Published in Proc Natl Acad Sci U S A on April 25, 1995
The enigmatic X gene of hepatitis B virus. J Virol (2004) 2.98
The hepatitis B virus HBx protein is a dual specificity cytoplasmic activator of Ras and nuclear activator of transcription factors. EMBO J (1995) 2.68
Hepatitis B virus HBx protein deregulates cell cycle checkpoint controls. Proc Natl Acad Sci U S A (1995) 2.11
Cloning and characterization of a novel hepatitis B virus x binding protein that inhibits viral replication. J Virol (1998) 1.96
Mitochondrially associated hepatitis B virus X protein constitutively activates transcription factors STAT-3 and NF-kappa B via oxidative stress. Mol Cell Biol (2001) 1.93
Hepatitis B virus HBx protein induces transcription factor AP-1 by activation of extracellular signal-regulated and c-Jun N-terminal mitogen-activated protein kinases. J Virol (1996) 1.89
Hepatitis B virus HBx protein sensitizes cells to apoptotic killing by tumor necrosis factor alpha. Proc Natl Acad Sci U S A (1997) 1.79
Muscle LIM protein promotes myogenesis by enhancing the activity of MyoD. Mol Cell Biol (1997) 1.66
Hepatitis B virus HBx protein activates transcription factor NF-kappaB by acting on multiple cytoplasmic inhibitors of rel-related proteins. J Virol (1996) 1.65
Hepatitis B virus and hepatocellular carcinoma. Int J Exp Pathol (2001) 1.59
Activation of Src family kinases by hepatitis B virus HBx protein and coupled signaling to Ras. Mol Cell Biol (1997) 1.58
The basic domain of myogenic basic helix-loop-helix (bHLH) proteins is the novel target for direct inhibition by another bHLH protein, Twist. Mol Cell Biol (1997) 1.56
The hepatitis B virus X gene induces p53-mediated programmed cell death. Proc Natl Acad Sci U S A (1997) 1.46
Hepatitis B virus pX activates NF-kappa B-dependent transcription through a Raf-independent pathway. J Virol (1996) 1.35
Role of NF-kappaB and myc proteins in apoptosis induced by hepatitis B virus HBx protein. J Virol (2001) 1.32
The hepatitis B virus X protein increases the cellular level of TATA-binding protein, which mediates transactivation of RNA polymerase III genes. Mol Cell Biol (1995) 1.32
CpG-methylation regulates a class of Epstein-Barr virus promoters. PLoS Pathog (2010) 1.28
Hepatitis B virus X protein induces RNA polymerase III-dependent gene transcription and increases cellular TATA-binding protein by activating the Ras signaling pathway. Mol Cell Biol (1997) 1.25
Hepatitis B virus HBx protein activation of cyclin A-cyclin-dependent kinase 2 complexes and G1 transit via a Src kinase pathway. J Virol (2001) 1.20
Transcriptional regulation of the TATA-binding protein by Ras cellular signaling. Mol Cell Biol (2000) 1.19
Regulation of RNA polymerase I-dependent promoters by the hepatitis B virus X protein via activated Ras and TATA-binding protein. Mol Cell Biol (1998) 1.19
A truncated mutant (residues 58-140) of the hepatitis B virus X protein retains transactivation function. Proc Natl Acad Sci U S A (1996) 1.18
Mitogen-activated protein kinase kinase 1/2 inhibitors and 17-allylamino-17-demethoxygeldanamycin synergize to kill human gastrointestinal tumor cells in vitro via suppression of c-FLIP-s levels and activation of CD95. Mol Cancer Ther (2008) 1.10
Direct association and nuclear import of the hepatitis B virus X protein with the NF-kappaB inhibitor IkappaBalpha. Mol Cell Biol (1999) 1.09
Regulation of hepatocyte nuclear factor 1 activity by wild-type and mutant hepatitis B virus X proteins. J Virol (2002) 1.06
The ICP22 protein of equine herpesvirus 1 cooperates with the IE protein to regulate viral gene expression. J Virol (1997) 1.03
Activation of focal adhesion kinase by hepatitis B virus HBx protein: multiple functions in viral replication. J Virol (2006) 1.01
Hepatitis B virus HBx protein localized to the nucleus restores HBx-deficient virus replication in HepG2 cells and in vivo in hydrodynamically-injected mice. Virology (2009) 1.00
Differential gene regulation by selective association of transcriptional coactivators and bZIP DNA-binding domains. Mol Cell Biol (2006) 0.99
Enhancement of gene transactivation activity of androgen receptor by hepatitis B virus X protein. Virology (2007) 0.99
Hepatitis B virus X protein and the estrogen receptor variant lacking exon 5 inhibit estrogen receptor signaling in hepatoma cells. Nucleic Acids Res (2006) 0.98
Deregulated direct targets of the hepatitis B virus (HBV) protein, HBx, identified through chromatin immunoprecipitation and expression microarray profiling. J Biol Chem (2009) 0.96
Hepatitis B virus X protein activates the p38 mitogen-activated protein kinase pathway in dedifferentiated hepatocytes. J Virol (2002) 0.94
