Published in Virology on July 01, 1976
Viral integration and excision: structure of the lambda att sites. Science (1977) 6.66
Site-specific recombination functions of bacteriophage lambda: DNA sequence of regulatory regions and overlapping structural genes for Int and Xis. Proc Natl Acad Sci U S A (1980) 3.08
Integrative recombination of bacteriophage lambda: extent of the DNA sequence involved in attachment site function. Proc Natl Acad Sci U S A (1980) 1.97
Mutations in an integration host factor-binding site: effect on lambda site-specific recombination and regulatory implications. J Bacteriol (1986) 1.42
Nucleotide sequence of a secondary attachment site for bacteriophage lambda on the Escherichia coli chromosome. Nucleic Acids Res (1979) 1.00
Structure of the lambda att sites generated by int-dependent deletions. Proc Natl Acad Sci U S A (1978) 0.98
Secondary lambda attachment site in the threonine operon attenuator of Escherichia coli. J Bacteriol (1981) 0.90
Determination of the endpoints of partial deletion mutants of the attachment site of bacteriophage lambda by DNA sequencing. Nucleic Acids Res (1978) 0.85
Nalidixic acid resistance: a second genetic character involved in DNA gyrase activity. Proc Natl Acad Sci U S A (1977) 18.37
DNA gyrase: an enzyme that introduces superhelical turns into DNA. Proc Natl Acad Sci U S A (1976) 17.42
Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells. Cell (1986) 8.53
Retroviral DNA integration: structure of an integration intermediate. Cell (1988) 8.48
Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues. Proc Natl Acad Sci U S A (1987) 7.38
Biochemical, cellular, and pharmacological aspects of the multidrug transporter. Annu Rev Pharmacol Toxicol (1999) 6.62
HIV-1 DNA integration: mechanism of viral DNA cleavage and DNA strand transfer. Cell (1991) 6.54
Expression of a multidrug-resistance gene in human tumors and tissues. Proc Natl Acad Sci U S A (1987) 5.65
DNA gyrase: subunit structure and ATPase activity of the purified enzyme. Proc Natl Acad Sci U S A (1978) 5.60
Crystal structure of an IHF-DNA complex: a protein-induced DNA U-turn. Cell (1996) 5.38
Extrachromosomal DNA substrates in pre-B cells undergo inversion or deletion at immunoglobulin V-(D)-J joining signals. Cell (1987) 4.70
Genetics and function of DNA ligase in Escherichia coli. J Mol Biol (1973) 4.52
Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine. Proc Natl Acad Sci U S A (1987) 4.43
The defect in murine severe combined immune deficiency: joining of signal sequences but not coding segments in V(D)J recombination. Cell (1988) 4.34
V(D)J recombination: a functional definition of the joining signals. Genes Dev (1989) 3.96
DNA gyrase action involves the introduction of transient double-strand breaks into DNA. Proc Natl Acad Sci U S A (1980) 3.87
Developmental stage specificity of the lymphoid V(D)J recombination activity. Genes Dev (1987) 3.65
Similarities between initiation of V(D)J recombination and retroviral integration. Science (1996) 3.64
T4 endonuclease VII cleaves holliday structures. Cell (1982) 3.47
Modulation of activity of the promoter of the human MDR1 gene by Ras and p53. Science (1992) 3.41
Site-specific recognition of the bacteriophage Mu ends by the Mu A protein. Cell (1984) 3.33
Restriction assay for integrative recombination of bacteriophage lambda DNA in vitro: requirement for closed circular DNA substrate. Proc Natl Acad Sci U S A (1976) 3.32
Isolation and genetic characterization of human KB cell lines resistant to multiple drugs. Somat Cell Mol Genet (1985) 3.23
Human multidrug-resistant cell lines: increased mdr1 expression can precede gene amplification. Science (1986) 3.22
Isolation of human mdr DNA sequences amplified in multidrug-resistant KB carcinoma cells. Proc Natl Acad Sci U S A (1986) 3.19
DNA gyrase and DNA supercoiling. Cold Spring Harb Symp Quant Biol (1979) 3.16
Reduced drug accumulation in multiply drug-resistant human KB carcinoma cell lines. Cancer Res (1985) 3.15
The human multidrug resistance (mdr1) gene. cDNA cloning and transcription initiation. J Biol Chem (1987) 3.13
Cruciform structures in palindromic DNA are favored by DNA supercoiling. J Mol Biol (1982) 3.03
Structure and function of the phage lambda att site: size, int-binding sites, and location of the crossover point. Cold Spring Harb Symp Quant Biol (1981) 2.99
