Published in Cell on May 19, 1995
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Microtubules induce self-organization of polarized PAR domains in Caenorhabditis elegans zygotes. Nat Cell Biol (2011) 1.58
Stabilization of cell polarity by the C. elegans RING protein PAR-2. Dev Cell (2006) 1.57
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Dynein modifiers in C. elegans: light chains suppress conditional heavy chain mutants. PLoS Genet (2007) 1.47
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Immune system dysfunction and autoimmune disease in mice lacking Emk (Par-1) protein kinase. Mol Cell Biol (2001) 1.43
Elaborating polarity: PAR proteins and the cytoskeleton. Development (2011) 1.40
A mutational analysis of dishevelled in Drosophila defines novel domains in the dishevelled protein as well as novel suppressing alleles of axin. Genetics (2002) 1.39
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PAR-1 kinase phosphorylates Dlg and regulates its postsynaptic targeting at the Drosophila neuromuscular junction. Neuron (2007) 1.31
ncl-1 is required for the regulation of cell size and ribosomal RNA synthesis in Caenorhabditis elegans. J Cell Biol (1998) 1.30
Myotactin, a novel hypodermal protein involved in muscle-cell adhesion in Caenorhabditis elegans. J Cell Biol (1999) 1.30
Interaction of PAR-6 with CDC-42 is required for maintenance but not establishment of PAR asymmetry in C. elegans. Dev Biol (2006) 1.28
Symmetry breaking and polarization of the C. elegans zygote by the polarity protein PAR-2. Development (2010) 1.28
MARK2/EMK1/Par-1Balpha phosphorylation of Rab11-family interacting protein 2 is necessary for the timely establishment of polarity in Madin-Darby canine kidney cells. Mol Biol Cell (2006) 1.27
Loss of the Par-1b/MARK2 polarity kinase leads to increased metabolic rate, decreased adiposity, and insulin hypersensitivity in vivo. Proc Natl Acad Sci U S A (2007) 1.25
The coronin-like protein POD-1 is required for anterior-posterior axis formation and cellular architecture in the nematode caenorhabditis elegans. Genes Dev (1999) 1.22
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LKB1 regulates polarity remodeling and adherens junction formation in the Drosophila eye. Proc Natl Acad Sci U S A (2009) 1.20
Numb-associated kinase interacts with the phosphotyrosine binding domain of Numb and antagonizes the function of Numb in vivo. Mol Cell Biol (1998) 1.19
Phenotypic and molecular analysis of mes-3, a maternal-effect gene required for proliferation and viability of the germ line in C. elegans. Genetics (1995) 1.19
The development of cell processes induced by tau protein requires phosphorylation of serine 262 and 356 in the repeat domain and is inhibited by phosphorylation in the proline-rich domains. Mol Biol Cell (1999) 1.17
Regulation of the MEX-5 gradient by a spatially segregated kinase/phosphatase cycle. Cell (2011) 1.17
Functional overlap between the mec-8 gene and five sym genes in Caenorhabditis elegans. Genetics (1999) 1.15
A genomewide screen for suppressors of par-2 uncovers potential regulators of PAR protein-dependent cell polarity in Caenorhabditis elegans. Genetics (2006) 1.15
Bazooka and atypical protein kinase C are required to regulate oocyte differentiation in the Drosophila ovary. Proc Natl Acad Sci U S A (2001) 1.15
A C. elegans patched gene, ptc-1, functions in germ-line cytokinesis. Genes Dev (2000) 1.15
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Modulation of KSR activity in Caenorhabditis elegans by Zn ions, PAR-1 kinase and PP2A phosphatase. EMBO J (2003) 1.15
The polarity-inducing kinase Par-1 controls Xenopus gastrulation in cooperation with 14-3-3 and aPKC. EMBO J (2004) 1.14
Post-transcriptional regulation of sex determination in Caenorhabditis elegans: widespread expression of the sex-determining gene fem-1 in both sexes. Mol Biol Cell (1996) 1.12
