COPD. Eur Respir J (2002) 2.04
Exhaled 8-isoprostane as an in vivo biomarker of lung oxidative stress in patients with COPD and healthy smokers. Am J Respir Crit Care Med (2000) 2.03
The effect of airway epithelium on smooth muscle contractility in bovine trachea. Br J Pharmacol (1985) 1.98
Oxidative stress reduces histone deacetylase 2 activity and enhances IL-8 gene expression: role of tyrosine nitration. Biochem Biophys Res Commun (2004) 1.98
Exacerbations of asthma: a descriptive study of 425 severe exacerbations. The FACET International Study Group. Am J Respir Crit Care Med (1999) 1.96
Expression of inducible nitric oxide in human lung epithelial cells. Biochem Biophys Res Commun (1994) 1.96
Effect of high dose inhaled steroid on cells, cytokines, and proteases in induced sputum in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (1999) 1.94
Increased 8-isoprostane, a marker of oxidative stress, in exhaled condensate of asthma patients. Am J Respir Crit Care Med (1999) 1.92
Granulocyte activation markers in induced sputum: comparison between chronic obstructive pulmonary disease, asthma, and normal subjects. Am J Respir Crit Care Med (1997) 1.91
A calcium antagonist, nifedipine, modifies exercise-induced asthma. Thorax (1981) 1.90
Autoradiographic visualization of beta-adrenoceptor subtypes in human lung. Am Rev Respir Dis (1985) 1.89
T helper type 17-related cytokine expression is increased in the bronchial mucosa of stable chronic obstructive pulmonary disease patients. Clin Exp Immunol (2009) 1.89
Tumor necrosis factor-alpha increases airway responsiveness and sputum neutrophilia in normal human subjects. Am J Respir Crit Care Med (1995) 1.84
A comparison of low-dose inhaled budesonide plus theophylline and high-dose inhaled budesonide for moderate asthma. N Engl J Med (1997) 1.84
Induction of cyclo-oxygenase-2 by cytokines in human pulmonary epithelial cells: regulation by dexamethasone. Br J Pharmacol (1994) 1.82
Increased nitric oxide in exhaled air of normal human subjects with upper respiratory tract infections. Eur Respir J (1995) 1.80
Brittle asthma. Thorax (1998) 1.77
Importance of inhaler devices in the management of airway disease. Respir Med (2007) 1.76
Evidence for systemic rather than pulmonary effects of interleukin-5 administration in asthma. Thorax (2001) 1.76
Airway inflammation after controlled exposure to diesel exhaust particulates. Am J Respir Crit Care Med (2000) 1.75
Circulating catecholamines in acute asthma. Br Med J (Clin Res Ed) (1985) 1.73
Is immunotherapy for asthma worthwhile? N Engl J Med (1996) 1.72
Effect of inhaled corticosteroids on bones and growth. Eur Respir J (1998) 1.68
Supplementary oxygen in healthy subjects and those with COPD increases oxidative stress and airway inflammation. Thorax (2004) 1.68
Reproducibility of exhaled nitric oxide measurements in healthy and asthmatic adults and children. Eur Respir J (2003) 1.68
Elevated levels of exhaled nitric oxide in bronchiectasis. Am J Respir Crit Care Med (1995) 1.67
Pseudo-steroid resistant asthma. Thorax (1999) 1.67
Nitric oxide is the endogenous neurotransmitter of bronchodilator nerves in humans. Eur J Pharmacol (1992) 1.67
Allergen-induced late asthmatic reactions are associated with elevation of exhaled nitric oxide. Am J Respir Crit Care Med (1995) 1.67
Late response to allergen is associated with increased concentrations of tumor necrosis factor-alpha and IL-5 in induced sputum. J Allergy Clin Immunol (1997) 1.65
Inhaled corticosteroids increase interleukin-10 but reduce macrophage inflammatory protein-1alpha, granulocyte-macrophage colony-stimulating factor, and interferon-gamma release from alveolar macrophages in asthma. Am J Respir Crit Care Med (1998) 1.65