Cloning and simplified purification of Escherichia coli DNA gyrase A and B proteins. J Biol Chem (1984) 2.98
Multiple drug-resistant human KB carcinoma cells independently selected for high-level resistance to colchicine, adriamycin, or vinblastine show changes in expression of specific proteins. J Biol Chem (1986) 2.93
DNA sequence of the E. coli gyrB gene: application of a new sequencing strategy. Nucleic Acids Res (1987) 2.93
HIV-1 protease inhibitors are substrates for the MDR1 multidrug transporter. Biochemistry (1998) 2.87
Site-specific interaction of DNA gyrase with DNA. Proc Natl Acad Sci U S A (1981) 2.75
Transposition of Mu DNA: joining of Mu to target DNA can be uncoupled from cleavage at the ends of Mu. Cell (1987) 2.73
Is the multidrug transporter a flippase? Trends Biochem Sci (1992) 2.68
Characterization of bacteriophage lambda reverse as an Escherichia coli phage carrying a unique set of host-derived recombination functions. J Mol Biol (1974) 2.64
The coding function of nucleotide sequences can be discerned by statistical analysis. J Theor Biol (1981) 2.61
Mechanism of transposition of bacteriophage Mu: structure of a transposition intermediate. Cell (1985) 2.59
Fluorescent cellular indicators are extruded by the multidrug resistance protein. J Biol Chem (1993) 2.52
A defined system for the DNA strand-transfer reaction at the initiation of bacteriophage Mu transposition: protein and DNA substrate requirements. Proc Natl Acad Sci U S A (1985) 2.50
Structure of the bacteriophage Mu transposase core: a common structural motif for DNA transposition and retroviral integration. Cell (1995) 2.44
Mutant immunoglobulin genes have repetitive DNA elements inserted into their intervening sequences. Proc Natl Acad Sci U S A (1982) 2.44
ATP-dependent transport of vinblastine in vesicles from human multidrug-resistant cells. Proc Natl Acad Sci U S A (1988) 2.44
alpha-Galactosidase A deficient mice: a model of Fabry disease. Proc Natl Acad Sci U S A (1997) 2.43
Slow cruciform transitions in palindromic DNA. Proc Natl Acad Sci U S A (1983) 2.42
Deletions in immunoglobulin mu chains. EMBO J (1982) 2.35
Production of functional chimaeric mouse/human antibody. Nature (1985) 2.35
Novel strand exchanges in V(D)J recombination. Cell (1988) 2.31
Assembly of the active form of the transposase-Mu DNA complex: a critical control point in Mu transposition. Cell (1992) 2.30
Localization of multidrug resistance-associated DNA sequences to human chromosome 7. Somat Cell Mol Genet (1986) 2.27
Mechanism of bacteriophage mu transposition. Annu Rev Genet (1986) 2.26
Role of DNA topology in Mu transposition: mechanism of sensing the relative orientation of two DNA segments. Cell (1986) 2.18
The phage Mu transpososome core: DNA requirements for assembly and function. EMBO J (1995) 2.14
Single cell analysis of daunomycin uptake and efflux in multidrug-resistant and -sensitive KB cells: effects of verapamil and other drugs. Cancer Res (1986) 2.12
Barrier-to-autointegration factor (BAF) bridges DNA in a discrete, higher-order nucleoprotein complex. Proc Natl Acad Sci U S A (2000) 2.12
Evidence for two nonidentical drug-interaction sites in the human P-glycoprotein. Proc Natl Acad Sci U S A (1997) 2.10
In vitro transposition of bacteriophage Mu: a biochemical approach to a novel replication reaction. Cell (1983) 2.08
Membrane vesicles from multidrug-resistant human cancer cells contain a specific 150- to 170-kDa protein detected by photoaffinity labeling. Proc Natl Acad Sci U S A (1986) 2.08
Mu transpositional recombination: donor DNA cleavage and strand transfer in trans by the Mu transposase. Cell (1996) 2.08
Involement of supertwisted DNA in integrative recombination of bacteriophage lambda. J Mol Biol (1978) 2.07
Functional immunoglobulin M production after transfection of cloned immunoglobulin heavy and light chain genes into lymphoid cells. Proc Natl Acad Sci U S A (1983) 2.03
In vitro assembly of homopolymer and copolymer filaments from intermediate filament subunits of muscle and fibroblastic cells. Proc Natl Acad Sci U S A (1981) 2.02
Certain calcium channel blockers bind specifically to multidrug-resistant human KB carcinoma membrane vesicles and inhibit drug binding to P-glycoprotein. J Biol Chem (1987) 1.99