Autosomal genes of autosomal/X-linked duplicated gene pairs and germ-line proliferation in Caenorhabditis elegans. Genetics (2005) 1.11
A critical role for the PAR-1/MARK-tau axis in mediating the toxic effects of Aβ on synapses and dendritic spines. Hum Mol Genet (2011) 1.10
aPKC Cycles between Functionally Distinct PAR Protein Assemblies to Drive Cell Polarity. Dev Cell (2017) 1.10
High-throughput phenotyping of multicellular organisms: finding the link between genotype and phenotype. Genome Biol (2011) 1.09
The C. elegans homolog of Drosophila Lethal giant larvae functions redundantly with PAR-2 to maintain polarity in the early embryo. Development (2010) 1.09
Par-1 promotes a hepatic mode of apical protein trafficking in MDCK cells. Proc Natl Acad Sci U S A (2004) 1.09
Postembryonic RNAi in Heterorhabditis bacteriophora: a nematode insect parasite and host for insect pathogenic symbionts. BMC Dev Biol (2007) 1.09
ROCK1-directed basement membrane positioning coordinates epithelial tissue polarity. Development (2012) 1.08
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New genes with roles in the C. elegans embryo revealed using RNAi of ovary-enriched ORFeome clones. Genome Res (2005) 1.07
The role of LKB1 in lung cancer. Fam Cancer (2011) 1.07
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The PAR network: redundancy and robustness in a symmetry-breaking system. Philos Trans R Soc Lond B Biol Sci (2013) 1.06
Transgenic nonhuman primates for neurodegenerative diseases. Reprod Biol Endocrinol (2004) 1.06
Specification of germ cell fates by FOG-3 has been conserved during nematode evolution. Genetics (2001) 1.03
Role of partitioning-defective 1/microtubule affinity-regulating kinases in the morphogenetic activity of Helicobacter pylori CagA. J Biol Chem (2009) 1.03
Caenorhabditis elegans screen reveals role of PAR-5 in RAB-11-recycling endosome positioning and apicobasal cell polarity. Nat Cell Biol (2012) 1.03
Shhh! Silencing by microRNA-155. Philos Trans R Soc Lond B Biol Sci (2009) 1.02
MES-1, a protein required for unequal divisions of the germline in early C. elegans embryos, resembles receptor tyrosine kinases and is localized to the boundary between the germline and gut cells. Development (2000) 1.01
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Regulation of neurocoel morphogenesis by Pard6 gamma b. Dev Biol (2008) 1.01
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An atypical PKC directly associates and colocalizes at the epithelial tight junction with ASIP, a mammalian homologue of Caenorhabditis elegans polarity protein PAR-3. J Cell Biol (1998) 3.04
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Asymmetrically distributed PAR-3 protein contributes to cell polarity and spindle alignment in early C. elegans embryos. Cell (1995) 2.90
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Crossing over during Caenorhabditis elegans meiosis requires a conserved MutS-based pathway that is partially dispensable in budding yeast. Genetics (1999) 2.54
Atypical protein kinase C cooperates with PAR-3 to establish embryonic polarity in Caenorhabditis elegans. Development (1998) 2.47
par-6, a gene involved in the establishment of asymmetry in early C. elegans embryos, mediates the asymmetric localization of PAR-3. Development (1996) 2.31
PAR-6 is a conserved PDZ domain-containing protein that colocalizes with PAR-3 in Caenorhabditis elegans embryos. Development (1999) 2.21
A non-muscle myosin required for embryonic polarity in Caenorhabditis elegans. Nature (1996) 2.14
PAR-2 is asymmetrically distributed and promotes association of P granules and PAR-1 with the cortex in C. elegans embryos. Development (1996) 2.00
Mutations affecting the meiotic and mitotic divisions of the early Caenorhabditis elegans embryo. Genetics (1990) 1.97
Two loci required for cytoplasmic organization in early embryos of Caenorhabditis elegans. Dev Biol (1986) 1.86
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