Increased exhaled nitric oxide in asthma is mainly derived from the lower respiratory tract. Am J Respir Crit Care Med (1996) 1.65
Prostaglandin D2 potentiates airway responsiveness to histamine and methacholine. Am Rev Respir Dis (1986) 1.65
Low-dose theophylline enhances the anti-inflammatory effects of steroids during exacerbations of COPD. Thorax (2009) 1.65
Morphine and neurotransmitter substances: Microiontophoretic study in the rat brain stem. Br J Pharmacol (1974) 1.65
Exhaled nitric oxide: a new lung function test. Thorax (1996) 1.64
Evidence for involvement of NF-kappaB in the transcriptional control of COX-2 gene expression by IL-1beta. Biochem Biophys Res Commun (1997) 1.63
Low-dose theophylline reduces eosinophilic inflammation but not exhaled nitric oxide in mild asthma. Am J Respir Crit Care Med (2001) 1.63
Adenosine as a vasodilator in primary pulmonary hypertension. Circulation (1991) 1.63
Raised levels of exhaled carbon monoxide are associated with an increased expression of heme oxygenase-1 in airway macrophages in asthma: a new marker of oxidative stress. Thorax (1998) 1.63
Relative corticosteroid insensitivity of alveolar macrophages in severe asthma compared with non-severe asthma. Thorax (2008) 1.62
Bronchoconstrictor response to inhaled capsaicin in humans. J Appl Physiol (1985) (1985) 1.61
Exhaled nitric oxide in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (1998) 1.60
Effect of low-dose theophylline plus beclometasone on lung function in smokers with asthma: a pilot study. Eur Respir J (2009) 1.59
Haplotype associated with low interleukin-10 production in patients with severe asthma. Lancet (1998) 1.59
Dose-response curves to inhaled beta-adrenoceptor agonists in normal and asthmatic subjects. Br J Clin Pharmacol (1983) 1.58
Exhaled carbon monoxide and nitric oxide in COPD. Chest (2001) 1.58
Capsazepine inhibits cough induced by capsaicin and citric acid but not by hypertonic saline in guinea pigs. J Appl Physiol (1985) (1995) 1.58
Specific immunological and bronchopulmonary responses following intradermal sensitization to free trimellitic anhydride in guinea pigs. Clin Exp Allergy (1992) 1.57
Effect of inhaled furosemide on metabisulfite- and methacholine-induced bronchoconstriction and nasal potential difference in asthmatic subjects. Am Rev Respir Dis (1990) 1.57
Bradykinin-induced airway microvascular leakage and bronchoconstriction are mediated via a bradykinin B2 receptor. Am Rev Respir Dis (1990) 1.57
Exhaled leukotrienes and prostaglandins in COPD. Thorax (2003) 1.55
Loop diuretics and asthma. Pulm Pharmacol (1992) 1.55
The need to improve inhalation technique in Europe: a report from the Aerosol Drug Management Improvement Team. Respir Med (2006) 1.54
Defective macrophage phagocytosis of bacteria in COPD. Eur Respir J (2009) 1.52
Effects of recombinant human interleukin-12 on eosinophils, airway hyper-responsiveness, and the late asthmatic response. Lancet (2001) 1.52
Increased levels of the chemokines GROalpha and MCP-1 in sputum samples from patients with COPD. Thorax (2002) 1.51
Effect of platelet-activating factor on airway vascular permeability: possible mechanisms. J Appl Physiol (1985) (1987) 1.50
Effects of cyclo-oxygenase inhibition on exhaled eicosanoids in patients with COPD. Thorax (2005) 1.50
Abnormal glucocorticoid receptor-activator protein 1 interaction in steroid-resistant asthma. J Exp Med (1995) 1.47
Effect of a nitric oxide synthase inhibitor and a glucocorticosteroid on exhaled nitric oxide. Am J Respir Crit Care Med (1995) 1.47
Resveratrol, an extract of red wine, inhibits lipopolysaccharide induced airway neutrophilia and inflammatory mediators through an NF-kappaB-independent mechanism. FASEB J (2005) 1.47
Increased pulmonary alpha-adrenergic and reduced beta-adrenergic receptors in experimental asthma. Nature (1980) 1.46