Integrative recombination of bacteriophage lambda: extent of the DNA sequence involved in attachment site function. Proc Natl Acad Sci U S A (1980) 1.97
Target immunity of Mu transposition reflects a differential distribution of Mu B protein. Cell (1988) 1.96
Lymphoid V(D)J recombination: nucleotide insertion at signal joints as well as coding joints. Proc Natl Acad Sci U S A (1988) 1.95
A large nucleoprotein assembly at the ends of the viral DNA mediates retroviral DNA integration. EMBO J (1997) 1.94
Efficient Mu transposition requires interaction of transposase with a DNA sequence at the Mu operator: implications for regulation. Cell (1989) 1.93
Acquisition of a determinant for chloramphenicol resistance by coliphage lambda. Proc Natl Acad Sci U S A (1975) 1.93
Immunohistochemical localization in normal tissues of different epitopes in the multidrug transport protein P170: evidence for localization in brain capillaries and crossreactivity of one antibody with a muscle protein. J Histochem Cytochem (1989) 1.89
Multidrug resistance of DNA-mediated transformants is linked to transfer of the human mdr1 gene. Mol Cell Biol (1986) 1.89
DNA-promoted assembly of the active tetramer of the Mu transposase. Genes Dev (1992) 1.88
CHO mutants resistant to colchicine, colcemid or griseofulvin have an altered beta-tubulin. Cell (1980) 1.88
Photosensitized labeling of a functional multidrug transporter in living drug-resistant tumor cells. J Biol Chem (1990) 1.86
Integrative recombination of bacteriophage lambda: in vitro study of the intermolecular reaction. Cold Spring Harb Symp Quant Biol (1979) 1.86
Properties of recombination-deficient mutants of bacteriophage lambda. J Mol Biol (1970) 1.80
Regulation of DNA supercoiling in Escherichia coli. Cold Spring Harb Symp Quant Biol (1983) 1.77
Imaging the function of P-glycoprotein with radiotracers: pharmacokinetics and in vivo applications. Clin Pharmacol Ther (2009) 1.77
MuB protein allosterically activates strand transfer by the transposase of phage Mu. Cell (1991) 1.75
Human P-glycoprotein exhibits reduced affinity for substrates during a catalytic transition state. Biochemistry (1998) 1.75
Increased vinblastine binding to membrane vesicles from multidrug-resistant KB cells. J Biol Chem (1986) 1.74
Division of labor among monomers within the Mu transposase tetramer. Cell (1993) 1.73
The mdr1 gene, responsible for multidrug-resistance, codes for P-glycoprotein. Biochem Biophys Res Commun (1986) 1.71
Partial purification and reconstitution of the human multidrug-resistance pump: characterization of the drug-stimulatable ATP hydrolysis. Proc Natl Acad Sci U S A (1992) 1.70
Homologous recombination can restore normal immunoglobulin production in a mutant hybridoma cell line. Proc Natl Acad Sci U S A (1988) 1.70
Amplification of DNA sequences in human multidrug-resistant KB carcinoma cells. Proc Natl Acad Sci U S A (1985) 1.66
A rapid in vitro assay for HIV DNA integration. Nucleic Acids Res (1991) 1.65
B protein of bacteriophage mu is an ATPase that preferentially stimulates intermolecular DNA strand transfer. Proc Natl Acad Sci U S A (1987) 1.64
Interaction of proteins located at a distance along DNA: mechanism of target immunity in the Mu DNA strand-transfer reaction. Cell (1989) 1.62
A retrovirus carrying an MDR1 cDNA confers multidrug resistance and polarized expression of P-glycoprotein in MDCK cells. Proc Natl Acad Sci U S A (1988) 1.60
Mutations affecting the structure and function of immunoglobulin M. Mol Cell Biol (1982) 1.58
DNA sequence and transcription of the region upstream of the E. coli gyrB gene. Nucleic Acids Res (1984) 1.57
MDR1 gene expression in lung cancer. J Natl Cancer Inst (1989) 1.57
Immunoglobulin production by lymphocyte hybridomas. Eur J Immunol (1978) 1.56
Transposition of two different intracisternal A particle elements into an immunoglobulin kappa-chain gene. Mol Cell Biol (1984) 1.55
DNA-PKcs: a T-cell tumour suppressor encoded at the mouse scid locus. Nat Genet (1997) 1.55
Genomic organization of the human multidrug resistance (MDR1) gene and origin of P-glycoproteins. J Biol Chem (1990) 1.54
Paclitaxel chemotherapy after autologous stem-cell transplantation and engraftment of hematopoietic cells transduced with a retrovirus containing the multidrug resistance complementary DNA (MDR1) in metastatic breast cancer patients. Clin Cancer Res (1999) 1.54