Hepatitis B virus protein X-induced expression of the CXC chemokine IP-10 is mediated through activation of NF-kappaB and increases migration of leukocytes. J Biol Chem (2010) 0.92
Different regions of hepatitis B virus X protein are required for enhancement of bZip-mediated transactivation versus transrepression. J Virol (2000) 0.89
CREB: A Key Regulator of Normal and Neoplastic Hematopoiesis. Adv Hematol (2009) 0.88
Reconstitution of gene expression from a regulatory-protein-deficient hepatitis B virus genome by cell-permeable HBx protein. EMBO Rep (2003) 0.86
Targeting of the visna virus tat protein to AP-1 sites: interactions with the bZIP domains of fos and jun in vitro and in vivo. J Virol (1999) 0.84
Altered binding site selection of p53 transcription cassettes by hepatitis B virus X protein. Mol Cell Biol (2012) 0.83
Casein kinase II interacts with the bZIP domains of several transcription factors. Nucleic Acids Res (1998) 0.83
Up-regulation of activating transcription factor-5 suppresses SAP expression to activate T cells in hemophagocytic syndrome associated with Epstein-Barr virus infection and immune disorders. Am J Pathol (2008) 0.80
The DNA virus white spot syndrome virus uses an internal ribosome entry site for translation of the highly expressed nonstructural protein ICP35. J Virol (2013) 0.79
Protein-x of hepatitis B virus in interaction with CCAAT/enhancer-binding protein α (C/EBPα)--an in silico analysis approach. Theor Biol Med Model (2011) 0.78
Genomic responses to hepatitis B virus (HBV) infection in primary human hepatocytes. Oncotarget (2015) 0.78
Single-Nucleotide Resolution Mapping of Hepatitis B Virus Promoters in Infected Human Livers and Hepatocellular Carcinoma. J Virol (2016) 0.76
The mitogenic function of hepatitis B virus X protein resides within amino acids 51 to 140 and is modulated by N- and C-terminal regulatory regions. J Virol (2006) 0.76
Hepatitis B Virus X Protein Upregulates hELG1/ ATAD5 Expression through E2F1 in Hepatocellular Carcinoma. Int J Biol Sci (2016) 0.75
An RNAi based high-throughput screening assay to identify small molecule inhibitors of Hepatitis B Virus replication. J Biol Chem (2017) 0.75
Sequencing end-labeled DNA with base-specific chemical cleavages. Methods Enzymol (1980) 287.68
Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes. J Mol Biol (1986) 55.34
A bacteriophage T7 RNA polymerase/promoter system for controlled exclusive expression of specific genes. Proc Natl Acad Sci U S A (1985) 46.59
The hepatitis B virus. Nature (1985) 8.71
A gene activated by growth factors is related to the oncogene v-jun. Proc Natl Acad Sci U S A (1988) 7.47
A cluster of phosphorylation sites on the cyclic AMP-regulated nuclear factor CREB predicted by its sequence. Nature (1989) 5.89
HBx gene of hepatitis B virus induces liver cancer in transgenic mice. Nature (1991) 5.34
Cyclic AMP-responsive DNA-binding protein: structure based on a cloned placental cDNA. Science (1988) 5.29
Induction of proto-oncogene JUN/AP-1 by serum and TPA. Nature (1988) 5.18
Transcriptional activation of c-jun during the G0/G1 transition in mouse fibroblasts. Nature (1988) 5.04
CREM gene: use of alternative DNA-binding domains generates multiple antagonists of cAMP-induced transcription. Cell (1991) 4.11
Hepatitis B virus transactivator HBx uses a tumour promoter signalling pathway. Nature (1993) 3.88
HBV X protein alters the DNA binding specificity of CREB and ATF-2 by protein-protein interactions. Science (1991) 3.78
Expression and purification of the leucine zipper and DNA-binding domains of Fos and Jun: both Fos and Jun contact DNA directly. Proc Natl Acad Sci U S A (1990) 3.31
HTLV-I Tax protein stimulation of DNA binding of bZIP proteins by enhancing dimerization. Science (1993) 3.05
trans-activation of viral enhancers by the hepatitis B virus X protein. J Virol (1988) 3.04
Trans-activation of the human immunodeficiency virus long terminal repeat by the hepatitis B virus X protein. Proc Natl Acad Sci U S A (1988) 2.79
Transactivation by the hepatitis B virus X protein depends on AP-2 and other transcription factors. Nature (1990) 2.69
Transcriptional trans-activating function of hepatitis B virus. J Virol (1987) 2.46
Altered protein conformation on DNA binding by Fos and Jun. Nature (1990) 2.34
Transcriptional activation of homologous and heterologous genes by the hepatitis B virus X gene product in cells permissive for viral replication. J Virol (1989) 2.21
Transactivation by hepatitis B virus X protein is promiscuous and dependent on mitogen-activated cellular serine/threonine kinases. Proc Natl Acad Sci U S A (1993) 2.06
A secondary phosphorylation of CREB341 at Ser129 is required for the cAMP-mediated control of gene expression. A role for glycogen synthase kinase-3 in the control of gene expression. J Biol Chem (1994) 1.94
Cellular factors that interact with the hepatitis B virus enhancer. Mol Cell Biol (1989) 1.78
Hepatitis B virus X gene can transactivate heterologous viral sequences. Proc Natl Acad Sci U S A (1989) 1.77
Antibodies to peptides detect new hepatitis B antigen: serological correlation with hepatocellular carcinoma. Science (1985) 1.63
The hepatitis B virus-encoded transcriptional trans-activator hbx appears to be a novel protein serine/threonine kinase. Cell (1990) 1.61
Hepatitis B virus X gene activates kappa B-like enhancer sequences in the long terminal repeat of human immunodeficiency virus 1. Proc Natl Acad Sci U S A (1989) 1.61
Induction of the DNA-binding activity of c-jun/c-fos heterodimers by the hepatitis B virus transactivator pX. Mol Cell Biol (1994) 1.56
trans-activation of viral enhancers including long terminal repeat of the human immunodeficiency virus by the hepatitis B virus X protein. Virology (1989) 1.55
The X protein of the hepatitis B virus acts as a transcription factor when targeted to its responsive element. EMBO J (1990) 1.45
Three sequence-specific DNA-protein complexes are formed with the same promoter element essential for expression of the rat somatostatin gene. Mol Cell Biol (1988) 1.24
In vitro transcription directed from the somatostatin promoter is dependent upon a purified 43-kDa DNA-binding protein. Proc Natl Acad Sci U S A (1989) 1.07
cAMP-dependent protein kinase, but not the cGMP-dependent enzyme, rapidly phosphorylates delta-CREB, and a synthetic delta-CREB peptide. Biochem Cell Biol (1993) 1.00
Hepatitis B virus X protein produced in Escherichia coli is biologically functional. J Virol (1990) 0.96
Bacterial expression and characterization of the CREB bZip module: circular dichroism and 2D 1H-NMR studies. Protein Sci (1993) 0.94
Viral transactivation. Pleiotropy and henchman X. Nature (1993) 0.88
Binding constant determination studies utilizing recombinant delta CREB protein. DNA Cell Biol (1993) 0.87
Involvement of lysine residues 289 and 291 of the cAMP-responsive element-binding protein in the recognition of the cAMP-responsive element. J Biol Chem (1991) 0.80
A secondary phosphorylation of CREB341 at Ser129 is required for the cAMP-mediated control of gene expression. A role for glycogen synthase kinase-3 in the control of gene expression. J Biol Chem (1994) 1.94
Differential immediate early gene expression in conditional hepatitis B virus pX-transforming versus nontransforming hepatocyte cell lines. J Biol Chem (1999) 1.22
Identification of the promoter sequences involved in the cell specific expression of the rat somatostatin gene. Nucleic Acids Res (1987) 1.10
The hepatitis B virus X protein enhances the DNA binding potential and transcription efficacy of bZip transcription factors. J Biol Chem (1997) 1.01
cAMP-dependent protein kinase, but not the cGMP-dependent enzyme, rapidly phosphorylates delta-CREB, and a synthetic delta-CREB peptide. Biochem Cell Biol (1993) 1.00
The hepatitis B virus HBx protein induces adherens junction disruption in a src-dependent manner. Oncogene (2001) 1.00
Hepatitis B virus X protein differentially activates RAS-RAF-MAPK and JNK pathways in X-transforming versus non-transforming AML12 hepatocytes. J Biol Chem (2001) 0.98
Bacterial expression and characterization of the CREB bZip module: circular dichroism and 2D 1H-NMR studies. Protein Sci (1993) 0.94
BMP-2 stimulates tyrosinase gene expression and melanogenesis in differentiated melanocytes. Pigment Cell Res (2001) 0.93
Different regions of hepatitis B virus X protein are required for enhancement of bZip-mediated transactivation versus transrepression. J Virol (2000) 0.89
Cyclic AMP signaling functions as a bimodal switch in sympathoadrenal cell development in cultured primary neural crest cells. Mol Cell Biol (2000) 0.87
Binding constant determination studies utilizing recombinant delta CREB protein. DNA Cell Biol (1993) 0.87
Integration, expression and germ-line transmission of foreign growth hormone genes in medaka (Oryzias latipes). Mol Mar Biol Biotechnol (1993) 0.86
Purification and characterization of a 43-kDa transcription factor required for rat somatostatin gene expression. J Biol Chem (1989) 0.85
Differential expression of sympathoadrenal lineage-determining genes and phenotypic markers in cultured primary neural crest cells. In Vitro Cell Dev Biol Anim (2001) 0.80
Cloning of the canine interleukin-2-encoding cDNA. Gene (1995) 0.75
Multiple regions of the porcine alpha-skeletal actin gene modulate muscle-specific expression in cell culture and directly injected skeletal muscle. Anim Biotechnol (1998) 0.75